BRPI0414460A - compostos derivados de carboxamida do tipo de amida, composição farmacêutica e respectivo uso - Google Patents

compostos derivados de carboxamida do tipo de amida, composição farmacêutica e respectivo uso

Info

Publication number
BRPI0414460A
BRPI0414460A BRPI0414460-0A BRPI0414460A BRPI0414460A BR PI0414460 A BRPI0414460 A BR PI0414460A BR PI0414460 A BRPI0414460 A BR PI0414460A BR PI0414460 A BRPI0414460 A BR PI0414460A
Authority
BR
Brazil
Prior art keywords
group
formula
pharmaceutical composition
amide type
carboxamide derivatives
Prior art date
Application number
BRPI0414460-0A
Other languages
English (en)
Inventor
Takayuki Kawaguchi
Hidenori Akatsuka
Masamichi Morimoto
Toru Iijima
Jun Murakami
Tatsuya Watanabe
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of BRPI0414460A publication Critical patent/BRPI0414460A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)

Abstract

"COMPOSTOS DERIVADOS DE CARBOXAMIDA DO TIPO DE AMIDA, COMPOSIçãO FARMACêUTICA E RESPECTIVO USO". A presente invenção refere-se a um derivado de carboxamida do tipo amida da fórmula ¢1!: em que X é um grupo da fórmula: -N= ou da fórmula: -CH=; R¬ 1¬ é um átomo de halogênio, um grupo alquila inferior, e similares; R¬ 2¬ é um grupo da fórmula: e similares; Y¬ 1¬ e Y¬ 2¬ são os mesmos ou diferentes e cada um é um grupo selecionado entre um átomo de halogênio, um grupo alquila inferior, um grupo alcóxi inferior, e similares; anel A é grupo fenila, e similares, ou um sal farmaceuticamente aceitável do mesmo, o qual é útila como um inibidor de FXa.
BRPI0414460-0A 2003-09-26 2004-09-24 compostos derivados de carboxamida do tipo de amida, composição farmacêutica e respectivo uso BRPI0414460A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003334595 2003-09-26
PCT/JP2004/013892 WO2005030706A1 (ja) 2003-09-26 2004-09-24 アミド型カルボキサミド誘導体

Publications (1)

Publication Number Publication Date
BRPI0414460A true BRPI0414460A (pt) 2006-11-14

Family

ID=34386034

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414460-0A BRPI0414460A (pt) 2003-09-26 2004-09-24 compostos derivados de carboxamida do tipo de amida, composição farmacêutica e respectivo uso

Country Status (17)

Country Link
US (1) US7375119B2 (pt)
EP (1) EP1666455A4 (pt)
JP (1) JP4571075B2 (pt)
KR (1) KR100740820B1 (pt)
CN (1) CN100475777C (pt)
AR (1) AR045816A1 (pt)
AU (1) AU2004276128B2 (pt)
BR (1) BRPI0414460A (pt)
CA (1) CA2538072C (pt)
IL (1) IL174188A0 (pt)
MX (1) MXPA06003382A (pt)
NO (1) NO20061832L (pt)
NZ (1) NZ546160A (pt)
RU (1) RU2307829C2 (pt)
TW (1) TW200512181A (pt)
WO (1) WO2005030706A1 (pt)
ZA (1) ZA200602131B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7875627B2 (en) 2004-12-07 2011-01-25 Abbott Laboratories Thienopyridyl compounds that inhibit vanilloid receptor subtype 1 (VR1) and uses thereof
TW200734304A (en) * 2005-11-08 2007-09-16 Astellas Pharma Inc Benzene derivative or salt thereof
CN102675279A (zh) 2006-11-15 2012-09-19 Viro化学制药公司 用于治疗或预防黄病毒属感染的噻吩类似物
ATE518872T1 (de) 2007-02-02 2011-08-15 Pfizer Prod Inc Trizyklische verbindungen und deren verwendung als glucocorticoidrezeptormodulatoren
EP2070924A1 (de) 2007-12-10 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Neue 2-Hetarylthiazol-4-carbonsäureamid-Derivative, deren Herstellung und Verwendung als Arzneimittel
EP2070916A1 (de) 2007-12-10 2009-06-17 Bayer Schering Pharma Aktiengesellschaft 2-Aryl-thiazol-4-carbonsäureamid-Derivate, deren Herstellung und Verwendung als Arzneimittel
EP2070925A1 (de) 2007-12-10 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Neue 2-substituierte Tiazol-4-carbonsäureamid-Derivative deren Herstellung und Verwendung als Arzneimittel
US8178583B2 (en) * 2008-12-19 2012-05-15 Hoffmann-La Roche Inc. Compounds
WO2010132554A2 (en) * 2009-05-12 2010-11-18 Mallinckrodt Inc. Diaza heterocyclic compounds for phototherapy
US20130261130A1 (en) * 2010-11-01 2013-10-03 Shaheen Ahmed Neurotrypsin inhibitors

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9306453D0 (en) * 1993-03-29 1993-05-19 Zeneca Ltd Heterocyclic derivatives
WO1999000121A1 (en) 1997-06-26 1999-01-07 Eli Lilly And Company Antithrombotic agents
EP1040108B1 (en) * 1997-12-19 2004-02-25 Schering Aktiengesellschaft Ortho-anthranilamide derivatives as anti-coagulants
EP0937711A1 (de) 1998-02-18 1999-08-25 Roche Diagnostics GmbH Neue Thiobenzamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
US6956988B2 (en) 1998-08-21 2005-10-18 Avanex Corporation Optical interleaver
WO2000039118A1 (en) * 1998-12-23 2000-07-06 Eli Lilly And Company Aromatic amides
ES2316383T3 (es) 1999-09-17 2009-04-16 Millennium Pharmaceuticals, Inc. Benzamidas e inhibidores relacionados del factor xa.
US7112594B2 (en) 2000-08-09 2006-09-26 Mitsubishi Pharma Corporation Fused bicyclic amide compounds and medicinal use thereof
US7163938B2 (en) * 2000-11-28 2007-01-16 Eli Lilly And Company Substituted carboxamides
DE60221505D1 (de) 2001-03-30 2007-09-13 Millennium Pharm Inc FAKTOR Xa BENZAMIDIN INHIBITOREN
US7312235B2 (en) 2001-03-30 2007-12-25 Millennium Pharmaceuticals, Inc. Benzamide inhibitors of factor Xa
CN110894196A (zh) * 2001-09-21 2020-03-20 百时美-施贵宝控股爱尔兰无限公司 含有内酰胺的化合物及其衍生物作为Xa因子的抑制剂
WO2003048081A2 (en) * 2001-12-04 2003-06-12 Bristol-Myers Squibb Company Glycinamides as factor xa inhibitors
ATE454381T1 (de) * 2002-03-28 2010-01-15 Mitsubishi Tanabe Pharma Corp Benzofuranderivat
JP2005104838A (ja) 2003-01-09 2005-04-21 Tanabe Seiyaku Co Ltd 縮合フラン化合物

Also Published As

Publication number Publication date
US20060287329A1 (en) 2006-12-21
EP1666455A4 (en) 2009-02-25
ZA200602131B (en) 2007-02-28
JPWO2005030706A1 (ja) 2006-12-07
AR045816A1 (es) 2005-11-16
IL174188A0 (en) 2006-08-01
KR20060095982A (ko) 2006-09-05
US7375119B2 (en) 2008-05-20
CN1860097A (zh) 2006-11-08
WO2005030706A1 (ja) 2005-04-07
AU2004276128B2 (en) 2007-11-29
MXPA06003382A (es) 2006-06-08
CN100475777C (zh) 2009-04-08
JP4571075B2 (ja) 2010-10-27
TW200512181A (en) 2005-04-01
EP1666455A1 (en) 2006-06-07
RU2006114055A (ru) 2006-09-10
KR100740820B1 (ko) 2007-07-19
AU2004276128A1 (en) 2005-04-07
CA2538072A1 (en) 2005-04-07
NO20061832L (no) 2006-04-25
RU2307829C2 (ru) 2007-10-10
NZ546160A (en) 2008-09-26
CA2538072C (en) 2009-08-25

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: MITSUBISHI TANABE PHARMA CORPORATION (JP)

Free format text: ALTERADO DE: TANABE SEIYAKU CO., LTD.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2168 DE 24/07/2012.