BRPI0810821A2 - Derivados de anéis aromáticos de seis membros contendo nitrogênio e produtos farmacêuticos contendo os mesmos - Google Patents

Derivados de anéis aromáticos de seis membros contendo nitrogênio e produtos farmacêuticos contendo os mesmos

Info

Publication number: BRPI0810821A2
Authority: BR; Brazil
Prior art keywords: same; aromatic ring; pharmaceutical products; ring derivatives; members
Prior art date: 2007-04-27

Application number

Other languages

English (en)

Inventor

Naohiro Takemoto

Kenji Murata

Norihito Murayama

Chikaomi Yamada

Original Assignee

Asubio Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-04-27

Filing date

2008-04-25

Publication date

2014-10-29

2008-04-25 Application filed by Asubio Pharma Co Ltd filed Critical Asubio Pharma Co Ltd

2014-10-29 Publication of BRPI0810821A2 publication Critical patent/BRPI0810821A2/pt

2015-09-15 Publication of BRPI0810821A8 publication Critical patent/BRPI0810821A8/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

BRPI0810821A 2007-04-27 2008-04-25 Derivados de anéis aromáticos de seis membros contendo nitrogênio e produtos farmacêuticos contendo os mesmos BRPI0810821A8 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2007118768		2007-04-27
PCT/JP2008/058081 WO2008139894A1 (ja)	2007-04-27	2008-04-25	含窒素芳香族６員環誘導体並びにそれらを含む医薬

Publications (2)

Publication Number	Publication Date
BRPI0810821A2 true BRPI0810821A2 (pt)	2014-10-29
BRPI0810821A8 BRPI0810821A8 (pt)	2015-09-15

Family

ID=40002110

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0810821A BRPI0810821A8 (pt)	2007-04-27	2008-04-25	Derivados de anéis aromáticos de seis membros contendo nitrogênio e produtos farmacêuticos contendo os mesmos

Country Status (18)

Country	Link
US (4)	US8592435B2 (pt)
EP (2)	EP2151439B1 (pt)
JP (1)	JP5197584B2 (pt)
KR (1)	KR101456316B1 (pt)
CN (2)	CN101730691A (pt)
AU (1)	AU2008249329C1 (pt)
BR (1)	BRPI0810821A8 (pt)
CA (1)	CA2683941C (pt)
CY (1)	CY1115377T1 (pt)
DK (1)	DK2151439T3 (pt)
ES (2)	ES2453590T3 (pt)
HR (1)	HRP20140326T1 (pt)
MX (1)	MX2009011369A (pt)
PL (1)	PL2151439T3 (pt)
PT (1)	PT2151439E (pt)
RU (1)	RU2470927C2 (pt)
SI (1)	SI2151439T1 (pt)
WO (1)	WO2008139894A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR112012002807B1 (pt) *	2009-08-07	2018-07-10	Adama Makhteshim Ltd.	Derivados de 5-flúor-2-oxopirimidina-1(2h)- caboxilato, composição e processo para controle e prevenção de ataque fúngico em uma planta de ataque fúngico em uma planta
UA112284C2 (uk) *	2009-08-07	2016-08-25	ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі	Похідні 5-фторпіримідинону
JP6324994B2 (ja)	2012-12-28	2018-05-16	アダマ・マクテシム・リミテッド	Ｎ−（置換）−５−フルオロ−４−イミノ−３−メチル−２−オキソ−３，４−ジヒドロピリミジン−１（２ｈ）−カルボキシレート誘導体
KR20150100869A (ko)	2012-12-28	2015-09-02	다우 아그로사이언시즈 엘엘씨	N-(치환된)-5-플루오로-4-이미노-3-메틸-2-옥소-3,4-디히드로피리미딘-1(2h)-카르복스아미드 유도체
CN105007737A (zh)	2012-12-31	2015-10-28	美国陶氏益农公司	作为杀真菌剂的3-烷基-5-氟-4-取代的-亚氨基-3,4-二氢嘧啶-2(1h)-酮衍生物
WO2016047662A1 (ja) *	2014-09-25	2016-03-31	第一三共株式会社	脳卒中の治療剤
WO2016086105A1 (en) *	2014-11-25	2016-06-02	Shriners Hospitals For Children	MODEL SYSTEMS FOR SCREENING MODULATORS OF mTOR SIGNALING
CN114570418B (zh) *	2022-02-22	2023-10-17	陕西延长石油（集团）有限责任公司	一种羟基乙酸甲酯制备肌氨酸甲酯及肌氨酸的催化剂及其制备方法与应用

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CA1260474A (en)	1984-12-03	1989-09-26	Raymond A. Stokbroekx	Benzoxazol- and benzothiazolamine derivatives
GB8912700D0 (en) *	1989-06-02	1989-07-19	Shell Int Research	Herbicidal compounds
EP0347811B1 (en)	1988-06-20	1994-03-30	Kumiai Chemical Industry Co., Ltd.	Alkanoic acid derivatives and herbicidal compositions
JP2771604B2 (ja)	1988-06-20	1998-07-02	クミアイ化学工業株式会社	除草剤及びその有効成分となる新規なアルカン酸誘導体
GB8917476D0 (en)	1989-07-31	1989-09-13	Shell Int Research	Sulphonamide herbicides
CA2315050C (en)	1998-10-16	2009-02-03	Suntory Limited	Aminophenoxyacetic acid derivatives and pharmaceutical composition containing thereof
SE9902987D0 (sv)	1999-08-24	1999-08-24	Astra Pharma Prod	Novel compounds
WO2001079170A2 (en) *	2000-04-13	2001-10-25	Suntory Limited	Aminophenoxyacetamide derivatives and pharmaceutical composition containing thereof
EP1389616B1 (en)	2001-04-27	2011-07-27	Mitsubishi Tanabe Pharma Corporation	3,4-Dihalobenzylpiperidine derivatives and their medical use
US7205307B2 (en)	2002-02-14	2007-04-17	Icagen, Inc.	Pyrimidines as novel openers of potassium ion channels
CN100509804C (zh)	2002-06-24	2009-07-08	阿卡蒂亚药品公司	N-取代哌啶衍生物作为血清素受体试剂
MY142362A (en)	2004-01-29	2010-11-30	Otsuka Pharma Co Ltd	Pharmaceutical composition for promoting angiogenesis
JP4916115B2 (ja)	2004-01-29	2012-04-11	大塚製薬株式会社	血管新生促進剤
TW200538098A (en)	2004-03-22	2005-12-01	Astrazeneca Ab	Therapeutic agents
EP1994003A4 (en)	2006-03-07	2009-12-02	Astrazeneca Ab	PIPERIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS THERAPEUTIC AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEY

2008
- 2008-04-25 US US12/596,054 patent/US8592435B2/en not_active Expired - Fee Related
- 2008-04-25 RU RU2009143850/04A patent/RU2470927C2/ru not_active IP Right Cessation
- 2008-04-25 JP JP2009514083A patent/JP5197584B2/ja not_active Expired - Fee Related
- 2008-04-25 ES ES08764246T patent/ES2453590T3/es active Active
- 2008-04-25 AU AU2008249329A patent/AU2008249329C1/en not_active Ceased
- 2008-04-25 MX MX2009011369A patent/MX2009011369A/es active IP Right Grant
- 2008-04-25 PT PT87642468T patent/PT2151439E/pt unknown
- 2008-04-25 SI SI200831176T patent/SI2151439T1/sl unknown
- 2008-04-25 WO PCT/JP2008/058081 patent/WO2008139894A1/ja not_active Ceased
- 2008-04-25 CN CN200880021294A patent/CN101730691A/zh active Pending
- 2008-04-25 CA CA 2683941 patent/CA2683941C/en not_active Expired - Fee Related
- 2008-04-25 EP EP20080764246 patent/EP2151439B1/en active Active
- 2008-04-25 ES ES13185144.6T patent/ES2566327T3/es active Active
- 2008-04-25 KR KR1020097024649A patent/KR101456316B1/ko not_active Expired - Fee Related
- 2008-04-25 PL PL08764246T patent/PL2151439T3/pl unknown
- 2008-04-25 DK DK08764246T patent/DK2151439T3/en active
- 2008-04-25 BR BRPI0810821A patent/BRPI0810821A8/pt not_active Application Discontinuation
- 2008-04-25 CN CN201310302307.2A patent/CN103396399B/zh not_active Expired - Fee Related
- 2008-04-25 HR HRP20140326AT patent/HRP20140326T1/hr unknown
- 2008-04-25 EP EP13185144.6A patent/EP2679586B1/en not_active Not-in-force
2012
- 2012-05-29 US US13/482,375 patent/US8685989B2/en not_active Expired - Fee Related
2014
- 2014-02-05 US US14/173,327 patent/US9139559B2/en not_active Expired - Fee Related
- 2014-05-26 CY CY20141100376T patent/CY1115377T1/el unknown
- 2014-07-22 US US14/337,586 patent/US9156817B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2683941A1 (en)	2008-11-20
MX2009011369A (es)	2009-12-15
CN103396399B (zh)	2015-04-29
US9139559B2 (en)	2015-09-22
RU2470927C2 (ru)	2012-12-27
HRP20140326T1 (hr)	2014-05-09
RU2009143850A (ru)	2011-06-10
CN101730691A (zh)	2010-06-09
US9156817B2 (en)	2015-10-13
JPWO2008139894A1 (ja)	2010-07-29
ES2566327T3 (es)	2016-04-12
KR20100017388A (ko)	2010-02-16
KR101456316B1 (ko)	2014-11-03
ES2453590T3 (es)	2014-04-08
JP5197584B2 (ja)	2013-05-15
CN103396399A (zh)	2013-11-20
US8592435B2 (en)	2013-11-26
EP2151439B1 (en)	2014-02-26
CY1115377T1 (el)	2017-01-04
AU2008249329A1 (en)	2008-11-20
SI2151439T1 (sl)	2014-05-30
AU2008249329C1 (en)	2013-07-04
US20100130739A1 (en)	2010-05-27
DK2151439T3 (en)	2014-03-10
PL2151439T3 (pl)	2014-08-29
EP2151439A4 (en)	2012-08-01
EP2679586A1 (en)	2014-01-01
US20120258978A1 (en)	2012-10-11
US20140336209A1 (en)	2014-11-13
US8685989B2 (en)	2014-04-01
AU2008249329B2 (en)	2012-12-06
EP2151439A1 (en)	2010-02-10
BRPI0810821A8 (pt)	2015-09-15
WO2008139894A1 (ja)	2008-11-20
CA2683941C (en)	2014-08-12
EP2679586B1 (en)	2016-02-10
US20140221409A1 (en)	2014-08-07
PT2151439E (pt)	2014-04-10

Publication	Publication Date	Title
BRPI0810821A2 (pt)	2014-10-29	Derivados de anéis aromáticos de seis membros contendo nitrogênio e produtos farmacêuticos contendo os mesmos
PL3938047T3 (pl)	2022-11-07	Zmostkowane tricykliczne związki karbamoilopirydonowe i ich zastosowanie farmaceutyczne
IL268756B (en)	2020-08-31	Piperazine-2,5-dione derivatives, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments
DK3421471T3 (da)	2021-06-14	Purin- og deazapurinderivater som farmaceutiske forbindelser
BRPI0815385A2 (pt)	2009-02-12	Produtos medicinais farmaceuticamente revestidos melhorados, fabricação e uso dos mesmos
IL195491A (en)	2014-11-30	Pharmaceutical compositions of tmc278 and processes for their preparation
EP2101745A4 (en)	2009-12-30	ADMINISTRATION OF MEDICINES
BRPI0809667A2 (pt)	2014-10-07	Composto, medicamento e composição farmacêutica que o contém e uso do composto
DE602004017510D1 (de)	2008-12-11	Medizinprodukt vom kapseltyp
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