ATE312100T1 - Chinuclidin-verbindungen und medikamente die diese als aktive wirkstoffe enthalten - Google Patents

Chinuclidin-verbindungen und medikamente die diese als aktive wirkstoffe enthalten

Info

Publication number: ATE312100T1
Authority: AT; Austria
Prior art keywords: optionally substituted; chain; substituted; denotes; represented
Prior art date: 1999-09-28

Application number

AT00962889T

Other languages

English (en)

Inventor

Toshimi Okada

Nobuyuki Kurusu

Keigo Tanaka

Kazuki Miyazaki

Daisuke Shinmyo

Hiroyuki Sugumi

Hironori Ikuta

Hironobu Hiyoshi

Takao Saeki

Mamoru Yanagimachi

Masashi Ito

Original Assignee

Eisai Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-28

Filing date

2000-09-27

Publication date

2005-12-15

2000-09-27 Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd

2005-12-15 Application granted granted Critical

2005-12-15 Publication of ATE312100T1 publication Critical patent/ATE312100T1/de

Links

239000004480 active ingredient Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
SBYHFKPVCBCYGV-UHFFFAOYSA-N quinuclidine Chemical class C1CC2CCN1CC2 SBYHFKPVCBCYGV-UHFFFAOYSA-N 0.000 title 1
YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 abstract 1
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
125000006590 (C2-C6) alkenylene group Chemical group 0.000 abstract 1
125000006591 (C2-C6) alkynylene group Chemical group 0.000 abstract 1
BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 abstract 1
229940125532 enzyme inhibitor Drugs 0.000 abstract 1
239000002532 enzyme inhibitor Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940031439 squalene Drugs 0.000 abstract 1
TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT00962889T 1999-09-28 2000-09-27 Chinuclidin-verbindungen und medikamente die diese als aktive wirkstoffe enthalten ATE312100T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP27390599		1999-09-28
JP2000179352		2000-06-15
PCT/JP2000/006665 WO2001023383A1 (en)	1999-09-28	2000-09-27	Quinuclidine compounds and drugs containing the same as the active ingredient

Publications (1)

Publication Number	Publication Date
ATE312100T1 true ATE312100T1 (de)	2005-12-15

Family

ID=26550809

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00962889T ATE312100T1 (de)	1999-09-28	2000-09-27	Chinuclidin-verbindungen und medikamente die diese als aktive wirkstoffe enthalten

Country Status (20)

Country	Link
US (1)	US6599917B1 (de)
EP (1)	EP1217001B1 (de)
JP (1)	JP4206212B2 (de)
KR (1)	KR100694687B1 (de)
CN (1)	CN100334085C (de)
AT (1)	ATE312100T1 (de)
AU (1)	AU782114B2 (de)
BR (1)	BR0014331A (de)
CA (1)	CA2385995C (de)
DE (1)	DE60024651T2 (de)
DK (1)	DK1217001T3 (de)
ES (1)	ES2252063T3 (de)
HU (1)	HUP0203514A3 (de)
IL (2)	IL148631A0 (de)
MX (1)	MXPA02003167A (de)
NO (1)	NO328218B1 (de)
NZ (1)	NZ517788A (de)
RU (1)	RU2266905C2 (de)
TW (1)	TWI282794B (de)
WO (1)	WO2001023383A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0010955D0 (en) *	2000-05-05	2000-06-28	Novartis Ag	Organic compounds
JP4225787B2 (ja) *	2001-03-27	2009-02-18	エーザイ・アール・アンド・ディー・マネジメント株式会社	Ｎ−アリール環状アミン誘導体およびそれを有効成分として含有する医薬
EP1256573A1 (de)	2001-05-09	2002-11-13	Eisai Co., Ltd.	Verfahren zur Herstellung eines Stereoisomers von Pyrrolidinderivat
KR20050030169A (ko) *	2001-10-17	2005-03-29	유씨비 소시에떼아노님	퀴누클리딘 유도체, 이의 제조 방법 및 ｍ2 및/또는 ｍ3무스카린 수용체 억제제로서의 이의 용도
US7361671B2 (en) *	2001-11-15	2008-04-22	The Institute For Pharmaceutical Discovery, Inc.	Substituted heteroarylalkanoic acids
DE10225537A1 (de) *	2002-06-10	2003-12-18	Bayer Ag	N-alkylierte Thiazoliumsalze und Verfahren zu deren Herstellung
GB0218876D0 (en) *	2002-08-13	2002-09-25	Merck Sharp & Dohme	Therapeutic agents
PL210065B1 (pl)	2002-09-25	2011-11-30	Memory Pharm Corp	Związki indazole, benzotiazole i benzoizotiazole, kompozycje farmaceutyczne je zawierające oraz zastosowanie związków
DE10334724A1 (de) *	2003-07-30	2005-02-24	Bayer Healthcare Ag	N-Biarylamide
WO2005046683A1 (en) *	2003-10-07	2005-05-26	Renovis, Inc.	Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
CA2560741C (en)	2004-03-25	2013-08-06	Memory Pharmaceuticals Corporation	Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
US8106066B2 (en)	2005-09-23	2012-01-31	Memory Pharmaceuticals Corporation	Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
JP2010519328A (ja)	2007-02-26	2010-06-03	ファイザー・プロダクツ・インク	Ｈ−ｐｇｄｓの阻害剤としてのニコチンアミド誘導体およびプロスタグランジンｄ２が媒介する疾患の治療のためのそれらの使用
TW201111385A (en)	2009-08-27	2011-04-01	Biocryst Pharm Inc	Heterocyclic compounds as janus kinase inhibitors
US8420661B2 (en) *	2010-04-13	2013-04-16	Hoffmann-La Roche Inc.	Arylethynyl derivatives
KR20130083389A (ko)	2010-05-28	2013-07-22	바이오크리스트파마슈티컬즈,인코포레이티드	야누스 키나아제 억제제로서 헤테로사이클릭 화합물
ES2790358T3 (es)	2011-12-28	2020-10-27	Global Blood Therapeutics Inc	Compuestos de heteroaril aldehído sustituido y métodos para su uso en el aumento de la oxigenación tisular
CA3142817A1 (en)	2011-12-28	2013-07-04	Global Blood Therapeutics, Inc.	Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
WO2014060381A1 (de)	2012-10-18	2014-04-24	Bayer Cropscience Ag	Heterocyclische verbindungen als schädlingsbekämpfungsmittel
CN104884449A (zh)	2012-10-31	2015-09-02	拜尔农作物科学股份公司	作为害虫防治剂的新的杂环化合物
US9802900B2 (en)	2013-03-15	2017-10-31	Global Blood Therapeutics, Inc.	Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
EP3919056B1 (de)	2013-03-15	2024-08-28	Global Blood Therapeutics, Inc.	Verbindungen und verwendungen davon zur modulation von hämoglobin
US20140274961A1 (en)	2013-03-15	2014-09-18	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
CN112500338A (zh)	2013-03-15	2021-03-16	全球血液疗法股份有限公司	化合物及其用于调节血红蛋白的用途
US9604999B2 (en)	2013-03-15	2017-03-28	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
EP2968299B1 (de)	2013-03-15	2021-01-20	Global Blood Therapeutics, Inc.	Verbindungen und verwendungen davon zur modulation von hämoglobin
US10266551B2 (en)	2013-03-15	2019-04-23	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en)	2013-03-15	2015-02-10	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en)	2013-03-15	2016-10-04	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en)	2013-03-15	2016-08-23	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US10100043B2 (en)	2013-03-15	2018-10-16	Global Blood Therapeutics, Inc.	Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
EA202092627A1 (ru)	2013-11-18	2021-09-30	Глобал Блад Терапьютикс, Инк.	Соединения и их применения для модуляции гемоглобина
SG10201911662YA (en)	2014-02-07	2020-02-27	Global Blood Therapeutics Inc	Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
MA41841A (fr)	2015-03-30	2018-02-06	Global Blood Therapeutics Inc	Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
JP6603334B2 (ja)	2015-06-03	2019-11-06	エフ．ホフマン−ラロシュアーゲー	エチニル誘導体
HUE072191T2 (hu)	2015-12-04	2025-10-28	Global Blood Therapeutics Inc	A 2-hidoxi-6-((2-(1-izopropil-1H-pirazol-5-il)piridin-3-il)metoxi)benzaldehid adagolási rendje
TWI825524B (zh)	2016-05-12	2023-12-11	美商全球血液治療公司	用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
TWI778983B (zh)	2016-10-12	2022-10-01	美商全球血液治療公司	包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
CN112996795B (zh)	2018-09-18	2024-11-12	尼坎治疗公司	作为src同源-2磷酸酶抑制剂的稠合的三环衍生物
US11014884B2 (en)	2018-10-01	2021-05-25	Global Blood Therapeutics, Inc.	Modulators of hemoglobin

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2105655A1 (en) *	1991-03-08	1992-09-09	Kent Neuenschwander	Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors
US5135935A (en) *	1991-05-17	1992-08-04	Merck & Co., Inc.	Squalene synthetase inhibitors
GB9127279D0 (en) *	1991-12-23	1992-02-19	Ici Plc	Heterocyclic derivatives
JPH05310732A (ja) *	1992-03-12	1993-11-22	Mitsubishi Kasei Corp	シンノリン−３−カルボン酸誘導体
GB9207961D0 (en) *	1992-04-10	1992-05-27	Ici Plc	Heterocyclic derivatives
GB9218334D0 (en) *	1992-08-28	1992-10-14	Ici Plc	Heterocyclic compounds
AU7394394A (en) *	1992-10-13	1995-12-05	Rhone-Poulenc Rorer Pharmaceuticals Inc.	3-hydroxyquinuclidin-3-ylphenylquinolines as squalene synthase inhibitors
GB9226573D0 (en)	1992-12-21	1993-02-17	Ici Plc	Heterocyclic compounds
IL109451A0 (en)	1993-04-29	1994-07-31	Zeneca Ltd	Heterocyclic derivatives
GB9412145D0 (en) *	1994-06-17	1994-08-10	Zeneca Ltd	Heterocycles
JPH08134067A (ja) *	1994-11-11	1996-05-28	Yamanouchi Pharmaceut Co Ltd	キヌクリジン誘導体
JPH08269056A (ja) *	1995-03-29	1996-10-15	Chugai Pharmaceut Co Ltd	スクアレンシンセターゼ阻害作用を有するキヌクリジン誘導体
US5712270A (en) *	1995-11-06	1998-01-27	American Home Products Corporation	2-arylamidothiazole derivatives with CNS activity
CA2254769A1 (en) *	1996-05-20	1997-11-27	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone

2000
- 2000-09-27 US US10/088,554 patent/US6599917B1/en not_active Expired - Fee Related
- 2000-09-27 WO PCT/JP2000/006665 patent/WO2001023383A1/ja not_active Ceased
- 2000-09-27 RU RU2002111344/04A patent/RU2266905C2/ru not_active IP Right Cessation
- 2000-09-27 MX MXPA02003167A patent/MXPA02003167A/es active IP Right Grant
- 2000-09-27 DE DE60024651T patent/DE60024651T2/de not_active Expired - Lifetime
- 2000-09-27 JP JP2001526535A patent/JP4206212B2/ja not_active Expired - Fee Related
- 2000-09-27 AU AU74464/00A patent/AU782114B2/en not_active Ceased
- 2000-09-27 TW TW089119958A patent/TWI282794B/zh not_active IP Right Cessation
- 2000-09-27 CA CA002385995A patent/CA2385995C/en not_active Expired - Fee Related
- 2000-09-27 AT AT00962889T patent/ATE312100T1/de not_active IP Right Cessation
- 2000-09-27 ES ES00962889T patent/ES2252063T3/es not_active Expired - Lifetime
- 2000-09-27 DK DK00962889T patent/DK1217001T3/da active
- 2000-09-27 KR KR1020027003952A patent/KR100694687B1/ko not_active Expired - Fee Related
- 2000-09-27 NZ NZ517788A patent/NZ517788A/en not_active IP Right Cessation
- 2000-09-27 IL IL14863100A patent/IL148631A0/xx unknown
- 2000-09-27 CN CNB00813541XA patent/CN100334085C/zh not_active Expired - Fee Related
- 2000-09-27 EP EP00962889A patent/EP1217001B1/de not_active Expired - Lifetime
- 2000-09-27 BR BR0014331-6A patent/BR0014331A/pt not_active Application Discontinuation
- 2000-09-27 HU HU0203514A patent/HUP0203514A3/hu unknown
2002
- 2002-03-12 IL IL148631A patent/IL148631A/en not_active IP Right Cessation
- 2002-03-26 NO NO20021528A patent/NO328218B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP1217001B1 (de)	2005-12-07
CN1377349A (zh)	2002-10-30
IL148631A0 (en)	2002-09-12
DE60024651T2 (de)	2006-09-28
CN100334085C (zh)	2007-08-29
BR0014331A (pt)	2003-06-10
NO328218B1 (no)	2010-01-11
NZ517788A (en)	2003-11-28
HUP0203514A3 (en)	2004-01-28
JP4206212B2 (ja)	2009-01-07
KR100694687B1 (ko)	2007-03-13
IL148631A (en)	2010-04-29
EP1217001A1 (de)	2002-06-26
EP1217001A4 (de)	2002-12-18
NO20021528D0 (no)	2002-03-26
TWI282794B (en)	2007-06-21
US6599917B1 (en)	2003-07-29
NO20021528L (no)	2002-05-28
KR20020034197A (ko)	2002-05-08
AU782114B2 (en)	2005-07-07
ES2252063T3 (es)	2006-05-16
HUP0203514A2 (hu)	2003-03-28
MXPA02003167A (es)	2003-10-06
WO2001023383A1 (en)	2001-04-05
DE60024651D1 (de)	2006-01-12
CA2385995C (en)	2009-06-16
AU7446400A (en)	2001-04-30
RU2266905C2 (ru)	2005-12-27
DK1217001T3 (da)	2006-03-20
CA2385995A1 (en)	2001-04-05

Legal Events

Date

Code

Title

Description

2006-08-15

UEP

Publication of translation of european patent specification

Ref document number: 1217001

Country of ref document: EP

2008-07-15

EEIH

Change in the person of patent owner

2011-06-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE312100T1 (de)	2005-12-15	Chinuclidin-verbindungen und medikamente die diese als aktive wirkstoffe enthalten
DE60119894D1 (de)	2006-06-29	Piperidinverbindungen und diese enthaltenden medikamente
MXPA04001258A (es)	2005-06-06	Activador para el receptor d que responde al proliferador de peroxisoma.
ES2166359T3 (es)	2002-04-16	Derivado de depsipeptido, su produccion y uso.
EA200601830A1 (ru)	2007-04-27	Ортозамещённые арильные или гетероарильные амидные соединения
PT976748E (pt)	2004-03-31	Derivados de pirrolidina com actividade inibidora de fosfolipase a2
ATE260255T1 (de)	2004-03-15	5-oxo-pyrrolidine-2-carbonsäure- hydroxamidderivate
DE60012751D1 (de)	2004-09-09	Verwendung von ep4 rezeptorliganden zur behandlung von neuropathischen schmerz
AU8799201A (en)	2002-04-08	Pharmaceutically active benzsulfonamide derivatives as inhibitors of protein junkinases
DE69921151D1 (de)	2004-11-18	Fluorszierende marker
DE60223904D1 (de)	2008-01-17	Benzylaminanalogen
EA200600570A1 (ru)	2006-12-29	Замещенные 2-карбониламино-6-пиперидинаминопиридины и замещенные 1-карбониламино-3-пиперидинаминобензолы как агонисты 5-ht
NO982873D0 (no)	1998-06-19	1-metylkarbapenemderivater
ATE366248T1 (de)	2007-07-15	N-aryl-substituiertes cyclisches aminderivat und medizin, die dieses als wirkstoff enthält
BG105123A (en)	2001-11-30	Tetrahydroquinaline derivatives as glycine antagonists
ES2129123T3 (es)	1999-06-01	Nuevo derivado de bisoxadiazolidina.
EA200100967A1 (ru)	2002-02-28	Новое иммунодепрессивное средство
EP1000620A4 (de)	2004-03-17	Lp(a)MINDERE MITTEL UND INHIBITOREN DER APOPROTEIN (a) PRODUKTION
EA200001157A2 (ru)	2001-06-25	Новые замещенные производные (дигидро)бензоксазина и (дигидро)бензотиазина, способ их получения и содержащие их фармацевтические композиции
ATE220544T1 (de)	2002-08-15	Neue verwendung von pyrazolopyridinverbindungen
ATE370116T1 (de)	2007-09-15	Substituierte (4-aminocyclohexen-1-yl) phenyl and (4-aminocyclohexen-1-yl) pyridinyl verbindungen als 5-ht1f agonisten