BRPI0812288A2 - Purificação de imunoglobulina. - Google Patents

Purificação de imunoglobulina.

Info

Publication number
BRPI0812288A2
BRPI0812288A2 BRPI0812288-1A2A BRPI0812288A BRPI0812288A2 BR PI0812288 A2 BRPI0812288 A2 BR PI0812288A2 BR PI0812288 A BRPI0812288 A BR PI0812288A BR PI0812288 A2 BRPI0812288 A2 BR PI0812288A2
Authority
BR
Brazil
Prior art keywords
immunoglobulin purification
immunoglobulin
purification
Prior art date
Application number
BRPI0812288-1A2A
Other languages
English (en)
Inventor
Roberto Falkenstein
Claudia Giessel
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38440174&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0812288(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0812288A2 publication Critical patent/BRPI0812288A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
BRPI0812288-1A2A 2007-06-01 2008-05-28 Purificação de imunoglobulina. BRPI0812288A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07010840 2007-06-01
PCT/EP2008/004231 WO2008145351A1 (en) 2007-06-01 2008-05-28 Immunoglobulin purification

Publications (1)

Publication Number Publication Date
BRPI0812288A2 true BRPI0812288A2 (pt) 2014-11-25

Family

ID=38440174

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0812288-1A2A BRPI0812288A2 (pt) 2007-06-01 2008-05-28 Purificação de imunoglobulina.

Country Status (14)

Country Link
US (3) US9493548B2 (pt)
EP (1) EP2152745B2 (pt)
JP (1) JP5064558B2 (pt)
KR (1) KR101226353B1 (pt)
CN (1) CN101679509A (pt)
AU (1) AU2008256411B2 (pt)
BR (1) BRPI0812288A2 (pt)
CA (1) CA2687837A1 (pt)
ES (1) ES2449148T5 (pt)
IL (1) IL201388A0 (pt)
MX (1) MX2009012786A (pt)
RU (1) RU2009148891A (pt)
TW (1) TWI395609B (pt)
WO (1) WO2008145351A1 (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0812288A2 (pt) 2007-06-01 2014-11-25 Hoffmann La Roche Purificação de imunoglobulina.
EP2281000A2 (en) * 2008-05-15 2011-02-09 Novo Nordisk A/S Antibody purification process
ES2488542T3 (es) * 2008-12-22 2014-08-27 F. Hoffmann-La Roche Ag Purificación de inmunoglobulinas
EP2513134B1 (en) 2009-12-18 2017-09-06 Novartis AG Wash solution and method for affinity chromatography
US20130178608A1 (en) * 2009-12-29 2013-07-11 Samir Kulkarni Protein purification by ion exchange
US9884904B2 (en) 2010-03-10 2018-02-06 Hoffmann-La Roche Inc. Method for purifying polypeptide solutions
RU2012146448A (ru) 2010-04-14 2014-05-20 Ф.Хоффманн-Ля Рош Аг Удаление агрегатов иммуноглобулинов
EP4492053A3 (en) 2010-05-25 2025-03-19 F. Hoffmann-La Roche AG Methods of purifying polypeptides
WO2011159074A2 (ko) * 2010-06-17 2011-12-22 Jeon Sook Yeong 치료용 면역글로불린 제제 제조장치 및 이를 이용한 제조방법
WO2012030512A1 (en) * 2010-09-03 2012-03-08 Percivia Llc. Flow-through protein purification process
CA2814781A1 (en) 2010-11-01 2012-05-10 Diderik Reinder Kremer Single unit ion exchange chromatography antibody purification
US8911992B2 (en) * 2011-04-28 2014-12-16 Bio-Rad Laboratories, Inc. DNA removal in target molecule purification
IL212911A0 (en) * 2011-05-16 2011-07-31 Omrix Biopharmaceuticals Ltd Immunoglobulin reduced in thrombogenic contaminants and preparation thereof
SG10201605397PA (en) * 2011-07-01 2016-08-30 Hoffmann La Roche Method For Separation Of Monomeric Polypeptides From Aggregated Polypeptides
US9096648B2 (en) 2011-08-19 2015-08-04 Emd Millipore Corporation Methods of reducing level of one or more impurities in a sample during protein purification
BR112014010406A2 (pt) 2011-11-02 2017-04-25 Genentech Inc cromatografia de sobrecarga e eluto
SG10201701224UA (en) * 2012-03-12 2017-04-27 Merck Patent Gmbh Removal of protein aggregates from biopharmaceutical preparations in a flowthrough mode
ES2381828B1 (es) * 2012-03-20 2012-11-16 Grifols, S.A. PROCEDIMIENTO PARA OBTENER UNA COMPOSICION DE IgG MEDIANTE TRATAMIENTO TERMICO
EP2682168A1 (en) 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
WO2015088677A1 (en) 2013-12-12 2015-06-18 Emd Millipore Corporation Protein separations using an acrylamide containing filter
KR102382402B1 (ko) * 2014-02-04 2022-04-01 바이오젠 엠에이 인코포레이티드 번역 후 변형을 강화시키기 위한 통류 방식 양이온 교환 크로마토그래피의 용도
CA2941232C (en) 2014-03-11 2020-08-25 Green Cross Holdings Corporation Method for purifying immunoglobulin
EP3119490B1 (en) 2014-03-21 2021-09-08 F. Hoffmann-La Roche AG In vitro prediction of in vivo half-life of antibodies
RS59340B1 (sr) 2014-11-06 2019-10-31 Hoffmann La Roche Varijante fc regiona sa modifikovanim vezivanjem za fcrn i metode upotrebe
JPWO2016093251A1 (ja) * 2014-12-08 2017-05-25 旭化成メディカル株式会社 生理活性物質の精製方法
JP2021519339A (ja) * 2018-04-03 2021-08-10 メルク パテント ゲーエムベーハー Ｃｅｘクロマトグラフィー媒体及び生物製剤供給原料からの標的タンパク質の低塩溶出
CN109336970A (zh) * 2018-11-09 2019-02-15 杭州奕安济世生物药业有限公司 阳离子交换层析法纯化抗体的方法
EP4006047A1 (en) 2019-07-31 2022-06-01 Kyowa Kirin Co., Ltd. Method for purifying antibody using adsorbent

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US4604208A (en) 1983-12-29 1986-08-05 Chaokang Chu Liquid filtration using an anionic microporous membrane
GB2201904B (en) 1987-02-14 1990-12-19 Domnick Hunter Filters Ltd Device for liquid chromatography or immobilised enzyme reaction
US5118796A (en) 1987-12-09 1992-06-02 Centocor, Incorporated Efficient large-scale purification of immunoglobulins and derivatives
US4889632A (en) 1987-12-10 1989-12-26 Ceskoslovenska Akademie Ved Macroporous polymeric membranes for the separation of polymers and a method of their application
WO1989006692A1 (en) 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
US4983722A (en) 1988-06-08 1991-01-08 Miles Inc. Removal of protein A from antibody preparations
DE59009020D1 (de) 1990-03-22 1995-06-08 Biotest Pharma Gmbh Verfahren zur Herstellung eines intravenös verträglichen Immunglobulin-G-Präparates.
WO1992015694A1 (en) 1991-03-08 1992-09-17 The Salk Institute For Biological Studies Flp-mediated gene modification in mammalian cells, and compositions and cells useful therefor
DE4118912C1 (pt) 1991-06-08 1992-07-02 Biotest Pharma Gmbh, 6072 Dreieich, De
CA2116246A1 (en) 1992-06-26 1994-01-06 Roland Beliard Human monoclonal anti-rhesus (d) antibodies and cell lines producing same
IT1271461B (it) 1993-12-01 1997-05-28 Menarini Ricerche Sud Spa Anticorpo monoclonale bispecifico anti-cd3/anti-egfr,processo per la produzione e suo uso.
JPH07155194A (ja) 1993-12-10 1995-06-20 Teijin Ltd タンパク質の精製法
US5429746A (en) 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
US5610285A (en) * 1994-08-24 1997-03-11 Bayer Corporation Purification of α-1 proteinase inhibitor using novel chromatographic separation conditions
CA2289665C (en) 1997-06-13 2005-08-09 Genentech, Inc. Protein recovery by chromatography followed by filtration upon a charged layer
PT1308456E (pt) * 1998-05-06 2007-12-03 Genentech Inc Purificação de anticorpos por cromatografia de permuta iónica
EP1500661A1 (en) 1998-06-01 2005-01-26 Genetech, Inc. Separation of protein monomers from aggregates by use of ion-exchange chromatography
US6962700B1 (en) 2000-09-13 2005-11-08 Atopix Pharmaceuticals Corporation Method of manufacturing immune globulin
AU2002213441B2 (en) * 2000-10-12 2006-10-26 Genentech, Inc. Reduced-viscosity concentrated protein formulations
WO2003040166A2 (en) 2001-11-02 2003-05-15 Millipore Corporation Membrane adsorber device
SI1543038T2 (sl) 2002-09-11 2020-12-31 Genentech, Inc. Čiščenje proteinov
AU2004215653B2 (en) 2003-02-28 2011-03-17 Lonza Biologics Plc. Antibody purification by protein A and ion exchange chromatography
GB0304576D0 (en) 2003-02-28 2003-04-02 Lonza Biologics Plc Protein a chromatography
EP1628749B1 (en) 2003-05-30 2019-07-31 VGXI, Inc. Devices and methods for biomaterial production
SE0400501D0 (sv) * 2004-02-27 2004-02-27 Amersham Biosciences Ab Antibody purification
US20080312425A1 (en) 2004-08-30 2008-12-18 Lonza Biologics Plc. Ion Exchange Chromatography and Purification of Antibodies
EP1693108A1 (en) 2004-12-04 2006-08-23 MERCK PATENT GmbH Mixed-modal anion-exchange type separation material
TW200902555A (en) 2005-01-03 2009-01-16 Hoffmann La Roche Antibodies against IL-13 receptor alpha 1 and uses thereof
CA2600601A1 (en) 2005-03-08 2006-09-14 Pharmacia & Upjohn Company Llc Anti-m-csf antibody compositions having reduced levels of endotoxin
TWI391399B (zh) 2005-05-25 2013-04-01 Hoffmann La Roche 測定溶離多肽之鹽濃度之方法
WO2007075283A2 (en) * 2005-12-06 2007-07-05 Amgen Inc. Polishing steps used in multi-step protein purification processes
BRPI0812288A2 (pt) * 2007-06-01 2014-11-25 Hoffmann La Roche Purificação de imunoglobulina.
US20100069617A1 (en) * 2008-09-12 2010-03-18 Ge Healthcare Bio-Sciences Ab Enhanced protein aggregate removal by mixed mode chromatography on hydrophobic interaction media in the presence of protein-excluded zwitterions
SG10201605397PA (en) 2011-07-01 2016-08-30 Hoffmann La Roche Method For Separation Of Monomeric Polypeptides From Aggregated Polypeptides

Also Published As

Publication number Publication date
US20170137497A1 (en) 2017-05-18
US11261238B2 (en) 2022-03-01
WO2008145351A1 (en) 2008-12-04
RU2009148891A (ru) 2011-07-20
MX2009012786A (es) 2009-12-10
ES2449148T5 (es) 2023-06-14
ES2449148T3 (es) 2014-03-18
KR20100028064A (ko) 2010-03-11
AU2008256411A1 (en) 2008-12-04
JP5064558B2 (ja) 2012-10-31
EP2152745A1 (en) 2010-02-17
EP2152745B1 (en) 2014-01-08
CA2687837A1 (en) 2008-12-04
US9493548B2 (en) 2016-11-15
TWI395609B (zh) 2013-05-11
CN101679509A (zh) 2010-03-24
EP2152745B2 (en) 2023-03-15
AU2008256411B2 (en) 2013-08-22
US20100311952A1 (en) 2010-12-09
KR101226353B1 (ko) 2013-01-24
TW200904503A (en) 2009-02-01
IL201388A0 (en) 2010-05-31
JP2010528076A (ja) 2010-08-19
US20200377574A1 (en) 2020-12-03
US10590186B2 (en) 2020-03-17

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2329 DE 25-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.