BRPI0414597A - derivados de benzofurano do tipo carbamoìla - Google Patents

derivados de benzofurano do tipo carbamoìla

Info

Publication number
BRPI0414597A
BRPI0414597A BRPI0414597-6A BRPI0414597A BRPI0414597A BR PI0414597 A BRPI0414597 A BR PI0414597A BR PI0414597 A BRPI0414597 A BR PI0414597A BR PI0414597 A BRPI0414597 A BR PI0414597A
Authority
BR
Brazil
Prior art keywords
carbamoyl
formula
type
benzofuran derivatives
ring
Prior art date
Application number
BRPI0414597-6A
Other languages
English (en)
Inventor
Takayuki Kawaguchi
Hidenori Akatsuka
Masamichi Morimoto
Tatsuya Watanabe
Toru Iijima
Jun Murakami
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of BRPI0414597A publication Critical patent/BRPI0414597A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE BENZOFURANO DO TIPO CARBAMOìLA". A presente invenção refere-se a um derivado de benzofurano do tipo carbamoíla da fórmula ¢1!: em que o Anel Z é um grupo da fórmula: etc.; A é uma ligação simples e similares; Y é um grupo cicloalcanodiila, etc.; R¬ 4¬ e R¬ 5¬ São os mesmos ou diferentes e cada um é um grupo alquila inferior opcionalmente substituído, etc.; R¬ 1¬ é um átomo de halogênio, etc.; o Anel B da fórmula: é um anel de benzeno opcionalmente substituído; e R¬ 3¬ é um átomo de hidrogênio, etc. ou um sal farmaceuticamente aceitável dos mesmos, o qual é usado como um inibidor de FXa.
BRPI0414597-6A 2003-09-26 2004-09-24 derivados de benzofurano do tipo carbamoìla BRPI0414597A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003334597 2003-09-26
PCT/JP2004/013891 WO2005030759A1 (ja) 2003-09-26 2004-09-24 カルバモイル型ベンゾフラン誘導体

Publications (1)

Publication Number Publication Date
BRPI0414597A true BRPI0414597A (pt) 2006-11-07

Family

ID=34386035

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414597-6A BRPI0414597A (pt) 2003-09-26 2004-09-24 derivados de benzofurano do tipo carbamoìla

Country Status (18)

Country Link
US (1) US7605158B2 (pt)
EP (1) EP1666478A4 (pt)
JP (1) JP4277022B2 (pt)
KR (1) KR100763294B1 (pt)
CN (1) CN100430392C (pt)
AR (1) AR046027A1 (pt)
AU (1) AU2004276127B2 (pt)
BR (1) BRPI0414597A (pt)
CA (1) CA2539471A1 (pt)
IL (1) IL174187A0 (pt)
MX (1) MXPA06003378A (pt)
MY (1) MY139258A (pt)
NO (1) NO20061831L (pt)
NZ (1) NZ546159A (pt)
RU (1) RU2319700C1 (pt)
TW (1) TW200524915A (pt)
WO (1) WO2005030759A1 (pt)
ZA (1) ZA200602130B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003221178B2 (en) * 2002-03-28 2006-06-15 Tanabe Seiyaku Co., Ltd. Benzofuran derivative
US20070049748A1 (en) * 2005-08-26 2007-03-01 Uppala Venkata Bhaskara R Preparation of ezetimibe
US9647851B2 (en) 2008-10-13 2017-05-09 Ppc Broadband, Inc. Ingress noise inhibiting network interface device and method for cable television networks
WO2013192517A2 (en) * 2012-06-21 2013-12-27 Whitehead Institute For Biomedical Research Compounds for treating infectious diseases
US20170312297A1 (en) * 2014-11-10 2017-11-02 Glaxosmithkline Intellectual Property (No. 2) Limited Long Acting Pharmaceutical Compositions For Hepatitis C
IL274291B2 (en) * 2017-11-03 2023-10-01 Univ Montreal Compounds and their use in proliferation of stem cells and/or progenitor cells
CN110407697A (zh) * 2019-08-28 2019-11-05 上海毕得医药科技有限公司 一种4-甲酰基-3-羟基苯甲酸甲酯的合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK148292D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Forbindelser
KR960703856A (ko) 1994-06-06 1996-08-31 가와노 다케히코 축합 고리를 갖는 카르복실산 화합물, 이의 염 및 이의 약학적 용도(novel fused-ring carboxylic acid compound or salt thereof, and medicinal use thereof)
CN1219171A (zh) * 1996-05-20 1999-06-09 达尔文发现有限公司 苯并呋喃甲酰胺及其治疗用途
US6140351A (en) 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
EP1040108B1 (en) * 1997-12-19 2004-02-25 Schering Aktiengesellschaft Ortho-anthranilamide derivatives as anti-coagulants
EP0937711A1 (de) * 1998-02-18 1999-08-25 Roche Diagnostics GmbH Neue Thiobenzamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
ATE272633T1 (de) * 1998-12-23 2004-08-15 Lilly Co Eli Aromatische amiden
US6720317B1 (en) 1999-09-17 2004-04-13 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
DE60040676D1 (de) 1999-09-17 2008-12-11 Millennium Pharm Inc BENZAMIDE UND ÄHNLICHE INHIBITOREN VON FAKTOR Xa
WO2002012189A1 (en) 2000-08-09 2002-02-14 Mitsubishi Pharma Corporation Fused bicyclic amide compounds and medicinal use thereof
ATE368643T1 (de) * 2001-03-30 2007-08-15 Millennium Pharm Inc Faktor xa benzamidin inhibitoren
AU2003221178B2 (en) * 2002-03-28 2006-06-15 Tanabe Seiyaku Co., Ltd. Benzofuran derivative
JP2005104838A (ja) * 2003-01-09 2005-04-21 Tanabe Seiyaku Co Ltd 縮合フラン化合物

Also Published As

Publication number Publication date
RU2319700C1 (ru) 2008-03-20
EP1666478A4 (en) 2008-12-03
JP4277022B2 (ja) 2009-06-10
CN100430392C (zh) 2008-11-05
CN1856488A (zh) 2006-11-01
WO2005030759A1 (ja) 2005-04-07
US20060247273A1 (en) 2006-11-02
EP1666478A1 (en) 2006-06-07
MXPA06003378A (es) 2006-06-08
MY139258A (en) 2009-09-30
CA2539471A1 (en) 2005-04-07
NZ546159A (en) 2009-06-26
AU2004276127B2 (en) 2008-02-07
AR046027A1 (es) 2005-11-23
ZA200602130B (en) 2007-03-28
TW200524915A (en) 2005-08-01
IL174187A0 (en) 2006-08-01
NO20061831L (no) 2006-04-25
AU2004276127A1 (en) 2005-04-07
US7605158B2 (en) 2009-10-20
JPWO2005030759A1 (ja) 2006-12-07
RU2006114056A (ru) 2007-11-10
KR20060073963A (ko) 2006-06-29
KR100763294B1 (ko) 2007-10-04

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: MITSUBISHI TANABE PHARMA CORPORATION (JP)

Free format text: ALTERADO DE: TANABE SEIYAKU CO., LTD.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2168 DE 24/07/2012.