BRPI0514643A - processo para a produção de sais de tiotrópio - Google Patents

processo para a produção de sais de tiotrópio

Info

Publication number
BRPI0514643A
BRPI0514643A BRPI0514643-7A BRPI0514643A BRPI0514643A BR PI0514643 A BRPI0514643 A BR PI0514643A BR PI0514643 A BRPI0514643 A BR PI0514643A BR PI0514643 A BRPI0514643 A BR PI0514643A
Authority
BR
Brazil
Prior art keywords
production
tiotropium salts
salts
tiotropium
general formula
Prior art date
Application number
BRPI0514643-7A
Other languages
English (en)
Inventor
Ralf Lock
Werner Belzer
Rainer Hamm
Monika Hofmann
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35745545&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0514643(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of BRPI0514643A publication Critical patent/BRPI0514643A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCESSO PARA A PRODUçãO DE SAIS DE TIOTRóPIO A invenção refere-se a um novo processo para a produção de sais de tiotrópio da fórmula geral (I), na qual X» pode ter os significados mencionados nas reivindicações e no relatório descritivo.
BRPI0514643-7A 2004-08-26 2005-08-23 processo para a produção de sais de tiotrópio BRPI0514643A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004041253A DE102004041253A1 (de) 2004-08-26 2004-08-26 Neues Verfahren zur Herstellung von Tiotropiumsalzen
PCT/EP2005/054131 WO2006021559A2 (de) 2004-08-26 2005-08-23 Verfahren zur herstellung von tiotropiumsalzen und silicium-derivate als zwischenprodukte

Publications (1)

Publication Number Publication Date
BRPI0514643A true BRPI0514643A (pt) 2008-06-17

Family

ID=35745545

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514643-7A BRPI0514643A (pt) 2004-08-26 2005-08-23 processo para a produção de sais de tiotrópio

Country Status (16)

Country Link
US (2) US7491824B2 (pt)
EP (1) EP1794158A2 (pt)
JP (1) JP5173421B2 (pt)
KR (1) KR101274455B1 (pt)
CN (1) CN100532382C (pt)
AR (1) AR050714A1 (pt)
AU (1) AU2005276432B2 (pt)
BR (1) BRPI0514643A (pt)
CA (1) CA2573373C (pt)
DE (1) DE102004041253A1 (pt)
IL (3) IL181522A (pt)
NZ (1) NZ553840A (pt)
RU (1) RU2384575C2 (pt)
TW (2) TWI387595B (pt)
WO (1) WO2006021559A2 (pt)
ZA (1) ZA200610503B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2083007T3 (da) * 2003-11-03 2013-07-29 Boehringer Ingelheim Int Tiotropiumsalte, fremgangsmåder til deres fremstilling og lægemiddelformuleringer indeholdende disse
JP5165244B2 (ja) * 2003-11-03 2013-03-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング チオトロピウム塩の製法、チオトロピウム塩及びそれを含有する医薬組成物
WO2006117299A2 (en) * 2005-05-02 2006-11-09 Boehringer Ingelheim International Gmbh Novel crystalline forms of tiotropium bromide
NZ564697A (en) * 2005-06-15 2010-04-30 Boehringer Ingelheim Int Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
US20080051582A1 (en) * 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
TR201007108A2 (tr) * 2010-08-25 2012-03-21 B�Lg�� Mahmut Yeni tiotropyum bromür kristali ve üretim yöntemi.@
US9707375B2 (en) 2011-03-14 2017-07-18 Rochester Medical Corporation, a subsidiary of C. R. Bard, Inc. Catheter grip and method
ITRM20110508A1 (it) 2011-09-27 2013-03-28 Lusochimica Spa Processo per la preparazione degli esteri della scopina.
US8680297B2 (en) 2011-10-06 2014-03-25 Drug Process Licensing Assoc., LLC Manufacturing process for tiotropium bromide
CZ304808B6 (cs) 2012-03-16 2014-11-05 Zentiva, K.S. Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu a jeho nová forma
CZ305012B6 (cs) 2012-03-30 2015-03-25 Zentiva, K.S. Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu
AU2014248455B2 (en) 2013-04-01 2018-12-06 Pulmatrix Operating Company, Inc. Tiotropium dry powders
WO2019129801A1 (en) 2017-12-28 2019-07-04 Linnea S.A. Process for the purification of methyl-2,2-dithienylglycolate

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ220791A (en) * 1986-06-27 1990-08-28 Marion Laboratories Inc 1-phenyl-7-aminohept-5-yn-2-one derivatives
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE4108393A1 (de) * 1991-03-15 1992-09-17 Boehringer Ingelheim Kg Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln
US5554120A (en) * 1994-07-25 1996-09-10 Advanced Cardiovascular Systems, Inc. Polymer blends for use in making medical devices including catheters and balloons for dilatation catheters
DE10200943A1 (de) 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern

Also Published As

Publication number Publication date
JP5173421B2 (ja) 2013-04-03
WO2006021559A3 (de) 2006-08-17
CN101001855A (zh) 2007-07-18
KR101274455B1 (ko) 2013-06-18
TW201231466A (en) 2012-08-01
IL213717A0 (en) 2011-07-31
JP2008510774A (ja) 2008-04-10
ZA200610503B (en) 2008-09-25
US8008495B2 (en) 2011-08-30
CA2573373A1 (en) 2006-03-02
EP1794158A2 (de) 2007-06-13
IL181522A0 (en) 2007-07-04
AR050714A1 (es) 2006-11-15
TWI429646B (zh) 2014-03-11
RU2384575C2 (ru) 2010-03-20
WO2006021559A8 (de) 2006-11-16
TW200617006A (en) 2006-06-01
TWI387595B (zh) 2013-03-01
RU2007110951A (ru) 2008-10-10
AU2005276432B2 (en) 2011-11-10
KR20070046196A (ko) 2007-05-02
US7491824B2 (en) 2009-02-17
IL213720A0 (en) 2011-07-31
NZ553840A (en) 2010-06-25
US20060047120A1 (en) 2006-03-02
IL213720A (en) 2012-03-29
CA2573373C (en) 2014-05-06
WO2006021559A2 (de) 2006-03-02
IL181522A (en) 2011-08-31
CN100532382C (zh) 2009-08-26
AU2005276432A1 (en) 2006-03-02
US20090118511A1 (en) 2009-05-07
DE102004041253A1 (de) 2006-03-02

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]