BRPI0605940A2 - sìntese de aminas dissubstituìdas úteis em uma etapa - Google Patents

sìntese de aminas dissubstituìdas úteis em uma etapa

Info

Publication number
BRPI0605940A2
BRPI0605940A2 BRPI0605940-6A BRPI0605940A BRPI0605940A2 BR PI0605940 A2 BRPI0605940 A2 BR PI0605940A2 BR PI0605940 A BRPI0605940 A BR PI0605940A BR PI0605940 A2 BRPI0605940 A2 BR PI0605940A2
Authority
BR
Brazil
Prior art keywords
synthesis
amines useful
useful
disubstituted amines
compounds
Prior art date
Application number
BRPI0605940-6A
Other languages
English (en)
Inventor
Rudolf Schmid
Rene Trussardi
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0605940A2 publication Critical patent/BRPI0605940A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/52—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SìNTESE DE AMINAS DISSUBSTITUìDAS úTEIS EM UMA ETAPA. A presente invenção relaciona-se à fabricação dos compostos de fórmula (I), tais compostos de fórmula (I), ou seus sais de lítio, sendo intermediários úteis na fabricação de análogos de Dolastatina, que são úteis no tratamento de câncer.
BRPI0605940-6A 2005-01-13 2006-01-05 sìntese de aminas dissubstituìdas úteis em uma etapa BRPI0605940A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05100180 2005-01-13
PCT/EP2006/000046 WO2006074873A2 (en) 2005-01-13 2006-01-05 New one-step synthesis of useful disubstituted amines

Publications (1)

Publication Number Publication Date
BRPI0605940A2 true BRPI0605940A2 (pt) 2009-05-26

Family

ID=36654131

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0605940-6A BRPI0605940A2 (pt) 2005-01-13 2006-01-05 sìntese de aminas dissubstituìdas úteis em uma etapa

Country Status (12)

Country Link
US (1) US20060155110A1 (pt)
EP (1) EP1838660A2 (pt)
JP (1) JP2008526908A (pt)
KR (1) KR20070087025A (pt)
CN (1) CN101102993A (pt)
AU (1) AU2006205909A1 (pt)
BR (1) BRPI0605940A2 (pt)
CA (1) CA2592969A1 (pt)
IL (1) IL184354A0 (pt)
MX (1) MX2007008349A (pt)
TW (1) TW200720225A (pt)
WO (1) WO2006074873A2 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011100403A1 (en) 2010-02-10 2011-08-18 Immunogen, Inc Cd20 antibodies and uses thereof
CN102816203B (zh) * 2011-06-10 2014-09-03 上海医药工业研究院 一种取代喹啉类化合物及其制备方法、药物组合物和应用
US10832917B2 (en) 2017-06-09 2020-11-10 International Business Machines Corporation Low oxygen cleaning for CMP equipment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2173150C (en) * 1993-10-01 2004-11-30 Kyoichi Sakakibara Novel peptide derivatives
ES2208967T3 (es) * 1996-12-18 2004-06-16 Teva Pharmaceutical Industries, Ltd. Derivados de feniletilamina.
US6737409B2 (en) * 2001-07-19 2004-05-18 Hoffmann-La Roche Inc. Dolastatin 10 derivatives

Also Published As

Publication number Publication date
IL184354A0 (en) 2007-10-31
TW200720225A (en) 2007-06-01
AU2006205909A1 (en) 2006-07-20
EP1838660A2 (en) 2007-10-03
WO2006074873A3 (en) 2006-11-02
CA2592969A1 (en) 2006-07-20
WO2006074873A2 (en) 2006-07-20
MX2007008349A (es) 2007-07-25
US20060155110A1 (en) 2006-07-13
KR20070087025A (ko) 2007-08-27
JP2008526908A (ja) 2008-07-24
CN101102993A (zh) 2008-01-09

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]