BRPI0607053A2 - produção de proteìnas heterooligoméricas em plantas - Google Patents

produção de proteìnas heterooligoméricas em plantas

Info

Publication number
BRPI0607053A2
BRPI0607053A2 BRPI0607053-1A BRPI0607053A BRPI0607053A2 BR PI0607053 A2 BRPI0607053 A2 BR PI0607053A2 BR PI0607053 A BRPI0607053 A BR PI0607053A BR PI0607053 A2 BRPI0607053 A2 BR PI0607053A2
Authority
BR
Brazil
Prior art keywords
plant
viral vector
protein subunit
plants
production
Prior art date
Application number
BRPI0607053-1A
Other languages
English (en)
Inventor
Anatoly Giritch
Sylvestre Marillonnet
Victor Klimyuk
Yuri Gleba
Original Assignee
Icon Genetics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icon Genetics Gmbh filed Critical Icon Genetics Gmbh
Publication of BRPI0607053A2 publication Critical patent/BRPI0607053A2/pt
Publication of BRPI0607053B1 publication Critical patent/BRPI0607053B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8251—Amino acid content, e.g. synthetic storage proteins, altering amino acid biosynthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8202—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by biological means, e.g. cell mediated or natural vector
    • C12N15/8203—Virus mediated transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Reproductive Health (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PRODUçãO DE PROTEìNAS HETEROOLIGOMéRICAS EM PLANTAS. A presente invenção refere-se a um processo para produzir em uma planta, em um tecido da planta, ou em células da planta, uma proteína heterooligomérica que compreende pelo menos uma primeira e uma segunda subunidade da proteína, sendo que o dito processo compreende expressar em células da planta pelo menos a dita primeira e a dita segunda subunidade da proteína, (i) disponibilizar para a dita planta, o dito tecido da planta ou as ditas células da planta, um vetor viral de RNA de fita simples, sentido positivo, que codifica pelo menos a dita primeira e a dita segunda subunidade da proteína, ou (ii) disponibilizar para a dita planta, o dito tecido da planta ou as ditas células da planta, um primeiro e um segundo vetor viral de RNA de fita simples, sentido positivo, sendo que o dito primeiro vetor viral codifica pelo menos a dita primeira subunidade da proteína, o dito segundo vetor viral codifica pelo menos a dita segunda subunidade da proteína, com o que pelo menos o dito primeiro vetor viral e o dito segundo vetor viral são vetores virais não-competitivos.
BRPI0607053-1A 2005-01-28 2006-01-27 Processo para produzir em uma planta, tecido vegetal, ou em células vegetais, um anticorpo como uma proteína hetero-oligomérica que compreende pelo menos uma primeira e uma segunda subunidade proteica BRPI0607053B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US59360605P 2005-01-28 2005-01-28
EP05001819A EP1686176A1 (en) 2005-01-28 2005-01-28 Production of antibodies in plants with plus-sense single-stranded viral RNA vectors
EP05001819.1 2005-01-28
US60/593.606 2005-01-28
PCT/EP2006/000721 WO2006079546A2 (en) 2005-01-28 2006-01-27 Production of antibodies in plants with plus -sense single -stranded viral rna vectors

Publications (2)

Publication Number Publication Date
BRPI0607053A2 true BRPI0607053A2 (pt) 2009-08-04
BRPI0607053B1 BRPI0607053B1 (pt) 2018-02-06

Family

ID=34933496

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607053-1A BRPI0607053B1 (pt) 2005-01-28 2006-01-27 Processo para produzir em uma planta, tecido vegetal, ou em células vegetais, um anticorpo como uma proteína hetero-oligomérica que compreende pelo menos uma primeira e uma segunda subunidade proteica

Country Status (14)

Country Link
US (2) US8940963B2 (pt)
EP (2) EP1686176A1 (pt)
JP (1) JP5015012B2 (pt)
KR (1) KR101293218B1 (pt)
CN (1) CN101115842B (pt)
AT (1) ATE547429T1 (pt)
AU (1) AU2006208631B2 (pt)
BR (1) BRPI0607053B1 (pt)
CA (1) CA2595328C (pt)
DK (1) DK1844152T3 (pt)
ES (1) ES2383670T3 (pt)
IL (1) IL184574A (pt)
MX (1) MX2007008993A (pt)
WO (1) WO2006079546A2 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1764414A1 (en) 2005-09-17 2007-03-21 Icon Genetics AG Plant viral particles comprising a plurality of fusion proteins consisting of a plant viral coat protein, a peptide linker and a recombinant protein and use of such plant viral particles for protein purification
EP1897953A1 (en) * 2006-09-06 2008-03-12 Icon Genetics GmbH Potexvirus-derived replicon
EP2118274A4 (en) * 2007-01-29 2010-09-01 Univ Ohio State Res Found GENE EXPRESSION SYSTEM IN PLANTS WITH A VIRUS-BASED EXPRESSION VECTOR
US8933297B2 (en) 2009-06-15 2015-01-13 Icon Genetics Gmbh Nicotiana benthamiana plants deficient in xylosyltransferase activity
SI23374A (sl) 2010-05-24 2011-11-30 Nacionalni@inštitut@za@biologijo Uporaba glikozidaz in glikoziltransferaz za povečano proizvodnjo proteinov
CA2813986C (en) * 2010-10-08 2019-10-01 Fraunhofer Usa Inc. Closterovirus-based nucleic acid molecules and uses thereof
US20140290135A1 (en) * 2010-12-22 2014-10-02 Philip Morris Products S.A. Method and system for the vacuum infiltration of plants
EP2500035A1 (en) 2011-03-15 2012-09-19 Icon Genetics GmbH Pharmaceutical formulation containing immunglobulin
EP2551348B1 (en) 2011-07-29 2014-09-24 Icon Genetics GmbH Production of galactosylated N-glycans in plants
AU2012320847B2 (en) 2011-10-04 2018-03-08 Icon Genetics Gmbh Nicotiana benthamiana plants deficient in fucosyltransferase activity
JP6350995B2 (ja) 2013-02-20 2018-07-04 国立研究開発法人産業技術総合研究所 植物において外来遺伝子を発現させるための核酸分子及び方法
EP2777711A1 (en) 2013-03-11 2014-09-17 Icon Genetics GmbH Her2/Neu cancer vaccine
KR20150132096A (ko) * 2013-03-22 2015-11-25 프라운호퍼-게젤샤프트 츄어 푀르더룽 데어 안게반텐 포르슝에.파우. 플러스-센스 단일 가닥 rna 바이러스 벡터 및 킷트를 사용하여 폴리펩티드를 생산하기 위한 방법
GB201617109D0 (en) * 2016-10-07 2016-11-23 Rothamsted Res Ltd Vectors and methods for protein expression in plants
JP7011327B2 (ja) * 2017-02-15 2022-02-10 国立研究開発法人農業・食品産業技術総合研究機構 植物ウイルスベクターを利用したゲノム編集植物の生産方法
CN107372609A (zh) * 2017-07-27 2017-11-24 河南柏裕植物免疫科技有限公司 苹果病毒病疫苗
EP3456829A1 (en) 2017-09-18 2019-03-20 Nomad Bioscience GmbH Method of improving potexviral vector stability
AU2019381736A1 (en) * 2018-11-13 2021-06-03 The Regents Of The University Of California Plant vectors, compositions and uses relating thereto
JPWO2020226176A1 (pt) * 2019-05-09 2020-11-12
JP7667540B2 (ja) * 2019-07-21 2025-04-23 国立大学法人大阪大学 植物を用いた塩基性線維芽細胞増殖因子の製造方法
WO2021097086A1 (en) 2019-11-12 2021-05-20 University Of Maryland, College Park Plant vectors, compositions and uses relating thereto
CN115298544B (zh) 2020-03-26 2026-02-24 电化株式会社 含有Fc区域的一部分缺失的抗体的试剂
EP4582810A3 (en) 2020-12-25 2025-12-31 Denka Company Limited METHOD FOR MEASURING TARGET ANTIGEN, AND INSOLUBLE PARTICLES AND TARGET ANTIGEN MEASUREMENT KIT USED THEREIN

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2329074A1 (en) * 1998-10-30 2000-05-11 Thomas Jefferson University Production of biomedical peptides and proteins in plants using plant virus vectors
AU8066701A (en) 2000-07-20 2002-02-05 Neurogen Corp Capsaicin receptor ligands
DE10121283B4 (de) * 2001-04-30 2011-08-11 Icon Genetics GmbH, 80333 Verfahren und Vektoren zur Amplifikation oder Expression von gewünschten Nucleinsäuresequenzen in Pflanzen
CA2450019A1 (en) * 2001-06-08 2002-12-19 Icon Genetics, Inc. Production of proteins in plants
GB0221940D0 (en) * 2002-09-20 2002-10-30 Athena Biodetection Aps Antibody and screening method
US7763430B2 (en) 2003-04-22 2010-07-27 Baxter International Inc. Diagnostic assay for anti-von Willebrand Factor cleaving protease (ADAMTS13) antibodies
EP1769068B1 (en) * 2004-02-20 2014-12-31 iBio, Inc. Systems and methods for clonal expression in plants

Also Published As

Publication number Publication date
CA2595328C (en) 2015-03-24
ES2383670T3 (es) 2012-06-25
JP2008535473A (ja) 2008-09-04
KR20070102570A (ko) 2007-10-18
KR101293218B1 (ko) 2013-08-05
JP5015012B2 (ja) 2012-08-29
MX2007008993A (es) 2007-12-07
AU2006208631B2 (en) 2011-09-22
US20090111145A1 (en) 2009-04-30
CN101115842A (zh) 2008-01-30
IL184574A (en) 2013-05-30
BRPI0607053B1 (pt) 2018-02-06
EP1686176A1 (en) 2006-08-02
CA2595328A1 (en) 2006-08-03
US20150315604A1 (en) 2015-11-05
EP1844152A2 (en) 2007-10-17
US8940963B2 (en) 2015-01-27
ATE547429T1 (de) 2012-03-15
CN101115842B (zh) 2012-10-03
EP1844152B1 (en) 2012-02-29
AU2006208631A1 (en) 2006-08-03
DK1844152T3 (da) 2012-04-30
IL184574A0 (en) 2007-10-31
WO2006079546A3 (en) 2006-10-05
WO2006079546A2 (en) 2006-08-03

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06H Technical and formal requirements: requirement cancelled [chapter 6.8 patent gazette]

Free format text: ANULACAO DA EXIGENCIA 6.6 POR TER SIDO INDEVIDA REFERENTE A RPI NO 2199 DE 26/02/2013.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]