ATE420170T1 - Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle - Google Patents

Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle

Info

Publication number
ATE420170T1
ATE420170T1 AT05806601T AT05806601T ATE420170T1 AT E420170 T1 ATE420170 T1 AT E420170T1 AT 05806601 T AT05806601 T AT 05806601T AT 05806601 T AT05806601 T AT 05806601T AT E420170 T1 ATE420170 T1 AT E420170T1
Authority
AT
Austria
Prior art keywords
molecule
oligonucleotide
mattrice
small molecule
reaction wells
Prior art date
Application number
AT05806601T
Other languages
English (en)
Inventor
Peter Birk Rasmussen
Original Assignee
Peter Birk Rasmussen
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36407493&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE420170(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Peter Birk Rasmussen filed Critical Peter Birk Rasmussen
Application granted granted Critical
Publication of ATE420170T1 publication Critical patent/ATE420170T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1065Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1068Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT05806601T 2004-11-22 2005-11-22 Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle ATE420170T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200401809 2004-11-22

Publications (1)

Publication Number Publication Date
ATE420170T1 true ATE420170T1 (de) 2009-01-15

Family

ID=36407493

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05806601T ATE420170T1 (de) 2004-11-22 2005-11-22 Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle

Country Status (6)

Country Link
US (8) US8168381B2 (de)
EP (1) EP1828381B1 (de)
AT (1) ATE420170T1 (de)
DE (1) DE602005012319D1 (de)
DK (1) DK1828381T3 (de)
WO (1) WO2006053571A2 (de)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1401850A1 (de) 2001-06-20 2004-03-31 Nuevolution A/S Nukleosidderivate zur herstellung einer verbindungsbibliothek
US10731151B2 (en) 2002-03-15 2020-08-04 Nuevolution A/S Method for synthesising templated molecules
AU2003214031A1 (en) 2002-03-15 2003-09-29 Nuevolution A/S An improved method for synthesising templated molecules
EP1539980B1 (de) 2002-08-01 2016-02-17 Nuevolution A/S MEHRSTUFENSYNTHESE VON MIT MATRIZEN ASSOZIIERTE MOLEKüLEN
EP2348124B1 (de) 2002-10-30 2013-12-11 Nuevolution A/S Synthese bifunktioneller Komplexe
WO2004056994A2 (en) 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US7915201B2 (en) 2003-03-20 2011-03-29 Nuevolution A/S Ligational encoding of small molecules
US11118215B2 (en) 2003-09-18 2021-09-14 Nuevolution A/S Method for obtaining structural information concerning an encoded molecule and method for selecting compounds
US7972994B2 (en) 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
EP1694693A2 (de) 2003-12-17 2006-08-30 Praecis Pharmaceuticals Inc. Verfahren zur synthese codierter bibliotheken
DE602005017370D1 (de) 2004-03-22 2009-12-10 Nuevolution As Ligationscodierung unter verwendung von oligonukleotidbausteinen
ATE420170T1 (de) * 2004-11-22 2009-01-15 Peter Birk Rasmussen Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle
DK1910538T3 (da) * 2005-06-09 2011-08-08 Praecis Pharm Inc Fremgangsmåder til syntese af kodede biblioteker
JP2009513135A (ja) 2005-10-28 2009-04-02 プリーシス・ファーマシューティカルズ・インコーポレイテッド エンコードされたライブラリーを用いて興味のある化合物を同定する方法
PT3305900T (pt) * 2005-12-01 2021-10-27 Nuevolution As Métodos de codificação enzimática para síntese eficaz de bibliotecas grandes
GB0712245D0 (en) * 2007-06-25 2007-08-01 Cythera Technologies Ltd Combinatorial libraries and related methods
ES2638324T3 (es) 2009-02-13 2017-10-19 X-Chem, Inc. Métodos de creación y examen de bibliotecas codificadas por ADN
EP2446033B1 (de) 2009-06-22 2013-10-23 Université de Strasbourg Methode zur herstellung eines adduktes
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
EP3540059A1 (de) * 2010-04-16 2019-09-18 Nuevolution A/S Bifunktionelle komplexe und verfahren zur herstellung sowie verwendung derartiger komplexe
WO2012041633A1 (en) 2010-09-27 2012-04-05 Vipergen A method for making an enriched library
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
US9695530B2 (en) * 2011-08-11 2017-07-04 Deborah Jean Hall Apparatus to facilitate the commencement and execution of off-loom bead weaving stitches and method(s) of using same
LT2944693T (lt) * 2011-08-26 2019-08-26 Gen9, Inc. Kompozicijos ir būdai, skirti nukleorūgščių didelio tikslumo sąrankai
IN2014CN02574A (de) 2011-09-07 2015-06-26 Chem Inc X
SG10201907347YA (en) 2012-07-13 2019-09-27 X Chem Inc Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
EP4592400A3 (de) 2012-10-17 2025-10-29 10x Genomics Sweden AB Verfahren und produkt zur optimierung einer lokalisierten oder räumlichen detektion einer genexpression in einer gewebeprobe
MX2015016371A (es) 2013-06-04 2017-02-15 Tribiotica Llc Métodos y composiciones para ensamblaje templado de heterocompuestos específicos de acido nucleico.
CA2916662C (en) 2013-06-25 2022-03-08 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
US9765375B2 (en) 2013-06-28 2017-09-19 General Electric Company Methods for developing binding-elements and uses thereof
WO2015179790A1 (en) * 2014-05-23 2015-11-26 Centrillion Technology Holding Corporation Oligonucleotide probe inversion process for in situ synthesized probe arrays
WO2016074683A1 (en) 2014-11-11 2016-05-19 Lundorf Pedersen Materials Aps Method for identification of molecules with desired characteristics
US10900065B2 (en) 2014-11-14 2021-01-26 University Of Washington Methods and kits for labeling cellular molecules
NL2013857B1 (en) * 2014-11-21 2016-10-11 Piculet Biosciences Tech B V Self-assembled bivalent ligand complex (SABLC) libraries and methods for screening such libraries.
CA2968552A1 (en) 2014-12-02 2016-06-09 Tribiotica Llc Methods and kits for theranostic applications
EP3901282B1 (de) 2015-04-10 2023-06-28 Spatial Transcriptomics AB Räumlich getrennte multiplex-nukleinsäureanalyse von biologischen proben
US10695735B2 (en) 2015-08-18 2020-06-30 Centrillion Technology Holdings Corporation Probe inversion process for in situ synthesized probe arrays
US11124791B2 (en) 2015-09-14 2021-09-21 Arizona Board Of Regents On Behalf Of Arizona State University Generating recombinant affinity reagents with arrayed targets
WO2017218293A1 (en) 2016-06-16 2017-12-21 Richard Edward Watts Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules
US11186839B2 (en) 2016-11-21 2021-11-30 Tribiotica Llc Methods for preventing titration of bimolecular templated assembly reactions by structurally-determined differential hybridizations
JP2020501530A (ja) * 2016-11-21 2020-01-23 トリビオティカ・エルエルシー 近接増強反応性による分割タンパク質の鋳型アセンブリ方法
CN110121559A (zh) * 2016-11-21 2019-08-13 特里比奥迪卡有限责任公司 通过模板化组装反应进行蛋白质的定向折叠组装或二聚化的方法
KR102222242B1 (ko) 2017-03-17 2021-03-04 히트젠 주식회사 코드 라이브러리 합성방법 및 조성물
US11795580B2 (en) 2017-05-02 2023-10-24 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
WO2020123316A2 (en) 2018-12-10 2020-06-18 10X Genomics, Inc. Methods for determining a location of a biological analyte in a biological sample
US12529094B2 (en) 2018-12-10 2026-01-20 10X Genomics, Inc. Imaging system hardware
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
CA3127137A1 (en) 2019-01-22 2020-07-30 Vipergen Aps A method for screening of an in vitro display library within a cell
CN113631764A (zh) * 2019-02-21 2021-11-09 斯特拉托斯基因公司 用于固态合成在单分子测序中使用的可扩展聚合物的方法、组合物和装置
WO2020243579A1 (en) 2019-05-30 2020-12-03 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
WO2021092433A2 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Enhancing specificity of analyte binding
CN112794874A (zh) * 2019-11-13 2021-05-14 成都先导药物开发股份有限公司 一种On-DNA Petasis反应的合成方法
ES2982420T3 (es) 2019-12-23 2024-10-16 10X Genomics Inc Métodos para el análisis espacial mediante el uso de la ligazón con plantilla de ARN
EP4081656A1 (de) 2019-12-23 2022-11-02 10X Genomics, Inc. Zusammensetzungen und verfahren zur verwendung von fixierten biologischen proben bei partitionsbasierten tests
CN115135984B (zh) 2019-12-23 2025-12-23 10X基因组学有限公司 可逆固定试剂及其使用方法
US12365942B2 (en) 2020-01-13 2025-07-22 10X Genomics, Inc. Methods of decreasing background on a spatial array
US12405264B2 (en) 2020-01-17 2025-09-02 10X Genomics, Inc. Electrophoretic system and method for analyte capture
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US20210230681A1 (en) 2020-01-24 2021-07-29 10X Genomics, Inc. Methods for spatial analysis using proximity ligation
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
WO2021158925A1 (en) 2020-02-07 2021-08-12 10X Genomics, Inc. Quantitative and automated permeabilization performance evaluation for spatial transcriptomics
US12281357B1 (en) 2020-02-14 2025-04-22 10X Genomics, Inc. In situ spatial barcoding
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
EP4139485B1 (de) 2020-04-22 2023-09-06 10X Genomics, Inc. Verfahren zur räumlichen analyse unter verwendung von gezieltem rna-abbau
EP4153776B1 (de) 2020-05-22 2025-03-05 10X Genomics, Inc. Räumliche analyse zur erkennung von sequenzvarianten
EP4414459B1 (de) 2020-05-22 2025-09-03 10X Genomics, Inc. Simultane räumlich-zeitliche messung der genexpression und der zellaktivität
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
EP4421186B1 (de) 2020-06-08 2025-08-13 10X Genomics, Inc. Verfahren zur bestimmung eines chirurgischen randes und verfahren zur verwendung davon
EP4165207B1 (de) 2020-06-10 2024-09-25 10X Genomics, Inc. Verfahren zur bestimmung der position eines analyten in einer biologischen probe
ES2994976T3 (en) 2020-06-25 2025-02-05 10X Genomics Inc Spatial analysis of dna methylation
US12209280B1 (en) 2020-07-06 2025-01-28 10X Genomics, Inc. Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
EP4729631A2 (de) 2020-12-21 2026-04-22 10X Genomics, Inc. Verfahren, zusammensetzungen und systeme zur erfassung von sonden und/oder barcodes
EP4305196B1 (de) 2021-04-14 2025-04-02 10X Genomics, Inc. Verfahren zur messung der fehllokalisierung eines analyten
EP4320271B1 (de) 2021-05-06 2025-03-19 10X Genomics, Inc. Verfahren zur erhöhung der auflösung von räumlicher analyse
WO2022256503A1 (en) 2021-06-03 2022-12-08 10X Genomics, Inc. Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis
AU2022292804A1 (en) * 2021-06-17 2024-01-18 Insitro, Inc. Methods of preparing bivalent molecules
WO2023034489A1 (en) 2021-09-01 2023-03-09 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
WO2023086880A1 (en) 2021-11-10 2023-05-19 10X Genomics, Inc. Methods, compositions, and kits for determining the location of an analyte in a biological sample
WO2023102118A2 (en) 2021-12-01 2023-06-08 10X Genomics, Inc. Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis
EP4482979B1 (de) 2022-11-09 2025-10-01 10X Genomics, Inc. Verfahren, zusammensetzungen und kits zur bestimmung der position mehrerer analyten in einer biologischen probe
CN116064758B (zh) * 2022-11-17 2025-03-07 纳昂达(南京)生物科技有限公司 选择抑制性环化辅助序列及应用
CN118373729A (zh) * 2024-04-24 2024-07-23 扬州市普林斯医药科技有限公司 一种小分子单分散聚乙二醇的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770358A (en) 1991-09-18 1998-06-23 Affymax Technologies N.V. Tagged synthetic oligomer libraries
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
EP1423400B2 (de) 2001-03-19 2013-05-22 President and Fellows of Harvard College Entwicklung neuer molekularer funktionen
IL159268A0 (en) 2001-06-20 2004-06-01 Nuevolution As Templated molecules and methods for using such molecules
AU2003214031A1 (en) 2002-03-15 2003-09-29 Nuevolution A/S An improved method for synthesising templated molecules
WO2004016767A2 (en) * 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function
EP2348124B1 (de) 2002-10-30 2013-12-11 Nuevolution A/S Synthese bifunktioneller Komplexe
US7915201B2 (en) * 2003-03-20 2011-03-29 Nuevolution A/S Ligational encoding of small molecules
EP1694693A2 (de) * 2003-12-17 2006-08-30 Praecis Pharmaceuticals Inc. Verfahren zur synthese codierter bibliotheken
ATE420170T1 (de) * 2004-11-22 2009-01-15 Peter Birk Rasmussen Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle

Also Published As

Publication number Publication date
US20150203841A1 (en) 2015-07-23
WO2006053571A2 (en) 2006-05-26
US20140235509A1 (en) 2014-08-21
US20090209430A1 (en) 2009-08-20
US8951728B2 (en) 2015-02-10
US20150126381A1 (en) 2015-05-07
EP1828381B1 (de) 2009-01-07
EP1828381A2 (de) 2007-09-05
US20140066336A1 (en) 2014-03-06
US20130237459A1 (en) 2013-09-12
US20180251756A1 (en) 2018-09-06
US20180163199A1 (en) 2018-06-14
WO2006053571A3 (en) 2006-08-17
US8168381B2 (en) 2012-05-01
DK1828381T3 (da) 2009-02-23
DE602005012319D1 (de) 2009-02-26

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