ATE312100T1 - Chinuclidin-verbindungen und medikamente die diese als aktive wirkstoffe enthalten - Google Patents

Chinuclidin-verbindungen und medikamente die diese als aktive wirkstoffe enthalten

Info

Publication number: ATE312100T1
Authority: AT; Austria
Prior art keywords: optionally substituted; chain; substituted; denotes; represented
Prior art date: 1999-09-28

Application number

AT00962889T

Other languages

English (en)

Inventor

Toshimi Okada

Nobuyuki Kurusu

Keigo Tanaka

Kazuki Miyazaki

Daisuke Shinmyo

Hiroyuki Sugumi

Hironori Ikuta

Hironobu Hiyoshi

Takao Saeki

Mamoru Yanagimachi

Masashi Ito

Original Assignee

Eisai Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-28

Filing date

2000-09-27

Publication date

2005-12-15

2000-09-27 Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd

2005-12-15 Application granted granted Critical

2005-12-15 Publication of ATE312100T1 publication Critical patent/ATE312100T1/de

Links

239000004480 active ingredient Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
SBYHFKPVCBCYGV-UHFFFAOYSA-N quinuclidine Chemical class C1CC2CCN1CC2 SBYHFKPVCBCYGV-UHFFFAOYSA-N 0.000 title 1
YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 abstract 1
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
125000006590 (C2-C6) alkenylene group Chemical group 0.000 abstract 1
125000006591 (C2-C6) alkynylene group Chemical group 0.000 abstract 1
BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 abstract 1
229940125532 enzyme inhibitor Drugs 0.000 abstract 1
239000002532 enzyme inhibitor Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940031439 squalene Drugs 0.000 abstract 1
TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT00962889T 1999-09-28 2000-09-27 Chinuclidin-verbindungen und medikamente die diese als aktive wirkstoffe enthalten ATE312100T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP27390599		1999-09-28
JP2000179352		2000-06-15
PCT/JP2000/006665 WO2001023383A1 (en)	1999-09-28	2000-09-27	Quinuclidine compounds and drugs containing the same as the active ingredient

Publications (1)

Publication Number	Publication Date
ATE312100T1 true ATE312100T1 (de)	2005-12-15

Family

ID=26550809

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00962889T ATE312100T1 (de)	1999-09-28	2000-09-27	Chinuclidin-verbindungen und medikamente die diese als aktive wirkstoffe enthalten

Country Status (20)

Country	Link
US (1)	US6599917B1 (de)
EP (1)	EP1217001B1 (de)
JP (1)	JP4206212B2 (de)
KR (1)	KR100694687B1 (de)
CN (1)	CN100334085C (de)
AT (1)	ATE312100T1 (de)
AU (1)	AU782114B2 (de)
BR (1)	BR0014331A (de)
CA (1)	CA2385995C (de)
DE (1)	DE60024651T2 (de)
DK (1)	DK1217001T3 (de)
ES (1)	ES2252063T3 (de)
HU (1)	HUP0203514A3 (de)
IL (2)	IL148631A0 (de)
MX (1)	MXPA02003167A (de)
NO (1)	NO328218B1 (de)
NZ (1)	NZ517788A (de)
RU (1)	RU2266905C2 (de)
TW (1)	TWI282794B (de)
WO (1)	WO2001023383A1 (de)

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US7361671B2 (en) *	2001-11-15	2008-04-22	The Institute For Pharmaceutical Discovery, Inc.	Substituted heteroarylalkanoic acids
DE10225537A1 (de) *	2002-06-10	2003-12-18	Bayer Ag	N-alkylierte Thiazoliumsalze und Verfahren zu deren Herstellung
GB0218876D0 (en) *	2002-08-13	2002-09-25	Merck Sharp & Dohme	Therapeutic agents
MXPA05003317A (es)	2002-09-25	2005-07-05	Memory Pharm Corp	Indazoles, benzotiazoles y benzoisotiazoles asi como preparacion y usos de los mismos.
DE10334724A1 (de) *	2003-07-30	2005-02-24	Bayer Healthcare Ag	N-Biarylamide
MXPA06003951A (es) *	2003-10-07	2006-06-27	Renovis Inc	Derivados de amida como ligandos del canal de ion y composiciones farmaceuticas y sus metodos de uso.
EP1735306A2 (de)	2004-03-25	2006-12-27	Memory Pharmaceuticals Corporation	Indazole, benzothiazole, benzoisothiazole, benzisoxazole und deren herstellung und verwendungen
US8106066B2 (en)	2005-09-23	2012-01-31	Memory Pharmaceuticals Corporation	Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
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MX2012013824A (es)	2010-05-28	2013-03-12	Biocryst Pharm Inc	Compuestos heterociclicos como inhibidores de cinasa janus.
HK1203412A1 (en)	2011-12-28	2015-10-30	Global Blood Therapeutics, Inc.	Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
WO2013102142A1 (en)	2011-12-28	2013-07-04	Global Blood Therapeutics, Inc.	Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
WO2014060381A1 (de)	2012-10-18	2014-04-24	Bayer Cropscience Ag	Heterocyclische verbindungen als schädlingsbekämpfungsmittel
JP2016503395A (ja)	2012-10-31	2016-02-04	バイエル・クロップサイエンス・アクチェンゲゼルシャフト	病害生物防除剤としての複素環化合物
US9422279B2 (en)	2013-03-15	2016-08-23	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
EP3919056B1 (de)	2013-03-15	2024-08-28	Global Blood Therapeutics, Inc.	Verbindungen und verwendungen davon zur modulation von hämoglobin
US8952171B2 (en)	2013-03-15	2015-02-10	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
SG10201802911RA (en)	2013-03-15	2018-05-30	Global Blood Therapeutics Inc	Compounds and uses thereof for the modulation of hemoglobin
US20140274961A1 (en)	2013-03-15	2014-09-18	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en)	2013-03-15	2019-04-23	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
AP2015008718A0 (en)	2013-03-15	2015-09-30	Global Blood Therapeutics Inc	Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en)	2013-03-15	2016-10-04	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en)	2013-03-15	2017-10-31	Global Blood Therapeutics, Inc.	Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en)	2013-03-15	2017-03-28	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
WO2014145040A1 (en)	2013-03-15	2014-09-18	Global Blood Therapeutics, Inc.	Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
EA202092627A1 (ru)	2013-11-18	2021-09-30	Глобал Блад Терапьютикс, Инк.	Соединения и их применения для модуляции гемоглобина
ES2860648T5 (es)	2014-02-07	2024-11-27	Global Blood Therapeutics Inc	Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1H-pirazol-5-il)piridin-3-il)metoxi)benzaldehído
MA41841A (fr)	2015-03-30	2018-02-06	Global Blood Therapeutics Inc	Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
RS60199B1 (sr)	2015-06-03	2020-06-30	Hoffmann La Roche	Derivati etinila
US11020382B2 (en)	2015-12-04	2021-06-01	Global Blood Therapeutics, Inc.	Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
TWI825524B (zh)	2016-05-12	2023-12-11	美商全球血液治療公司	用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
TW202332423A (zh)	2016-10-12	2023-08-16	美商全球血液治療公司	包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
CR20210175A (es)	2018-09-18	2021-06-01	Nikang Therapeutics Inc	Derivados de anillo tricíclico condensado como inhibidores de la fosfatasa de homología a src 2 (shp2)
EP3860975B1 (de)	2018-10-01	2023-10-18	Global Blood Therapeutics, Inc.	Modulatoren von hämoglobin zur behandlung von sichelzellenanämie

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JPH08134067A (ja) *	1994-11-11	1996-05-28	Yamanouchi Pharmaceut Co Ltd	キヌクリジン誘導体
JPH08269056A (ja) *	1995-03-29	1996-10-15	Chugai Pharmaceut Co Ltd	スクアレンシンセターゼ阻害作用を有するキヌクリジン誘導体
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2000
- 2000-09-27 NZ NZ517788A patent/NZ517788A/en not_active IP Right Cessation
- 2000-09-27 EP EP00962889A patent/EP1217001B1/de not_active Expired - Lifetime
- 2000-09-27 MX MXPA02003167A patent/MXPA02003167A/es active IP Right Grant
- 2000-09-27 WO PCT/JP2000/006665 patent/WO2001023383A1/ja not_active Ceased
- 2000-09-27 CA CA002385995A patent/CA2385995C/en not_active Expired - Fee Related
- 2000-09-27 CN CNB00813541XA patent/CN100334085C/zh not_active Expired - Fee Related
- 2000-09-27 AT AT00962889T patent/ATE312100T1/de not_active IP Right Cessation
- 2000-09-27 KR KR1020027003952A patent/KR100694687B1/ko not_active Expired - Fee Related
- 2000-09-27 IL IL14863100A patent/IL148631A0/xx unknown
- 2000-09-27 DK DK00962889T patent/DK1217001T3/da active
- 2000-09-27 HU HU0203514A patent/HUP0203514A3/hu unknown
- 2000-09-27 BR BR0014331-6A patent/BR0014331A/pt not_active Application Discontinuation
- 2000-09-27 DE DE60024651T patent/DE60024651T2/de not_active Expired - Lifetime
- 2000-09-27 JP JP2001526535A patent/JP4206212B2/ja not_active Expired - Fee Related
- 2000-09-27 US US10/088,554 patent/US6599917B1/en not_active Expired - Fee Related
- 2000-09-27 ES ES00962889T patent/ES2252063T3/es not_active Expired - Lifetime
- 2000-09-27 RU RU2002111344/04A patent/RU2266905C2/ru not_active IP Right Cessation
- 2000-09-27 AU AU74464/00A patent/AU782114B2/en not_active Ceased
- 2000-09-27 TW TW089119958A patent/TWI282794B/zh not_active IP Right Cessation
2002
- 2002-03-12 IL IL148631A patent/IL148631A/en not_active IP Right Cessation
- 2002-03-26 NO NO20021528A patent/NO328218B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN100334085C (zh)	2007-08-29
DK1217001T3 (da)	2006-03-20
JP4206212B2 (ja)	2009-01-07
IL148631A0 (en)	2002-09-12
NZ517788A (en)	2003-11-28
NO20021528D0 (no)	2002-03-26
AU7446400A (en)	2001-04-30
EP1217001A4 (de)	2002-12-18
BR0014331A (pt)	2003-06-10
WO2001023383A1 (en)	2001-04-05
MXPA02003167A (es)	2003-10-06
DE60024651T2 (de)	2006-09-28
NO20021528L (no)	2002-05-28
AU782114B2 (en)	2005-07-07
HUP0203514A3 (en)	2004-01-28
EP1217001A1 (de)	2002-06-26
KR100694687B1 (ko)	2007-03-13
CN1377349A (zh)	2002-10-30
KR20020034197A (ko)	2002-05-08
HUP0203514A2 (hu)	2003-03-28
RU2266905C2 (ru)	2005-12-27
TWI282794B (en)	2007-06-21
CA2385995C (en)	2009-06-16
EP1217001B1 (de)	2005-12-07
ES2252063T3 (es)	2006-05-16
IL148631A (en)	2010-04-29
NO328218B1 (no)	2010-01-11
DE60024651D1 (de)	2006-01-12
CA2385995A1 (en)	2001-04-05
US6599917B1 (en)	2003-07-29

Legal Events

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2006-08-15

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Publication of translation of european patent specification

Ref document number: 1217001

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2008-07-15

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Change in the person of patent owner

2011-06-15

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Publication	Publication Date	Title
ATE312100T1 (de)	2005-12-15	Chinuclidin-verbindungen und medikamente die diese als aktive wirkstoffe enthalten
DE60119894D1 (de)	2006-06-29	Piperidinverbindungen und diese enthaltenden medikamente
MXPA04001258A (es)	2005-06-06	Activador para el receptor d que responde al proliferador de peroxisoma.
ES2166359T3 (es)	2002-04-16	Derivado de depsipeptido, su produccion y uso.
EA200601830A1 (ru)	2007-04-27	Ортозамещённые арильные или гетероарильные амидные соединения
EP0976748A4 (de)	2001-08-08	Pyrrolidin-derivate die eine phospholipase-a2-hemmende wirkung haben
DE60012751D1 (de)	2004-09-09	Verwendung von ep4 rezeptorliganden zur behandlung von neuropathischen schmerz
AU8799201A (en)	2002-04-08	Pharmaceutically active benzsulfonamide derivatives as inhibitors of protein junkinases
DE69921151D1 (de)	2004-11-18	Fluorszierende marker
DE60223904D1 (de)	2008-01-17	Benzylaminanalogen
EA200600570A1 (ru)	2006-12-29	Замещенные 2-карбониламино-6-пиперидинаминопиридины и замещенные 1-карбониламино-3-пиперидинаминобензолы как агонисты 5-ht
NO982873D0 (no)	1998-06-19	1-metylkarbapenemderivater
ATE366248T1 (de)	2007-07-15	N-aryl-substituiertes cyclisches aminderivat und medizin, die dieses als wirkstoff enthält
BG105123A (en)	2001-11-30	Tetrahydroquinaline derivatives as glycine antagonists
ES2129123T3 (es)	1999-06-01	Nuevo derivado de bisoxadiazolidina.
EP1197211A4 (de)	2004-09-01	Wirkstoffe zur vorbeugung und behandlung von krebs
EP1000620A4 (de)	2004-03-17	Lp(a)MINDERE MITTEL UND INHIBITOREN DER APOPROTEIN (a) PRODUKTION
EA200001157A2 (ru)	2001-06-25	Новые замещенные производные (дигидро)бензоксазина и (дигидро)бензотиазина, способ их получения и содержащие их фармацевтические композиции
DE602005027246D1 (de)	2011-05-12	Mittel zur linderung von niereninsuffizienz
DE69622393D1 (de)	2002-08-22	Neue verwendung von pyrazolopyridinverbindungen
ATE370116T1 (de)	2007-09-15	Substituierte (4-aminocyclohexen-1-yl) phenyl and (4-aminocyclohexen-1-yl) pyridinyl verbindungen als 5-ht1f agonisten