ATE420170T1 - Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle - Google Patents

Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle

Info

Publication number
ATE420170T1
ATE420170T1 AT05806601T AT05806601T ATE420170T1 AT E420170 T1 ATE420170 T1 AT E420170T1 AT 05806601 T AT05806601 T AT 05806601T AT 05806601 T AT05806601 T AT 05806601T AT E420170 T1 ATE420170 T1 AT E420170T1
Authority
AT
Austria
Prior art keywords
molecule
oligonucleotide
mattrice
small molecule
reaction wells
Prior art date
Application number
AT05806601T
Other languages
English (en)
Inventor
Peter Birk Rasmussen
Original Assignee
Peter Birk Rasmussen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36407493&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE420170(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Peter Birk Rasmussen filed Critical Peter Birk Rasmussen
Application granted granted Critical
Publication of ATE420170T1 publication Critical patent/ATE420170T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT05806601T 2004-11-22 2005-11-22 Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle ATE420170T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200401809 2004-11-22

Publications (1)

Publication Number Publication Date
ATE420170T1 true ATE420170T1 (de) 2009-01-15

Family

ID=36407493

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05806601T ATE420170T1 (de) 2004-11-22 2005-11-22 Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle

Country Status (6)

Country Link
US (8) US8168381B2 (de)
EP (1) EP1828381B1 (de)
AT (1) ATE420170T1 (de)
DE (1) DE602005012319D1 (de)
DK (1) DK1828381T3 (de)
WO (1) WO2006053571A2 (de)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1401850A1 (de) 2001-06-20 2004-03-31 Nuevolution A/S Nukleosidderivate zur herstellung einer verbindungsbibliothek
DE60324778D1 (de) 2002-03-15 2009-01-02 Nuevolution As Eine verbesserte methode zur synthese von matritzenabhängigen molekülen
US10731151B2 (en) 2002-03-15 2020-08-04 Nuevolution A/S Method for synthesising templated molecules
WO2004013070A2 (en) 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
DK3299463T3 (da) 2002-10-30 2020-12-07 Nuevolution As Enzymatisk kodning
ATE450609T1 (de) 2002-12-19 2009-12-15 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US7915201B2 (en) 2003-03-20 2011-03-29 Nuevolution A/S Ligational encoding of small molecules
WO2005026387A1 (en) 2003-09-18 2005-03-24 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
RU2470077C2 (ru) 2003-12-17 2012-12-20 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи Биологически активное соединение, содержащее кодирующий олигонуклеотид (варианты), способ его синтеза, библиотека соединений (варианты), способ ее синтеза и способ поиска соединения, связывающегося с биологической мишенью (варианты)
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DK3299463T3 (da) * 2002-10-30 2020-12-07 Nuevolution As Enzymatisk kodning
US7915201B2 (en) * 2003-03-20 2011-03-29 Nuevolution A/S Ligational encoding of small molecules
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EP1828381B1 (de) * 2004-11-22 2009-01-07 Peter Birk Rasmussen Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle

Also Published As

Publication number Publication date
US20090209430A1 (en) 2009-08-20
US20150126381A1 (en) 2015-05-07
US8951728B2 (en) 2015-02-10
US8168381B2 (en) 2012-05-01
US20180163199A1 (en) 2018-06-14
DK1828381T3 (da) 2009-02-23
WO2006053571A3 (en) 2006-08-17
US20130237459A1 (en) 2013-09-12
WO2006053571A2 (en) 2006-05-26
US20140235509A1 (en) 2014-08-21
DE602005012319D1 (de) 2009-02-26
US20140066336A1 (en) 2014-03-06
EP1828381A2 (de) 2007-09-05
US20150203841A1 (en) 2015-07-23
EP1828381B1 (de) 2009-01-07
US20180251756A1 (en) 2018-09-06

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