BRPI0714844B8 - molécula de ácido nucleico e seus usos, composição farmaceutica e complexo - Google Patents

molécula de ácido nucleico e seus usos, composição farmaceutica e complexo

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Publication number
BRPI0714844B8
BRPI0714844B8 BRPI0714844A BRPI0714844A BRPI0714844B8 BR PI0714844 B8 BRPI0714844 B8 BR PI0714844B8 BR PI0714844 A BRPI0714844 A BR PI0714844A BR PI0714844 A BRPI0714844 A BR PI0714844A BR PI0714844 B8 BRPI0714844 B8 BR PI0714844B8
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BR
Brazil
Prior art keywords
nucleic acid
acid molecule
complex
pharmaceutical composition
type
Prior art date
Application number
BRPI0714844A
Other languages
English (en)
Inventor
Purschke Werner
Jarosch Florian
Eulberg Dirk
Klussmann Sven
Buchner Klaus
Maasch Christian
Dinse Nicole
Original Assignee
Noxxon Pharma Ag
TME Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noxxon Pharma Ag, TME Pharma AG filed Critical Noxxon Pharma Ag
Publication of BRPI0714844A2 publication Critical patent/BRPI0714844A2/pt
Publication of BRPI0714844B1 publication Critical patent/BRPI0714844B1/pt
Publication of BRPI0714844B8 publication Critical patent/BRPI0714844B8/pt

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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6813—Hybridisation assays
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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Abstract

MOLÉCULA DE ÁCIDO NUCLEICO, SUA COMPOSIÇÃO FARMACEUTICA, SEUS USOS, SEU COMPLEXO, MÉTODOS DE TRIAGEM, KIT E ANTAGONISTA DE SDF-1. A presente invenção refere-se a uma molécula de ácido nucleico, preferencialmente ligando a SDF-1, selecionada entre o grupo compreendendo moléculas de ácido nucleico tipo A, moléculas de ácido nucleico tipo B, moléculas de ácido nucleico tipo C e moléculas de ácido nucleico tendo uma sequência de ácido nucleico de acordo com qualquer de SEQ. ID. N° 142, SEQ. ID. N° 143 e SEQ. ID. N° 144.
BRPI0714844A 2006-07-18 2007-07-18 molécula de ácido nucleico e seus usos, composição farmaceutica e complexo BRPI0714844B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06014957 2006-07-18
EP06014957.2 2006-07-18
PCT/EP2007/006387 WO2008009437A2 (en) 2006-07-18 2007-07-18 Sdf-i binding nucleic acids

Publications (3)

Publication Number Publication Date
BRPI0714844A2 BRPI0714844A2 (pt) 2013-11-26
BRPI0714844B1 BRPI0714844B1 (pt) 2019-10-01
BRPI0714844B8 true BRPI0714844B8 (pt) 2023-04-18

Family

ID=38947372

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0714844A BRPI0714844B8 (pt) 2006-07-18 2007-07-18 molécula de ácido nucleico e seus usos, composição farmaceutica e complexo

Country Status (16)

Country Link
US (5) US8314223B2 (pt)
EP (1) EP2041282B1 (pt)
JP (1) JP5380287B2 (pt)
KR (2) KR101561652B1 (pt)
CN (2) CN103555725B (pt)
AR (1) AR061929A1 (pt)
AU (1) AU2007276435C1 (pt)
BR (1) BRPI0714844B8 (pt)
CA (1) CA2658267C (pt)
DK (1) DK2041282T3 (pt)
ES (1) ES2663404T3 (pt)
MX (1) MX2009000656A (pt)
PL (1) PL2041282T3 (pt)
PT (1) PT2041282T (pt)
RU (1) RU2590709C2 (pt)
WO (1) WO2008009437A2 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
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EP2041282B1 (en) 2006-07-18 2018-01-03 Noxxon Pharma AG Sdf-i binding nucleic acids
CN101796188B (zh) * 2007-08-06 2014-10-29 诺松制药股份公司 Sdf-1结合核酸及其用途
JP5463621B2 (ja) 2008-02-27 2014-04-09 ソニー株式会社 標的物質の定量方法
EP2304031A2 (en) * 2008-06-11 2011-04-06 Bionucleon S.r.l. Inhibition of hrp-3 using modified oligonucleotides
TWI578992B (zh) * 2009-04-30 2017-04-21 諾克森製藥股份有限公司 與鐵調節激素（ｈｅｐｃｉｄｉｎ）結合之核酸類
WO2012025251A1 (en) * 2010-08-27 2012-03-01 Noxxon Pharma Ag Nucleic acids for treatment of chronic complications of diabetes
CN103108641B (zh) * 2010-09-09 2016-01-13 诺松制药股份公司 Sdf-1结合性核酸及其在癌症治疗中的用途
JP2014503187A (ja) * 2010-10-29 2014-02-13 ノクソン ファーマ エージー 身体からヘプシジンを除去するためのヘプシジン結合核酸の使用
CN112007045B (zh) 2012-07-13 2026-01-06 波涛生命科学有限公司 手性控制
JP2018505144A (ja) * 2014-12-17 2018-02-22 キャンサー・リサーチ・テクノロジー・リミテッドＣａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ｔｅｃｈｎｏｌｏｇｙ Ｌｉｍｉｔｅｄ 抗ｃｘｃｌ１２抗体分子およびその使用
EP3443095A1 (en) * 2016-04-15 2019-02-20 Noxxon Pharma AG Method of modulating the number and the distribution of tumor-infiltrating leukocytes in tumors
US11221270B2 (en) * 2018-02-27 2022-01-11 Kevan M Evans Method and apparatus for detecting slow leaks
WO2021178923A1 (en) 2020-03-06 2021-09-10 Drinksavvy, Inc. Devices and methods for detecting a target analyte of interest
JP7327855B2 (ja) 2020-06-26 2023-08-16 ラクオリア創薬株式会社 レチノイドとがん治療薬との併用療法が有効ながん患者の選択方法およびレチノイドとがん治療薬との併用医薬
WO2023154452A1 (en) 2022-02-11 2023-08-17 Waypoint Bio, Inc. Cellular staining probes for analyte detection
TW202430127A (zh) * 2023-01-19 2024-08-01 國立陽明交通大學 可用於遞送內質網壓力誘導劑或免疫療法的複合奈米粒及其用途

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Also Published As

Publication number Publication date
EP2041282A2 (en) 2009-04-01
BRPI0714844B1 (pt) 2019-10-01
AR061929A1 (es) 2008-10-01
AU2007276435B2 (en) 2013-01-24
MX2009000656A (es) 2009-03-25
US8314223B2 (en) 2012-11-20
PL2041282T3 (pl) 2018-07-31
WO2008009437A2 (en) 2008-01-24
CN101506364A (zh) 2009-08-12
CN101506364B (zh) 2013-10-30
US9035038B2 (en) 2015-05-19
US9822369B2 (en) 2017-11-21
EP2041282B1 (en) 2018-01-03
CA2658267A1 (en) 2008-01-24
DK2041282T3 (en) 2018-04-16
KR20090039717A (ko) 2009-04-22
US20210139909A1 (en) 2021-05-13
AU2007276435A1 (en) 2008-01-24
US20130041019A1 (en) 2013-02-14
JP5380287B2 (ja) 2014-01-08
HK1131184A1 (en) 2010-01-15
CA2658267C (en) 2021-03-30
ES2663404T3 (es) 2018-04-12
KR101466931B1 (ko) 2014-12-02
RU2009105494A (ru) 2010-08-27
US20150232853A1 (en) 2015-08-20
CN103555725A (zh) 2014-02-05
CN103555725B (zh) 2017-05-24
PT2041282T (pt) 2018-03-13
KR101561652B1 (ko) 2015-10-20
BRPI0714844A2 (pt) 2013-11-26
RU2590709C2 (ru) 2016-07-10
US20180163207A1 (en) 2018-06-14
JP2009543567A (ja) 2009-12-10
WO2008009437A3 (en) 2008-03-27
US20110112172A1 (en) 2011-05-12
KR20130090428A (ko) 2013-08-13
AU2007276435C1 (en) 2013-06-13

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Owner name: TME PHARMA AKTIENGESELLSCHAFT (DE)