BRPI0607053A2 - produção de proteìnas heterooligoméricas em plantas - Google Patents

produção de proteìnas heterooligoméricas em plantas

Info

Publication number
BRPI0607053A2
BRPI0607053A2 BRPI0607053-1A BRPI0607053A BRPI0607053A2 BR PI0607053 A2 BRPI0607053 A2 BR PI0607053A2 BR PI0607053 A BRPI0607053 A BR PI0607053A BR PI0607053 A2 BRPI0607053 A2 BR PI0607053A2
Authority
BR
Brazil
Prior art keywords
plant
viral vector
protein subunit
plants
production
Prior art date
Application number
BRPI0607053-1A
Other languages
English (en)
Inventor
Anatoly Giritch
Sylvestre Marillonnet
Victor Klimyuk
Yuri Gleba
Original Assignee
Icon Genetics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icon Genetics Gmbh filed Critical Icon Genetics Gmbh
Publication of BRPI0607053A2 publication Critical patent/BRPI0607053A2/pt
Publication of BRPI0607053B1 publication Critical patent/BRPI0607053B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8251—Amino acid content, e.g. synthetic storage proteins, altering amino acid biosynthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8202—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by biological means, e.g. cell mediated or natural vector
    • C12N15/8203—Virus mediated transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PRODUçãO DE PROTEìNAS HETEROOLIGOMéRICAS EM PLANTAS. A presente invenção refere-se a um processo para produzir em uma planta, em um tecido da planta, ou em células da planta, uma proteína heterooligomérica que compreende pelo menos uma primeira e uma segunda subunidade da proteína, sendo que o dito processo compreende expressar em células da planta pelo menos a dita primeira e a dita segunda subunidade da proteína, (i) disponibilizar para a dita planta, o dito tecido da planta ou as ditas células da planta, um vetor viral de RNA de fita simples, sentido positivo, que codifica pelo menos a dita primeira e a dita segunda subunidade da proteína, ou (ii) disponibilizar para a dita planta, o dito tecido da planta ou as ditas células da planta, um primeiro e um segundo vetor viral de RNA de fita simples, sentido positivo, sendo que o dito primeiro vetor viral codifica pelo menos a dita primeira subunidade da proteína, o dito segundo vetor viral codifica pelo menos a dita segunda subunidade da proteína, com o que pelo menos o dito primeiro vetor viral e o dito segundo vetor viral são vetores virais não-competitivos.
BRPI0607053-1A 2005-01-28 2006-01-27 Processo para produzir em uma planta, tecido vegetal, ou em células vegetais, um anticorpo como uma proteína hetero-oligomérica que compreende pelo menos uma primeira e uma segunda subunidade proteica BRPI0607053B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US59360605P 2005-01-28 2005-01-28
EP05001819A EP1686176A1 (en) 2005-01-28 2005-01-28 Production of antibodies in plants with plus-sense single-stranded viral RNA vectors
US60/593.606 2005-01-28
EP05001819.1 2005-01-28
PCT/EP2006/000721 WO2006079546A2 (en) 2005-01-28 2006-01-27 Production of antibodies in plants with plus -sense single -stranded viral rna vectors

Publications (2)

Publication Number Publication Date
BRPI0607053A2 true BRPI0607053A2 (pt) 2009-08-04
BRPI0607053B1 BRPI0607053B1 (pt) 2018-02-06

Family

ID=34933496

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607053-1A BRPI0607053B1 (pt) 2005-01-28 2006-01-27 Processo para produzir em uma planta, tecido vegetal, ou em células vegetais, um anticorpo como uma proteína hetero-oligomérica que compreende pelo menos uma primeira e uma segunda subunidade proteica

Country Status (14)

Country Link
US (2) US8940963B2 (pt)
EP (2) EP1686176A1 (pt)
JP (1) JP5015012B2 (pt)
KR (1) KR101293218B1 (pt)
CN (1) CN101115842B (pt)
AT (1) ATE547429T1 (pt)
AU (1) AU2006208631B2 (pt)
BR (1) BRPI0607053B1 (pt)
CA (1) CA2595328C (pt)
DK (1) DK1844152T3 (pt)
ES (1) ES2383670T3 (pt)
IL (1) IL184574A (pt)
MX (1) MX2007008993A (pt)
WO (1) WO2006079546A2 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1764414A1 (en) 2005-09-17 2007-03-21 Icon Genetics AG Plant viral particles comprising a plurality of fusion proteins consisting of a plant viral coat protein, a peptide linker and a recombinant protein and use of such plant viral particles for protein purification
EP1897953A1 (en) 2006-09-06 2008-03-12 Icon Genetics GmbH Potexvirus-derived replicon
EP2118274A4 (en) * 2007-01-29 2010-09-01 Univ Ohio State Res Found GENE EXPRESSION SYSTEM IN PLANTS WITH A VIRUS-BASED EXPRESSION VECTOR
JP5925677B2 (ja) 2009-06-15 2016-06-01 アイコン・ジェネティクス・ゲーエムベーハー キシロシルトランスフェラーゼ活性の欠損したベンサミアナタバコ（Ｎｉｃｏｔｉａｎａｂｅｎｔｈａｍｉａｎａ）植物
SI23374A (sl) 2010-05-24 2011-11-30 Nacionalni@inštitut@za@biologijo Uporaba glikozidaz in glikoziltransferaz za povečano proizvodnjo proteinov
WO2012048221A1 (en) * 2010-10-08 2012-04-12 Fraunhofer Usa Inc. Closterovirus-based nucleic acid molecules and uses thereof
US20140290135A1 (en) * 2010-12-22 2014-10-02 Philip Morris Products S.A. Method and system for the vacuum infiltration of plants
EP2500035A1 (en) 2011-03-15 2012-09-19 Icon Genetics GmbH Pharmaceutical formulation containing immunglobulin
US9181532B2 (en) 2011-07-29 2015-11-10 Icon Genetics Gmbh Production of galactosylated N-glycans in plants
WO2013050155A1 (en) 2011-10-04 2013-04-11 Icon Genetics Gmbh Nicotiana benthamiana plants deficient in fucosyltransferase activity
US20160002654A1 (en) 2013-02-20 2016-01-07 National Institute Of Advanced Industrial Science And Technology Nucleic acid molecule for expressing foreign gene in plant and method therefor
EP2777711A1 (en) 2013-03-11 2014-09-17 Icon Genetics GmbH Her2/Neu cancer vaccine
US10190128B2 (en) * 2013-03-22 2019-01-29 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Kits comprising plus-sense single stranded RNA viral vectors and methods for producing polypeptides using the kits
GB201617109D0 (en) * 2016-10-07 2016-11-23 Rothamsted Res Ltd Vectors and methods for protein expression in plants
JP7011327B2 (ja) * 2017-02-15 2022-02-10 国立研究開発法人農業・食品産業技術総合研究機構 植物ウイルスベクターを利用したゲノム編集植物の生産方法
CN107372609A (zh) * 2017-07-27 2017-11-24 河南柏裕植物免疫科技有限公司 苹果病毒病疫苗
EP3456829A1 (en) 2017-09-18 2019-03-20 Nomad Bioscience GmbH Method of improving potexviral vector stability
EP3880828A4 (en) * 2018-11-13 2022-08-03 University of Maryland, College Park PLANT VECTORS, COMPOSITIONS AND USES RELATED THERETO
JPWO2020226176A1 (pt) * 2019-05-09 2020-11-12
JP7667540B2 (ja) * 2019-07-21 2025-04-23 国立大学法人大阪大学 植物を用いた塩基性線維芽細胞増殖因子の製造方法
CN115052979A (zh) * 2019-11-12 2022-09-13 马里兰大学派克分院 植物载体、组合物及其相关用途
JP7626753B2 (ja) 2020-03-26 2025-02-04 デンカ株式会社 Ｆｃ領域の一部を欠損した抗体を含む試薬
CN116601168A (zh) 2020-12-25 2023-08-15 电化株式会社 靶抗原的测定方法以及用于其的不溶性粒子及靶抗原测定用试剂盒

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000025574A1 (en) * 1998-10-30 2000-05-11 Thomas Jefferson University Production of biomedical peptides and proteins in plants using plant virus vectors
EP1301484A2 (en) 2000-07-20 2003-04-16 Neurogen Corporation Capsaicin receptor ligands
DE10121283B4 (de) * 2001-04-30 2011-08-11 Icon Genetics GmbH, 80333 Verfahren und Vektoren zur Amplifikation oder Expression von gewünschten Nucleinsäuresequenzen in Pflanzen
CN1533438A (zh) * 2001-06-08 2004-09-29 �����Ŵ��Ƽ���˾ 在植物生产蛋白质的方法
GB0221940D0 (en) * 2002-09-20 2002-10-30 Athena Biodetection Aps Antibody and screening method
US7763430B2 (en) 2003-04-22 2010-07-27 Baxter International Inc. Diagnostic assay for anti-von Willebrand Factor cleaving protease (ADAMTS13) antibodies
EP1769068B1 (en) * 2004-02-20 2014-12-31 iBio, Inc. Systems and methods for clonal expression in plants

Also Published As

Publication number Publication date
AU2006208631A1 (en) 2006-08-03
CA2595328C (en) 2015-03-24
ATE547429T1 (de) 2012-03-15
WO2006079546A3 (en) 2006-10-05
IL184574A0 (en) 2007-10-31
JP5015012B2 (ja) 2012-08-29
US8940963B2 (en) 2015-01-27
KR20070102570A (ko) 2007-10-18
CA2595328A1 (en) 2006-08-03
AU2006208631B2 (en) 2011-09-22
CN101115842A (zh) 2008-01-30
BRPI0607053B1 (pt) 2018-02-06
IL184574A (en) 2013-05-30
DK1844152T3 (da) 2012-04-30
JP2008535473A (ja) 2008-09-04
EP1686176A1 (en) 2006-08-02
CN101115842B (zh) 2012-10-03
KR101293218B1 (ko) 2013-08-05
US20150315604A1 (en) 2015-11-05
MX2007008993A (es) 2007-12-07
EP1844152B1 (en) 2012-02-29
EP1844152A2 (en) 2007-10-17
ES2383670T3 (es) 2012-06-25
US20090111145A1 (en) 2009-04-30
WO2006079546A2 (en) 2006-08-03

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06H Technical and formal requirements: requirement cancelled [chapter 6.8 patent gazette]

Free format text: ANULACAO DA EXIGENCIA 6.6 POR TER SIDO INDEVIDA REFERENTE A RPI NO 2199 DE 26/02/2013.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]