BRPI0512911A - anticorpo humano isolado, ácido nucléico, vetor, célula, método de produzir um anticorpo anti-kir humano, composição farmacêutica, e, método de potenciar a atividade da célula nk em um paciente em necessidade do mesmo - Google Patents

anticorpo humano isolado, ácido nucléico, vetor, célula, método de produzir um anticorpo anti-kir humano, composição farmacêutica, e, método de potenciar a atividade da célula nk em um paciente em necessidade do mesmo

Info

Publication number
BRPI0512911A
BRPI0512911A BRPI0512911-7A BRPI0512911A BRPI0512911A BR PI0512911 A BRPI0512911 A BR PI0512911A BR PI0512911 A BRPI0512911 A BR PI0512911A BR PI0512911 A BRPI0512911 A BR PI0512911A
Authority
BR
Brazil
Prior art keywords
cell
antibody
patient
cell activity
vector
Prior art date
Application number
BRPI0512911-7A
Other languages
English (en)
Inventor
Alessandro Moretta
Mariella Della Chiesa
Pascale Andre
Laurent Gauthier
Francois Romagne
Peter Andreas Nicolai Wagtmann
Ivan Svendsen
Stefan Zahn
Anders Svensson
Matthias Th Rolfsson
Soren Berg Padkaer
Kristian Kjaergaard
Pieter Spee
Original Assignee
Novo Nordisk As
Innate Pharma Sas
Univ Genova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2004/002464 external-priority patent/WO2005003172A2/en
Application filed by Novo Nordisk As, Innate Pharma Sas, Univ Genova filed Critical Novo Nordisk As
Priority claimed from PCT/EP2005/053122 external-priority patent/WO2006003179A2/en
Publication of BRPI0512911A publication Critical patent/BRPI0512911A/pt
Publication of BRPI0512911B1 publication Critical patent/BRPI0512911B1/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • E—FIXED CONSTRUCTIONS
    • E06—DOORS, WINDOWS, SHUTTERS, OR ROLLER BLINDS IN GENERAL; LADDERS
    • E06B—FIXED OR MOVABLE CLOSURES FOR OPENINGS IN BUILDINGS, VEHICLES, FENCES OR LIKE ENCLOSURES IN GENERAL, e.g. DOORS, WINDOWS, BLINDS, GATES
    • E06B7/00—Special arrangements or measures in connection with doors or windows
    • E06B7/02—Special arrangements or measures in connection with doors or windows for providing ventilation, e.g. through double windows; Arrangement of ventilation roses
    • E06B7/08—Louvre doors, windows or grilles
    • E06B7/084—Louvre doors, windows or grilles with rotatable lamellae
    • E06B7/086—Louvre doors, windows or grilles with rotatable lamellae interconnected for concurrent movement
    • E—FIXED CONSTRUCTIONS
    • E06—DOORS, WINDOWS, SHUTTERS, OR ROLLER BLINDS IN GENERAL; LADDERS
    • E06B—FIXED OR MOVABLE CLOSURES FOR OPENINGS IN BUILDINGS, VEHICLES, FENCES OR LIKE ENCLOSURES IN GENERAL, e.g. DOORS, WINDOWS, BLINDS, GATES
    • E06B9/00—Screening or protective devices for wall or similar openings, with or without operating or securing mechanisms; Closures of similar construction
    • E06B9/02—Shutters, movable grilles, or other safety closing devices, e.g. against burglary
    • E06B9/06—Shutters, movable grilles, or other safety closing devices, e.g. against burglary collapsible or foldable, e.g. of the bellows or lazy-tongs type
    • E06B9/0607—Shutters, movable grilles, or other safety closing devices, e.g. against burglary collapsible or foldable, e.g. of the bellows or lazy-tongs type comprising a plurality of similar rigid closing elements movable to a storage position
    • E06B9/0615—Shutters, movable grilles, or other safety closing devices, e.g. against burglary collapsible or foldable, e.g. of the bellows or lazy-tongs type comprising a plurality of similar rigid closing elements movable to a storage position characterised by the closing elements
    • E06B9/0638—Slats or panels
    • E—FIXED CONSTRUCTIONS
    • E06—DOORS, WINDOWS, SHUTTERS, OR ROLLER BLINDS IN GENERAL; LADDERS
    • E06B—FIXED OR MOVABLE CLOSURES FOR OPENINGS IN BUILDINGS, VEHICLES, FENCES OR LIKE ENCLOSURES IN GENERAL, e.g. DOORS, WINDOWS, BLINDS, GATES
    • E06B9/00—Screening or protective devices for wall or similar openings, with or without operating or securing mechanisms; Closures of similar construction
    • E06B9/02—Shutters, movable grilles, or other safety closing devices, e.g. against burglary
    • E06B9/06—Shutters, movable grilles, or other safety closing devices, e.g. against burglary collapsible or foldable, e.g. of the bellows or lazy-tongs type
    • E06B9/0607—Shutters, movable grilles, or other safety closing devices, e.g. against burglary collapsible or foldable, e.g. of the bellows or lazy-tongs type comprising a plurality of similar rigid closing elements movable to a storage position
    • E06B9/0646—Shutters, movable grilles, or other safety closing devices, e.g. against burglary collapsible or foldable, e.g. of the bellows or lazy-tongs type comprising a plurality of similar rigid closing elements movable to a storage position characterised by the relative arrangement of the closing elements in the stored position
    • E06B9/0653—Shutters, movable grilles, or other safety closing devices, e.g. against burglary collapsible or foldable, e.g. of the bellows or lazy-tongs type comprising a plurality of similar rigid closing elements movable to a storage position characterised by the relative arrangement of the closing elements in the stored position stored side by side in the closing plane
    • E06B9/0661—Lazy tongue, pantograph or scissor-like systems in the plane of the opening
    • E—FIXED CONSTRUCTIONS
    • E06—DOORS, WINDOWS, SHUTTERS, OR ROLLER BLINDS IN GENERAL; LADDERS
    • E06B—FIXED OR MOVABLE CLOSURES FOR OPENINGS IN BUILDINGS, VEHICLES, FENCES OR LIKE ENCLOSURES IN GENERAL, e.g. DOORS, WINDOWS, BLINDS, GATES
    • E06B9/00—Screening or protective devices for wall or similar openings, with or without operating or securing mechanisms; Closures of similar construction
    • E06B9/24—Screens or other constructions affording protection against light, especially against sunshine; Similar screens for privacy or appearance; Slat blinds
    • E06B9/26—Lamellar or like blinds, e.g. venetian blinds
    • E06B9/28—Lamellar or like blinds, e.g. venetian blinds with horizontal lamellae, e.g. non-liftable
    • E06B9/30—Lamellar or like blinds, e.g. venetian blinds with horizontal lamellae, e.g. non-liftable liftable
    • E06B9/302—Lamellar or like blinds, e.g. venetian blinds with horizontal lamellae, e.g. non-liftable liftable without ladder-tape, e.g. with lazy-tongs, with screw spindle
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • E—FIXED CONSTRUCTIONS
    • E06—DOORS, WINDOWS, SHUTTERS, OR ROLLER BLINDS IN GENERAL; LADDERS
    • E06B—FIXED OR MOVABLE CLOSURES FOR OPENINGS IN BUILDINGS, VEHICLES, FENCES OR LIKE ENCLOSURES IN GENERAL, e.g. DOORS, WINDOWS, BLINDS, GATES
    • E06B9/00—Screening or protective devices for wall or similar openings, with or without operating or securing mechanisms; Closures of similar construction
    • E06B9/02—Shutters, movable grilles, or other safety closing devices, e.g. against burglary
    • E06B9/06—Shutters, movable grilles, or other safety closing devices, e.g. against burglary collapsible or foldable, e.g. of the bellows or lazy-tongs type
    • E06B9/0607—Shutters, movable grilles, or other safety closing devices, e.g. against burglary collapsible or foldable, e.g. of the bellows or lazy-tongs type comprising a plurality of similar rigid closing elements movable to a storage position
    • E06B9/0646—Shutters, movable grilles, or other safety closing devices, e.g. against burglary collapsible or foldable, e.g. of the bellows or lazy-tongs type comprising a plurality of similar rigid closing elements movable to a storage position characterised by the relative arrangement of the closing elements in the stored position
    • E06B9/0653—Shutters, movable grilles, or other safety closing devices, e.g. against burglary collapsible or foldable, e.g. of the bellows or lazy-tongs type comprising a plurality of similar rigid closing elements movable to a storage position characterised by the relative arrangement of the closing elements in the stored position stored side by side in the closing plane
    • E—FIXED CONSTRUCTIONS
    • E06—DOORS, WINDOWS, SHUTTERS, OR ROLLER BLINDS IN GENERAL; LADDERS
    • E06B—FIXED OR MOVABLE CLOSURES FOR OPENINGS IN BUILDINGS, VEHICLES, FENCES OR LIKE ENCLOSURES IN GENERAL, e.g. DOORS, WINDOWS, BLINDS, GATES
    • E06B9/00—Screening or protective devices for wall or similar openings, with or without operating or securing mechanisms; Closures of similar construction
    • E06B9/02—Shutters, movable grilles, or other safety closing devices, e.g. against burglary
    • E06B9/06—Shutters, movable grilles, or other safety closing devices, e.g. against burglary collapsible or foldable, e.g. of the bellows or lazy-tongs type
    • E06B9/0607—Shutters, movable grilles, or other safety closing devices, e.g. against burglary collapsible or foldable, e.g. of the bellows or lazy-tongs type comprising a plurality of similar rigid closing elements movable to a storage position
    • E06B9/0646—Shutters, movable grilles, or other safety closing devices, e.g. against burglary collapsible or foldable, e.g. of the bellows or lazy-tongs type comprising a plurality of similar rigid closing elements movable to a storage position characterised by the relative arrangement of the closing elements in the stored position
    • E06B9/0676—Shutters, movable grilles, or other safety closing devices, e.g. against burglary collapsible or foldable, e.g. of the bellows or lazy-tongs type comprising a plurality of similar rigid closing elements movable to a storage position characterised by the relative arrangement of the closing elements in the stored position stored in a stacked configuration

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Structural Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Civil Engineering (AREA)
  • Architecture (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Blinds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

ANTICORPO HUMANO ISOLADO, áCIDO NUCLEICO, VETOR, CéLULA, MéTODO DE PRODUZIR UM ANTICORPO ANTI-KIR HUMANO, COMPOSIçãO FARMACêUTICA, E, MéTODO DE POTENCIAR A ATIVIDADE DA CéLULA NK EM UM PACIENTE EM NECESSIDADE DO MESMO Composições e métodos para regular uma resposta imune em um paciente são descritos. Mais particularmente, são descritos anticorpos humanos que regulam a atividade de células NK e possibilitam uma potenciação da citotoxicidade de célula NK em pacientes mamíferos e anticorpos tendo propriedades de ligação de antígeno similares àquelas do anticorpo monoclonal humano 1-7F9 ou 14F1. Também são descritos fragmentos e derivados de tais anticorpos, assim como composições farmacêuticas que compreendem os mesmos e seus usos, particularmente para o uso em terapia, para aumentar a atividade ou citotoxicidade da célula NK em pacientes.
BRPI0512911-7A 2004-07-01 2005-07-01 Anticorpo humano isolado, ácido nucleico, vetor, célula, método de produzir um anticorpo anti-kir humano, composição farmacêutica, e, método de potenciar a atividade da célula nk em um paciente em necessidade do mesmo BRPI0512911B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
PCT/IB2004/002464 WO2005003172A2 (en) 2003-07-02 2004-07-01 Pan-kir2dl nk-receptor antibodies and their use in diagnostik and therapy
PCT/DK2004/000470 WO2005003168A2 (en) 2003-07-02 2004-07-01 Methods for the production and cytotoxicity evaluation of kir2dl nk-receptor antibodies
IBPCT/IB2004/002464 2004-07-01
DKPCT/DK2004/000470 2004-07-01
DKPA200500025 2005-01-06
DKPA200500025 2005-01-06
PCT/EP2005/053122 WO2006003179A2 (en) 2004-07-01 2005-07-01 Antibodies binding to receptors kir2dl1, -2, 3 but not kir2ds4 and their therapeutic use

Publications (2)

Publication Number Publication Date
BRPI0512911A true BRPI0512911A (pt) 2008-04-15
BRPI0512911B1 BRPI0512911B1 (pt) 2023-05-16

Family

ID=38462469

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Application Number Title Priority Date Filing Date
BRPI0512911-7A BRPI0512911B1 (pt) 2004-07-01 2005-07-01 Anticorpo humano isolado, ácido nucleico, vetor, célula, método de produzir um anticorpo anti-kir humano, composição farmacêutica, e, método de potenciar a atividade da célula nk em um paciente em necessidade do mesmo

Country Status (24)

Country Link
US (5) US8119775B2 (pt)
EP (3) EP1791868B1 (pt)
JP (2) JP5112863B2 (pt)
KR (1) KR101299167B1 (pt)
CN (2) CN103509111A (pt)
AT (1) ATE499386T1 (pt)
AU (1) AU2005259221B2 (pt)
BR (1) BRPI0512911B1 (pt)
CA (1) CA2601417C (pt)
CY (1) CY1122391T1 (pt)
DE (1) DE602005026538D1 (pt)
DK (2) DK1791868T3 (pt)
ES (2) ES2360467T3 (pt)
HU (1) HUE045639T2 (pt)
IL (1) IL179635A0 (pt)
LT (1) LT2287195T (pt)
MX (1) MX2007000210A (pt)
NO (2) NO341198B1 (pt)
PL (1) PL2287195T3 (pt)
PT (2) PT1791868E (pt)
RU (1) RU2410396C2 (pt)
SI (1) SI2287195T1 (pt)
TW (2) TWI472338B (pt)
ZA (1) ZA200700736B (pt)

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