CR9850A - Carbamoylbenzotriazole derivatives as inhibitors of lipases and phospholipases - Google Patents
Carbamoylbenzotriazole derivatives as inhibitors of lipases and phospholipasesInfo
- Publication number
- CR9850A CR9850A CR9850A CR9850A CR9850A CR 9850 A CR9850 A CR 9850A CR 9850 A CR9850 A CR 9850A CR 9850 A CR9850 A CR 9850A CR 9850 A CR9850 A CR 9850A
- Authority
- CR
- Costa Rica
- Prior art keywords
- phospholipases
- lipases
- inhibitors
- carbamoylbenzotriazole
- derivatives
- Prior art date
Links
- VKMHAJDSSBSCEM-UHFFFAOYSA-N 2h-benzotriazole-4-carboxamide Chemical class NC(=O)C1=CC=CC2=C1N=NN2 VKMHAJDSSBSCEM-UHFFFAOYSA-N 0.000 title 1
- 102000004882 Lipase Human genes 0.000 title 1
- 108090001060 Lipase Proteins 0.000 title 1
- 239000004367 Lipase Substances 0.000 title 1
- 102000015439 Phospholipases Human genes 0.000 title 1
- 108010064785 Phospholipases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005049953A DE102005049953A1 (de) | 2005-10-19 | 2005-10-19 | Carbamoylbenzotriazol-derivate als Inhibitoren von Lipasen und Phospholipasen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR9850A true CR9850A (es) | 2008-06-18 |
Family
ID=37667178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR9850A CR9850A (es) | 2005-10-19 | 2008-03-28 | Carbamoylbenzotriazole derivatives as inhibitors of lipases and phospholipases |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US7897625B2 (es) |
| EP (1) | EP1940807B1 (es) |
| JP (1) | JP2009512650A (es) |
| KR (1) | KR20080063474A (es) |
| CN (1) | CN101291918A (es) |
| AR (1) | AR057554A1 (es) |
| AU (1) | AU2006303552A1 (es) |
| BR (1) | BRPI0617613A2 (es) |
| CA (1) | CA2625722A1 (es) |
| CR (1) | CR9850A (es) |
| DE (1) | DE102005049953A1 (es) |
| DO (1) | DOP2006000226A (es) |
| EC (1) | ECSP088377A (es) |
| GT (1) | GT200600463A (es) |
| HN (1) | HN2006035238A (es) |
| IL (1) | IL190714A0 (es) |
| MA (1) | MA29858B1 (es) |
| NO (1) | NO20081942L (es) |
| NZ (1) | NZ567573A (es) |
| PE (1) | PE20070724A1 (es) |
| RU (1) | RU2430096C2 (es) |
| TN (1) | TNSN08177A1 (es) |
| TW (1) | TW200730513A (es) |
| UY (1) | UY29872A1 (es) |
| WO (1) | WO2007045393A1 (es) |
| ZA (1) | ZA200802370B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2667082A1 (en) * | 2006-10-04 | 2008-04-10 | Schering Corporation | Bicyclic and tricyclic derivatives as thrombin receptor antagonists |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| UY31968A (es) | 2008-07-09 | 2010-01-29 | Sanofi Aventis | Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos |
| EP2351744B1 (en) | 2008-10-17 | 2015-01-07 | Shionogi & Co., Ltd. | Acetic acid amide derivative having inhibitory activity on vascular endothelial lipase |
| SG172301A1 (en) * | 2008-12-24 | 2011-07-28 | Bial Portela & Ca Sa | Pharmaceutical compounds |
| WO2011022312A1 (en) * | 2009-08-20 | 2011-02-24 | Merck Sharp & Dohme Corp. | Ether benzotriazole derivatives |
| US8754113B2 (en) | 2009-12-15 | 2014-06-17 | Shionogi & Co., Ltd. | Oxadiazole derivative having endothelial lipase inhibitory activity |
| WO2011140296A1 (en) * | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Triazoles as inhibitors of fatty acid synthase |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| WO2012047580A1 (en) * | 2010-09-27 | 2012-04-12 | Janssen Pharmaceutica Nv | Alpha-ketoamide derivatives useful endothelial lipase inhibitors |
| RS57962B1 (sr) | 2013-02-25 | 2019-01-31 | Aurigene Discovery Tech Ltd | Derivati trisupstituisanog benzotriazola kao inhibitori dihidroorotat oksigenaze |
| RU2563254C2 (ru) * | 2013-07-08 | 2015-09-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ получения производных 7-(гетеро)арил-4,5,6,7-тетрагидро[1,2,3]триазоло[1,5-a]пиридина |
| RU2553987C1 (ru) * | 2013-12-26 | 2015-06-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный университет" (СПбГУ) | N-адамантилбензотриазолы, проявляющие активность против вируса гриппа а, и способ их получения |
| CN104292172B (zh) * | 2014-09-12 | 2016-08-17 | 浙江理工大学 | 一种苯并三氮唑类衍生物及其制备方法 |
| CN110662539B (zh) | 2017-04-24 | 2023-08-15 | 奥里吉恩探索技术有限公司 | 三取代的苯并三唑衍生物作为二氢乳清酸加氧酶抑制剂的使用方法 |
| US20180369206A1 (en) | 2017-04-24 | 2018-12-27 | Aurigene Discovery Technologies Limited | Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors |
| EP3755324B1 (en) | 2018-02-20 | 2025-07-30 | Les Laboratoires Servier | Benzotriazole derivative for use in treating double and triple hit diffuse large b cell lymphoma |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1035188A (en) * | 1974-08-15 | 1978-07-25 | Eastman Kodak Company | Blocked development restrainers |
| US4273860A (en) * | 1977-12-28 | 1981-06-16 | Eastman Kodak Company | Inhibition of image formation utilizing cobalt(III) complexes |
| CA1126999A (en) | 1978-10-20 | 1982-07-06 | Michael J. Simons | Use of azole compounds with a n,n disubstituted carbamoyl group on a ring nitrogen as development restrainer precursors in photographic elements |
| JPS6239573A (ja) * | 1985-08-13 | 1987-02-20 | Sumitomo Chem Co Ltd | シクロアルケニルアミド誘導体、その製造法およびそれを有効成分とする土壌病害防除剤 |
| US6372421B1 (en) * | 2000-06-13 | 2002-04-16 | Eastman Kodak Company | Photothermographic imaging element having improved contrast and methods of image formation |
| US6440648B1 (en) * | 2000-06-13 | 2002-08-27 | Eastman Kodak Company | Color photographic element having improved contrast and compatibility with both dry and conventional processing |
| MXPA03010129A (es) | 2001-05-05 | 2004-03-10 | Smithkline Beecham Plc | N-aroilaminas-ciclicas. |
| KR20040068240A (ko) | 2001-12-14 | 2004-07-30 | 노보 노르디스크 에이/에스 | 호르몬 민감성 리파아제의 활성을 감소시키기 위한 화합물및 그들의 사용 |
| DE10247680B4 (de) * | 2002-10-12 | 2005-09-01 | Aventis Pharma Deutschland Gmbh | Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase |
| WO2004093872A1 (en) * | 2003-03-31 | 2004-11-04 | Eli Lilly And Company | 3-oxo-1, 3-dihydro-indazole-2-carboxylic acid amide derivatives as phospholipase inhibitors |
-
2005
- 2005-10-19 DE DE102005049953A patent/DE102005049953A1/de not_active Ceased
-
2006
- 2006-10-12 NZ NZ567573A patent/NZ567573A/en not_active IP Right Cessation
- 2006-10-12 CA CA002625722A patent/CA2625722A1/en not_active Abandoned
- 2006-10-12 WO PCT/EP2006/009857 patent/WO2007045393A1/de not_active Ceased
- 2006-10-12 RU RU2008119460/04A patent/RU2430096C2/ru not_active IP Right Cessation
- 2006-10-12 BR BRPI0617613-5A patent/BRPI0617613A2/pt not_active IP Right Cessation
- 2006-10-12 EP EP06806216.5A patent/EP1940807B1/de active Active
- 2006-10-12 AU AU2006303552A patent/AU2006303552A1/en not_active Abandoned
- 2006-10-12 KR KR1020087009298A patent/KR20080063474A/ko not_active Withdrawn
- 2006-10-12 CN CNA2006800384397A patent/CN101291918A/zh active Pending
- 2006-10-12 JP JP2008535942A patent/JP2009512650A/ja not_active Abandoned
- 2006-10-17 PE PE2006001257A patent/PE20070724A1/es not_active Application Discontinuation
- 2006-10-17 TW TW095138145A patent/TW200730513A/zh unknown
- 2006-10-17 DO DO2006000226A patent/DOP2006000226A/es unknown
- 2006-10-17 AR ARP060104521A patent/AR057554A1/es unknown
- 2006-10-17 GT GT200600463A patent/GT200600463A/es unknown
- 2006-10-18 UY UY29872A patent/UY29872A1/es not_active Application Discontinuation
- 2006-10-18 HN HN2006035238A patent/HN2006035238A/es unknown
-
2008
- 2008-03-13 ZA ZA200802370A patent/ZA200802370B/xx unknown
- 2008-03-28 CR CR9850A patent/CR9850A/es not_active Application Discontinuation
- 2008-04-08 IL IL190714A patent/IL190714A0/en unknown
- 2008-04-08 MA MA30825A patent/MA29858B1/fr unknown
- 2008-04-09 US US12/099,924 patent/US7897625B2/en not_active Expired - Fee Related
- 2008-04-17 EC EC2008008377A patent/ECSP088377A/es unknown
- 2008-04-18 TN TNP2008000177A patent/TNSN08177A1/en unknown
- 2008-04-23 NO NO20081942A patent/NO20081942L/no not_active Application Discontinuation
-
2011
- 2011-01-20 US US13/009,951 patent/US20110118321A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009512650A (ja) | 2009-03-26 |
| WO2007045393A1 (de) | 2007-04-26 |
| DOP2006000226A (es) | 2007-05-15 |
| AR057554A1 (es) | 2007-12-05 |
| GT200600463A (es) | 2007-05-21 |
| US7897625B2 (en) | 2011-03-01 |
| RU2430096C2 (ru) | 2011-09-27 |
| US20110118321A1 (en) | 2011-05-19 |
| BRPI0617613A2 (pt) | 2011-08-02 |
| CN101291918A (zh) | 2008-10-22 |
| HN2006035238A (es) | 2010-05-24 |
| ECSP088377A (es) | 2008-05-30 |
| IL190714A0 (en) | 2008-11-03 |
| CA2625722A1 (en) | 2007-04-26 |
| UY29872A1 (es) | 2007-05-31 |
| NO20081942L (no) | 2008-04-23 |
| TNSN08177A1 (en) | 2009-10-30 |
| RU2008119460A (ru) | 2009-11-27 |
| US20080287503A1 (en) | 2008-11-20 |
| NZ567573A (en) | 2010-06-25 |
| AU2006303552A1 (en) | 2007-04-26 |
| TW200730513A (en) | 2007-08-16 |
| EP1940807B1 (de) | 2015-06-17 |
| PE20070724A1 (es) | 2007-08-07 |
| MA29858B1 (fr) | 2008-10-03 |
| EP1940807A1 (de) | 2008-07-09 |
| ZA200802370B (en) | 2008-12-31 |
| DE102005049953A1 (de) | 2007-04-26 |
| KR20080063474A (ko) | 2008-07-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal (granting procedure) |