MA27881A1 - Derives d'imidazole utilises comme antagonistes du recepteur du glutamate - Google Patents

Derives d'imidazole utilises comme antagonistes du recepteur du glutamate

Info

Publication number
MA27881A1
MA27881A1 MA28648A MA28648A MA27881A1 MA 27881 A1 MA27881 A1 MA 27881A1 MA 28648 A MA28648 A MA 28648A MA 28648 A MA28648 A MA 28648A MA 27881 A1 MA27881 A1 MA 27881A1
Authority
MA
Morocco
Prior art keywords
receptor antagonists
imidazole derivatives
glutamate receptor
derivatives
mglur5 receptor
Prior art date
Application number
MA28648A
Other languages
English (en)
Inventor
Bernd Buettelmann
Simona Maria Ceccarelli
Georg Jaeschke
Richard Hugh Philip Porter
Eric Vieira
Sabine Kolczewski
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA27881A1 publication Critical patent/MA27881A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des dérivés imidazole qui sont des antagonistes du récepteur mGluR5, et qui sont représentés par la formule générale (I): dans laquelle R1, R2, R3 et R4 sont tels que définis dans le descriptif, un procédé permettant de produire ces dérivés, ainsi que des sels pharmaceutiquement acceptables servant à la préparation d'un médicament destiné au traitement ou à la prévention de troubles dans lesquels le récepteur mGluR5 intervient comme médiateur, tels que les troubles neurologiques aigus et/ou chroniques.
MA28648A 2003-06-05 2005-12-09 Derives d'imidazole utilises comme antagonistes du recepteur du glutamate MA27881A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03012200 2003-06-05

Publications (1)

Publication Number Publication Date
MA27881A1 true MA27881A1 (fr) 2006-05-02

Family

ID=33483899

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28648A MA27881A1 (fr) 2003-06-05 2005-12-09 Derives d'imidazole utilises comme antagonistes du recepteur du glutamate

Country Status (38)

Country Link
US (3) US7332510B2 (fr)
EP (1) EP1636206B1 (fr)
JP (1) JP4401384B2 (fr)
KR (1) KR100778948B1 (fr)
CN (1) CN100408572C (fr)
AR (1) AR044478A1 (fr)
AT (1) ATE377008T1 (fr)
AU (1) AU2004245208B2 (fr)
BR (1) BRPI0411095B8 (fr)
CA (1) CA2527315C (fr)
CL (1) CL2004001347A1 (fr)
CR (1) CR8094A (fr)
CY (1) CY1107856T1 (fr)
DE (1) DE602004009796T2 (fr)
DK (1) DK1636206T3 (fr)
EA (1) EA010577B1 (fr)
EC (1) ECSP056202A (fr)
ES (1) ES2294504T3 (fr)
GT (1) GT200400117A (fr)
HN (1) HN2004000208A (fr)
HR (1) HRP20070529T3 (fr)
IL (1) IL171930A (fr)
MA (1) MA27881A1 (fr)
MX (1) MXPA05013149A (fr)
MY (2) MY137272A (fr)
NO (1) NO332143B1 (fr)
NZ (1) NZ543637A (fr)
PA (1) PA8604101A1 (fr)
PE (1) PE20050162A1 (fr)
PL (1) PL1636206T3 (fr)
PT (1) PT1636206E (fr)
RS (1) RS53183B (fr)
SI (1) SI1636206T1 (fr)
TN (2) TNSN05309A1 (fr)
TW (1) TWI338007B (fr)
UA (1) UA80888C2 (fr)
WO (1) WO2004108701A1 (fr)
ZA (2) ZA200509807B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA80888C2 (en) * 2003-06-05 2007-11-12 Hoffmann La Roche Imidazole derivatives as glutmate receptor antagonists
US7531529B2 (en) 2003-06-05 2009-05-12 Roche Palo Alto Llc Imidazole derivatives
US7452909B2 (en) 2003-09-04 2008-11-18 Hoffman-La Roche Inc. Imidazole derivatives
HRP20080363T3 (hr) 2004-06-01 2008-09-30 F. Hoffmann - La Roche Ag Piridin-4-il-etinil-imidazoli i pirazoli kao antagonisti mglu5 receptora
GB0514296D0 (en) * 2005-07-12 2005-08-17 Novartis Ag Organic compounds
DE102006011574A1 (de) * 2006-03-10 2007-10-31 Grünenthal GmbH Substituierte Imidazo[2,1-b]thiazol-Verbindungen und ihre Verwendung zur Herstellung von Arzneimitteln
AU2007336369B2 (en) * 2006-12-21 2013-01-17 F. Hoffmann-La Roche Ag Polymorphs of a mGluR5 receptor antagonist
US8334287B2 (en) * 2009-07-17 2012-12-18 Hoffmann-La Roche Inc. Imidazoles
US20120040008A1 (en) 2010-08-11 2012-02-16 Ashish Chatterji Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists
US20120039999A1 (en) 2010-08-11 2012-02-16 Ashish Chatterji Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists
EA201391348A8 (ru) 2011-03-18 2014-11-28 Новартис Аг КОМБИНАЦИИ АКТИВАТОРОВ АЛЬФА-7 НИКОТИНОВОГО АЦЕТИЛХОЛИНОВОГО РЕЦЕПТОРА И АНТАГОНИСТОВ mGluR5, ПРЕДНАЗНАЧЕННЫЕ ДЛЯ ПРИМЕНЕНИЯ ПРИ ВЫЗВАННОЙ ДОПАМИНОМ ДИСКИНЕЗИИ, СВЯЗАННОЙ С БОЛЕЗНЬЮ ПАРКИНСОНА
UA114008C2 (xx) * 2012-10-18 2017-04-10 Похідні етинілу як модулятори активності рецептора mglur5
MY168937A (en) * 2012-10-18 2019-01-10 Hoffmann La Roche Ethynyl derivatives as modulators of mglur5 receptor activity
ES2975136T3 (es) * 2016-03-30 2024-07-03 Sinntaxis AB Moduladores alost alostéricos negativos de MGLUR5 para uso en el tratamiento de daños cerebrales maduros
CN114746408B (zh) * 2019-12-02 2025-02-14 豪夫迈·罗氏有限公司 炔基-(杂芳基)-甲酰胺hcn1抑制剂
MX2022015407A (es) 2020-06-05 2023-05-16 Noema Pharma Ag Metodos de tratamiento del complejo de esclerosis tuberosa.
TWI924682B (zh) * 2020-07-30 2026-05-11 瑞士商諾埃瑪製藥公司 三叉神經痛之治療方法
CN120641098A (zh) 2023-02-02 2025-09-12 诺埃玛制药公司 Dravet综合征的治疗方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4508560A (en) 1981-11-11 1985-04-02 Ciba Geigy Corporation Certain pyridylacetylene compounds, compositions containing same and herbicidal methods of use
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
JP4815083B2 (ja) 1999-08-31 2011-11-16 メルク・シャープ・エンド・ドーム・コーポレイション 複素環化合物およびそれの使用方法
JP5154728B2 (ja) * 2000-07-24 2013-02-27 クレニツキー・ファーマシューティカルズ，インコーポレイテッド 神経栄養活性を有する置換５−アルキニルピリミジン
NZ525917A (en) * 2000-12-04 2005-11-25 F Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists and their use in treating mGLuR5 receptor mediated disorders
EP1458385A4 (fr) * 2001-12-19 2005-12-21 Merck & Co Inc Imidazoles substitues par heteroaryle modulateurs du recepteur metabotropique du glutamate de type 5
JP2006513996A (ja) * 2002-10-24 2006-04-27 メルク　エンド　カムパニー　インコーポレーテッド 代謝調節型グルタミン酸受容体結合用トレーサーとしてのアルキン誘導体
TWI292318B (en) * 2003-03-10 2008-01-11 Hoffmann La Roche Imidazol-4-yl-ethynyl-pyridine derivatives
UA80888C2 (en) * 2003-06-05 2007-11-12 Hoffmann La Roche Imidazole derivatives as glutmate receptor antagonists
US7091222B2 (en) * 2003-07-03 2006-08-15 Hoffmann-La Roche Inc. Imidazole derivatives

Also Published As

Publication number Publication date
PA8604101A1 (es) 2004-12-16
EA010577B1 (ru) 2008-10-30
AR044478A1 (es) 2005-09-14
TW200509920A (en) 2005-03-16
DE602004009796D1 (de) 2007-12-13
ES2294504T3 (es) 2008-04-01
CN100408572C (zh) 2008-08-06
UA80888C2 (en) 2007-11-12
ZA200509807B (en) 2006-12-27
RS53183B (sr) 2014-06-30
DK1636206T3 (da) 2008-02-11
ATE377008T1 (de) 2007-11-15
EP1636206B1 (fr) 2007-10-31
PE20050162A1 (es) 2005-03-22
HK1093070A1 (zh) 2007-02-23
US7332510B2 (en) 2008-02-19
KR100778948B1 (ko) 2007-11-28
NO20055465L (no) 2005-11-18
CR8094A (es) 2006-05-30
GT200400117A (es) 2005-02-07
NO332143B1 (no) 2012-07-02
PL1636206T3 (pl) 2008-04-30
MXPA05013149A (es) 2006-03-17
HN2004000208A (es) 2009-02-03
CA2527315A1 (fr) 2004-12-16
NZ543637A (en) 2008-04-30
BRPI0411095A (pt) 2006-07-18
JP4401384B2 (ja) 2010-01-20
ECSP056202A (es) 2006-04-19
SI1636206T1 (sl) 2008-02-29
ZA200609681B (en) 2008-06-25
BRPI0411095B8 (pt) 2021-05-25
US20040248888A1 (en) 2004-12-09
TNSN05309A1 (fr) 2007-07-10
RS20050892A (sr) 2007-12-31
EP1636206A1 (fr) 2006-03-22
MY137272A (en) 2009-01-30
AU2004245208A1 (en) 2004-12-16
IL171930A0 (en) 2006-04-10
IL171930A (en) 2010-12-30
JP2006526588A (ja) 2006-11-24
BRPI0411095B1 (pt) 2018-04-03
DE602004009796T2 (de) 2008-08-28
HRP20070529T3 (hr) 2008-05-31
CL2004001347A1 (es) 2005-05-06
PT1636206E (pt) 2008-01-28
WO2004108701A1 (fr) 2004-12-16
US20080119489A1 (en) 2008-05-22
TNSN06391A1 (fr) 2008-02-22
CN1802367A (zh) 2006-07-12
TWI338007B (en) 2011-03-01
US8481548B2 (en) 2013-07-09
CY1107856T1 (el) 2013-06-19
MY143353A (en) 2011-04-29
CA2527315C (fr) 2010-08-10
EA200501887A1 (ru) 2006-10-27
KR20060057537A (ko) 2006-05-26
US20080103306A1 (en) 2008-05-01
AU2004245208B2 (en) 2007-04-26
US7973165B2 (en) 2011-07-05

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