BRPI0416912A - ácido nucleico isolado, método para preparar uma sesquiterpeno sintase funcional variante, sintase, polipeptìdeo, vetor, célula hospedeira, organismo não humano, e, métodos para produzir uma célula hospedeira recombinante, uma sesquiterpeno sintase, e pelo menos um terpenóide - Google Patents
ácido nucleico isolado, método para preparar uma sesquiterpeno sintase funcional variante, sintase, polipeptìdeo, vetor, célula hospedeira, organismo não humano, e, métodos para produzir uma célula hospedeira recombinante, uma sesquiterpeno sintase, e pelo menos um terpenóideInfo
- Publication number
- BRPI0416912A BRPI0416912A BRPI0416912-3A BRPI0416912A BRPI0416912A BR PI0416912 A BRPI0416912 A BR PI0416912A BR PI0416912 A BRPI0416912 A BR PI0416912A BR PI0416912 A BRPI0416912 A BR PI0416912A
- Authority
- BR
- Brazil
- Prior art keywords
- synthase
- host cell
- methods
- sesquiterpene
- sesquiterpene synthase
- Prior art date
Links
- 101710093888 Pentalenene synthase Proteins 0.000 title abstract 6
- 101710115850 Sesquiterpene synthase Proteins 0.000 title abstract 6
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 150000003505 terpenes Chemical class 0.000 title 1
- VWFJDQUYCIWHTN-YFVJMOTDSA-N 2-trans,6-trans-farnesyl diphosphate Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CO[P@](O)(=O)OP(O)(O)=O VWFJDQUYCIWHTN-YFVJMOTDSA-N 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- VWFJDQUYCIWHTN-UHFFFAOYSA-N Farnesyl pyrophosphate Natural products CC(C)=CCCC(C)=CCCC(C)=CCOP(O)(=O)OP(O)(O)=O VWFJDQUYCIWHTN-UHFFFAOYSA-N 0.000 abstract 1
- 240000002505 Pogostemon cablin Species 0.000 abstract 1
- 235000011751 Pogostemon cablin Nutrition 0.000 abstract 1
- 210000005260 human cell Anatomy 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- -1 patchulol Chemical class 0.000 abstract 1
- 229930004725 sesquiterpene Natural products 0.000 abstract 1
- 150000004354 sesquiterpene derivatives Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Abstract
"áCIDO NUCLEICO ISOLADO, MéTODO PARA PREPARAR UMA SESQUITERPENO SINTASE FUNCIONAL VARIANTE, SINTASE, POLIPEPTìDEO, VETOR, CéLULA HOSPEDEIRA, ORGANISMO NAO HUMANO, E, MéTODOS PARA PRODUZIR UMA CéLULA HOSPEDEIRA RECOMBINANTE, UMA SESQUITERPENO SINTASE, E PELO MENOS UM TERPENóIDE". A invenção diz respeito a sesquiterpeno sintases de plantas de Patchuli (Pogostemon cablin), e a métodos de sua produção e uso. Em uma forma de realização, a invenção fornece ácidos nucleicos compreendendo uma seqüência de nucleotídeos conforme aqui descrito, que codifica para pelo menos uma sesquiterpeno sintase. Em uma outra forma de realização, a invenção também leva em conta sesquiterpeno sintases e métodos de produzir e usar estas enzimas. Por exemplo, as sesquiterpeno sintases da invenção podem ser usadas para transformar farnesil-pirofosfato em vários sesquiterpenos, incluindo o patchulol, o <sym>-curcumeno e outros sesquiteipenos do tipo do germacreno.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52551203P | 2003-11-26 | 2003-11-26 | |
| PCT/IB2003/006459 WO2005056803A1 (en) | 2003-12-09 | 2003-12-09 | Sesquiterpene synthases from patchouli |
| PCT/IB2004/003836 WO2005052163A2 (en) | 2003-11-26 | 2004-11-19 | Sesquiterpene synthases from patchouli |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0416912A true BRPI0416912A (pt) | 2007-01-16 |
| BRPI0416912B1 BRPI0416912B1 (pt) | 2020-01-28 |
Family
ID=34635470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0416912A BRPI0416912B1 (pt) | 2003-11-26 | 2004-11-19 | método para a produção de patchoulol, método para preparar uma patchoulol sintase funcional variante, construção de ácido nucleico, vetor, método de obtenção de uma célula hospedeira recombinante, célula de microrganismo hospedeira, método de fabricação de uma patchoulol sintase |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7622288B2 (pt) |
| EP (1) | EP1697519B1 (pt) |
| JP (1) | JP4700617B2 (pt) |
| CN (1) | CN1886508B (pt) |
| AT (1) | ATE424460T1 (pt) |
| BR (1) | BRPI0416912B1 (pt) |
| DE (1) | DE602004019811D1 (pt) |
| IL (1) | IL175728A (pt) |
| RU (1) | RU2006122534A (pt) |
| WO (1) | WO2005052163A2 (pt) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8017835B2 (en) | 2005-04-19 | 2011-09-13 | University Of Kentucky Research Foundation | Transformed plants accumulating terpenes |
| ATE486133T1 (de) * | 2005-07-01 | 2010-11-15 | Univ Kentucky Res Found | Transformierte pflanzen mit anreicherung von mono-und/oder sesquiterpenen |
| WO2008100251A1 (en) * | 2007-02-13 | 2008-08-21 | Ls9, Inc. | Modified microorganism uses therefor |
| DE602007008067D1 (de) | 2006-02-14 | 2010-09-09 | Firmenich & Cie | Verfahren zur herstellung von terpenen und mep-transformierte mikroorganismen dafür |
| US8110670B2 (en) | 2006-05-19 | 2012-02-07 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
| US20100242345A1 (en) | 2006-05-19 | 2010-09-30 | LS9, Inc | Production of fatty acids & derivatives thereof |
| US7399323B2 (en) | 2006-10-10 | 2008-07-15 | Amyris Biotechnologies, Inc. | Fuel compositions comprising farnesane and farnesane derivatives and method of making and using same |
| EP2425007A4 (en) | 2009-04-27 | 2013-01-02 | Ls9 Inc | PREPARATION OF FATTY ACID ESTERS |
| WO2011141855A1 (en) | 2010-05-10 | 2011-11-17 | Firmenich Sa | Method for producing patchoulol and 7 - epi - alpha - slinene |
| US10053703B2 (en) * | 2013-06-28 | 2018-08-21 | University Of Copenhagen | Heterologous production of patchoulol, β-santalene, and sclareol in moss cells |
| CN103352034A (zh) * | 2013-07-12 | 2013-10-16 | 中国医学科学院药用植物研究所 | 沉香倍半萜合酶蛋白ass4及其编码基因和应用 |
| CN105579585B (zh) * | 2013-09-05 | 2019-03-15 | 国立大学法人新潟大学 | 龙涎香醇的制造方法 |
| GB201516911D0 (en) * | 2015-09-24 | 2015-11-11 | Givaudan Sa | Perfume compositions |
| US11421199B2 (en) * | 2016-11-04 | 2022-08-23 | Tianjin Institute Of Industrial Biotechnology, Chinese Academy Of Sciences | Recombinant yeast and use thereof |
| NL2019473B1 (en) * | 2017-09-01 | 2019-03-11 | Isobionics B V | Terpene Synthase producing patchoulol and elemol, and preferably also pogostol |
| EP3495489A1 (en) | 2017-12-05 | 2019-06-12 | Givaudan SA | Production of guaiene and rotundone |
| WO2019161141A1 (en) | 2018-02-14 | 2019-08-22 | Ginkgo Bioworks | Chimeric terpene synthases |
| CN109735523B (zh) * | 2019-02-02 | 2022-08-30 | 中国科学院昆明植物研究所 | 雪松醇合酶Lc-CedS编码基因及其应用 |
| CN114107233B (zh) * | 2021-10-27 | 2024-01-09 | 武汉合生科技有限公司 | 佛术烯的合成酶基因和高产菌株以及用途 |
| CN116574718B (zh) * | 2023-06-09 | 2024-04-16 | 中国中医科学院中药研究所 | SoSTPS2在作为倍半萜合酶中的应用 |
| CN117987434B (zh) * | 2024-04-07 | 2024-06-21 | 北京未名拾光生物技术有限公司 | 广藿香醇合酶编码基因及其表达体系 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ503985A (en) | 1997-10-06 | 2001-06-29 | Univ Washington | Isolation and expression of farnesene synthase from peppermint, mentha X piperita, L. |
| AU2490399A (en) | 1998-02-02 | 1999-08-16 | Regents Of The University Of California, The | Germacrene c synthase gene of (lycopersicon esculentum) |
| AR022383A1 (es) * | 1998-09-18 | 2002-09-04 | Univ Kentucky Res Found | Sintasas |
| AU3810300A (en) | 1999-03-12 | 2000-10-04 | Research Institute For Agrobiology And Soil Fertility (Ab-Dl O) | Sesquiterpenoid synthase genes and their use for influencing bitterness and resistance in plants |
| EP1231273A1 (en) * | 2001-02-12 | 2002-08-14 | Plant Research International B.V. | Terpene synthase/cyclase and olefin synthase and uses thereof |
| JP2005503163A (ja) | 2001-09-17 | 2005-02-03 | プラント リサーチ インターナショナル ビー． ブイ． | 生物的転化のための植物酵素 |
-
2004
- 2004-11-19 DE DE602004019811T patent/DE602004019811D1/de not_active Expired - Lifetime
- 2004-11-19 WO PCT/IB2004/003836 patent/WO2005052163A2/en not_active Ceased
- 2004-11-19 EP EP04798949A patent/EP1697519B1/en not_active Expired - Lifetime
- 2004-11-19 AT AT04798949T patent/ATE424460T1/de not_active IP Right Cessation
- 2004-11-19 RU RU2006122534/13A patent/RU2006122534A/ru not_active Application Discontinuation
- 2004-11-19 BR BRPI0416912A patent/BRPI0416912B1/pt active IP Right Grant
- 2004-11-19 JP JP2006540658A patent/JP4700617B2/ja not_active Expired - Lifetime
- 2004-11-19 CN CN2004800350480A patent/CN1886508B/zh not_active Expired - Lifetime
-
2006
- 2006-05-17 IL IL175728A patent/IL175728A/en active IP Right Grant
- 2006-05-23 US US11/440,105 patent/US7622288B2/en not_active Expired - Lifetime
-
2009
- 2009-02-05 US US12/366,573 patent/US8058046B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20090205060A1 (en) | 2009-08-13 |
| WO2005052163A3 (en) | 2005-12-01 |
| EP1697519B1 (en) | 2009-03-04 |
| ATE424460T1 (de) | 2009-03-15 |
| EP1697519A2 (en) | 2006-09-06 |
| JP4700617B2 (ja) | 2011-06-15 |
| JP2007514416A (ja) | 2007-06-07 |
| BRPI0416912B1 (pt) | 2020-01-28 |
| US20060206957A1 (en) | 2006-09-14 |
| WO2005052163A2 (en) | 2005-06-09 |
| CN1886508A (zh) | 2006-12-27 |
| RU2006122534A (ru) | 2008-01-10 |
| IL175728A0 (en) | 2006-09-05 |
| IL175728A (en) | 2011-05-31 |
| HK1094456A1 (en) | 2007-03-30 |
| DE602004019811D1 (de) | 2009-04-16 |
| US8058046B2 (en) | 2011-11-15 |
| CN1886508B (zh) | 2012-07-18 |
| US7622288B2 (en) | 2009-11-24 |
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
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| B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
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