DK2061803T3 - Fremgangsmåde til oprensning af fc-holdige proteiner - Google Patents
Fremgangsmåde til oprensning af fc-holdige proteiner Download PDFInfo
- Publication number
- DK2061803T3 DK2061803T3 DK07802925T DK07802925T DK2061803T3 DK 2061803 T3 DK2061803 T3 DK 2061803T3 DK 07802925 T DK07802925 T DK 07802925T DK 07802925 T DK07802925 T DK 07802925T DK 2061803 T3 DK2061803 T3 DK 2061803T3
- Authority
- DK
- Denmark
- Prior art keywords
- cleaning
- procedure
- containing proteins
- proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06119611 | 2006-08-28 | ||
| US84254206P | 2006-09-06 | 2006-09-06 | |
| PCT/EP2007/058887 WO2008025748A1 (en) | 2006-08-28 | 2007-08-27 | Process for the purification of fc-containing proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK2061803T3 true DK2061803T3 (da) | 2019-11-18 |
| DK2061803T4 DK2061803T4 (da) | 2022-12-05 |
Family
ID=38610939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07802925.3T DK2061803T4 (da) | 2006-08-28 | 2007-08-27 | Fremgangsmåde til oprensning af fc-holdige proteiner |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8513393B2 (da) |
| EP (1) | EP2061803B2 (da) |
| JP (1) | JP2010501623A (da) |
| KR (1) | KR101770312B1 (da) |
| AR (1) | AR062570A1 (da) |
| AU (1) | AU2007291283B2 (da) |
| CA (1) | CA2661748C (da) |
| DK (1) | DK2061803T4 (da) |
| EA (1) | EA017152B1 (da) |
| ES (1) | ES2755386T5 (da) |
| FI (1) | FI2061803T4 (da) |
| HU (1) | HUE045898T2 (da) |
| IL (1) | IL197220A (da) |
| LT (1) | LT2061803T (da) |
| MX (1) | MX2009002014A (da) |
| PL (1) | PL2061803T5 (da) |
| PT (1) | PT2061803T (da) |
| SI (1) | SI2061803T2 (da) |
| UA (1) | UA99262C2 (da) |
| WO (1) | WO2008025748A1 (da) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR058568A1 (es) | 2005-12-20 | 2008-02-13 | Bristol Myers Squibb Co | Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo |
| PT2253644E (pt) | 2005-12-20 | 2014-01-23 | Bristol Myers Squibb Co | Composições e métodos para a produção de uma composição |
| JP2010501623A (ja) † | 2006-08-28 | 2010-01-21 | アレス トレーディング ソシエテ アノニム | Fc含有タンパク質の精製法 |
| HUE024877T2 (en) * | 2007-10-30 | 2016-02-29 | Genentech Inc | Antibody purification by cation exchange chromatography |
| CN104974251A (zh) * | 2008-10-20 | 2015-10-14 | Abbvie公司 | 在抗体纯化过程中的病毒灭活 |
| CN102257004A (zh) * | 2008-10-20 | 2011-11-23 | 雅培制药有限公司 | 与il-12结合的抗体及其纯化方法 |
| CA2739077A1 (en) * | 2008-10-20 | 2010-04-29 | Robert K. Hickman | Antibodies that bind to il-18 and methods of purifying the same |
| CA2932207A1 (en) * | 2008-10-20 | 2010-12-09 | Abbvie Inc. | Isolation and purification of antibodies using protein a affinity chromatography |
| US8536316B2 (en) * | 2009-08-07 | 2013-09-17 | Emd Millipore Corporation | Methods for purifying a target protein from one or more impurities in a sample |
| BR112012014937B1 (pt) | 2009-12-18 | 2021-01-19 | Novartis Ag | método de produção de um anticorpo, fragmento de anticorpo ou proteína de fusão fc purificada usando uma matriz de cromatografia de afinidade |
| CA2787009C (en) | 2010-01-15 | 2018-04-03 | Bio-Rad Laboratories, Inc. | Surface neutralization of apatite |
| US8895707B2 (en) * | 2010-08-18 | 2014-11-25 | Bio-Rad Laboratories, Inc. | Elution of proteins from hydroxyapatite resins without resin deterioration |
| JP5798307B2 (ja) * | 2010-09-03 | 2015-10-21 | 国立大学法人名古屋大学 | グロボトリアオシルセラミドを特異的に認識するモノクローナル抗体及びその作製法 |
| WO2012084829A1 (en) | 2010-12-21 | 2012-06-28 | F. Hoffmann-La Roche Ag | Isoform enriched antibody preparation and method for obtaining it |
| JP5881744B2 (ja) | 2011-02-02 | 2016-03-09 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | アルカリ溶液でのアパタイトの表面中和方法 |
| EP2691411B1 (en) | 2011-03-29 | 2020-02-26 | GlaxoSmithKline LLC | Buffer system for protein purification |
| SG10201701224UA (en) * | 2012-03-12 | 2017-04-27 | Merck Patent Gmbh | Removal of protein aggregates from biopharmaceutical preparations in a flowthrough mode |
| US9815695B2 (en) | 2012-05-30 | 2017-11-14 | Bio-Rad Laboratories, Inc. | In situ restoration of apatite-based chromatography resins |
| EP2682168A1 (en) | 2012-07-02 | 2014-01-08 | Millipore Corporation | Purification of biological molecules |
| WO2015189832A1 (en) * | 2014-06-13 | 2015-12-17 | Lupin Limited | Process for the purification of tnfr:fc fusion protein |
| EP3157863B1 (en) | 2014-06-23 | 2023-06-21 | Bio-Rad Laboratories, Inc. | Apatite in-situ restoration |
| CN105392569B (zh) | 2014-06-23 | 2019-08-20 | 生物辐射实验室股份有限公司 | 磷灰石预处理 |
| EP2975050B1 (en) * | 2014-07-18 | 2019-05-29 | Sandoz Ag | Quantification of misfolded TNFR2:Fc |
| CA2959629C (en) * | 2014-09-03 | 2023-10-31 | Boehringer Ingelheim International Gmbh | Compound targeting il-23a and tnf-alpha and uses thereof |
| BR112017018365A2 (pt) * | 2015-03-13 | 2018-04-10 | Bristol-Myers Squibb Company | uso de lavagens alcalinas durante cromatografia para remoção de impurezas |
| EP3694870A1 (en) | 2017-10-10 | 2020-08-19 | Alpine Immune Sciences, Inc. | Ctla-4 variant immunomodulatory proteins and uses thereof |
| US12202882B2 (en) | 2020-05-08 | 2025-01-21 | Alpine Immune Sciences, Inc. | APRIL and BAFF inhibitory immunomodulatory proteins and methods of use thereof |
| CN116322775A (zh) | 2020-06-02 | 2023-06-23 | 阿雷斯贸易股份有限公司 | IgA肾病治疗的相关方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2065346C (en) | 1989-09-05 | 2005-03-29 | Craig A. Smith | Tumor necrosis factor-.alpha. and-.beta. receptors |
| US5447851B1 (en) * | 1992-04-02 | 1999-07-06 | Univ Texas System Board Of | Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells |
| NZ256293A (en) | 1992-09-15 | 1997-06-24 | Immunex Corp | Method of treating tumour necrosis factor - mediated inflammation by use of tnf antagonist |
| ATE175979T1 (de) * | 1993-12-27 | 1999-02-15 | Rotkreuzstiftung Zentrallab | Verfahren zur herstellung eines konzentrates von anti-d-immunoglobulin g und pharmazeutische zusammensetzung, die dieses enthält |
| ES2227598T3 (es) * | 1995-06-08 | 2005-04-01 | Immunex Corporation | Enzima conversiva de tnf-alfa. |
| US6406901B1 (en) | 1995-06-08 | 2002-06-18 | Immunex Corporation | TNF-a converting enzyme |
| US5969102A (en) | 1997-03-03 | 1999-10-19 | St. Jude Children's Research Hospital | Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof |
| IL121900A (en) † | 1997-10-07 | 2001-12-23 | Omrix Biopharmaceuticals Ltd | A method for the purification of immunoglobulins |
| ATE370961T1 (de) † | 1998-05-06 | 2007-09-15 | Genentech Inc | Reinigung von antikörpern durch ionenaustauschchromatographie |
| ES2228052T3 (es) | 1998-06-01 | 2005-04-01 | Genentech, Inc. | Separacion demonomeros de anticuerpos de sus multimeros utilizando cromatografia de intercambio de iones. |
| ID27417A (id) † | 1998-06-09 | 2001-04-05 | Statens Seruminstitut | Proses untuk memproduksi immunoglobulin untuk pemberian melalui intravena dan produk-produk immunoglobulin lainnya |
| CZ303272B6 (cs) | 1999-01-07 | 2012-07-11 | Zymogenetics, Inc. | Farmaceutický prostredek obsahující fúzní protein, izolovaná molekula polynukleotidu, expresní vektor, kultivovaná bunka, zpusob prípravy polypeptidu a izolovaný polypeptid |
| DE19955558C2 (de) | 1999-11-18 | 2003-03-20 | Stefan Kochanek | Permanente Amniozyten-Zelllinie, ihre Herstellung und Verwendung zur Herstellung von Gentransfervektoren |
| AU2001263114A1 (en) * | 2000-05-12 | 2001-11-26 | Amgen Inc | Methods and compositions of matter concerning april/g70, bcma, blys/agp-3, and taci |
| PL403488A1 (pl) * | 2001-05-24 | 2013-07-08 | Zymogenetics, Inc. | Zastosowanie bialka fuzyjnego TACI-immunoglobulina, bialko fuzyjne, czasteczka kwasu nukleinowego kodujaca bialko fuzyjne, kompozycja farmaceutyczna i sposób wytwarzania bialka fuzyjnego TACI-immunoglobulina |
| TR201809678T4 (tr) † | 2001-06-26 | 2018-07-23 | Amgen Fremont Inc | Opgl ye karşi antikorlar. |
| JP4363986B2 (ja) | 2001-12-21 | 2009-11-11 | イミュネックス・コーポレーション | タンパク質の精製方法 |
| SI1501369T1 (sl) † | 2002-04-26 | 2015-10-30 | Genentech, Inc. | Neafinitetno čiščenje proteinov |
| PT1543038T (pt) † | 2002-09-11 | 2017-07-07 | Genentech Inc | Purificação de proteína |
| CN100522989C (zh) | 2002-09-11 | 2009-08-05 | 中外制药株式会社 | 纯化蛋白质的方法 |
| WO2004076485A1 (en) | 2003-02-28 | 2004-09-10 | Lonza Biologics Plc. | Antibody purification by protein a and ion exchange chromatography |
| US20060257972A1 (en) * | 2003-03-31 | 2006-11-16 | Takashi Ishihara | Purification of human monoclonal antibody and human polyclonal antibody |
| TWI353991B (en) * | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| BRPI0415887B1 (pt) | 2003-10-27 | 2021-01-26 | Wyeth | métodos para a remoção de agregados de elevado peso molecular utilizando cromatografia de hidroxiapatita |
| BRPI0406605B8 (pt) * | 2003-11-13 | 2021-05-25 | Hanmi Holdings Co Ltd | conjugado de proteína, método para a preparação do mesmo e composição farmacêutica para intensificar a duração e estabilidade in vivo de um polipeptídeo fisiologicamente ativo |
| CN1946739A (zh) * | 2004-04-14 | 2007-04-11 | 豪夫迈-罗氏公司 | 纯化的白细胞介素-15/Fc融合蛋白及其制备 |
| BRPI0608584B8 (pt) | 2005-03-11 | 2021-05-25 | Wyeth Corp | métodos de recuperar um produto purificado |
| WO2006110277A1 (en) * | 2005-04-11 | 2006-10-19 | Medarex, Inc. | Protein purification using hcic amd ion exchange chromatography |
| BRPI0611600B8 (pt) * | 2005-06-17 | 2021-05-25 | Wyeth Corp | método para purificação de uma proteína tendo uma região fc a partir de um líquido fonte compreendendo a proteína e uma ou mais impurezas, e kit |
| EP2069387A4 (en) † | 2006-06-14 | 2011-02-02 | Glaxosmithkline Llc | METHODS OF PURIFYING ANTIBODIES USING HYDROXYAPATITE CERAMIC |
| JP2010501623A (ja) † | 2006-08-28 | 2010-01-21 | アレス トレーディング ソシエテ アノニム | Fc含有タンパク質の精製法 |
| JP2010516651A (ja) * | 2007-01-17 | 2010-05-20 | メルク セローノ ソシエテ アノニム | Fc含有タンパク質の精製のための方法 |
-
2007
- 2007-08-27 JP JP2009526068A patent/JP2010501623A/ja active Pending
- 2007-08-27 KR KR1020097006443A patent/KR101770312B1/ko active Active
- 2007-08-27 AU AU2007291283A patent/AU2007291283B2/en active Active
- 2007-08-27 CA CA2661748A patent/CA2661748C/en active Active
- 2007-08-27 MX MX2009002014A patent/MX2009002014A/es active IP Right Grant
- 2007-08-27 WO PCT/EP2007/058887 patent/WO2008025748A1/en not_active Ceased
- 2007-08-27 US US12/377,122 patent/US8513393B2/en active Active
- 2007-08-27 LT LT07802925T patent/LT2061803T/lt unknown
- 2007-08-27 DK DK07802925.3T patent/DK2061803T4/da active
- 2007-08-27 PL PL07802925.3T patent/PL2061803T5/pl unknown
- 2007-08-27 PT PT78029253T patent/PT2061803T/pt unknown
- 2007-08-27 EP EP07802925.3A patent/EP2061803B2/en active Active
- 2007-08-27 SI SI200732135T patent/SI2061803T2/sl unknown
- 2007-08-27 EA EA200970231A patent/EA017152B1/ru not_active IP Right Cessation
- 2007-08-27 FI FIEP07802925.3T patent/FI2061803T4/fi active
- 2007-08-27 ES ES07802925T patent/ES2755386T5/es active Active
- 2007-08-27 UA UAA200902854A patent/UA99262C2/uk unknown
- 2007-08-27 HU HUE07802925A patent/HUE045898T2/hu unknown
- 2007-08-28 AR ARP070103817A patent/AR062570A1/es not_active Application Discontinuation
-
2009
- 2009-02-24 IL IL197220A patent/IL197220A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| FI2061803T4 (fi) | 2023-03-14 |
| CA2661748C (en) | 2016-02-09 |
| US8513393B2 (en) | 2013-08-20 |
| CA2661748A1 (en) | 2008-03-06 |
| SI2061803T2 (sl) | 2023-01-31 |
| HK1131400A1 (en) | 2010-01-22 |
| PL2061803T5 (pl) | 2023-03-27 |
| EA017152B1 (ru) | 2012-10-30 |
| WO2008025748A1 (en) | 2008-03-06 |
| KR101770312B1 (ko) | 2017-08-22 |
| AU2007291283B2 (en) | 2012-09-20 |
| LT2061803T (lt) | 2019-11-25 |
| US20100190961A1 (en) | 2010-07-29 |
| EP2061803B1 (en) | 2019-08-14 |
| AU2007291283A1 (en) | 2008-03-06 |
| EA200970231A1 (ru) | 2009-08-28 |
| ES2755386T5 (es) | 2023-04-05 |
| UA99262C2 (uk) | 2012-08-10 |
| KR20090057296A (ko) | 2009-06-04 |
| IL197220A0 (en) | 2009-12-24 |
| EP2061803B2 (en) | 2022-11-16 |
| AR062570A1 (es) | 2008-11-19 |
| SI2061803T1 (sl) | 2019-12-31 |
| PT2061803T (pt) | 2019-11-21 |
| MX2009002014A (es) | 2009-03-09 |
| HUE045898T2 (hu) | 2020-01-28 |
| DK2061803T4 (da) | 2022-12-05 |
| EP2061803A1 (en) | 2009-05-27 |
| ES2755386T3 (es) | 2020-04-22 |
| IL197220A (en) | 2013-06-27 |
| JP2010501623A (ja) | 2010-01-21 |
| PL2061803T3 (pl) | 2020-02-28 |
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