BRPI0419213A - formas secas de formulação de dosagem de ácido biliar solubilizada aquosa: preparação e usos destas - Google Patents
formas secas de formulação de dosagem de ácido biliar solubilizada aquosa: preparação e usos destasInfo
- Publication number
- BRPI0419213A BRPI0419213A BRPI0419213-3A BRPI0419213A BRPI0419213A BR PI0419213 A BRPI0419213 A BR PI0419213A BR PI0419213 A BRPI0419213 A BR PI0419213A BR PI0419213 A BRPI0419213 A BR PI0419213A
- Authority
- BR
- Brazil
- Prior art keywords
- bile acid
- aqueous
- dry forms
- preparation
- dosage formulation
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 7
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 title abstract 6
- 239000003613 bile acid Substances 0.000 title abstract 6
- 238000009472 formulation Methods 0.000 title abstract 3
- 229920002472 Starch Polymers 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000002244 precipitate Substances 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 235000019698 starch Nutrition 0.000 abstract 2
- 239000008107 starch Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012084 conversion product Substances 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
FORMAS SECAS DE FORMULAçãO DE DOSAGEM DE AGIDO BILIAR SOLUBILIZADA AQUOSA: PREPARAçãO E USOS DESTAS. Composições para usos farmacêuticos e outros que compreendem soluções aquosas claras de ácidos biliares que não formam quaisquer precipitados detectáveis sobre as faixas selecionadas de valores de pH da solução aquosa e métodos de preparar tais soluções são descritas. Composições da descrição podem compreender água; um ácido biliar na forma de um ácido biliar, sal de ácido biliar ou ácido biliar conjugado com uma amina por uma ligação de amida; e qualquer um ou ambos os produtos de conversão de amido solúvel aquoso e um polissacarídeo de não amido solúvel aquoso. A composição permanece na solução sem formar um precipitado sobre uma faixa de todos os valores de pH obteníveis em um sistema aquoso. A composição, de acordo com algumas modalidades, pode também conter um composto farmacêutico em uma quantidade farmaceuticamente eficaz. A descrição também fornece formas secas de formulações de ácido biliar solubilizadas aquosas primárias e métodos de preparar tais formas secas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2004/039507 WO2006057637A1 (en) | 2004-11-24 | 2004-11-24 | Dried forms of aqueous solubilized bile acid dosage formulation: preparation and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0419213A true BRPI0419213A (pt) | 2007-12-18 |
Family
ID=34959579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0419213-3A BRPI0419213A (pt) | 2004-11-24 | 2004-11-24 | formas secas de formulação de dosagem de ácido biliar solubilizada aquosa: preparação e usos destas |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1819318A1 (pt) |
| JP (1) | JP2008521800A (pt) |
| CN (1) | CN101065110A (pt) |
| AU (1) | AU2004325203A1 (pt) |
| BR (1) | BRPI0419213A (pt) |
| CA (1) | CA2588168A1 (pt) |
| WO (1) | WO2006057637A1 (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7772220B2 (en) | 2004-10-15 | 2010-08-10 | Seo Hong Yoo | Methods and compositions for reducing toxicity of a pharmaceutical compound |
| US7145125B2 (en) | 2003-06-23 | 2006-12-05 | Advanced Optical Technologies, Llc | Integrating chamber cone light using LED sources |
| ES2339790T3 (es) | 2004-08-30 | 2010-05-25 | Seo Hong Yoo | Efecto neuroprotector de udca solubilizado en modelo isquemico focal. |
| DE602005027727D1 (de) * | 2004-10-15 | 2011-06-09 | Seo Hong Yoo | Zusammensetzungen zur verringerung der toxizität von cisplatin, carboplatin und oxaliplatin |
| CN106075449A (zh) | 2005-07-14 | 2016-11-09 | 尼奥塞蒂克斯公司 | 用于局部脂肪组织治疗的持续释放的增强性脂肪分解性制剂 |
| EP2367554A4 (en) | 2008-11-26 | 2020-03-25 | Satiogen Pharmaceuticals, Inc. | Bile acid reflux inhibitor for the treatment of obesity and diabetes |
| US8318663B2 (en) | 2008-11-26 | 2012-11-27 | Satiogen Pharmaceuticals, Inc. | Methods of treating diabetes and/or obesity using an enteroendocrine peptide secretion enhancing agent |
| JP5420946B2 (ja) | 2009-03-23 | 2014-02-19 | 富士フイルム株式会社 | 胆汁酸を含むミノキシジル水性組成物 |
| US9132084B2 (en) | 2009-05-27 | 2015-09-15 | Neothetics, Inc. | Methods for administration and formulations for the treatment of regional adipose tissue |
| WO2011075539A2 (en) * | 2009-12-18 | 2011-06-23 | Satiogen Pharmaceuticals, Inc. | Treatment of obesity or diabetes with bile acid sequestrants |
| EP4137137A1 (en) | 2010-05-26 | 2023-02-22 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| CN101843823B (zh) * | 2010-05-27 | 2014-04-09 | 宫兆荣 | 感抗注射液及其制备方法 |
| BR112013012994A2 (pt) | 2010-11-24 | 2016-09-13 | Lithera Inc | formulações monoterapêuticas de beta-agonista de longa duração, lipofílicas e seletivas e métodos para o tratamento cosmético da adiposidade e saliência de contorno |
| JP6217938B2 (ja) | 2011-10-28 | 2017-10-25 | ルメナ ファーマシューティカルズ エルエルシー | 小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤 |
| EA038594B1 (ru) | 2011-10-28 | 2021-09-21 | Шайр Хьюман Дженетик Терапис, Инк. | Ингибиторы рециркуляции желчных кислот для лечения гиперхолемии и холестатического заболевания печени |
| KR20180036580A (ko) | 2016-09-30 | 2018-04-09 | 주식회사 유스바이오팜 | 수가용화(水加溶化)된 우르소데옥시콜산을 함유하는 염증성 피부질환 또는 중증 소양증 예방 또는 치료용 조성물 |
| KR102252450B1 (ko) * | 2017-02-09 | 2021-05-14 | 주식회사 아미코젠파마 | 우르소데옥시콜산을 함유하는 시각장애 예방 또는 치료용 조성물 |
| CN108272824A (zh) * | 2018-03-11 | 2018-07-13 | 张显英 | 一种胆汁提取工艺 |
| KR102297982B1 (ko) * | 2019-09-27 | 2021-09-02 | 건양대학교 산학협력단 | 담즙산을 이용한 장내 미생물 억제능 예측 키트를 이용한 억제능 예측방법 |
| CN112138026A (zh) * | 2020-10-28 | 2020-12-29 | 中南民族大学 | 一种熊胆粉在抗醉酒及预防急性酒精性脂肪肝药物中的应用 |
| KR20250100660A (ko) | 2022-10-25 | 2025-07-03 | 베라더믹스 인코포레이티드 | 변형 방출 미녹시딜의 조성물 및 사용 방법 |
| CN115671408A (zh) * | 2022-10-29 | 2023-02-03 | 金傅(北京)医疗科技有限公司 | 一种能够避免肉芽组织增生的物质 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61171421A (ja) * | 1985-08-23 | 1986-08-02 | Yamanouchi Pharmaceut Co Ltd | 安定なプロスタグランジンｅ類製剤の製造方法 |
| JPS62153220A (ja) * | 1985-12-27 | 1987-07-08 | Tokyo Tanabe Co Ltd | 胆汁酸内用水剤 |
| JPH0747539B2 (ja) * | 1986-10-22 | 1995-05-24 | 東京田辺製薬株式会社 | 胆汁酸固形製剤 |
| JPS63243031A (ja) * | 1987-03-28 | 1988-10-07 | Tokyo Tanabe Co Ltd | 胆汁酸の固形製剤 |
| JPH0624991A (ja) * | 1991-06-20 | 1994-02-01 | Tokyo Tanabe Co Ltd | ウルソデスオキシコール酸持続性製剤 |
| US5578304A (en) * | 1992-06-22 | 1996-11-26 | Digestive Care Inc. | Compositions of digestive enzymes and salts of bile acids and process for preparation thereof |
| IT1255968B (it) * | 1992-11-27 | 1995-11-17 | Composizioni farmaceutiche contenenti acido ursodesossicolico | |
| LU88375A1 (fr) * | 1993-07-12 | 1994-04-01 | Michel Urso Prof Medecin Et Ch | Produit énergétique stimulant la puissance virile |
| CN100558407C (zh) * | 2000-02-04 | 2009-11-11 | 柳署弘 | 制备含有胆汁酸的澄清水溶液剂型 |
-
2004
- 2004-11-24 EP EP04812094A patent/EP1819318A1/en not_active Withdrawn
- 2004-11-24 BR BRPI0419213-3A patent/BRPI0419213A/pt not_active IP Right Cessation
- 2004-11-24 JP JP2007543006A patent/JP2008521800A/ja active Pending
- 2004-11-24 CA CA002588168A patent/CA2588168A1/en not_active Abandoned
- 2004-11-24 WO PCT/US2004/039507 patent/WO2006057637A1/en not_active Ceased
- 2004-11-24 CN CNA2004800444670A patent/CN101065110A/zh active Pending
- 2004-11-24 AU AU2004325203A patent/AU2004325203A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008521800A (ja) | 2008-06-26 |
| AU2004325203A1 (en) | 2006-06-01 |
| CA2588168A1 (en) | 2006-06-01 |
| EP1819318A1 (en) | 2007-08-22 |
| WO2006057637A1 (en) | 2006-06-01 |
| CN101065110A (zh) | 2007-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: dismissal - article 86 of industrial property law |
Free format text: REFERENTE A 6A E 7A ANUIDADE(S) |
|
| B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011. |