BRPI0720116B8 - método para determinar uma suscetibilidade à arritmia cardíaca ou acidente vascular cerebral em um indivíduo humano, uso de uma sonda de oligonucleotídeo, e, aparelho para determinar um indicador genético para a arritmia cardíaca e/ou acidente vascular cerebral em um indivíduo humano - Google Patents
método para determinar uma suscetibilidade à arritmia cardíaca ou acidente vascular cerebral em um indivíduo humano, uso de uma sonda de oligonucleotídeo, e, aparelho para determinar um indicador genético para a arritmia cardíaca e/ou acidente vascular cerebral em um indivíduo humanoInfo
- Publication number
- BRPI0720116B8 BRPI0720116B8 BRPI0720116A BRPI0720116A BRPI0720116B8 BR PI0720116 B8 BRPI0720116 B8 BR PI0720116B8 BR PI0720116 A BRPI0720116 A BR PI0720116A BR PI0720116 A BRPI0720116 A BR PI0720116A BR PI0720116 B8 BRPI0720116 B8 BR PI0720116B8
- Authority
- BR
- Brazil
- Prior art keywords
- stroke
- determining
- human subject
- cardiac arrhythmia
- susceptibility
- Prior art date
Links
- 206010003119 arrhythmia Diseases 0.000 title 2
- 108020005187 Oligonucleotide Probes Proteins 0.000 title 1
- 230000002068 genetic effect Effects 0.000 title 1
- 239000002751 oligonucleotide probe Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/40—Population genetics; Linkage disequilibrium
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Physiology (AREA)
- Ecology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Chemical Kinetics & Catalysis (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IS8576 | 2006-12-05 | ||
| IS8576A IS8576A (is) | 2006-12-05 | 2006-12-05 | Genetic susceptibility variants of atrial fibrillation and stroke |
| IS8658 | 2007-06-29 | ||
| IS8658 | 2007-06-29 | ||
| PCT/IS2007/000021 WO2008068780A2 (en) | 2006-12-05 | 2007-12-05 | Genetic markers for risk management of cardiac arrhythmia |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0720116A2 BRPI0720116A2 (pt) | 2014-01-14 |
| BRPI0720116B1 BRPI0720116B1 (pt) | 2018-05-02 |
| BRPI0720116B8 true BRPI0720116B8 (pt) | 2021-07-27 |
Family
ID=39133840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0720116A BRPI0720116B8 (pt) | 2006-12-05 | 2007-12-05 | método para determinar uma suscetibilidade à arritmia cardíaca ou acidente vascular cerebral em um indivíduo humano, uso de uma sonda de oligonucleotídeo, e, aparelho para determinar um indicador genético para a arritmia cardíaca e/ou acidente vascular cerebral em um indivíduo humano |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8637244B2 (pt) |
| EP (1) | EP2121979B1 (pt) |
| JP (1) | JP5646174B2 (pt) |
| KR (2) | KR101582321B1 (pt) |
| AU (1) | AU2007330306B2 (pt) |
| BR (1) | BRPI0720116B8 (pt) |
| CA (1) | CA2673123C (pt) |
| DK (1) | DK2121979T3 (pt) |
| EA (1) | EA017529B1 (pt) |
| IL (1) | IL199049A (pt) |
| MX (1) | MX2009005651A (pt) |
| NO (1) | NO20092530L (pt) |
| NZ (1) | NZ577805A (pt) |
| SG (1) | SG177185A1 (pt) |
| WO (1) | WO2008068780A2 (pt) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| BRPI0720116B8 (pt) * | 2006-12-05 | 2021-07-27 | Decode Genetics Ehf | método para determinar uma suscetibilidade à arritmia cardíaca ou acidente vascular cerebral em um indivíduo humano, uso de uma sonda de oligonucleotídeo, e, aparelho para determinar um indicador genético para a arritmia cardíaca e/ou acidente vascular cerebral em um indivíduo humano |
| CA2751090A1 (en) * | 2009-01-30 | 2010-08-05 | Electrophoretics Limited | Method for the in vitro diagnosis of stroke |
| EP2414543B1 (en) * | 2009-04-03 | 2016-10-12 | Decode Genetics EHF | Genetic markers for risk management of atrial fibrillation and stroke |
| US20120264636A1 (en) * | 2009-10-07 | 2012-10-18 | Decode Genetics Ehf. | Genetic variants indicative of vascular conditions |
| AU2011227108A1 (en) * | 2010-03-19 | 2012-10-11 | Cardiodx, Inc. | Determining susceptibility to a sudden cardiac event |
| WO2011153428A1 (en) * | 2010-06-03 | 2011-12-08 | Medtronic, Inc. | System and method for assessing a likelihood of a patient to experience a future cardiac arrhythmia using dynamic changes in a biological parameter |
| WO2012000119A1 (en) * | 2010-07-02 | 2012-01-05 | Prognomix Inc. | A method of determining a predisposition to atrial fibrillation in a subject |
| US8715646B2 (en) * | 2010-07-29 | 2014-05-06 | The Board Of Trustees Of The University Of Illinois | Methods of determining need for anti-coagulation therapy |
| KR101230088B1 (ko) * | 2010-11-24 | 2013-02-05 | 연세대학교 산학협력단 | 심방세동의 예후 예측 방법 |
| KR101331787B1 (ko) * | 2011-10-04 | 2013-11-21 | 한국과학기술연구원 | 심장 부정맥 진단용 바이오마커 및 이를 이용한 심장 부정맥 진단 방법 |
| EP3088900B1 (en) | 2011-10-17 | 2020-08-12 | Roche Diagniostics GmbH | Troponin as marker for intermittent atrial fibrillation |
| US20140364334A1 (en) * | 2011-12-21 | 2014-12-11 | Nuclea Biotechnologies, Inc. | Congestive heart failure biomarkers |
| BR112014024537A2 (pt) | 2012-04-02 | 2017-08-08 | Berg Llc | métodos para identificar moduladores de um sistema biológico, de um processo de doença, e de angiogênese |
| KR101462006B1 (ko) * | 2013-07-23 | 2014-11-18 | 한국과학기술연구원 | 심장 부정맥 진단용 바이오마커 및 이를 이용한 심장 부정맥 진단 방법 |
| CA2920835A1 (en) | 2013-08-20 | 2015-02-26 | Anutra Medical, Inc. | Syringe fill system and method |
| USD774182S1 (en) | 2014-06-06 | 2016-12-13 | Anutra Medical, Inc. | Anesthetic delivery device |
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| CA2960837A1 (en) * | 2014-09-11 | 2016-03-17 | Berg Llc | Bayesian causal relationship network models for healthcare diagnosis and treatment based on patient data |
| US10678367B1 (en) * | 2015-09-11 | 2020-06-09 | Apple Inc. | Compressive touch sensing |
| CA2999890A1 (en) * | 2015-09-24 | 2017-03-30 | Caris Science, Inc. | Method, apparatus, and computer program product for analyzing biological data |
| KR101883657B1 (ko) * | 2016-05-13 | 2018-07-31 | 연세대학교 산학협력단 | 단일염기다형성에 의한 심방세동의 예측 또는 진단에 관한 정보 제공 방법 |
| RU2657942C1 (ru) * | 2017-07-25 | 2018-06-18 | Федеральное государственное бюджетное образовательное учреждение высшего образования Читинская государственная медицинская академия Министерства здравоохранения российской федерации | Способ прогнозирования риска развития фибрилляции предсердий у женщин с ишемической болезнью сердца |
| RU2664430C1 (ru) * | 2017-12-14 | 2018-08-17 | Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Способ прогнозирования риска развития инсульта у мужчин на основе генетического тестирования |
| CN109324189B (zh) * | 2018-08-15 | 2021-10-01 | 泰达国际心血管病医院 | 多蛋白组合物的应用及先天性心脏病筛查试剂盒 |
| US12419863B2 (en) | 2018-11-02 | 2025-09-23 | Celltrion Inc. | Pharmaceutical composition for use in treatment of hypertrophic cardiomyopathy |
| US12117453B2 (en) | 2018-12-07 | 2024-10-15 | Washington University | Predicting patient response to sodium channel blockers |
| JP7165100B2 (ja) * | 2019-04-23 | 2022-11-02 | ジェネシスヘルスケア株式会社 | 心房細動及び／又は心室細動のリスクを判定する方法 |
| US20230002829A1 (en) * | 2019-12-13 | 2023-01-05 | Ischemia Care Llc | Biomarkers for the diagnosis of atrial fibrillation cause of stroke |
| KR102250719B1 (ko) * | 2020-01-07 | 2021-05-11 | 고려대학교 산학협력단 | 발작성 심방세동 환자의 재발 위험도 예측을 위한 바이오 마커 |
| US20230332236A1 (en) * | 2020-10-08 | 2023-10-19 | Ischemia Care Llc | Method for diagnosing stroke utilizing gene expression signatures |
| CA3192122A1 (en) * | 2020-10-20 | 2022-04-28 | Kevin Wong | Methods of assessing risk of developing a disease |
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| US4376110A (en) * | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| JPS60501339A (ja) * | 1983-01-10 | 1985-08-22 | ジエン−プロ−ブ インコ−ポレィテッド | 生物を検出、同定又は定量する方法およびキット |
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| US5424186A (en) * | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| US5288644A (en) * | 1990-04-04 | 1994-02-22 | The Rockefeller University | Instrument and method for the sequencing of genome |
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| DE69129154T2 (de) | 1990-12-03 | 1998-08-20 | Genentech, Inc., South San Francisco, Calif. | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
| DK0562025T3 (da) | 1990-12-06 | 2001-06-18 | Affymetrix Inc | Forbindelser og deres anvendelse i en binær syntesestrategi |
| DE69233697T2 (de) | 1991-03-01 | 2008-01-24 | Dyax Corp., Cambridge | Verfahren zur Entwicklung von bindenden Mikroproteinen |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| US5384261A (en) * | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| CA2134552A1 (en) | 1992-04-27 | 1993-11-11 | George D. Sorenson | Detection of gene sequences in biological fluids |
| US5837832A (en) * | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| US5858659A (en) * | 1995-11-29 | 1999-01-12 | Affymetrix, Inc. | Polymorphism detection |
| WO2004028341A2 (en) * | 2001-03-19 | 2004-04-08 | Decode Genetics Ehf. | Susceptibility gene for human stroke; methods of treatment |
| BRPI0720116B8 (pt) * | 2006-12-05 | 2021-07-27 | Decode Genetics Ehf | método para determinar uma suscetibilidade à arritmia cardíaca ou acidente vascular cerebral em um indivíduo humano, uso de uma sonda de oligonucleotídeo, e, aparelho para determinar um indicador genético para a arritmia cardíaca e/ou acidente vascular cerebral em um indivíduo humano |
-
2007
- 2007-12-05 BR BRPI0720116A patent/BRPI0720116B8/pt not_active IP Right Cessation
- 2007-12-05 SG SG2011089935A patent/SG177185A1/en unknown
- 2007-12-05 CA CA2673123A patent/CA2673123C/en not_active Expired - Fee Related
- 2007-12-05 MX MX2009005651A patent/MX2009005651A/es active IP Right Grant
- 2007-12-05 EA EA200970578A patent/EA017529B1/ru not_active IP Right Cessation
- 2007-12-05 EP EP07859637.6A patent/EP2121979B1/en active Active
- 2007-12-05 US US12/302,463 patent/US8637244B2/en active Active
- 2007-12-05 DK DK07859637.6T patent/DK2121979T3/en active
- 2007-12-05 KR KR1020097013898A patent/KR101582321B1/ko not_active Expired - Fee Related
- 2007-12-05 JP JP2009539875A patent/JP5646174B2/ja not_active Expired - Fee Related
- 2007-12-05 AU AU2007330306A patent/AU2007330306B2/en not_active Ceased
- 2007-12-05 WO PCT/IS2007/000021 patent/WO2008068780A2/en not_active Ceased
- 2007-12-05 NZ NZ577805A patent/NZ577805A/xx not_active IP Right Cessation
- 2007-12-05 KR KR1020157026224A patent/KR20150113216A/ko not_active Withdrawn
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2009
- 2009-06-01 IL IL199049A patent/IL199049A/en active IP Right Grant
- 2009-07-03 NO NO20092530A patent/NO20092530L/no not_active Application Discontinuation
-
2014
- 2014-01-13 US US14/153,926 patent/US20140227693A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP5646174B2 (ja) | 2014-12-24 |
| US20140227693A1 (en) | 2014-08-14 |
| EA017529B1 (ru) | 2013-01-30 |
| KR20090087494A (ko) | 2009-08-17 |
| US20090325163A1 (en) | 2009-12-31 |
| EP2121979B1 (en) | 2017-07-12 |
| BRPI0720116B1 (pt) | 2018-05-02 |
| CA2673123A1 (en) | 2008-06-12 |
| CA2673123C (en) | 2019-04-30 |
| KR20150113216A (ko) | 2015-10-07 |
| AU2007330306B2 (en) | 2013-10-24 |
| IL199049A (en) | 2014-09-30 |
| MX2009005651A (es) | 2009-06-08 |
| AU2007330306A1 (en) | 2008-06-12 |
| EP2121979A2 (en) | 2009-11-25 |
| US8637244B2 (en) | 2014-01-28 |
| NZ577805A (en) | 2012-09-28 |
| JP2010511404A (ja) | 2010-04-15 |
| WO2008068780A2 (en) | 2008-06-12 |
| SG177185A1 (en) | 2012-01-30 |
| DK2121979T3 (en) | 2017-09-25 |
| BRPI0720116A2 (pt) | 2014-01-14 |
| WO2008068780A3 (en) | 2008-10-09 |
| KR101582321B1 (ko) | 2016-01-05 |
| NO20092530L (no) | 2009-09-03 |
| EA200970578A1 (ru) | 2009-12-30 |
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