BRPI0808025A2 - Composto de benzimidazol e uso farmacêutico do mesmo - Google Patents
Composto de benzimidazol e uso farmacêutico do mesmoInfo
- Publication number
- BRPI0808025A2 BRPI0808025A2 BRPI0808025-9A2A BRPI0808025A BRPI0808025A2 BR PI0808025 A2 BRPI0808025 A2 BR PI0808025A2 BR PI0808025 A BRPI0808025 A BR PI0808025A BR PI0808025 A2 BRPI0808025 A2 BR PI0808025A2
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical use
- benzimidazole compound
- benzimidazole
- compound
- pharmaceutical
- Prior art date
Links
- -1 BENZIMIDAZOLE COMPOUND Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007051842 | 2007-03-01 | ||
| JP2007059260 | 2007-03-08 | ||
| JP2007078845 | 2007-03-26 | ||
| JP2007093846 | 2007-03-30 | ||
| PCT/JP2008/053524 WO2008105497A1 (ja) | 2007-03-01 | 2008-02-28 | ベンゾイミダゾール化合物およびその医薬用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0808025A2 true BRPI0808025A2 (pt) | 2014-06-24 |
Family
ID=39721321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0808025-9A2A BRPI0808025A2 (pt) | 2007-03-01 | 2008-02-28 | Composto de benzimidazol e uso farmacêutico do mesmo |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8877779B2 (pt) |
| EP (1) | EP2128154B1 (pt) |
| JP (2) | JP5313865B2 (pt) |
| KR (1) | KR101165504B1 (pt) |
| CN (1) | CN101622241B (pt) |
| AU (1) | AU2008219980B2 (pt) |
| BR (1) | BRPI0808025A2 (pt) |
| CA (1) | CA2679530C (pt) |
| ES (1) | ES2541133T3 (pt) |
| MX (1) | MX2009009355A (pt) |
| WO (1) | WO2008105497A1 (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5554709B2 (ja) * | 2007-08-31 | 2014-07-23 | パーデュー、ファーマ、リミテッド、パートナーシップ | 置換キノキサリンタイプピペリジン化合物とその使用 |
| ES2393849T7 (es) | 2008-07-21 | 2015-01-28 | Purdue Pharma Lp | Compuestos de piperidina puenteada, de tipo quinoxalina sustituida, y usos de los mismos |
| TW201016675A (en) | 2008-09-16 | 2010-05-01 | Mitsubishi Tanabe Pharma Corp | Crystalline benzoimidazole compound and salt thereof |
| JP5236019B2 (ja) * | 2009-02-03 | 2013-07-17 | 田辺三菱製薬株式会社 | 1−(4−ピペリジニル)ベンゾイミダゾロン誘導体の製造方法 |
| EP2976077A4 (en) | 2013-03-22 | 2016-11-30 | Scripps Research Inst | SUBSTITUTED BENZIMIDAZOLE AS NOCICEPTIN RECEPTOR MODULATORS |
| JP6146164B2 (ja) * | 2013-06-28 | 2017-06-14 | 三菱瓦斯化学株式会社 | テトラリン骨格を有する新規アルデヒド、およびその製造方法。 |
| TWI685497B (zh) | 2014-06-02 | 2020-02-21 | 西班牙商伊史帝夫製藥公司 | 具有多重模式抗疼痛活性的1-氧雜-4,9-二氮雜螺十一烷化合物之烷基衍生物 |
| TW201615643A (zh) | 2014-06-02 | 2016-05-01 | 伊史帝夫博士實驗室股份有限公司 | 具有多重模式抗疼痛活性之1-氧雜-4,9-二氮雜螺十一烷化合物之烷基與芳基衍生物 |
| TW201607923A (zh) | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環(4.5)癸烷衍生物 |
| ME03636B (me) | 2015-10-23 | 2020-07-20 | Esteve Pharmaceuticals Sa | Oksa-diazaspiro jedinjenja која imaju aktivnost protiv bola |
| US10927128B2 (en) | 2015-11-16 | 2021-02-23 | Esteve Pharmaceuticals. S.A. | Oxadiazaspiro compounds for the treatment of drug abuse and addiction |
| US11058674B2 (en) | 2016-11-28 | 2021-07-13 | Mitsubishi Tanabe Pharma Corporation | Drug for treating cocaine addiction or preventing recurrence of same |
| PT3697795T (pt) | 2017-10-17 | 2024-02-29 | Acondicionamiento Tarrasense | Sais de (r)-9-(2,5-difluorofenetil)-4-etil-2-metil-1-oxa-4,9-diazaespiro[5.5]undecan-3-ona |
| CA3224323A1 (en) * | 2021-07-14 | 2023-01-19 | Jian Wang | Piperidine derivative, and pharmaceutical composition thereof, preparation method therefor, and use thereof |
| WO2025146193A1 (zh) * | 2024-01-05 | 2025-07-10 | 宜昌人福药业有限责任公司 | 一种环己基取代哌啶衍生物、包含其的药物组合物及其用途 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2226058C (en) | 1997-01-30 | 2008-01-29 | F. Hoffmann-La Roche Ag | 8-substituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives |
| AU732329B2 (en) | 1997-05-30 | 2001-04-12 | Banyu Pharmaceutical Co., Ltd. | 2-oxoimidazole derivative |
| ATE212635T1 (de) | 1997-12-05 | 2002-02-15 | 1,3,8-triazaspiro(4,5)decan-4-on-derivate | |
| WO1999036421A1 (en) | 1998-01-19 | 1999-07-22 | Pfizer Pharmaceuticals Inc. | 4-(2-keto-1-benzimidazolinyl)piperidine compounds as orl1-receptor agonists |
| ES2181336T3 (es) | 1998-06-12 | 2003-02-16 | Hoffmann La Roche | Espiro(piperidin-4,1'-pirrolo(3,4-c)pirrol). |
| EP0963985B1 (en) | 1998-06-12 | 2003-03-12 | F. Hoffmann-La Roche Ag | Di-or triaza-spiro(4,5)decane derivatives |
| US6262066B1 (en) * | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
| ID29137A (id) | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
| AU8657398A (en) | 1998-07-30 | 2000-02-21 | Picower Institute For Medical Research, The | Immunotherapeutic anti-cancer pharmaceutical compositions |
| US7456198B2 (en) | 1999-12-06 | 2008-11-25 | Purdue Pharma L.P. | Benzimidazole compounds having nociceptin receptor affinity |
| IL158484A0 (en) * | 2001-04-18 | 2004-05-12 | Euro Celtique Sa | Nociceptin analogs |
| DK1491212T3 (da) | 2002-03-29 | 2012-10-29 | Mitsubishi Tanabe Pharma Corp | Middel til behandling af søvnforstyrrelser |
| US20030226657A1 (en) * | 2002-04-01 | 2003-12-11 | Wallace Thomas E. | Food delivery system and method for storing and heating food to a serving temperature |
| US8067603B2 (en) | 2003-09-25 | 2011-11-29 | Solvay Pharmaceuticals B.V. | Benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors |
| CN1856485A (zh) * | 2003-09-25 | 2006-11-01 | 索尔瓦药物有限公司 | 作为人orl1受体激动剂的苯并咪唑酮和喹唑啉酮衍生物 |
| DE102004030290A1 (de) | 2004-06-23 | 2006-01-19 | Siemens Ag | Aufbau einer Verbindung für den Austausch von Daten eines IP-basierten Dienstes |
| JP4122015B2 (ja) | 2005-08-19 | 2008-07-23 | 株式会社日本水処理技研 | プラント洗浄方法,アスベスト除去方法および解体処理方法 |
| JP2007059260A (ja) | 2005-08-25 | 2007-03-08 | Toshiba Lighting & Technology Corp | 照明装置及び照明器具 |
| JP4551848B2 (ja) | 2005-09-12 | 2010-09-29 | シャープ株式会社 | 現像装置およびそれを備える画像形成装置 |
| JP2007093846A (ja) | 2005-09-28 | 2007-04-12 | Sanyo Epson Imaging Devices Corp | 電気光学装置、および電子機器 |
-
2008
- 2008-02-28 WO PCT/JP2008/053524 patent/WO2008105497A1/ja not_active Ceased
- 2008-02-28 ES ES08712095.2T patent/ES2541133T3/es active Active
- 2008-02-28 AU AU2008219980A patent/AU2008219980B2/en not_active Ceased
- 2008-02-28 JP JP2009501298A patent/JP5313865B2/ja not_active Expired - Fee Related
- 2008-02-28 CA CA2679530A patent/CA2679530C/en not_active Expired - Fee Related
- 2008-02-28 BR BRPI0808025-9A2A patent/BRPI0808025A2/pt not_active IP Right Cessation
- 2008-02-28 EP EP08712095.2A patent/EP2128154B1/en not_active Not-in-force
- 2008-02-28 CN CN2008800068312A patent/CN101622241B/zh not_active Expired - Fee Related
- 2008-02-28 MX MX2009009355A patent/MX2009009355A/es not_active Application Discontinuation
- 2008-02-28 US US12/449,874 patent/US8877779B2/en active Active
- 2008-02-28 KR KR1020097020508A patent/KR101165504B1/ko not_active Expired - Fee Related
-
2013
- 2013-03-11 JP JP2013048087A patent/JP2013107910A/ja not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2128154A4 (en) | 2011-01-26 |
| KR20090115976A (ko) | 2009-11-10 |
| US8877779B2 (en) | 2014-11-04 |
| CN101622241B (zh) | 2013-05-22 |
| ES2541133T3 (es) | 2015-07-16 |
| CN101622241A (zh) | 2010-01-06 |
| JP5313865B2 (ja) | 2013-10-09 |
| EP2128154B1 (en) | 2015-04-08 |
| KR101165504B1 (ko) | 2012-07-13 |
| CA2679530C (en) | 2012-09-25 |
| EP2128154A1 (en) | 2009-12-02 |
| AU2008219980B2 (en) | 2012-01-12 |
| AU2008219980A1 (en) | 2008-09-04 |
| CA2679530A1 (en) | 2008-09-04 |
| JPWO2008105497A1 (ja) | 2010-06-03 |
| JP2013107910A (ja) | 2013-06-06 |
| WO2008105497A1 (ja) | 2008-09-04 |
| MX2009009355A (es) | 2009-09-11 |
| US20100120841A1 (en) | 2010-05-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2308 DE 31/03/2015. |