DK2061803T3 - Fremgangsmåde til oprensning af fc-holdige proteiner - Google Patents

Fremgangsmåde til oprensning af fc-holdige proteiner Download PDF

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Publication number
DK2061803T3
DK2061803T3 DK07802925T DK07802925T DK2061803T3 DK 2061803 T3 DK2061803 T3 DK 2061803T3 DK 07802925 T DK07802925 T DK 07802925T DK 07802925 T DK07802925 T DK 07802925T DK 2061803 T3 DK2061803 T3 DK 2061803T3
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DK
Denmark
Prior art keywords
cleaning
procedure
containing proteins
proteins
Prior art date
Application number
DK07802925T
Other languages
English (en)
Other versions
DK2061803T4 (da
Inventor
Alex Eon-Duval
Alain Lamproye
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38610939&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2061803(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Publication of DK2061803T3 publication Critical patent/DK2061803T3/da
Application granted granted Critical
Publication of DK2061803T4 publication Critical patent/DK2061803T4/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK07802925.3T 2006-08-28 2007-08-27 Fremgangsmåde til oprensning af fc-holdige proteiner DK2061803T4 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06119611 2006-08-28
US84254206P 2006-09-06 2006-09-06
PCT/EP2007/058887 WO2008025748A1 (en) 2006-08-28 2007-08-27 Process for the purification of fc-containing proteins

Publications (2)

Publication Number Publication Date
DK2061803T3 true DK2061803T3 (da) 2019-11-18
DK2061803T4 DK2061803T4 (da) 2022-12-05

Family

ID=38610939

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07802925.3T DK2061803T4 (da) 2006-08-28 2007-08-27 Fremgangsmåde til oprensning af fc-holdige proteiner

Country Status (20)

Country Link
US (1) US8513393B2 (da)
EP (1) EP2061803B2 (da)
JP (1) JP2010501623A (da)
KR (1) KR101770312B1 (da)
AR (1) AR062570A1 (da)
AU (1) AU2007291283B2 (da)
CA (1) CA2661748C (da)
DK (1) DK2061803T4 (da)
EA (1) EA017152B1 (da)
ES (1) ES2755386T5 (da)
FI (1) FI2061803T4 (da)
HU (1) HUE045898T2 (da)
IL (1) IL197220A (da)
LT (1) LT2061803T (da)
MX (1) MX2009002014A (da)
PL (1) PL2061803T5 (da)
PT (1) PT2061803T (da)
SI (1) SI2061803T2 (da)
UA (1) UA99262C2 (da)
WO (1) WO2008025748A1 (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
PT2253644E (pt) 2005-12-20 2014-01-23 Bristol Myers Squibb Co Composições e métodos para a produção de uma composição
JP2010501623A (ja) † 2006-08-28 2010-01-21 アレス トレーディング ソシエテ アノニム Fc含有タンパク質の精製法
HUE024877T2 (en) * 2007-10-30 2016-02-29 Genentech Inc Antibody purification by cation exchange chromatography
CN104974251A (zh) * 2008-10-20 2015-10-14 Abbvie公司 在抗体纯化过程中的病毒灭活
CN102257004A (zh) * 2008-10-20 2011-11-23 雅培制药有限公司 与il-12结合的抗体及其纯化方法
CA2739077A1 (en) * 2008-10-20 2010-04-29 Robert K. Hickman Antibodies that bind to il-18 and methods of purifying the same
CA2932207A1 (en) * 2008-10-20 2010-12-09 Abbvie Inc. Isolation and purification of antibodies using protein a affinity chromatography
US8536316B2 (en) * 2009-08-07 2013-09-17 Emd Millipore Corporation Methods for purifying a target protein from one or more impurities in a sample
BR112012014937B1 (pt) 2009-12-18 2021-01-19 Novartis Ag método de produção de um anticorpo, fragmento de anticorpo ou proteína de fusão fc purificada usando uma matriz de cromatografia de afinidade
CA2787009C (en) 2010-01-15 2018-04-03 Bio-Rad Laboratories, Inc. Surface neutralization of apatite
US8895707B2 (en) * 2010-08-18 2014-11-25 Bio-Rad Laboratories, Inc. Elution of proteins from hydroxyapatite resins without resin deterioration
JP5798307B2 (ja) * 2010-09-03 2015-10-21 国立大学法人名古屋大学 グロボトリアオシルセラミドを特異的に認識するモノクローナル抗体及びその作製法
WO2012084829A1 (en) 2010-12-21 2012-06-28 F. Hoffmann-La Roche Ag Isoform enriched antibody preparation and method for obtaining it
JP5881744B2 (ja) 2011-02-02 2016-03-09 バイオ−ラッド ラボラトリーズ インコーポレーティッド アルカリ溶液でのアパタイトの表面中和方法
EP2691411B1 (en) 2011-03-29 2020-02-26 GlaxoSmithKline LLC Buffer system for protein purification
SG10201701224UA (en) * 2012-03-12 2017-04-27 Merck Patent Gmbh Removal of protein aggregates from biopharmaceutical preparations in a flowthrough mode
US9815695B2 (en) 2012-05-30 2017-11-14 Bio-Rad Laboratories, Inc. In situ restoration of apatite-based chromatography resins
EP2682168A1 (en) 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
WO2015189832A1 (en) * 2014-06-13 2015-12-17 Lupin Limited Process for the purification of tnfr:fc fusion protein
EP3157863B1 (en) 2014-06-23 2023-06-21 Bio-Rad Laboratories, Inc. Apatite in-situ restoration
CN105392569B (zh) 2014-06-23 2019-08-20 生物辐射实验室股份有限公司 磷灰石预处理
EP2975050B1 (en) * 2014-07-18 2019-05-29 Sandoz Ag Quantification of misfolded TNFR2:Fc
CA2959629C (en) * 2014-09-03 2023-10-31 Boehringer Ingelheim International Gmbh Compound targeting il-23a and tnf-alpha and uses thereof
BR112017018365A2 (pt) * 2015-03-13 2018-04-10 Bristol-Myers Squibb Company uso de lavagens alcalinas durante cromatografia para remoção de impurezas
EP3694870A1 (en) 2017-10-10 2020-08-19 Alpine Immune Sciences, Inc. Ctla-4 variant immunomodulatory proteins and uses thereof
US12202882B2 (en) 2020-05-08 2025-01-21 Alpine Immune Sciences, Inc. APRIL and BAFF inhibitory immunomodulatory proteins and methods of use thereof
CN116322775A (zh) 2020-06-02 2023-06-23 阿雷斯贸易股份有限公司 IgA肾病治疗的相关方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2065346C (en) 1989-09-05 2005-03-29 Craig A. Smith Tumor necrosis factor-.alpha. and-.beta. receptors
US5447851B1 (en) * 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
NZ256293A (en) 1992-09-15 1997-06-24 Immunex Corp Method of treating tumour necrosis factor - mediated inflammation by use of tnf antagonist
ATE175979T1 (de) * 1993-12-27 1999-02-15 Rotkreuzstiftung Zentrallab Verfahren zur herstellung eines konzentrates von anti-d-immunoglobulin g und pharmazeutische zusammensetzung, die dieses enthält
ES2227598T3 (es) * 1995-06-08 2005-04-01 Immunex Corporation Enzima conversiva de tnf-alfa.
US6406901B1 (en) 1995-06-08 2002-06-18 Immunex Corporation TNF-a converting enzyme
US5969102A (en) 1997-03-03 1999-10-19 St. Jude Children's Research Hospital Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof
IL121900A (en) † 1997-10-07 2001-12-23 Omrix Biopharmaceuticals Ltd A method for the purification of immunoglobulins
ATE370961T1 (de) † 1998-05-06 2007-09-15 Genentech Inc Reinigung von antikörpern durch ionenaustauschchromatographie
ES2228052T3 (es) 1998-06-01 2005-04-01 Genentech, Inc. Separacion demonomeros de anticuerpos de sus multimeros utilizando cromatografia de intercambio de iones.
ID27417A (id) † 1998-06-09 2001-04-05 Statens Seruminstitut Proses untuk memproduksi immunoglobulin untuk pemberian melalui intravena dan produk-produk immunoglobulin lainnya
CZ303272B6 (cs) 1999-01-07 2012-07-11 Zymogenetics, Inc. Farmaceutický prostredek obsahující fúzní protein, izolovaná molekula polynukleotidu, expresní vektor, kultivovaná bunka, zpusob prípravy polypeptidu a izolovaný polypeptid
DE19955558C2 (de) 1999-11-18 2003-03-20 Stefan Kochanek Permanente Amniozyten-Zelllinie, ihre Herstellung und Verwendung zur Herstellung von Gentransfervektoren
AU2001263114A1 (en) * 2000-05-12 2001-11-26 Amgen Inc Methods and compositions of matter concerning april/g70, bcma, blys/agp-3, and taci
PL403488A1 (pl) * 2001-05-24 2013-07-08 Zymogenetics, Inc. Zastosowanie bialka fuzyjnego TACI-immunoglobulina, bialko fuzyjne, czasteczka kwasu nukleinowego kodujaca bialko fuzyjne, kompozycja farmaceutyczna i sposób wytwarzania bialka fuzyjnego TACI-immunoglobulina
TR201809678T4 (tr) † 2001-06-26 2018-07-23 Amgen Fremont Inc Opgl ye karşi antikorlar.
JP4363986B2 (ja) 2001-12-21 2009-11-11 イミュネックス・コーポレーション タンパク質の精製方法
SI1501369T1 (sl) † 2002-04-26 2015-10-30 Genentech, Inc. Neafinitetno čiščenje proteinov
PT1543038T (pt) † 2002-09-11 2017-07-07 Genentech Inc Purificação de proteína
CN100522989C (zh) 2002-09-11 2009-08-05 中外制药株式会社 纯化蛋白质的方法
WO2004076485A1 (en) 2003-02-28 2004-09-10 Lonza Biologics Plc. Antibody purification by protein a and ion exchange chromatography
US20060257972A1 (en) * 2003-03-31 2006-11-16 Takashi Ishihara Purification of human monoclonal antibody and human polyclonal antibody
TWI353991B (en) * 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
BRPI0415887B1 (pt) 2003-10-27 2021-01-26 Wyeth métodos para a remoção de agregados de elevado peso molecular utilizando cromatografia de hidroxiapatita
BRPI0406605B8 (pt) * 2003-11-13 2021-05-25 Hanmi Holdings Co Ltd conjugado de proteína, método para a preparação do mesmo e composição farmacêutica para intensificar a duração e estabilidade in vivo de um polipeptídeo fisiologicamente ativo
CN1946739A (zh) * 2004-04-14 2007-04-11 豪夫迈-罗氏公司 纯化的白细胞介素-15/Fc融合蛋白及其制备
BRPI0608584B8 (pt) 2005-03-11 2021-05-25 Wyeth Corp métodos de recuperar um produto purificado
WO2006110277A1 (en) * 2005-04-11 2006-10-19 Medarex, Inc. Protein purification using hcic amd ion exchange chromatography
BRPI0611600B8 (pt) * 2005-06-17 2021-05-25 Wyeth Corp método para purificação de uma proteína tendo uma região fc a partir de um líquido fonte compreendendo a proteína e uma ou mais impurezas, e kit
EP2069387A4 (en) † 2006-06-14 2011-02-02 Glaxosmithkline Llc METHODS OF PURIFYING ANTIBODIES USING HYDROXYAPATITE CERAMIC
JP2010501623A (ja) † 2006-08-28 2010-01-21 アレス トレーディング ソシエテ アノニム Fc含有タンパク質の精製法
JP2010516651A (ja) * 2007-01-17 2010-05-20 メルク セローノ ソシエテ アノニム Fc含有タンパク質の精製のための方法

Also Published As

Publication number Publication date
FI2061803T4 (fi) 2023-03-14
CA2661748C (en) 2016-02-09
US8513393B2 (en) 2013-08-20
CA2661748A1 (en) 2008-03-06
SI2061803T2 (sl) 2023-01-31
HK1131400A1 (en) 2010-01-22
PL2061803T5 (pl) 2023-03-27
EA017152B1 (ru) 2012-10-30
WO2008025748A1 (en) 2008-03-06
KR101770312B1 (ko) 2017-08-22
AU2007291283B2 (en) 2012-09-20
LT2061803T (lt) 2019-11-25
US20100190961A1 (en) 2010-07-29
EP2061803B1 (en) 2019-08-14
AU2007291283A1 (en) 2008-03-06
EA200970231A1 (ru) 2009-08-28
ES2755386T5 (es) 2023-04-05
UA99262C2 (uk) 2012-08-10
KR20090057296A (ko) 2009-06-04
IL197220A0 (en) 2009-12-24
EP2061803B2 (en) 2022-11-16
AR062570A1 (es) 2008-11-19
SI2061803T1 (sl) 2019-12-31
PT2061803T (pt) 2019-11-21
MX2009002014A (es) 2009-03-09
HUE045898T2 (hu) 2020-01-28
DK2061803T4 (da) 2022-12-05
EP2061803A1 (en) 2009-05-27
ES2755386T3 (es) 2020-04-22
IL197220A (en) 2013-06-27
JP2010501623A (ja) 2010-01-21
PL2061803T3 (pl) 2020-02-28

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