BRPI0516152A - formulação farmacêutica que compreende microcápsulas de estatinas ressuspensas em éster alquìlicos de ácidos graxos poli-insaturados (pufa) - Google Patents

formulação farmacêutica que compreende microcápsulas de estatinas ressuspensas em éster alquìlicos de ácidos graxos poli-insaturados (pufa)

Info

Publication number
BRPI0516152A
BRPI0516152A BRPI0516152-5A BRPI0516152A BRPI0516152A BR PI0516152 A BRPI0516152 A BR PI0516152A BR PI0516152 A BRPI0516152 A BR PI0516152A BR PI0516152 A BRPI0516152 A BR PI0516152A
Authority
BR
Brazil
Prior art keywords
pufa
microcapsules
pharmaceutical formulation
fatty acid
polyunsaturated fatty
Prior art date
Application number
BRPI0516152-5A
Other languages
English (en)
Inventor
Paolo Carminati
Antonio Parente
Original Assignee
Gp Pharm Sa
Defiante Farmaceutica Lda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gp Pharm Sa, Defiante Farmaceutica Lda filed Critical Gp Pharm Sa
Publication of BRPI0516152A publication Critical patent/BRPI0516152A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A61K9/5057—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

FORMULAçãO FARMACêUTICA QUE COMPREENDE MICROCáPSULAS DE ESTATINAS RESSUSPENSAS EM éSTER ALQUìLICOS DE áCIDOS GRAXOS POLI-INSATURADOS (PUFA). Formulação farmacêutica composta por uma suspensão que compreende um óleo com elevado conteúdo de Þsteres alquílicos de ácido graxo poli-insaturado (PUFA) e microcápsulas as quais compreendem pelo menos um polímero e uma estatina.
BRPI0516152-5A 2004-10-19 2005-10-13 formulação farmacêutica que compreende microcápsulas de estatinas ressuspensas em éster alquìlicos de ácidos graxos poli-insaturados (pufa) BRPI0516152A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200402492A ES2255426B1 (es) 2004-10-19 2004-10-19 Formulacion farmaceutica que comprende microcapsulas de estatinas suspendidas en ester alquilicos de acidos grasos poliinsaturados (pufa).
PCT/ES2005/000542 WO2006045865A1 (es) 2004-10-19 2005-10-13 Formulación farmacéutica que comprende microcapsulas de estatinas suspendidas en ester alquílicos de ácidos grasos poliinsaturados (pufa)

Publications (1)

Publication Number Publication Date
BRPI0516152A true BRPI0516152A (pt) 2008-08-26

Family

ID=36227494

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0516152-5A BRPI0516152A (pt) 2004-10-19 2005-10-13 formulação farmacêutica que compreende microcápsulas de estatinas ressuspensas em éster alquìlicos de ácidos graxos poli-insaturados (pufa)

Country Status (22)

Country Link
US (1) US20090196920A1 (pt)
EP (1) EP1803440B1 (pt)
JP (1) JP4976302B2 (pt)
KR (1) KR101413339B1 (pt)
CN (2) CN101043873A (pt)
AT (1) ATE469641T1 (pt)
AU (1) AU2005298587B2 (pt)
BR (1) BRPI0516152A (pt)
CA (1) CA2583756C (pt)
CY (1) CY1110751T1 (pt)
DE (1) DE602005021668D1 (pt)
DK (1) DK1803440T3 (pt)
EA (1) EA012371B1 (pt)
ES (2) ES2255426B1 (pt)
IL (1) IL182466A (pt)
MX (1) MX2007004655A (pt)
NZ (1) NZ554265A (pt)
PL (1) PL1803440T3 (pt)
PT (1) PT1803440E (pt)
SI (1) SI1803440T1 (pt)
WO (1) WO2006045865A1 (pt)
ZA (1) ZA200703509B (pt)

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Also Published As

Publication number Publication date
ES2347055T3 (es) 2010-10-25
EP1803440B1 (en) 2010-06-02
US20090196920A1 (en) 2009-08-06
IL182466A (en) 2013-06-27
SI1803440T1 (sl) 2010-10-29
MX2007004655A (es) 2008-03-10
DK1803440T3 (da) 2010-10-04
DE602005021668D1 (de) 2010-07-15
ES2255426A1 (es) 2006-06-16
AU2005298587A1 (en) 2006-05-04
NZ554265A (en) 2010-12-24
CA2583756C (en) 2013-12-24
CN102727462A (zh) 2012-10-17
AU2005298587B2 (en) 2010-08-05
IL182466A0 (en) 2007-07-24
ES2255426B1 (es) 2007-08-16
WO2006045865A1 (es) 2006-05-04
CA2583756A1 (en) 2006-05-04
CY1110751T1 (el) 2015-06-10
PL1803440T3 (pl) 2010-12-31
EA200700614A1 (ru) 2007-10-26
ZA200703509B (en) 2008-09-25
PT1803440E (pt) 2010-08-31
JP2008517040A (ja) 2008-05-22
CN101043873A (zh) 2007-09-26
EA012371B1 (ru) 2009-10-30
KR101413339B1 (ko) 2014-06-27
KR20070083715A (ko) 2007-08-24
EP1803440A1 (en) 2007-07-04
ATE469641T1 (de) 2010-06-15
JP4976302B2 (ja) 2012-07-18

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