BRPI0809693A2 - Derivados de imidazolidina carboxamida como inibidores de lipase e fosfolipase - Google Patents

Derivados de imidazolidina carboxamida como inibidores de lipase e fosfolipase

Info

Publication number: BRPI0809693A2
Authority: BR; Brazil
Prior art keywords: lipase; carboxamide; imidazolidine derivatives; phospholipase inhibitors; phospholipase
Prior art date: 2007-04-05

Application number

BRPI0809693-7A2A

Other languages

English (en)

Inventor

Gerhard Zoller

Stefan Petry

Guenter Mueller

Norbert Tennagels

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-04-05

Filing date

2008-03-20

Publication date

2014-10-07

2008-03-20 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2014-10-07 Publication of BRPI0809693A2 publication Critical patent/BRPI0809693A2/pt

Links

-1 CARBOXAMIDE IMIDAZOLIDINE DERIVATIVES Chemical class 0.000 title 1
102000004882 Lipase Human genes 0.000 title 1
108090001060 Lipase Proteins 0.000 title 1
239000004367 Lipase Substances 0.000 title 1
235000019421 lipase Nutrition 0.000 title 1
239000003428 phospholipase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
- C07D233/78—Radicals substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
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- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Obesity (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Ophthalmology & Optometry (AREA)
Psychology (AREA)
Child & Adolescent Psychology (AREA)

BRPI0809693-7A2A 2007-04-05 2008-03-20 Derivados de imidazolidina carboxamida como inibidores de lipase e fosfolipase BRPI0809693A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP07007161		2007-04-05
PCT/EP2008/002231 WO2008122352A1 (de)	2007-04-05	2008-03-20	Imidazolidin-carbonsäureamid-derivate als inhibitoren von lipasen und phospholipasen

Publications (1)

Publication Number	Publication Date
BRPI0809693A2 true BRPI0809693A2 (pt)	2014-10-07

Family

ID=38169713

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0809693-7A2A BRPI0809693A2 (pt)	2007-04-05	2008-03-20	Derivados de imidazolidina carboxamida como inibidores de lipase e fosfolipase

Country Status (20)

Country	Link
US (1)	US8735437B2 (pt)
EP (1)	EP2144885B1 (pt)
JP (1)	JP2010523503A (pt)
KR (1)	KR20090126293A (pt)
CN (1)	CN101646655A (pt)
AR (1)	AR065932A1 (pt)
AU (1)	AU2008235066A1 (pt)
BR (1)	BRPI0809693A2 (pt)
CA (1)	CA2682875A1 (pt)
CL (1)	CL2008000981A1 (pt)
CO (1)	CO6220934A2 (pt)
IL (1)	IL201255A0 (pt)
MA (1)	MA31296B1 (pt)
MX (1)	MX2009010485A (pt)
NZ (1)	NZ580127A (pt)
RU (1)	RU2009140761A (pt)
TW (1)	TW200904804A (pt)
UY (1)	UY31001A1 (pt)
WO (1)	WO2008122352A1 (pt)
ZA (1)	ZA200906211B (pt)

Families Citing this family (15)

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WO2011107494A1 (de)	2010-03-03	2011-09-09	Sanofi	Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de)	2010-06-18	2018-01-24	Sanofi	Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013048928A1 (en) *	2011-09-27	2013-04-04	Bristol-Myers Squibb Company	Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors
EP2760862B1 (en)	2011-09-27	2015-10-21	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760829B1 (en)	2011-09-27	2016-05-18	Bristol-Myers Squibb Company	Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors
US9249096B2 (en)	2011-09-27	2016-02-02	Bristol-Myers Squibb Company	Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors
US8933235B2 (en)	2011-09-30	2015-01-13	Bristol-Myers Squibb Company	Pyridinedione carboxamide inhibitors of endothelial lipase
US9199946B2 (en)	2012-04-03	2015-12-01	Bristol-Myers Squibb Company	Pyrimidinone carboxamide inhibitors of endothelial lipase
EP2847174B1 (en) *	2012-04-03	2017-05-17	Bristol-Myers Squibb Company	Pyrimidinone carboxamides as inhibitors of endothelial lipase
AR102942A1 (es)	2014-12-11	2017-04-05	Bayer Cropscience Ag	Derivados de arilsulfuro y arilsulfóxido de cinco miembros c-n-conectados, como plaguicidas

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH03227976A (ja) *	1990-02-01	1991-10-08	Otsuka Chem Co Ltd	イミダゾリジン―２―オン誘導体
JP3227976B2 (ja)	1993-02-26	2001-11-12	松下電器産業株式会社	光学的情報記録部材、記録再生方法、及び記録再生装置
JP3947283B2 (ja)	1997-11-19	2007-07-18	株式会社堀場製作所	イプロジオン及びその代謝物のハプテン化合物、抗体及び測定方法
ES2207614T3 (es) *	2000-05-18	2004-06-01	Neurocrine Biosciences, Inc.	Antagonistas del receptor de crf y metodos relacionados con estos.
EP1610779B1 (en)	2003-03-31	2009-09-09	Eli Lilly And Company	3-oxo-1,3-dihydro-indazole-2-carboxylic acid amide derivatives as phospholipase inhibitors
WO2004094393A1 (en)	2003-04-01	2004-11-04	Eli Lilly And Company	Phospholipase inhibitors
EP1615900A1 (en)	2003-04-01	2006-01-18	Eli Lilly And Company	Benzisothiazol-3-one-carboxylic acid amides as phospholipase inhibitors
WO2005087236A1 (en) *	2004-03-11	2005-09-22	Glaxo Group Limited	Novel m3 muscarinic acetylcholine receptor antagonists
DE102005018389A1 (de)	2005-04-20	2006-10-26	Sanofi-Aventis Deutschland Gmbh	Azolderivate als Inhibitoren von Lipasen und Phospholipasen

2008
- 2008-03-20 JP JP2010501401A patent/JP2010523503A/ja not_active Withdrawn
- 2008-03-20 CA CA002682875A patent/CA2682875A1/en not_active Abandoned
- 2008-03-20 WO PCT/EP2008/002231 patent/WO2008122352A1/de not_active Ceased
- 2008-03-20 NZ NZ580127A patent/NZ580127A/en unknown
- 2008-03-20 BR BRPI0809693-7A2A patent/BRPI0809693A2/pt not_active Application Discontinuation
- 2008-03-20 EP EP08734683.9A patent/EP2144885B1/de active Active
- 2008-03-20 KR KR1020097020794A patent/KR20090126293A/ko not_active Withdrawn
- 2008-03-20 AU AU2008235066A patent/AU2008235066A1/en not_active Abandoned
- 2008-03-20 MX MX2009010485A patent/MX2009010485A/es unknown
- 2008-03-20 RU RU2009140761/04A patent/RU2009140761A/ru not_active Application Discontinuation
- 2008-03-20 CN CN200880009966A patent/CN101646655A/zh active Pending
- 2008-04-02 TW TW097111925A patent/TW200904804A/zh unknown
- 2008-04-03 UY UY31001A patent/UY31001A1/es not_active Application Discontinuation
- 2008-04-03 AR ARP080101389A patent/AR065932A1/es unknown
- 2008-04-04 CL CL200800981A patent/CL2008000981A1/es unknown
2009
- 2009-09-08 ZA ZA200906211A patent/ZA200906211B/xx unknown
- 2009-09-30 CO CO09107074A patent/CO6220934A2/es not_active Application Discontinuation
- 2009-09-30 IL IL201255A patent/IL201255A0/en unknown
- 2009-10-02 US US12/572,462 patent/US8735437B2/en not_active Expired - Fee Related
- 2009-10-02 MA MA32251A patent/MA31296B1/fr unknown

Also Published As

Publication number	Publication date
IL201255A0 (en)	2010-05-31
NZ580127A (en)	2011-03-31
UY31001A1 (es)	2008-11-28
US20100105719A1 (en)	2010-04-29
ZA200906211B (en)	2010-05-26
KR20090126293A (ko)	2009-12-08
EP2144885A1 (de)	2010-01-20
AU2008235066A1 (en)	2008-10-16
WO2008122352A1 (de)	2008-10-16
CO6220934A2 (es)	2010-11-19
TW200904804A (en)	2009-02-01
CN101646655A (zh)	2010-02-10
MX2009010485A (es)	2009-10-19
MA31296B1 (fr)	2010-04-01
CL2008000981A1 (es)	2008-10-10
AR065932A1 (es)	2009-07-08
US8735437B2 (en)	2014-05-27
RU2009140761A (ru)	2011-05-10
CA2682875A1 (en)	2008-10-16
JP2010523503A (ja)	2010-07-15
EP2144885B1 (de)	2016-06-29

Legal Events

Date	Code	Title	Description
2015-06-02	B11A	Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
2015-09-01	B11Y	Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]

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