BRPI0716139A2 - processo para purificaÇço de proteÍnas de fusço fc - Google Patents

processo para purificaÇço de proteÍnas de fusço fc

Info

Publication number
BRPI0716139A2
BRPI0716139A2 BRPI0716139-5A2A BRPI0716139A BRPI0716139A2 BR PI0716139 A2 BRPI0716139 A2 BR PI0716139A2 BR PI0716139 A BRPI0716139 A BR PI0716139A BR PI0716139 A2 BRPI0716139 A2 BR PI0716139A2
Authority
BR
Brazil
Prior art keywords
fusion protein
purification process
protein purification
fusion
purification
Prior art date
Application number
BRPI0716139-5A2A
Other languages
English (en)
Inventor
Alex Eon-Duval
Alain Lamproye
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Publication of BRPI0716139A2 publication Critical patent/BRPI0716139A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/36Extraction; Separation; Purification by a combination of two or more processes of different types
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/18Ion-exchange chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/24Extraction; Separation; Purification by electrochemical means
    • C07K1/26Electrophoresis
    • C07K1/28Isoelectric focusing
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
BRPI0716139-5A2A 2006-08-28 2007-08-27 processo para purificaÇço de proteÍnas de fusço fc BRPI0716139A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06119610 2006-08-28
PCT/EP2007/058886 WO2008025747A1 (en) 2006-08-28 2007-08-27 Process for the purification of fc-fusion proteins

Publications (1)

Publication Number Publication Date
BRPI0716139A2 true BRPI0716139A2 (pt) 2013-09-17

Family

ID=37038258

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0716139-5A2A BRPI0716139A2 (pt) 2006-08-28 2007-08-27 processo para purificaÇço de proteÍnas de fusço fc

Country Status (15)

Country Link
US (1) US20100267932A1 (pt)
EP (1) EP2061802A1 (pt)
KR (1) KR20090058532A (pt)
CN (1) CN101541825B (pt)
AR (1) AR062569A1 (pt)
AU (1) AU2007291282B2 (pt)
BR (1) BRPI0716139A2 (pt)
CA (1) CA2661872A1 (pt)
EA (1) EA017733B1 (pt)
IL (1) IL197221A (pt)
MX (1) MX2009002013A (pt)
NZ (1) NZ574623A (pt)
UA (1) UA99263C2 (pt)
WO (1) WO2008025747A1 (pt)
ZA (1) ZA200900836B (pt)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
DK1969007T3 (da) 2005-12-20 2013-11-25 Bristol Myers Squibb Co Sammensætninger og fremgangsmåder til fremstilling af en sammensætning
EP2089429B1 (en) * 2006-10-19 2014-11-26 Janssen Biotech, Inc. Process for preparing unaggregated antibody fc domains
WO2008085988A1 (en) * 2007-01-05 2008-07-17 Amgen Inc. Methods of purifying proteins
WO2011015926A1 (en) * 2009-08-03 2011-02-10 Avesthagen Limited A process of fermentation, purification and production of recombinant soluble tumour necrosis factor alfa receptor (tnfr) - human igg fc fusion protein
EP3309168A1 (en) 2009-08-06 2018-04-18 F. Hoffmann-La Roche AG Method to improve virus removal in protein purification
EP2462157B1 (en) * 2009-08-07 2020-06-17 EMD Millipore Corporation Methods for purifying a target protein from one or more impurities in a sample
SI2473617T1 (sl) * 2009-09-01 2020-07-31 F. Hoffmann-La Roche Ag Izboljšano prečiščevanje beljakovin z modificirano elucijo beljakovine A
EP2480561B1 (en) * 2009-09-23 2016-07-13 E. R. Squibb & Sons, L.L.C. Cation exchange chromatography
EP2519536A4 (en) * 2009-12-29 2013-06-05 Reddys Lab Ltd Dr PROTEIN PURIFICATION BY ION EXCHANGE
CN102762585B (zh) 2010-02-12 2016-01-20 DPx控股有限公司 单一单元抗体纯化
WO2012030512A1 (en) * 2010-09-03 2012-03-08 Percivia Llc. Flow-through protein purification process
AU2011325341B2 (en) * 2010-11-01 2015-12-17 Dpx Holdings B.V. Single unit ion exchange chromatography antibody purification
CN107915769A (zh) 2011-03-29 2018-04-17 葛兰素史密斯克莱有限责任公司 用于蛋白纯化的缓冲液体系
KR101972446B1 (ko) * 2011-05-27 2019-04-25 글락소 그룹 리미티드 Bcma(cd269/tnfrsf17)­결합 단백질
UA112434C2 (uk) 2011-05-27 2016-09-12 Ґлаксо Ґруп Лімітед Антигензв'язувальний білок, який специфічно зв'язується з всма
US20140128577A1 (en) * 2011-06-24 2014-05-08 Dr. Reddy's Laboratories Limited Purification of chimeric protein
KR102231139B1 (ko) * 2011-06-28 2021-03-24 인히브릭스, 인크. 세르핀 융합 폴리펩타이드 및 이의 이용 방법
DK2729482T3 (en) 2011-07-08 2018-05-07 Merck Sharp & Dohme PROCEDURE FOR CLEANING FC-FUSION PROTEIN
US9096648B2 (en) * 2011-08-19 2015-08-04 Emd Millipore Corporation Methods of reducing level of one or more impurities in a sample during protein purification
HUE035685T2 (en) * 2011-11-02 2018-05-28 Hoffmann La Roche Overload and elute chromatography
EP2682168A1 (en) 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
CN104861060A (zh) * 2014-02-21 2015-08-26 神州细胞工程有限公司 一种纯化凝血因子viii的方法
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
EP3436473A4 (en) * 2016-03-29 2019-10-23 Navya Biologicals Pvt. Ltd. METHOD FOR PURIFYING FC FUSION PROTEINS
US10654887B2 (en) 2016-05-11 2020-05-19 Ge Healthcare Bio-Process R&D Ab Separation matrix
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
WO2017194592A1 (en) 2016-05-11 2017-11-16 Ge Healthcare Bioprocess R&D Ab Method of storing a separation matrix
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
US10513537B2 (en) 2016-05-11 2019-12-24 Ge Healthcare Bioprocess R&D Ab Separation matrix
WO2017194593A1 (en) 2016-05-11 2017-11-16 Ge Healthcare Bioprocess R&D Ab Method of cleaning and/or sanitizing a separation matrix
US10730908B2 (en) 2016-05-11 2020-08-04 Ge Healthcare Bioprocess R&D Ab Separation method
JP7031934B2 (ja) 2016-05-11 2022-03-08 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ 分離マトリックス
US10947268B2 (en) 2016-08-12 2021-03-16 Bristol-Myers Squibb Company Methods of purifying proteins
US12448411B2 (en) 2016-09-30 2025-10-21 Cytiva Bioprocess R&D Ab Separation method
US12516102B1 (en) * 2017-02-09 2026-01-06 Bracco Suisse Sa Process for the purification of soluble PSGL-1 protein variants
CN107151673A (zh) * 2017-03-10 2017-09-12 上海埃文生物科技有限公司 巴斯德毕赤酵母中人rank胞外段蛋白的表达纯化及其应用
EP3676280B1 (en) * 2017-08-30 2025-03-19 Fresenius Kabi Deutschland GmbH Method for purifying anti-il-6 receptor antibodies
JP2020531557A (ja) * 2017-08-30 2020-11-05 アレス トレーディング ソシエテ アノニム タンパク質の精製方法
JP7749319B2 (ja) 2017-10-10 2025-10-06 アルパイン イミューン サイエンシズ インコーポレイテッド Ctla-4変異型免疫調節タンパク質およびそれらの使用
BR112020013336A2 (pt) * 2018-01-31 2020-12-01 Regeneron Pharmaceuticals, Inc. produto farmacêutico proteico, métodos para caracterizar as impurezas do produto farmacêutico proteico de alto peso molecular intermediário, para produção de um anticorpo, e para caracterizar as impurezas de fármaco com variação de carga, anticorpo, e, sistema para caracterizar impurezas de fármaco de alto peso molecular intermediário.
US20240228573A9 (en) * 2019-10-17 2024-07-11 Jcr Pharmaceuticals Co., Ltd. Method for producing fusion protein of serum albumin and growth hormone
SG11202110968VA (en) 2019-12-06 2021-10-28 Regeneron Pharma Anti-vegf protein compositions and methods for producing the same
JP2023516089A (ja) * 2020-03-06 2023-04-17 アレタ・バイオセラピューティクス・インコーポレイテッド がんの治療のための組成物及び方法
AU2021268026A1 (en) 2020-05-08 2023-01-19 Regeneron Pharmaceuticals, Inc. VEGF traps and mini-traps and methods for treating ocular disorders and cancer
EP4146684A2 (en) 2020-05-08 2023-03-15 Alpine Immune Sciences, Inc. April and baff inhibitory immunomodulatory proteins with and without a t cell inhibitory protein and methods of use thereof
TWI891671B (zh) * 2020-10-29 2025-08-01 日商Jcr製藥股份有限公司 血清白蛋白與生長激素之融合蛋白質之製造方法
CN112574321B (zh) * 2020-12-30 2023-10-20 上海赛金生物医药有限公司 一种捕获单克隆抗体-肿瘤坏死因子融合蛋白的亲和纯化方法
CN114292328B (zh) * 2021-12-30 2025-07-25 武汉原谷生物科技有限责任公司 一种来源于美洲羊驼中天然抗体的纯化方法及其应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5447851B1 (en) * 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
AU670125B2 (en) * 1992-09-15 1996-07-04 Immunex Corporation Method of treating tnf-dependent inflammation using tumor necrosis factor antagonists
DE59309332D1 (de) * 1993-12-27 1999-03-04 Rotkreuzstiftung Zentratrallab Verfahren zur Herstellung eines Konzentrates von Anti-D-Immunoglobulin G und pharmazeutische Zusammensetzung, die dieses enthält
IL122305A0 (en) * 1995-06-08 1998-04-05 Immunex Corp Tace polypeptide its production and its use
US6406901B1 (en) * 1995-06-08 2002-06-18 Immunex Corporation TNF-a converting enzyme
US5969102A (en) * 1997-03-03 1999-10-19 St. Jude Children's Research Hospital Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof
NZ507557A (en) * 1998-05-06 2003-10-31 Genentech Inc Protein purification by ion exchange chromatography
WO2001087977A2 (en) * 2000-05-12 2001-11-22 Amgen Inc. Methods and compositions of matter concerning april/g70, bcma, blys/agp-3, and taci
BRPI0209933B8 (pt) * 2001-05-24 2021-05-25 Zymogenetics Inc proteína de fusão, e, molécula de ácido nucleico
ES2322945T5 (es) * 2001-12-21 2012-10-17 Immunex Corporation Métodos para purficación de proteína
WO2003102132A2 (en) * 2002-04-26 2003-12-11 Genetech, Inc. Non-affinity purification of proteins
EP3225625A1 (en) * 2002-09-11 2017-10-04 Chugai Seiyaku Kabushiki Kaisha Protein purification method
JPWO2004087761A1 (ja) * 2003-03-31 2006-07-27 麒麟麦酒株式会社 ヒトモノクローナル抗体およびヒトポリクローナル抗体の精製
TWI353991B (en) * 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
KR101221862B1 (ko) * 2003-10-27 2013-01-14 와이어쓰 엘엘씨 하이드록시아파타이트 크로마토그래피를 사용한 고분자량응집체의 제거
CN1234725C (zh) * 2004-04-07 2006-01-04 陈志南 一种高效快速纯化制备片段抗体的方法
ZA200710330B (en) * 2005-06-17 2009-12-30 Wyeth Corp Methods of purifying FC region containing proteins
AU2008206923A1 (en) * 2007-01-17 2008-07-24 Merck Serono S.A. Process for the purification of Fc-containing proteins

Also Published As

Publication number Publication date
ZA200900836B (en) 2010-05-26
MX2009002013A (es) 2009-03-09
EA017733B1 (ru) 2013-02-28
AU2007291282A1 (en) 2008-03-06
AU2007291282B2 (en) 2011-10-20
AR062569A1 (es) 2008-11-19
CN101541825A (zh) 2009-09-23
NZ574623A (en) 2011-12-22
KR20090058532A (ko) 2009-06-09
IL197221A (en) 2013-06-27
WO2008025747A1 (en) 2008-03-06
UA99263C2 (ru) 2012-08-10
CN101541825B (zh) 2013-08-14
EP2061802A1 (en) 2009-05-27
CA2661872A1 (en) 2008-03-06
EA200970230A1 (ru) 2009-08-28
IL197221A0 (en) 2009-12-24
US20100267932A1 (en) 2010-10-21

Similar Documents

Publication Publication Date Title
BRPI0716139A2 (pt) processo para purificaÇço de proteÍnas de fusço fc
ATE524493T1 (de) Exendin-fusionsproteine
BRPI0716508A2 (pt) Processo de recuperação de hidrocarbonetos
BRPI0716744A2 (pt) proteínas de fusão de albumina
IL187642A0 (en) METHODS FOR PURIFYING PROTEINS HAVING Fc REGIONS
PT2091872T (pt) Processo de combustão para a fusão de vidro
BRPI0718440A2 (pt) Processo de preparo de halogenetos de n-alquinaltrexona
BRPI0913843A2 (pt) processo de granulação por fusão
IL189122A (en) Method of manufacturing an optical system
UY3712Q (es) Botella
MA28989B1 (fr) MOLECULES Fc MODIFIEES
BRPI0918947A2 (pt) proteína de fusão de anticorpo
DE602007012976D1 (de) Lenksystem
DK2061803T3 (da) Fremgangsmåde til oprensning af fc-holdige proteiner
BRPI0718075A2 (pt) Processo de hidrogenação
BRPI0816159A2 (pt) Processo para recuperação otimizada de óleo
BRPI0813660A2 (pt) Processo para o cultivo de microalgas
BRPI0722077A2 (pt) Processo para o acabamento de poliolefina
BRPI0718386A2 (pt) Processo para preparação de catalisadores.
DE602007000850D1 (de) Windschutzscheibe
BRPI0816237A2 (pt) Processo de ciclopropanação
DK1989189T3 (da) Adsorbenter til proteinoprensning
ATE442898T1 (de) Filtrationsverfahren
ES2569360T8 (es) Proteínas de fusión de ácaros
BRPI0716382A2 (pt) processo para a purificaÇço de proteÍna contendo fc

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2277 DE 26/08/2014.