BRPI0711326A2 - miméticos de smac bivalentes e os usos destes - Google Patents

miméticos de smac bivalentes e os usos destes Download PDF

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Publication number
BRPI0711326A2
BRPI0711326A2 BRPI0711326-9A BRPI0711326A BRPI0711326A2 BR PI0711326 A2 BRPI0711326 A2 BR PI0711326A2 BR PI0711326 A BRPI0711326 A BR PI0711326A BR PI0711326 A2 BRPI0711326 A2 BR PI0711326A2
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BR
Brazil
Prior art keywords
smac mimetics
mimetics
divalent
relates
divalent smac
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BRPI0711326-9A
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English (en)
Inventor
Shaomeng Wang
Haiying Sun
Dongguang Qin
Zaneta Nikolovska-Coleska
Jianfeng Lu
Su Qiu
Yuefeng Peng
Qian Cai
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Univ Michigan
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Application filed by Univ Michigan filed Critical Univ Michigan
Publication of BRPI0711326A2 publication Critical patent/BRPI0711326A2/pt
Publication of BRPI0711326B1 publication Critical patent/BRPI0711326B1/pt
Publication of BRPI0711326B8 publication Critical patent/BRPI0711326B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/12—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

MIMéTICOS DE SMAC BIVALENTES E OS USOS DESTES. A invenção se refere aos miméticos bivalentes de Smac que funcionam como inibidores do Inibidor de Proteínas de Apoptose. A invenção também se refere ao uso destes miméticos para induzir a morte de célula apoptótica e para sensibilizar as células aos indutores de apoptose.
BRPI0711326A 2006-05-05 2007-05-04 compostos miméticos de smac bivalentes BRPI0711326B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US79801806P 2006-05-05 2006-05-05
US60/798.018 2006-05-05
US92341507P 2007-04-13 2007-04-13
US60/923.415 2007-04-13
PCT/US2007/010924 WO2007130626A2 (en) 2006-05-05 2007-05-04 Bivalent smac mimetics and the uses thereof

Publications (3)

Publication Number Publication Date
BRPI0711326A2 true BRPI0711326A2 (pt) 2011-08-30
BRPI0711326B1 BRPI0711326B1 (pt) 2020-12-01
BRPI0711326B8 BRPI0711326B8 (pt) 2021-05-25

Family

ID=38668354

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0711326A BRPI0711326B8 (pt) 2006-05-05 2007-05-04 compostos miméticos de smac bivalentes

Country Status (22)

Country Link
US (1) US7960372B2 (pt)
EP (1) EP2019671B1 (pt)
JP (1) JP5230610B2 (pt)
KR (1) KR101071516B1 (pt)
CN (1) CN101484151B (pt)
AU (1) AU2007248473B2 (pt)
BR (1) BRPI0711326B8 (pt)
CA (1) CA2651206C (pt)
CY (1) CY1115808T1 (pt)
DK (1) DK2019671T3 (pt)
EA (1) EA017279B1 (pt)
ES (1) ES2525585T3 (pt)
HR (1) HRP20141253T1 (pt)
IL (1) IL195075A (pt)
MX (1) MX2008014140A (pt)
NO (1) NO341896B1 (pt)
NZ (1) NZ572531A (pt)
PL (1) PL2019671T3 (pt)
PT (1) PT2019671E (pt)
SI (1) SI2019671T1 (pt)
WO (1) WO2007130626A2 (pt)
ZA (1) ZA200809496B (pt)

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NO341896B1 (no) 2018-02-12
IL195075A (en) 2015-03-31
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US7960372B2 (en) 2011-06-14
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JP2009536204A (ja) 2009-10-08
EA017279B1 (ru) 2012-11-30
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US20080089896A1 (en) 2008-04-17
EP2019671B1 (en) 2014-09-24
BRPI0711326B1 (pt) 2020-12-01
ES2525585T3 (es) 2014-12-26
CN101484151B (zh) 2012-11-21
AU2007248473B2 (en) 2011-01-27
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BRPI0711326B8 (pt) 2021-05-25
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