BRPI0719816A2 - uso do fator de crescimento epidérmico para a arestauração morfofuncional de nervos periféricos em neuropatia diabética - Google Patents

uso do fator de crescimento epidérmico para a arestauração morfofuncional de nervos periféricos em neuropatia diabética

Info

Publication number: BRPI0719816A2
Authority: BR; Brazil
Prior art keywords: growth factor; epidermal growth; diabetic neuropathy; peripheral nerves; morphofunctional
Prior art date: 2006-10-03

Application number

BRPI0719816A

Other languages

English (en)

Inventor

Danay Cibrian Vera

Diana Garcia Del Barco Herrera

Gerardo Enrique Guillen Nieto

Jorge Amador Berlanga Acosta

José Ignacio Fernández Montequín

Luis Saturnino Herrera Martinez

Raimundo Ubieta Gómez

Sonia González Blanco

Vivian María Sáez Martínez

Original Assignee

Ct De Ingeniería Genética Y Biotecnología

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-10-03

Filing date

2007-10-01

Publication date

2015-09-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38925545&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0719816(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-10-01 Application filed by Ct De Ingeniería Genética Y Biotecnología filed Critical Ct De Ingeniería Genética Y Biotecnología

2015-09-08 Publication of BRPI0719816A2 publication Critical patent/BRPI0719816A2/pt

2018-04-24 Publication of BRPI0719816B1 publication Critical patent/BRPI0719816B1/pt

2021-05-25 Publication of BRPI0719816B8 publication Critical patent/BRPI0719816B8/pt

Links

208000032131 Diabetic Neuropathies Diseases 0.000 title 1
102000009024 Epidermal Growth Factor Human genes 0.000 title 1
101800003838 Epidermal growth factor Proteins 0.000 title 1
229940116977 epidermal growth factor Drugs 0.000 title 1
210000000578 peripheral nerve Anatomy 0.000 title 1
VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

BRPI0719816A 2006-10-03 2007-10-01 uso do fator de crescimento epidérmico (egf) humano para preparar uma composição farmacêutica injetável para a restauração morfofuncional de nervos periféricos em neuropatia diabética e a referida composição BRPI0719816B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
CU20060192A CU23526B6 (es)	2006-10-03	2006-10-03	Método para la restauración morfofuncional de nervios periféricos en la neuropatía diabética
CU2006-0192		2006-10-03
PCT/CU2007/000018 WO2008040260A1 (es)	2006-10-03	2007-10-01	Uso del factor de crecimiento epidérmico para la restauración morfofuncional de nervios periféricos en la neuropatía diabética

Publications (3)

Publication Number	Publication Date
BRPI0719816A2 true BRPI0719816A2 (pt)	2015-09-08
BRPI0719816B1 BRPI0719816B1 (pt)	2018-04-24
BRPI0719816B8 BRPI0719816B8 (pt)	2021-05-25

Family

ID=38925545

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0719816A BRPI0719816B8 (pt)	2006-10-03	2007-10-01	uso do fator de crescimento epidérmico (egf) humano para preparar uma composição farmacêutica injetável para a restauração morfofuncional de nervos periféricos em neuropatia diabética e a referida composição

Country Status (20)

Country	Link
US (2)	US8642552B2 (pt)
EP (1)	EP2075004B1 (pt)
JP (1)	JP5508853B2 (pt)
KR (1)	KR101464208B1 (pt)
CN (1)	CN101573130B (pt)
AR (1)	AR063088A1 (pt)
AT (1)	ATE544462T1 (pt)
AU (1)	AU2007304640B2 (pt)
BR (1)	BRPI0719816B8 (pt)
CA (1)	CA2665117C (pt)
CL (1)	CL2007002862A1 (pt)
CU (1)	CU23526B6 (pt)
DK (1)	DK2075004T3 (pt)
ES (1)	ES2386058T3 (pt)
MX (1)	MX2009003678A (pt)
PL (1)	PL2075004T3 (pt)
PT (1)	PT2075004E (pt)
RU (1)	RU2460536C2 (pt)
WO (1)	WO2008040260A1 (pt)
ZA (1)	ZA200902311B (pt)

Families Citing this family (10)

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KR101252740B1 (ko) *	2011-05-25	2013-04-11	연세대학교 산학협력단	센서 및 센싱방법
EP2737895A1 (en) *	2012-11-30	2014-06-04	Praxis Pharmaceutical, S.A.	Microparticles with EGF, method of preparation and use
CA2891855A1 (en) *	2012-12-21	2014-06-26	Sykehuset Sorlandet Hf	Egfr targeted therapy of neurological disorders and pain
CA2920835A1 (en)	2013-08-20	2015-02-26	Anutra Medical, Inc.	Syringe fill system and method
IL312865B2 (en)	2013-09-11	2025-06-01	Eagle Biologics Inc	Liquid protein formulations containing viscosity-lowering agents
USD763433S1 (en)	2014-06-06	2016-08-09	Anutra Medical, Inc.	Delivery system cassette
USD750768S1 (en)	2014-06-06	2016-03-01	Anutra Medical, Inc.	Fluid administration syringe
USD774182S1 (en)	2014-06-06	2016-12-13	Anutra Medical, Inc.	Anesthetic delivery device
AU2015325055B2 (en)	2014-10-01	2021-02-25	Eagle Biologics, Inc.	Polysaccharide and nucleic acid formulations containing viscosity-lowering agents
RU2585421C1 (ru) *	2014-12-24	2016-05-27	Артур Владимирович Маргасов	Способ восстановления поврежденного нерва

Family Cites Families (17)

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US5130298A (en) *	1989-05-16	1992-07-14	Ethicon, Inc.	Stabilized compositions containing epidermal growth factor
SE9601243D0 (sv)	1996-03-29	1996-03-29	Hans Arne Hansson	Promotion of regeneration of organized tissues
AU2231399A (en) *	1998-01-20	1999-08-02	Aurx, Inc.	A herpes virus vector
US6444205B2 (en) *	1998-09-30	2002-09-03	Diacrin, Inc.	Transplantation of neural cells for the treatment of chronic pain or spasticity
SE9804064D0 (sv)	1998-11-25	1998-11-25	A & Science Invest Ab	Medicinal product and method for treatment of conditions affecting neural stem cells or progenitor cells
CA2365434A1 (en) *	1999-04-15	2000-10-26	St. Elizabeth's Medical Center Of Boston	Angiogenic growth factors for treatment of peripheral neuropathy
WO2002012335A2 (en) *	2000-08-10	2002-02-14	Pharmacia Corporation	A NEW EGF MOTIF REPEAT PROTEIN OBTAINED FROM A cDNA LIBRARY FROM HS-5 STROMAL CELL LINE
CU23157A1 (es)	2001-01-03	2006-07-18	Ct Ingenieria Genetica Biotech	COMPOSICION FARMACéUTICA PARA EL TRATAMIENTO DEL DANO TISULAR DEBIDO A FALTA DE IRRIGACION SANGUINEA ARTERIAL
DE60220894T2 (de) *	2001-03-12	2008-02-28	Institute Of Gene And Brain Science	Verwendung von interleukin-12 zur behandlung von nervenschäden
JP2006152001A (ja) *	2001-03-12	2006-06-15	Institute Of Gene & Brain Science	神経損傷の治療薬
CU23043A1 (es) *	2001-12-20	2005-05-20	Ct Ingenieria Genetica Biotech	Composicion farmaceutica que contiene factor de crecimiento epidrmico (egf) para la prevencion de la amputacion de pie diabetico.
US7465463B2 (en)	2002-09-04	2008-12-16	Polyheal, Ltd.	Compositions comprising microspheres with anti-inflammatory properties for healing of ocular tissues
US20070122487A1 (en) *	2003-03-19	2007-05-31	University Of Kentucky Research Foundation	(Poly(acryloyl-hydroxyethyl starch)-plga composition microspheres
CN103230415B (zh) *	2003-04-25	2016-05-04	匹兹堡大学联邦制高等教育	用于促进和增强神经修复和再生的肌肉来源的细胞（mdc）
WO2006012707A1 (en) *	2004-08-06	2006-02-09	Gropep Limited	Method for treating diabetes
AU2006206194A1 (en) *	2005-01-21	2006-07-27	Northwestern University	Methods and compositions for encapsulation of cells
KR100765496B1 (ko) *	2005-12-09	2007-10-10	경희대학교 산학협력단	히레귤린 베타1의 ｅｇｆ-성 도메인 펩타이드를 암호화하는ｄｎａ 서열을 포함하는 재조합 아데노바이러스 및 이를포함하는 신경세포 분화 및 재생용 약학 조성물

2006
- 2006-10-03 CU CU20060192A patent/CU23526B6/es active IP Right Grant
2007
- 2007-10-01 BR BRPI0719816A patent/BRPI0719816B8/pt not_active IP Right Cessation
- 2007-10-01 CN CN2007800422158A patent/CN101573130B/zh not_active Expired - Fee Related
- 2007-10-01 AT AT07817382T patent/ATE544462T1/de active
- 2007-10-01 AU AU2007304640A patent/AU2007304640B2/en not_active Ceased
- 2007-10-01 ES ES07817382T patent/ES2386058T3/es active Active
- 2007-10-01 PT PT07817382T patent/PT2075004E/pt unknown
- 2007-10-01 JP JP2009530751A patent/JP5508853B2/ja active Active
- 2007-10-01 MX MX2009003678A patent/MX2009003678A/es active IP Right Grant
- 2007-10-01 RU RU2009116646/15A patent/RU2460536C2/ru active
- 2007-10-01 DK DK07817382.0T patent/DK2075004T3/da active
- 2007-10-01 EP EP07817382A patent/EP2075004B1/en not_active Not-in-force
- 2007-10-01 PL PL07817382T patent/PL2075004T3/pl unknown
- 2007-10-01 KR KR1020097009188A patent/KR101464208B1/ko not_active Expired - Fee Related
- 2007-10-01 WO PCT/CU2007/000018 patent/WO2008040260A1/es not_active Ceased
- 2007-10-01 AR ARP070104350A patent/AR063088A1/es unknown
- 2007-10-01 CA CA2665117A patent/CA2665117C/en not_active Expired - Fee Related
- 2007-10-01 US US12/443,837 patent/US8642552B2/en not_active Expired - Fee Related
- 2007-10-03 CL CL200702862A patent/CL2007002862A1/es unknown
2009
- 2009-04-02 ZA ZA200902311A patent/ZA200902311B/xx unknown
2013
- 2013-12-26 US US14/140,849 patent/US9034826B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN101573130A (zh)	2009-11-04
CL2007002862A1 (es)	2008-05-23
RU2009116646A (ru)	2010-11-10
US8642552B2 (en)	2014-02-04
EP2075004A1 (en)	2009-07-01
ATE544462T1 (de)	2012-02-15
ZA200902311B (en)	2010-04-28
US20140105990A1 (en)	2014-04-17
WO2008040260A1 (es)	2008-04-10
RU2460536C2 (ru)	2012-09-10
US9034826B2 (en)	2015-05-19
CN101573130B (zh)	2012-10-31
MX2009003678A (es)	2009-04-22
CU23526B6 (es)	2010-05-19
EP2075004B1 (en)	2012-02-08
JP5508853B2 (ja)	2014-06-04
BRPI0719816B1 (pt)	2018-04-24
CA2665117A1 (en)	2008-04-10
AU2007304640B2 (en)	2013-01-17
KR101464208B1 (ko)	2014-12-04
PL2075004T3 (pl)	2012-09-28
DK2075004T3 (da)	2012-05-14
CA2665117C (en)	2015-04-14
AR063088A1 (es)	2008-12-23
JP2010505773A (ja)	2010-02-25
KR20090103862A (ko)	2009-10-01
US20100136062A1 (en)	2010-06-03
ES2386058T3 (es)	2012-08-08
PT2075004E (pt)	2012-05-02
BRPI0719816B8 (pt)	2021-05-25
AU2007304640A1 (en)	2008-04-10

Legal Events

Date	Code	Title	Description
2016-07-19	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2017-06-27	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2017-09-19	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2018-03-06	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2018-04-24	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
2021-05-25	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/10/2007 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF
2022-07-26	B21F	Lapse acc. art. 78, item iv - on non-payment of the annual fees in time	Free format text: REFERENTE A 15A ANUIDADE.
2022-11-16	B24J	Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)	Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2690 DE 26-07-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

Publication	Publication Date	Title
BRPI0719816A2 (pt)	2015-09-08	uso do fator de crescimento epidérmico para a arestauração morfofuncional de nervos periféricos em neuropatia diabética
BRPI1006823A2 (pt)	2017-05-30	composições redutoras de asfalto e produtos compreendendo um extensor derivado talóleo e métodos para fabricação e uso do mesmo
BRPI1014464A2 (pt)	2016-04-05	4-ciano-3-benzoilamino-n-fenil-benzamidas para uso no controle de pragas
EP2282724A4 (en)	2015-01-21	MODIFIED MEDICAMENTS FOR USE IN LIPOSOMAL NANOPARTICLES
BRPI0817198A2 (pt)	2015-03-17	(ciclopropilfenil)feniloxalamidas, método para a produção das mesmas, e uso das mesmas como um medicamento
BRPI0911770A2 (pt)	2015-08-04	Método para produzir produtos químicos finos, microorganismo recombinante, uso do mesmo, e, método para preparar um composto
BRPI0813762A2 (pt)	2014-10-07	Dosador de produtos químicos para uso diário
BRPI0906186A2 (pt)	2015-09-22	composto e uso de um composto
BRPI0911297A2 (pt)	2019-09-24	composição e métodos para preparo e uso das mesmas
BRPI0819986A2 (pt)	2019-09-24	ferramenta de poço para uso em um furo de poço
BRPI0908252A2 (pt)	2015-07-21	Processo para preparar um composto, e, uso de um composto
BRPI0919216A2 (pt)	2015-12-08	poliuretano, e, uso de um poliuretano
BRPI0808813A2 (pt)	2016-08-02	método para a preparação de compostos de borracha, e, uso de compostos
BRPI0910433A2 (pt)	2015-09-29	composição de polímero responsivo a estímulos de auto-estabelecimento em aditivos para o solo e métodos para o uso
BRPI0915134A2 (pt)	2016-02-16	composto, e, uso de um composto
BRPI0818189A2 (pt)	2015-04-14	Uso de um monoterpeno
BRPI0907254A2 (pt)	2015-07-14	Combinação biocida para uso em aplicações agrícolas
BRPI0920752A2 (pt)	2015-12-22	dispositivo implantável para a distribuição de octreotídeo e métodos de uso do mesmo
BRPI0906352A2 (pt)	2015-07-07	Derivado de tiazol e uso do mesmo como inibidores de vap-1
BRPI0911246A2 (pt)	2015-10-06	material de esteira de fibra contendo hidrocolóide, método para a fabricação deste e seu uso
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