BRPI0511796A - derivado de propano-1, 3-diona ou seu sal - Google Patents

derivado de propano-1, 3-diona ou seu sal

Info

Publication number
BRPI0511796A
BRPI0511796A BRPI0511796-8A BRPI0511796A BRPI0511796A BR PI0511796 A BRPI0511796 A BR PI0511796A BR PI0511796 A BRPI0511796 A BR PI0511796A BR PI0511796 A BRPI0511796 A BR PI0511796A
Authority
BR
Brazil
Prior art keywords
propane
compound
gnrh receptor
drugs
salt
Prior art date
Application number
BRPI0511796-8A
Other languages
English (en)
Inventor
Masaaki Hirano
Eiji Kawaminami
Isao Kinoyama
Shunichiro Matsumoto
Kei Ohnuki
Kazuyoshi Obitsu
Toshiyuki Kusayama
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of BRPI0511796A publication Critical patent/BRPI0511796A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

DERIVADO DE PROPANO-l,3-DIONA OU SEU SAL. O objetivo é prover um composto útil como um antagonista do receptor de GnRH. Resultados de estudos sobre derivados de propano-1,3-diona confirmaram que, dentre compostos de propano-l,3-diona tendo 2-(l,3-diidro-2H-benzimidazol-2-ilideno), um composto tendo um anel benzeno ou tiofeno substituído por um grupo derivado de 1- hidroxialquila tem excelentes propriedades de transferência de sangue além de um excelente antagonismo do receptor de GnRH. Devido a ter excelentes propriedades de transferência de sangue, além de um potente antagonismo do receptor de GnRH, espera-se que o composto acima exiba excelentes efeitos de droga in vivo e que seja útil no tratamento de doenças dependentes de hormónio sexual tais como câncer da próstata, câncer da mama, endométrio uterino, mioma uterino e hipertrofia da próstata. Além disso, esse composto é excelente na estabilidade metabólica de humanos e mostra poucas interações em contato com drogas. A saber, ele tem ainda propriedades preteridas como drogas a serem usadas para as doenças acima.
BRPI0511796-8A 2004-06-04 2005-06-02 derivado de propano-1, 3-diona ou seu sal BRPI0511796A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004166486 2004-06-04
JP2005099815 2005-03-30
PCT/JP2005/010184 WO2005118556A1 (ja) 2004-06-04 2005-06-02 プロパン－１，３－ジオン誘導体又はその塩

Publications (1)

Publication Number Publication Date
BRPI0511796A true BRPI0511796A (pt) 2008-01-15

Family

ID=35462868

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0511796-8A BRPI0511796A (pt) 2004-06-04 2005-06-02 derivado de propano-1, 3-diona ou seu sal

Country Status (16)

Country Link
US (2) US7709519B2 (pt)
EP (1) EP1752452A4 (pt)
JP (1) JP4595938B2 (pt)
CN (1) CN1964950A (pt)
AR (1) AR049436A1 (pt)
AU (1) AU2005250273B2 (pt)
BR (1) BRPI0511796A (pt)
CA (1) CA2568590C (pt)
IL (1) IL179437A (pt)
MX (1) MXPA06014131A (pt)
NO (1) NO20070074L (pt)
NZ (1) NZ552372A (pt)
RU (1) RU2347781C2 (pt)
TW (1) TWI342307B (pt)
UA (1) UA83928C2 (pt)
WO (1) WO2005118556A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1752452A4 (en) 2004-06-04 2010-07-14 Astellas Pharma Inc DERIVATIVE OF PROPANE-1, 3-DIONE OR ITS SALT
RU2404973C2 (ru) * 2005-03-31 2010-11-27 Астеллас Фарма Инк. Производное соединение пропан-1,3-диона или его соль
EP2095818A1 (en) * 2008-02-29 2009-09-02 AEterna Zentaris GmbH Use of LHRH antagonists at non-castrating doses
ES2879314T3 (es) * 2010-08-18 2021-11-22 Biosplice Therapeutics Inc Dicetonas e hidroxicetonas como activadores de la vía de señalización de catenina
JP6222094B2 (ja) * 2012-09-07 2017-11-01 アステラス製薬株式会社 スルホニルアミジン化合物の製造法
PL2968249T3 (pl) 2013-02-22 2019-06-28 Samumed, Llc Gamma-diketony jako aktywatory szlaku sygnałowego Wnt/beta-kateniny
US9618507B2 (en) 2014-02-24 2017-04-11 Betanien Hospital Methods of treating rheumatoid arthritis
US9795550B2 (en) 2014-08-20 2017-10-24 Samumed, Llc Gamma-diketones for treatment and prevention of aging skin and wrinkles
EP3185881B1 (en) 2014-08-26 2022-03-09 Betanien Hospital Methods, agents and compositions for treatment of inflammatory conditions
JPWO2017170884A1 (ja) * 2016-03-31 2019-02-14 富士フイルム富山化学株式会社 新規なヒドロキサム酸誘導体の製造方法およびその中間体

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Also Published As

Publication number Publication date
US8076367B2 (en) 2011-12-13
IL179437A0 (en) 2007-05-15
UA83928C2 (ru) 2008-08-26
MXPA06014131A (es) 2007-03-07
TW200613281A (en) 2006-05-01
US7709519B2 (en) 2010-05-04
JPWO2005118556A1 (ja) 2008-04-03
US20090018177A1 (en) 2009-01-15
EP1752452A1 (en) 2007-02-14
AU2005250273B2 (en) 2010-10-14
CN1964950A (zh) 2007-05-16
CA2568590C (en) 2011-01-18
JP4595938B2 (ja) 2010-12-08
US20100173946A1 (en) 2010-07-08
RU2006142689A (ru) 2008-06-10
CA2568590A1 (en) 2005-12-15
WO2005118556A1 (ja) 2005-12-15
AR049436A1 (es) 2006-08-02
NZ552372A (en) 2009-11-27
TWI342307B (en) 2011-05-21
AU2005250273A1 (en) 2005-12-15
IL179437A (en) 2011-11-30
NO20070074L (no) 2007-03-02
RU2347781C2 (ru) 2009-02-27
EP1752452A9 (en) 2007-12-12
EP1752452A4 (en) 2010-07-14

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2257 DE 08/04/2014.