BRPI0614062B8 - processo para preparar brometo de tiotrópio, composto de partida ou intermediário e seus usos - Google Patents

processo para preparar brometo de tiotrópio, composto de partida ou intermediário e seus usos

Info

Publication number
BRPI0614062B8
BRPI0614062B8 BRPI0614062A BRPI0614062A BRPI0614062B8 BR PI0614062 B8 BRPI0614062 B8 BR PI0614062B8 BR PI0614062 A BRPI0614062 A BR PI0614062A BR PI0614062 A BRPI0614062 A BR PI0614062A BR PI0614062 B8 BRPI0614062 B8 BR PI0614062B8
Authority
BR
Brazil
Prior art keywords
starting compound
tiotropium bromide
preparing tiotropium
preparing
production
Prior art date
Application number
BRPI0614062A
Other languages
English (en)
Inventor
Brandenburg Joerg
Pfrengle Waldemar
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of BRPI0614062A2 publication Critical patent/BRPI0614062A2/pt
Publication of BRPI0614062B1 publication Critical patent/BRPI0614062B1/pt
Publication of BRPI0614062B8 publication Critical patent/BRPI0614062B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

processo para a produção de sais de tiotrópio. a invenção refere-se a um novo processo para a produção de sais de tiotrópio da fórmula geral (1), em que x pode ter os significados mencionados nas reivindicações e no relatório descritivo.
BRPI0614062A 2005-07-27 2006-07-24 processo para preparar brometo de tiotrópio, composto de partida ou intermediário e seus usos BRPI0614062B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005035112A DE102005035112A1 (de) 2005-07-27 2005-07-27 Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
DE102005035112.3 2005-07-27
PCT/EP2006/064559 WO2007012626A2 (de) 2005-07-27 2006-07-24 Neues verfahren zur herstellung von tiotropiumsalzen

Publications (3)

Publication Number Publication Date
BRPI0614062A2 BRPI0614062A2 (pt) 2011-03-09
BRPI0614062B1 BRPI0614062B1 (pt) 2020-11-17
BRPI0614062B8 true BRPI0614062B8 (pt) 2021-05-25

Family

ID=37110331

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0614062A BRPI0614062B8 (pt) 2005-07-27 2006-07-24 processo para preparar brometo de tiotrópio, composto de partida ou intermediário e seus usos

Country Status (24)

Country Link
US (5) US20070027320A1 (pt)
EP (2) EP1910354B1 (pt)
JP (1) JP5210861B2 (pt)
KR (1) KR101299929B1 (pt)
CN (2) CN104356129A (pt)
AR (1) AR057690A1 (pt)
AU (1) AU2006274012B2 (pt)
BR (1) BRPI0614062B8 (pt)
CA (1) CA2616222C (pt)
DE (1) DE102005035112A1 (pt)
DK (1) DK1910354T3 (pt)
EA (1) EA014271B1 (pt)
EC (1) ECSP088138A (pt)
ES (1) ES2613952T3 (pt)
HU (1) HUE032259T2 (pt)
IL (1) IL188989A (pt)
MX (1) MX2008001093A (pt)
NO (2) NO340877B1 (pt)
NZ (1) NZ566039A (pt)
PL (1) PL1910354T3 (pt)
TW (3) TWI486346B (pt)
UA (1) UA94914C2 (pt)
WO (1) WO2007012626A2 (pt)
ZA (1) ZA200711113B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008089852A1 (de) * 2007-01-26 2008-07-31 Boehringer Ingelheim Pharma Gmbh & Co.Kg Neues verfahren zur herstellung von tiotropiumsalzen
EP1953156A1 (de) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopiniumsalzen
EP1950196A1 (de) * 2007-01-29 2008-07-30 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Ammoniumhexafluorophosphaten
EP1997819A1 (de) 2007-05-25 2008-12-03 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopinestern
EP2036898A2 (de) * 2007-09-13 2009-03-18 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von 1,3-Dioxolan-2Onen sowie von Carbonsäureestern durch Transacylierung unter Basischen Reaktionsbedingungen
DK2240477T3 (en) * 2008-01-10 2014-12-08 Generics Uk Ltd New process for the preparation of skopinestre
WO2011015884A1 (en) * 2009-08-07 2011-02-10 Generics [Uk] Limited Process to prepare scopine esters
NZ597920A (en) 2009-08-07 2014-05-30 Generics Uk Ltd Anhydrate of tiotropium bromide
CZ305012B6 (cs) * 2012-03-30 2015-03-25 Zentiva, K.S. Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu
WO2021133280A1 (en) * 2019-12-27 2021-07-01 Deva Holding An improved process for preparation of scopine hydrobromide

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US7441045B2 (en) * 1999-12-13 2008-10-21 F5 Networks, Inc. Method and system for balancing load distribution on a wide area network
US6934686B1 (en) 2000-06-30 2005-08-23 I2 Technologies Us, Inc. Warranty transaction system and method
US7574499B1 (en) * 2000-07-19 2009-08-11 Akamai Technologies, Inc. Global traffic management system using IP anycast routing and dynamic load-balancing
US6706726B2 (en) * 2000-10-14 2004-03-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics which may be used as medicaments as well as processes for preparing them
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
US6506900B1 (en) * 2001-01-31 2003-01-14 Boehringer Ingelheim Pharma Ag Process for preparing a scopine ester intermediate
US7237017B1 (en) * 2001-03-13 2007-06-26 Panamsat Corporation Micronode in a satellite based content delivery system
WO2002079905A2 (en) * 2001-04-02 2002-10-10 Akamai Technologies, Inc. Scalable, high performance and highly available distributed storage system for internet content
WO2002096423A2 (en) * 2001-05-25 2002-12-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Combination of a pde4 inhibitor and tiotropium or derivate thereof for treating obstructive airways
JP4160506B2 (ja) * 2001-09-28 2008-10-01 レヴェル ３ シーディーエヌ インターナショナル インコーポレーテッド． 構成可能な適応型広域トラフィック制御および管理
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
US7305429B2 (en) * 2002-06-10 2007-12-04 Utstarcom, Inc. Method and apparatus for global server load balancing
EP1504756A1 (en) * 2003-08-06 2005-02-09 Kyowa Hakko Kogyo Co., Ltd Medicament compositions comprising a heterocyclic compound and an anticholinergic
MXPA06004697A (es) * 2003-11-03 2006-07-05 Boehringer Ingelheim Int Procedimiento para la preparacion de sales de tiotropio, sles de tiotropio, asi como formulaciones medicamentosas que las contienen.
AU2004285685B2 (en) * 2003-11-03 2011-03-24 Boehringer Ingelheim International Gmbh Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same
DE102004041253A1 (de) * 2004-08-26 2006-03-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen
NZ564697A (en) * 2005-06-15 2010-04-30 Boehringer Ingelheim Int Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
CN101309920A (zh) 2008-11-19
WO2007012626A2 (de) 2007-02-01
ZA200711113B (en) 2010-08-25
TW200738704A (en) 2007-10-16
CN104356129A (zh) 2015-02-18
JP2009507769A (ja) 2009-02-26
ES2613952T3 (es) 2017-05-29
PL1910354T3 (pl) 2017-04-28
NO340877B1 (no) 2017-07-03
BRPI0614062A2 (pt) 2011-03-09
DE102005035112A1 (de) 2007-02-15
US20070027320A1 (en) 2007-02-01
US20130116435A1 (en) 2013-05-09
DK1910354T3 (en) 2017-02-13
EP1910354A2 (de) 2008-04-16
CA2616222A1 (en) 2007-02-01
WO2007012626A3 (de) 2010-05-06
IL188989A (en) 2012-10-31
TW201418252A (zh) 2014-05-16
US20140323732A1 (en) 2014-10-30
KR101299929B1 (ko) 2013-08-27
MX2008001093A (es) 2008-03-11
NO20170613A1 (no) 2008-02-13
UA94914C2 (ru) 2011-06-25
CA2616222C (en) 2014-09-23
EP3153512A1 (de) 2017-04-12
AR057690A1 (es) 2007-12-12
IL188989A0 (en) 2008-08-07
EA200800324A1 (ru) 2008-08-29
US20100210844A1 (en) 2010-08-19
ECSP088138A (es) 2008-02-20
HUE032259T2 (en) 2017-09-28
JP5210861B2 (ja) 2013-06-12
TWI486345B (zh) 2015-06-01
AU2006274012B2 (en) 2011-11-03
NO20076681L (no) 2008-02-13
BRPI0614062B1 (pt) 2020-11-17
NZ566039A (en) 2011-07-29
TWI486346B (zh) 2015-06-01
EA014271B1 (ru) 2010-10-29
TW201418253A (zh) 2014-05-16
AU2006274012A1 (en) 2007-02-01
US20150225395A1 (en) 2015-08-13
KR20080032634A (ko) 2008-04-15
EP1910354B1 (de) 2016-11-09
TWI443097B (zh) 2014-07-01

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 17/11/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/07/2006 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF