BRPI0812904A2 - COMPOSTOS ESPIROCICLOS, COMPOSIÇÃO COMPREENDENDO OS MESMOS, USOS DOS MESMOS, MÉTODOS DE INIBIÇÃO DA ATIVIDADE DE 11ßHSD1, DE INIBIÇÃO DA CONVERSÃO DE CORTISONA EM CORTISOL E DE INIBIÇÃO DA PRODUÇÃO DE CORTISOL EM UMA CÉLULA - Google Patents

COMPOSTOS ESPIROCICLOS, COMPOSIÇÃO COMPREENDENDO OS MESMOS, USOS DOS MESMOS, MÉTODOS DE INIBIÇÃO DA ATIVIDADE DE 11ßHSD1, DE INIBIÇÃO DA CONVERSÃO DE CORTISONA EM CORTISOL E DE INIBIÇÃO DA PRODUÇÃO DE CORTISOL EM UMA CÉLULA

Info

Publication number: BRPI0812904A2
Authority: BR; Brazil
Prior art keywords: cortisol; inhibition; same; spyrocycles; 11ßhsd1
Prior art date: 2007-06-21

Application number

BRPI0812904-5A2A

Other languages

English (en)

Portuguese (pt)

Inventor

Wenqing Yao

Jincong Zhuo

Colin Zhang

Original Assignee

Incyte Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-06-21

Filing date

2008-06-20

Publication date

2014-12-09

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39731144&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0812904(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-06-20 Application filed by Incyte Corp filed Critical Incyte Corp

2014-12-09 Publication of BRPI0812904A2 publication Critical patent/BRPI0812904A2/pt

Links

JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 title 6
229960000890 hydrocortisone Drugs 0.000 title 3
230000005764 inhibitory process Effects 0.000 title 2
238000006243 chemical reaction Methods 0.000 title 1
230000000694 effects Effects 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
238000000034 method Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Obesity (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Physical Education & Sports Medicine (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Psychiatry (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Child & Adolescent Psychology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Steroid Compounds (AREA)

BRPI0812904-5A2A 2007-06-21 2008-06-20 COMPOSTOS ESPIROCICLOS, COMPOSIÇÃO COMPREENDENDO OS MESMOS, USOS DOS MESMOS, MÉTODOS DE INIBIÇÃO DA ATIVIDADE DE 11ßHSD1, DE INIBIÇÃO DA CONVERSÃO DE CORTISONA EM CORTISOL E DE INIBIÇÃO DA PRODUÇÃO DE CORTISOL EM UMA CÉLULA BRPI0812904A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US94548707P	2007-06-21	2007-06-21
PCT/US2008/067637 WO2008157752A1 (en)	2007-06-21	2008-06-20	Spirocycles as inhibitors of 11-beta hydroxyl steroid dehydrogenase type 1

Publications (1)

Publication Number	Publication Date
BRPI0812904A2 true BRPI0812904A2 (pt)	2014-12-09

Family

ID=39731144

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0812904-5A2A BRPI0812904A2 (pt)	2007-06-21	2008-06-20	COMPOSTOS ESPIROCICLOS, COMPOSIÇÃO COMPREENDENDO OS MESMOS, USOS DOS MESMOS, MÉTODOS DE INIBIÇÃO DA ATIVIDADE DE 11ßHSD1, DE INIBIÇÃO DA CONVERSÃO DE CORTISONA EM CORTISOL E DE INIBIÇÃO DA PRODUÇÃO DE CORTISOL EM UMA CÉLULA

Country Status (30)

Country	Link
US (4)	US8278318B2 (es)
EP (3)	EP2918586A1 (es)
JP (2)	JP5364702B2 (es)
KR (1)	KR101554471B1 (es)
CN (1)	CN101815716B (es)
AR (1)	AR067090A1 (es)
AU (1)	AU2008265656B2 (es)
BR (1)	BRPI0812904A2 (es)
CA (1)	CA2691150C (es)
CL (1)	CL2008001839A1 (es)
CO (1)	CO6150151A2 (es)
CR (1)	CR11183A (es)
CY (2)	CY1113212T1 (es)
DK (2)	DK2173750T3 (es)
EA (1)	EA016017B1 (es)
EC (1)	ECSP109844A (es)
ES (2)	ES2531056T3 (es)
GE (1)	GEP20135754B (es)
HR (2)	HRP20120772T1 (es)
IL (1)	IL202842A (es)
MX (1)	MX2009014274A (es)
NZ (1)	NZ582524A (es)
PL (2)	PL2173750T3 (es)
PT (2)	PT2173750E (es)
RS (2)	RS52519B9 (es)
SI (2)	SI2540723T1 (es)
TW (1)	TWI428340B (es)
UA (1)	UA98651C2 (es)
WO (1)	WO2008157752A1 (es)
ZA (1)	ZA201000233B (es)

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Publication number	Publication date
EP2173750A1 (en)	2010-04-14
CY1113212T1 (el)	2016-04-13
TWI428340B (zh)	2014-03-01
US9006260B2 (en)	2015-04-14
DK2173750T3 (da)	2012-11-19
EP2540723A1 (en)	2013-01-02
AR067090A1 (es)	2009-09-30
CL2008001839A1 (es)	2009-01-16
CN101815716B (zh)	2012-12-26
SI2173750T1 (sl)	2012-11-30
US9371323B2 (en)	2016-06-21
RS52519B9 (sr)	2020-12-31
CY1116029T1 (el)	2017-01-25
EP2173750B1 (en)	2012-08-01
CN101815716A (zh)	2010-08-25
RS52519B (sr)	2013-04-30
EP2918586A1 (en)	2015-09-16
ZA201000233B (en)	2016-08-31
PL2173750T3 (pl)	2012-12-31
HK1180325A1 (en)	2013-10-18
CA2691150A1 (en)	2008-12-24
PT2173750E (pt)	2012-10-11
HK1143156A1 (en)	2010-12-24
JP5364702B2 (ja)	2013-12-11
AU2008265656A1 (en)	2008-12-24
MX2009014274A (es)	2010-03-25
US8278318B2 (en)	2012-10-02
ES2531056T3 (es)	2015-03-10
TW200909431A (en)	2009-03-01
US20160280708A1 (en)	2016-09-29
US9873698B2 (en)	2018-01-23
KR101554471B1 (ko)	2015-09-30
US20150210692A1 (en)	2015-07-30
EP2173750B9 (en)	2017-04-05
ES2390937T3 (es)	2012-11-19
WO2008157752A1 (en)	2008-12-24
JP5730956B2 (ja)	2015-06-10
CA2691150C (en)	2015-11-24
EP2540723B1 (en)	2014-11-26
UA98651C2 (ru)	2012-06-11
SI2540723T1 (sl)	2015-04-30
DK2540723T3 (en)	2015-01-19
ECSP109844A (es)	2010-02-26
CO6150151A2 (es)	2010-04-20
IL202842A (en)	2014-11-30
PL2540723T3 (pl)	2015-07-31
RS53839B1 (sr)	2015-06-30
GEP20135754B (en)	2013-02-25
IL202842A0 (en)	2010-06-30
EP2540723B8 (en)	2015-01-28
EA016017B1 (ru)	2012-01-30
JP2014015463A (ja)	2014-01-30
KR20100045440A (ko)	2010-05-03
PT2540723E (pt)	2015-03-06
HRP20150197T1 (en)	2015-03-27
HRP20120772T1 (hr)	2012-10-31
NZ582524A (en)	2012-05-25
US20130018068A1 (en)	2013-01-17
CR11183A (es)	2010-02-16
JP2010530893A (ja)	2010-09-16
EA201070039A1 (ru)	2010-06-30
US20080318991A1 (en)	2008-12-25
AU2008265656B2 (en)	2014-05-29

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2016-08-09	B25A	Requested transfer of rights approved	Owner name: INCYTE HOLDINGS CORPORATION (US)
2018-03-06	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2019-07-02	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]	Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI
2019-07-16	B06T	Formal requirements before examination [chapter 6.20 patent gazette]
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2020-09-24	B11T	Dismissal of application maintained [chapter 11.20 patent gazette]

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