BRPI0716139A2 - processo para purificaÇço de proteÍnas de fusço fc - Google Patents
processo para purificaÇço de proteÍnas de fusço fcInfo
- Publication number
- BRPI0716139A2 BRPI0716139A2 BRPI0716139-5A2A BRPI0716139A BRPI0716139A2 BR PI0716139 A2 BRPI0716139 A2 BR PI0716139A2 BR PI0716139 A BRPI0716139 A BR PI0716139A BR PI0716139 A2 BRPI0716139 A2 BR PI0716139A2
- Authority
- BR
- Brazil
- Prior art keywords
- fusion protein
- purification process
- protein purification
- fusion
- purification
- Prior art date
Links
- 108091006020 Fc-tagged proteins Proteins 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000001742 protein purification Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/24—Extraction; Separation; Purification by electrochemical means
- C07K1/26—Electrophoresis
- C07K1/28—Isoelectric focusing
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06119610 | 2006-08-28 | ||
| PCT/EP2007/058886 WO2008025747A1 (en) | 2006-08-28 | 2007-08-27 | Process for the purification of fc-fusion proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0716139A2 true BRPI0716139A2 (pt) | 2013-09-17 |
Family
ID=37038258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0716139-5A2A BRPI0716139A2 (pt) | 2006-08-28 | 2007-08-27 | processo para purificaÇço de proteÍnas de fusço fc |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20100267932A1 (pt) |
| EP (1) | EP2061802A1 (pt) |
| KR (1) | KR20090058532A (pt) |
| CN (1) | CN101541825B (pt) |
| AR (1) | AR062569A1 (pt) |
| AU (1) | AU2007291282B2 (pt) |
| BR (1) | BRPI0716139A2 (pt) |
| CA (1) | CA2661872A1 (pt) |
| EA (1) | EA017733B1 (pt) |
| IL (1) | IL197221A (pt) |
| MX (1) | MX2009002013A (pt) |
| NZ (1) | NZ574623A (pt) |
| UA (1) | UA99263C2 (pt) |
| WO (1) | WO2008025747A1 (pt) |
| ZA (1) | ZA200900836B (pt) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR058568A1 (es) | 2005-12-20 | 2008-02-13 | Bristol Myers Squibb Co | Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo |
| DK1969007T3 (da) | 2005-12-20 | 2013-11-25 | Bristol Myers Squibb Co | Sammensætninger og fremgangsmåder til fremstilling af en sammensætning |
| EP2089429B1 (en) * | 2006-10-19 | 2014-11-26 | Janssen Biotech, Inc. | Process for preparing unaggregated antibody fc domains |
| WO2008085988A1 (en) * | 2007-01-05 | 2008-07-17 | Amgen Inc. | Methods of purifying proteins |
| WO2011015926A1 (en) * | 2009-08-03 | 2011-02-10 | Avesthagen Limited | A process of fermentation, purification and production of recombinant soluble tumour necrosis factor alfa receptor (tnfr) - human igg fc fusion protein |
| EP3309168A1 (en) | 2009-08-06 | 2018-04-18 | F. Hoffmann-La Roche AG | Method to improve virus removal in protein purification |
| EP2462157B1 (en) * | 2009-08-07 | 2020-06-17 | EMD Millipore Corporation | Methods for purifying a target protein from one or more impurities in a sample |
| SI2473617T1 (sl) * | 2009-09-01 | 2020-07-31 | F. Hoffmann-La Roche Ag | Izboljšano prečiščevanje beljakovin z modificirano elucijo beljakovine A |
| EP2480561B1 (en) * | 2009-09-23 | 2016-07-13 | E. R. Squibb & Sons, L.L.C. | Cation exchange chromatography |
| EP2519536A4 (en) * | 2009-12-29 | 2013-06-05 | Reddys Lab Ltd Dr | PROTEIN PURIFICATION BY ION EXCHANGE |
| CN102762585B (zh) | 2010-02-12 | 2016-01-20 | DPx控股有限公司 | 单一单元抗体纯化 |
| WO2012030512A1 (en) * | 2010-09-03 | 2012-03-08 | Percivia Llc. | Flow-through protein purification process |
| AU2011325341B2 (en) * | 2010-11-01 | 2015-12-17 | Dpx Holdings B.V. | Single unit ion exchange chromatography antibody purification |
| CN107915769A (zh) | 2011-03-29 | 2018-04-17 | 葛兰素史密斯克莱有限责任公司 | 用于蛋白纯化的缓冲液体系 |
| KR101972446B1 (ko) * | 2011-05-27 | 2019-04-25 | 글락소 그룹 리미티드 | Bcma(cd269/tnfrsf17)결합 단백질 |
| UA112434C2 (uk) | 2011-05-27 | 2016-09-12 | Ґлаксо Ґруп Лімітед | Антигензв'язувальний білок, який специфічно зв'язується з всма |
| US20140128577A1 (en) * | 2011-06-24 | 2014-05-08 | Dr. Reddy's Laboratories Limited | Purification of chimeric protein |
| KR102231139B1 (ko) * | 2011-06-28 | 2021-03-24 | 인히브릭스, 인크. | 세르핀 융합 폴리펩타이드 및 이의 이용 방법 |
| DK2729482T3 (en) | 2011-07-08 | 2018-05-07 | Merck Sharp & Dohme | PROCEDURE FOR CLEANING FC-FUSION PROTEIN |
| US9096648B2 (en) * | 2011-08-19 | 2015-08-04 | Emd Millipore Corporation | Methods of reducing level of one or more impurities in a sample during protein purification |
| HUE035685T2 (en) * | 2011-11-02 | 2018-05-28 | Hoffmann La Roche | Overload and elute chromatography |
| EP2682168A1 (en) | 2012-07-02 | 2014-01-08 | Millipore Corporation | Purification of biological molecules |
| CN104861060A (zh) * | 2014-02-21 | 2015-08-26 | 神州细胞工程有限公司 | 一种纯化凝血因子viii的方法 |
| US11566082B2 (en) | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| EP3436473A4 (en) * | 2016-03-29 | 2019-10-23 | Navya Biologicals Pvt. Ltd. | METHOD FOR PURIFYING FC FUSION PROTEINS |
| US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
| US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| WO2017194592A1 (en) | 2016-05-11 | 2017-11-16 | Ge Healthcare Bioprocess R&D Ab | Method of storing a separation matrix |
| US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| US10513537B2 (en) | 2016-05-11 | 2019-12-24 | Ge Healthcare Bioprocess R&D Ab | Separation matrix |
| WO2017194593A1 (en) | 2016-05-11 | 2017-11-16 | Ge Healthcare Bioprocess R&D Ab | Method of cleaning and/or sanitizing a separation matrix |
| US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| JP7031934B2 (ja) | 2016-05-11 | 2022-03-08 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックス |
| US10947268B2 (en) | 2016-08-12 | 2021-03-16 | Bristol-Myers Squibb Company | Methods of purifying proteins |
| US12448411B2 (en) | 2016-09-30 | 2025-10-21 | Cytiva Bioprocess R&D Ab | Separation method |
| US12516102B1 (en) * | 2017-02-09 | 2026-01-06 | Bracco Suisse Sa | Process for the purification of soluble PSGL-1 protein variants |
| CN107151673A (zh) * | 2017-03-10 | 2017-09-12 | 上海埃文生物科技有限公司 | 巴斯德毕赤酵母中人rank胞外段蛋白的表达纯化及其应用 |
| EP3676280B1 (en) * | 2017-08-30 | 2025-03-19 | Fresenius Kabi Deutschland GmbH | Method for purifying anti-il-6 receptor antibodies |
| JP2020531557A (ja) * | 2017-08-30 | 2020-11-05 | アレス トレーディング ソシエテ アノニム | タンパク質の精製方法 |
| JP7749319B2 (ja) | 2017-10-10 | 2025-10-06 | アルパイン イミューン サイエンシズ インコーポレイテッド | Ctla-4変異型免疫調節タンパク質およびそれらの使用 |
| BR112020013336A2 (pt) * | 2018-01-31 | 2020-12-01 | Regeneron Pharmaceuticals, Inc. | produto farmacêutico proteico, métodos para caracterizar as impurezas do produto farmacêutico proteico de alto peso molecular intermediário, para produção de um anticorpo, e para caracterizar as impurezas de fármaco com variação de carga, anticorpo, e, sistema para caracterizar impurezas de fármaco de alto peso molecular intermediário. |
| US20240228573A9 (en) * | 2019-10-17 | 2024-07-11 | Jcr Pharmaceuticals Co., Ltd. | Method for producing fusion protein of serum albumin and growth hormone |
| SG11202110968VA (en) | 2019-12-06 | 2021-10-28 | Regeneron Pharma | Anti-vegf protein compositions and methods for producing the same |
| JP2023516089A (ja) * | 2020-03-06 | 2023-04-17 | アレタ・バイオセラピューティクス・インコーポレイテッド | がんの治療のための組成物及び方法 |
| AU2021268026A1 (en) | 2020-05-08 | 2023-01-19 | Regeneron Pharmaceuticals, Inc. | VEGF traps and mini-traps and methods for treating ocular disorders and cancer |
| EP4146684A2 (en) | 2020-05-08 | 2023-03-15 | Alpine Immune Sciences, Inc. | April and baff inhibitory immunomodulatory proteins with and without a t cell inhibitory protein and methods of use thereof |
| TWI891671B (zh) * | 2020-10-29 | 2025-08-01 | 日商Jcr製藥股份有限公司 | 血清白蛋白與生長激素之融合蛋白質之製造方法 |
| CN112574321B (zh) * | 2020-12-30 | 2023-10-20 | 上海赛金生物医药有限公司 | 一种捕获单克隆抗体-肿瘤坏死因子融合蛋白的亲和纯化方法 |
| CN114292328B (zh) * | 2021-12-30 | 2025-07-25 | 武汉原谷生物科技有限责任公司 | 一种来源于美洲羊驼中天然抗体的纯化方法及其应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5447851B1 (en) * | 1992-04-02 | 1999-07-06 | Univ Texas System Board Of | Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells |
| AU670125B2 (en) * | 1992-09-15 | 1996-07-04 | Immunex Corporation | Method of treating tnf-dependent inflammation using tumor necrosis factor antagonists |
| DE59309332D1 (de) * | 1993-12-27 | 1999-03-04 | Rotkreuzstiftung Zentratrallab | Verfahren zur Herstellung eines Konzentrates von Anti-D-Immunoglobulin G und pharmazeutische Zusammensetzung, die dieses enthält |
| IL122305A0 (en) * | 1995-06-08 | 1998-04-05 | Immunex Corp | Tace polypeptide its production and its use |
| US6406901B1 (en) * | 1995-06-08 | 2002-06-18 | Immunex Corporation | TNF-a converting enzyme |
| US5969102A (en) * | 1997-03-03 | 1999-10-19 | St. Jude Children's Research Hospital | Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof |
| NZ507557A (en) * | 1998-05-06 | 2003-10-31 | Genentech Inc | Protein purification by ion exchange chromatography |
| WO2001087977A2 (en) * | 2000-05-12 | 2001-11-22 | Amgen Inc. | Methods and compositions of matter concerning april/g70, bcma, blys/agp-3, and taci |
| BRPI0209933B8 (pt) * | 2001-05-24 | 2021-05-25 | Zymogenetics Inc | proteína de fusão, e, molécula de ácido nucleico |
| ES2322945T5 (es) * | 2001-12-21 | 2012-10-17 | Immunex Corporation | Métodos para purficación de proteína |
| WO2003102132A2 (en) * | 2002-04-26 | 2003-12-11 | Genetech, Inc. | Non-affinity purification of proteins |
| EP3225625A1 (en) * | 2002-09-11 | 2017-10-04 | Chugai Seiyaku Kabushiki Kaisha | Protein purification method |
| JPWO2004087761A1 (ja) * | 2003-03-31 | 2006-07-27 | 麒麟麦酒株式会社 | ヒトモノクローナル抗体およびヒトポリクローナル抗体の精製 |
| TWI353991B (en) * | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| KR101221862B1 (ko) * | 2003-10-27 | 2013-01-14 | 와이어쓰 엘엘씨 | 하이드록시아파타이트 크로마토그래피를 사용한 고분자량응집체의 제거 |
| CN1234725C (zh) * | 2004-04-07 | 2006-01-04 | 陈志南 | 一种高效快速纯化制备片段抗体的方法 |
| ZA200710330B (en) * | 2005-06-17 | 2009-12-30 | Wyeth Corp | Methods of purifying FC region containing proteins |
| AU2008206923A1 (en) * | 2007-01-17 | 2008-07-24 | Merck Serono S.A. | Process for the purification of Fc-containing proteins |
-
2007
- 2007-08-27 WO PCT/EP2007/058886 patent/WO2008025747A1/en not_active Ceased
- 2007-08-27 KR KR1020097006448A patent/KR20090058532A/ko not_active Ceased
- 2007-08-27 BR BRPI0716139-5A2A patent/BRPI0716139A2/pt not_active IP Right Cessation
- 2007-08-27 AU AU2007291282A patent/AU2007291282B2/en active Active
- 2007-08-27 EP EP07802924A patent/EP2061802A1/en not_active Withdrawn
- 2007-08-27 MX MX2009002013A patent/MX2009002013A/es active IP Right Grant
- 2007-08-27 CA CA002661872A patent/CA2661872A1/en not_active Abandoned
- 2007-08-27 CN CN2007800319195A patent/CN101541825B/zh active Active
- 2007-08-27 UA UAA200902919A patent/UA99263C2/ru unknown
- 2007-08-27 EA EA200970230A patent/EA017733B1/ru not_active IP Right Cessation
- 2007-08-27 NZ NZ574623A patent/NZ574623A/en not_active IP Right Cessation
- 2007-08-27 US US12/377,119 patent/US20100267932A1/en not_active Abandoned
- 2007-08-27 ZA ZA200900836A patent/ZA200900836B/xx unknown
- 2007-08-28 AR ARP070103816A patent/AR062569A1/es not_active Application Discontinuation
-
2009
- 2009-02-24 IL IL197221A patent/IL197221A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200900836B (en) | 2010-05-26 |
| MX2009002013A (es) | 2009-03-09 |
| EA017733B1 (ru) | 2013-02-28 |
| AU2007291282A1 (en) | 2008-03-06 |
| AU2007291282B2 (en) | 2011-10-20 |
| AR062569A1 (es) | 2008-11-19 |
| CN101541825A (zh) | 2009-09-23 |
| NZ574623A (en) | 2011-12-22 |
| KR20090058532A (ko) | 2009-06-09 |
| IL197221A (en) | 2013-06-27 |
| WO2008025747A1 (en) | 2008-03-06 |
| UA99263C2 (ru) | 2012-08-10 |
| CN101541825B (zh) | 2013-08-14 |
| EP2061802A1 (en) | 2009-05-27 |
| CA2661872A1 (en) | 2008-03-06 |
| EA200970230A1 (ru) | 2009-08-28 |
| IL197221A0 (en) | 2009-12-24 |
| US20100267932A1 (en) | 2010-10-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0716139A2 (pt) | processo para purificaÇço de proteÍnas de fusço fc | |
| ATE524493T1 (de) | Exendin-fusionsproteine | |
| BRPI0716508A2 (pt) | Processo de recuperação de hidrocarbonetos | |
| BRPI0716744A2 (pt) | proteínas de fusão de albumina | |
| IL187642A0 (en) | METHODS FOR PURIFYING PROTEINS HAVING Fc REGIONS | |
| PT2091872T (pt) | Processo de combustão para a fusão de vidro | |
| BRPI0718440A2 (pt) | Processo de preparo de halogenetos de n-alquinaltrexona | |
| BRPI0913843A2 (pt) | processo de granulação por fusão | |
| IL189122A (en) | Method of manufacturing an optical system | |
| UY3712Q (es) | Botella | |
| MA28989B1 (fr) | MOLECULES Fc MODIFIEES | |
| BRPI0918947A2 (pt) | proteína de fusão de anticorpo | |
| DE602007012976D1 (de) | Lenksystem | |
| DK2061803T3 (da) | Fremgangsmåde til oprensning af fc-holdige proteiner | |
| BRPI0718075A2 (pt) | Processo de hidrogenação | |
| BRPI0816159A2 (pt) | Processo para recuperação otimizada de óleo | |
| BRPI0813660A2 (pt) | Processo para o cultivo de microalgas | |
| BRPI0722077A2 (pt) | Processo para o acabamento de poliolefina | |
| BRPI0718386A2 (pt) | Processo para preparação de catalisadores. | |
| DE602007000850D1 (de) | Windschutzscheibe | |
| BRPI0816237A2 (pt) | Processo de ciclopropanação | |
| DK1989189T3 (da) | Adsorbenter til proteinoprensning | |
| ATE442898T1 (de) | Filtrationsverfahren | |
| ES2569360T8 (es) | Proteínas de fusión de ácaros | |
| BRPI0716382A2 (pt) | processo para a purificaÇço de proteÍna contendo fc |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2277 DE 26/08/2014. |