MA28863B1 - AMIDES DES ACIDES 5- ET 6-AMINOALKYLE INDOLE -2- CARBOXYLIQUES 3-SUBSTITUES ET COMPOSES ANALOGUES ASSOCIES EN TANT QU'INHIBITEURS DE LA CASEINE KINASE l Epsilon - Google Patents

AMIDES DES ACIDES 5- ET 6-AMINOALKYLE INDOLE -2- CARBOXYLIQUES 3-SUBSTITUES ET COMPOSES ANALOGUES ASSOCIES EN TANT QU'INHIBITEURS DE LA CASEINE KINASE l Epsilon

Info

Publication number
MA28863B1
MA28863B1 MA29757A MA29757A MA28863B1 MA 28863 B1 MA28863 B1 MA 28863B1 MA 29757 A MA29757 A MA 29757A MA 29757 A MA29757 A MA 29757A MA 28863 B1 MA28863 B1 MA 28863B1
Authority
MA
Morocco
Prior art keywords
epsilon
substituted
carboxylic acid
acid amides
kinase inhibitors
Prior art date
Application number
MA29757A
Other languages
English (en)
Inventor
William Arthur Metz Jr
Fa-Xiang Ding
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of MA28863B1 publication Critical patent/MA28863B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
MA29757A 2004-08-19 2007-03-14 AMIDES DES ACIDES 5- ET 6-AMINOALKYLE INDOLE -2- CARBOXYLIQUES 3-SUBSTITUES ET COMPOSES ANALOGUES ASSOCIES EN TANT QU'INHIBITEURS DE LA CASEINE KINASE l Epsilon MA28863B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60338004P 2004-08-19 2004-08-19

Publications (1)

Publication Number Publication Date
MA28863B1 true MA28863B1 (fr) 2007-09-03

Family

ID=35311279

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29757A MA28863B1 (fr) 2004-08-19 2007-03-14 AMIDES DES ACIDES 5- ET 6-AMINOALKYLE INDOLE -2- CARBOXYLIQUES 3-SUBSTITUES ET COMPOSES ANALOGUES ASSOCIES EN TANT QU'INHIBITEURS DE LA CASEINE KINASE l Epsilon

Country Status (26)

Country Link
US (2) US7629376B2 (fr)
EP (1) EP1794122B1 (fr)
JP (1) JP4843608B2 (fr)
KR (2) KR20130038409A (fr)
CN (1) CN101006055B (fr)
AR (1) AR050919A1 (fr)
AT (1) ATE508112T1 (fr)
AU (1) AU2005277523B2 (fr)
BR (1) BRPI0514380A (fr)
CA (1) CA2577667C (fr)
DE (1) DE602005027858D1 (fr)
GT (1) GT200500214A (fr)
IL (1) IL181156A (fr)
JO (1) JO2724B1 (fr)
MA (1) MA28863B1 (fr)
MX (1) MX2007001382A (fr)
NO (1) NO20071466L (fr)
NZ (1) NZ552800A (fr)
PA (1) PA8642901A1 (fr)
PE (1) PE20060498A1 (fr)
RU (1) RU2369599C2 (fr)
SV (1) SV2006002192A (fr)
TW (1) TWI357897B (fr)
UY (1) UY29078A1 (fr)
WO (1) WO2006023467A1 (fr)
ZA (1) ZA200700651B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4748823B2 (ja) * 2009-02-12 2011-08-17 株式会社ファルマデザイン カゼインキナーゼ１δ及びカゼインキナーゼ１ε阻害剤
SG175210A1 (en) * 2009-04-17 2011-11-28 Cylene Pharmaceuticals Inc Method of treating disorders associated with protein kinase ck2 activity
CA2877589C (fr) 2012-06-27 2019-11-26 4Sc Ag Inhibiteurs de kinase difluorodioxalane-aminobenzimidazole pour le traitement d'un cancer, d'une inflammation auto-immune et de troubles du snc
JP2021511364A (ja) 2018-01-29 2021-05-06 カディラ ヘルスケア リミティド 抗菌剤として有用な複素環式化合物
WO2022006377A2 (fr) 2020-07-02 2022-01-06 Mbq Pharma Inhibiteurs hétérocycliques de gtpases rho pour le traitement d'une maladie
US12209078B2 (en) 2021-10-06 2025-01-28 Mbq Pharma Crystalline forms of carbazole inhibitors of RhoGTPase for the treatment of disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5296471A (en) 1992-12-22 1994-03-22 Glycomed Incorporated Method for controlling o-desulfation of heparin and compositions produced thereby
KR100722176B1 (ko) 1999-06-08 2007-05-29 아벤티스 파마슈티칼스 인크. 일주기 리듬 단백질을 변화시키기 위한 스크리닝 방법
TWI310035B (en) * 2000-04-28 2009-05-21 Acadia Pharm Inc Muscarinic agonists
CA2494962C (fr) * 2002-08-09 2011-06-14 Merck & Co., Inc. Inhibiteurs de tyrosine kinases
CN100439367C (zh) * 2003-12-11 2008-12-03 安万特药物公司 作为酪蛋白激酶Iε抑制剂的取代的1H-吡咯并[3,2-b、3,2-c和2,3-c]吡啶-2-甲酰胺以及相关类似物

Also Published As

Publication number Publication date
EP1794122A1 (fr) 2007-06-13
CN101006055A (zh) 2007-07-25
CN101006055B (zh) 2011-06-22
US7629376B2 (en) 2009-12-08
HK1105196A1 (en) 2008-02-06
IL181156A0 (en) 2007-07-04
JP2008510017A (ja) 2008-04-03
AU2005277523A1 (en) 2006-03-02
BRPI0514380A (pt) 2008-06-10
SV2006002192A (es) 2006-06-28
EP1794122B1 (fr) 2011-05-04
GT200500214A (es) 2006-03-27
DE602005027858D1 (de) 2011-06-16
CA2577667C (fr) 2011-01-04
NZ552800A (en) 2010-11-26
TW200621711A (en) 2006-07-01
RU2007109783A (ru) 2008-09-27
MX2007001382A (es) 2007-04-19
RU2369599C2 (ru) 2009-10-10
IL181156A (en) 2011-09-27
PE20060498A1 (es) 2006-07-10
US7923466B2 (en) 2011-04-12
AU2005277523B2 (en) 2011-09-29
ATE508112T1 (de) 2011-05-15
JP4843608B2 (ja) 2011-12-21
WO2006023467A1 (fr) 2006-03-02
KR20070043012A (ko) 2007-04-24
US20090082340A1 (en) 2009-03-26
NO20071466L (no) 2007-04-19
CA2577667A1 (fr) 2006-03-02
ZA200700651B (en) 2008-09-25
KR20130038409A (ko) 2013-04-17
TWI357897B (en) 2012-02-11
PA8642901A1 (es) 2006-05-16
US20080027124A1 (en) 2008-01-31
AR050919A1 (es) 2006-12-06
JO2724B1 (en) 2013-09-15
UY29078A1 (es) 2006-03-31

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