BRPI0819273A2 - Produção de ácido dicarboxílico em eucariontes - Google Patents
Produção de ácido dicarboxílico em eucariontesInfo
- Publication number
- BRPI0819273A2 BRPI0819273A2 BRPI0819273-1A2A BRPI0819273A BRPI0819273A2 BR PI0819273 A2 BRPI0819273 A2 BR PI0819273A2 BR PI0819273 A BRPI0819273 A BR PI0819273A BR PI0819273 A2 BRPI0819273 A2 BR PI0819273A2
- Authority
- BR
- Brazil
- Prior art keywords
- eukariontes
- dicarboxylic acid
- acid production
- eukaryotic cell
- present
- Prior art date
Links
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 title 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 2
- 210000003527 eukaryotic cell Anatomy 0.000 abstract 2
- 239000001384 succinic acid Substances 0.000 abstract 2
- 241000233866 Fungi Species 0.000 abstract 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 102000019259 Succinate Dehydrogenase Human genes 0.000 abstract 1
- 108010012901 Succinate Dehydrogenase Proteins 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 239000001530 fumaric acid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fuel Cell (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07121113 | 2007-11-20 | ||
| EP07121117 | 2007-11-20 | ||
| EP07121113.0 | 2007-11-20 | ||
| EP07121117.1 | 2007-11-20 | ||
| EP07121120.5 | 2007-11-20 | ||
| EP07121120 | 2007-11-20 | ||
| EP08156961 | 2008-05-27 | ||
| EP08156960.0 | 2008-05-27 | ||
| EP08156960 | 2008-05-27 | ||
| EP08156959 | 2008-05-27 | ||
| PCT/EP2008/065588 WO2009065780A1 (en) | 2007-11-20 | 2008-11-14 | Dicarboxylic acid production in eukaryotes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0819273A2 true BRPI0819273A2 (pt) | 2014-10-14 |
| BRPI0819273B1 BRPI0819273B1 (pt) | 2022-05-17 |
| BRPI0819273B8 BRPI0819273B8 (pt) | 2022-07-19 |
Family
ID=40268299
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0819275A BRPI0819275B8 (pt) | 2007-11-20 | 2008-11-14 | Célula eucariótica recombinante produtora de ácido succínico e processo para a preparação de ácido succínico |
| BRPI0819273A BRPI0819273B8 (pt) | 2007-11-20 | 2008-11-14 | Célula microbiana eucariótica recombinante e processo para a preparação de um ácido dicarboxílico |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0819275A BRPI0819275B8 (pt) | 2007-11-20 | 2008-11-14 | Célula eucariótica recombinante produtora de ácido succínico e processo para a preparação de ácido succínico |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US9340804B2 (pt) |
| EP (3) | EP2220232B1 (pt) |
| JP (2) | JP5641938B2 (pt) |
| CN (3) | CN101903522B (pt) |
| AT (1) | ATE555203T1 (pt) |
| BR (2) | BRPI0819275B8 (pt) |
| CA (2) | CA2704654C (pt) |
| EA (1) | EA032726B1 (pt) |
| ES (2) | ES2383473T3 (pt) |
| WO (2) | WO2009065778A1 (pt) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2158323A4 (en) * | 2007-05-18 | 2011-06-22 | Microbia Prec Engineering Inc | PRODUCTION OF ORGANIC ACID BY PILZ CELLS |
| ATE555203T1 (de) * | 2007-11-20 | 2012-05-15 | Dsm Ip Assets Bv | Dicarbonsäureproduktion in eukaryonten |
| US20110104771A1 (en) * | 2008-02-15 | 2011-05-05 | Rene Verwall | Process for the production of a dicarboxylic acid |
| WO2010003728A1 (en) | 2008-07-08 | 2010-01-14 | Dsm Ip Assets B.V. | Dicarboxylic acid production by fermentation at low ph |
| RU2422526C2 (ru) * | 2009-01-30 | 2011-06-27 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов (ФГУП ГосНИИгенетика) | СПОСОБ ПОЛУЧЕНИЯ ЯНТАРНОЙ КИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ ДРОЖЖЕЙ, ПРИНАДЛЕЖАЩИХ К РОДУ Yarrowia |
| WO2010118932A1 (en) * | 2009-04-15 | 2010-10-21 | Dsm Ip Assets B.V. | Dicarboxylic acid production process |
| UA108853C2 (uk) | 2009-07-10 | 2015-06-25 | Спосіб ферментації галактози | |
| PL2470667T3 (pl) | 2009-08-27 | 2018-04-30 | Dsm Ip Assets B.V. | Sposób wytwarzania kwasu dikarboksylowego na drodze fermentacji |
| AU2010289725A1 (en) * | 2009-09-01 | 2012-04-05 | Novozymes, Inc. | Methods for improving malic acid production in filamentous fungi |
| US20120238722A1 (en) | 2009-11-24 | 2012-09-20 | Roquette Freres Sa | Process for the crystallization of succinic acid |
| JP2011120508A (ja) * | 2009-12-09 | 2011-06-23 | Oji Paper Co Ltd | コハク酸を製造する方法 |
| JP2013516180A (ja) | 2009-12-31 | 2013-05-13 | ミリアント・コーポレイション | コハク酸アンモニウムを含有する発酵ブロスからのコハク酸の精製 |
| CN102812127B (zh) | 2010-03-09 | 2014-12-03 | 三菱化学株式会社 | 琥珀酸的制造方法 |
| EP2371802A1 (en) | 2010-03-30 | 2011-10-05 | DSM IP Assets B.V. | Process for the crystallization of succinic acid |
| AR081827A1 (es) | 2010-04-21 | 2012-10-24 | Dsm Ip Assets Bv | Proceso para producir celulas capaces de convertir arabinosa |
| BR112012027464A2 (pt) | 2010-06-04 | 2019-09-24 | Novozymes Inc | célula hospedeira, método para produzir um ácido dicarboxílico c4, e, método para aumentar a produção de ácido dicarboxílico c4. |
| CN102947458B (zh) | 2010-06-21 | 2016-05-04 | 诺维信股份有限公司 | 用于丝状真菌中c4-二羧酸的改善的产生的方法 |
| WO2011163269A1 (en) | 2010-06-21 | 2011-12-29 | Novozymes, Inc. | Aspergillus aculeatus derived polypeptides having c4-dicarboxylic acid transporter activity and polynucleotides encoding same |
| WO2012031079A2 (en) * | 2010-09-01 | 2012-03-08 | University Of Florida Research Foundation, Inc. | L-malate production by metabolically engineered escherichia coli |
| WO2012038390A1 (en) | 2010-09-24 | 2012-03-29 | Dsm Ip Assets B.V. | Dicarboxylic acid production process |
| US8900834B2 (en) * | 2010-10-28 | 2014-12-02 | Total Research & Technology Feluy S.A. | Process for polylactic acid production using monascus |
| EP2495304A1 (en) | 2010-12-03 | 2012-09-05 | DSM IP Assets B.V. | Dicarboxylic acid production in a yeast cell |
| US9605285B2 (en) | 2011-01-25 | 2017-03-28 | Cargill, Incorporated | Compositions and methods for succinate production |
| WO2012118848A1 (en) | 2011-02-28 | 2012-09-07 | Novozymes, Inc. | Microorganism for c4-dicarboxylic acid production |
| ES2616790T3 (es) | 2011-07-01 | 2017-06-14 | Dsm Ip Assets B.V. | Proceso para producir ácidos dicarboxílicos empleando células fúngicas |
| BR112014003444A2 (pt) | 2011-08-19 | 2017-03-14 | Novozymes Inc | célula hospedeira recombinante, e, método para produzir um ácido c4-dicarboxílico |
| CN102559518B (zh) * | 2011-12-20 | 2013-10-16 | 江南大学 | 一种高产延胡索酸米根霉及其应用 |
| EP2807262A4 (en) * | 2012-01-25 | 2015-12-30 | Bioamber Internat S A R L | PROCESS FOR SUCCINATE MANUFACTURE |
| FR2987678B1 (fr) | 2012-03-02 | 2016-04-15 | Roquette Freres | Methode de mesure de la stabilite thermique d'un acide succinique cristallin destine a la fabrication de polymeres |
| FR2988733B1 (fr) | 2012-03-27 | 2016-02-05 | Carbios | Microorganisme recombinant |
| KR101464656B1 (ko) | 2012-06-15 | 2014-12-02 | 한국생명공학연구원 | 발효산물 고생성능을 가지는 변이 미생물 및 이를 이용한 발효산물의 제조방법 |
| US9850507B2 (en) | 2012-07-25 | 2017-12-26 | Cargill, Incorporated | Yeast cells having reductive TCA pathway from pyruvate to succinate and overexpressing an exogenous NAD(P)+ transhydrogenase enzyme |
| WO2014018755A1 (en) | 2012-07-25 | 2014-01-30 | Cargill Incorporated | Yeast cells having nadp(h)-dependent reductive tca pathway from pyruvate to succinate |
| US20150211024A1 (en) * | 2012-08-28 | 2015-07-30 | Braskem S.A. | Methods for production of a terpene and a co-product |
| JP2015528312A (ja) * | 2012-09-14 | 2015-09-28 | ミリアント・コーポレイションＭｙｒｉａｎｔ Ｃｏｒｐｏｒａｔｉｏｎ | 低ｐＨ条件下での発酵による有機酸の生産 |
| US9809833B2 (en) | 2012-09-20 | 2017-11-07 | Bioamber Inc. | Pathways to adipate semialdehyde and other organic products |
| US20160060385A1 (en) | 2013-03-08 | 2016-03-03 | Dsm Ip Assets B.V. | Polyester |
| CN118652942A (zh) * | 2013-07-18 | 2024-09-17 | 德希尼布能源法国公司 | 发酵方法 |
| ES2790573T3 (es) | 2013-12-12 | 2020-10-28 | Dsm Ip Assets Bv | Fumarato reductasas |
| WO2016002680A1 (ja) * | 2014-06-30 | 2016-01-07 | 旭硝子株式会社 | 形質転換体およびその製造方法、ならびに炭素数４のジカルボン酸の製造方法 |
| US9882151B2 (en) | 2014-11-14 | 2018-01-30 | Universal Display Corporation | Organic electroluminescent materials and devices |
| CA2969273C (en) | 2014-12-02 | 2023-05-09 | Roquette Freres | Process for manufacturing succinic acid from a fermentation broth using nano filtration to purify recycled mother liquor |
| EP3067378A1 (en) | 2015-03-11 | 2016-09-14 | DSM IP Assets B.V. | Polyester |
| CA2985231A1 (en) | 2015-06-04 | 2016-12-08 | Bioamber Inc. | Biobased production of functionalized alpha-substituted acrylates and c4-dicarboxylates |
| CA3008963A1 (en) * | 2015-12-23 | 2017-06-29 | Dsm Ip Assets B.V. | Host cells for dicarboxylic acid production |
| JP2017121184A (ja) * | 2016-01-04 | 2017-07-13 | 花王株式会社 | 変異リゾプス属菌 |
| CN109689864B (zh) * | 2016-07-13 | 2023-04-04 | 帝斯曼知识产权资产管理有限公司 | 苹果酸脱氢酶 |
| DE102016115425A1 (de) | 2016-08-19 | 2018-02-22 | Jacobs University Bremen Ggmbh | Gentechnisch veränderte Hefe zur Fermentation von Glycerol |
| EP3625284B1 (en) | 2017-05-18 | 2025-05-07 | Avantium Knowledge Centre B.V. | Polyester copolymer |
| EP3625283B1 (en) | 2017-05-18 | 2025-05-07 | Avantium Knowledge Centre B.V. | Polyester copolymer |
| US11608488B2 (en) * | 2017-07-11 | 2023-03-21 | Adisseo France S.A.S. | Enhanced metabolite-producing yeast |
| WO2019226972A1 (en) * | 2018-05-25 | 2019-11-28 | Danisco Us Inc | Overexpression of fumarate reductase results in an increased fermentation rate in yeast |
| KR102129379B1 (ko) * | 2018-10-10 | 2020-07-02 | 한국과학기술원 | 고활성의 말산 탈수소효소가 도입된 숙신산 생성용 변이 미생물 및 이를 이용한 숙신산 제조방법 |
| KR20210094600A (ko) | 2018-11-22 | 2021-07-29 | 아반티움 놀리지 센터 비.브이. | 하나 이상의 폴리에스터 공중합체의 제조방법, 하나 이상의 올리고머, 올리고머 조성물 및 폴리에스터 공중합체의 제조방법 |
| CN113249238B (zh) * | 2021-05-07 | 2022-08-23 | 江南大学 | 一株耐酸酿酒酵母及其在有机酸制备中的应用 |
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| EP2155885A4 (en) | 2007-05-18 | 2010-12-01 | Microbia Prec Engineering Inc | ACIDIC ACID PRODUCTION IN RECOMBINANT YEAST |
| ATE555203T1 (de) * | 2007-11-20 | 2012-05-15 | Dsm Ip Assets Bv | Dicarbonsäureproduktion in eukaryonten |
| EP2807262A4 (en) | 2012-01-25 | 2015-12-30 | Bioamber Internat S A R L | PROCESS FOR SUCCINATE MANUFACTURE |
| JP2015528312A (ja) | 2012-09-14 | 2015-09-28 | ミリアント・コーポレイションＭｙｒｉａｎｔ Ｃｏｒｐｏｒａｔｉｏｎ | 低ｐＨ条件下での発酵による有機酸の生産 |
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2008
- 2008-11-14 AT AT08851601T patent/ATE555203T1/de active
- 2008-11-14 CA CA2704654A patent/CA2704654C/en active Active
- 2008-11-14 EA EA201000837A patent/EA032726B1/ru not_active IP Right Cessation
- 2008-11-14 CA CA2875319A patent/CA2875319A1/en not_active Abandoned
- 2008-11-14 BR BRPI0819275A patent/BRPI0819275B8/pt active IP Right Grant
- 2008-11-14 EP EP08851178.7A patent/EP2220232B1/en active Active
- 2008-11-14 ES ES08851601T patent/ES2383473T3/es active Active
- 2008-11-14 CN CN200880117105.8A patent/CN101903522B/zh active Active
- 2008-11-14 CN CN200880117129.3A patent/CN101978063B/zh active Active
- 2008-11-14 WO PCT/EP2008/065583 patent/WO2009065778A1/en not_active Ceased
- 2008-11-14 BR BRPI0819273A patent/BRPI0819273B8/pt active IP Right Grant
- 2008-11-14 EP EP08851601A patent/EP2220233B1/en active Active
- 2008-11-14 US US12/743,927 patent/US9340804B2/en active Active
- 2008-11-14 JP JP2010533596A patent/JP5641938B2/ja active Active
- 2008-11-14 CN CN201510186003.3A patent/CN104818224A/zh active Pending
- 2008-11-14 EP EP13170415.7A patent/EP2687602A1/en not_active Withdrawn
- 2008-11-14 US US12/743,106 patent/US20120165569A1/en not_active Abandoned
- 2008-11-14 WO PCT/EP2008/065588 patent/WO2009065780A1/en not_active Ceased
- 2008-11-14 ES ES08851178.7T patent/ES2522622T3/es active Active
-
2013
- 2013-10-02 US US14/044,722 patent/US9689005B2/en active Active
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2014
- 2014-07-25 JP JP2014151882A patent/JP2014236739A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0819273B1 (pt) | 2022-05-17 |
| WO2009065778A1 (en) | 2009-05-28 |
| CA2704654A1 (en) | 2009-05-28 |
| EP2220232B1 (en) | 2014-09-03 |
| US9340804B2 (en) | 2016-05-17 |
| BRPI0819273B8 (pt) | 2022-07-19 |
| BRPI0819275B8 (pt) | 2022-07-19 |
| US20140031587A1 (en) | 2014-01-30 |
| EP2220233A1 (en) | 2010-08-25 |
| ES2383473T3 (es) | 2012-06-21 |
| ATE555203T1 (de) | 2012-05-15 |
| ES2522622T3 (es) | 2014-11-17 |
| BRPI0819275B1 (pt) | 2022-05-17 |
| EP2220232A1 (en) | 2010-08-25 |
| EP2687602A1 (en) | 2014-01-22 |
| CN101903522A (zh) | 2010-12-01 |
| US20110081694A1 (en) | 2011-04-07 |
| EP2220233B1 (en) | 2012-04-25 |
| CN101903522B (zh) | 2015-08-05 |
| WO2009065780A1 (en) | 2009-05-28 |
| CN101978063B (zh) | 2018-10-16 |
| CA2875319A1 (en) | 2009-05-28 |
| JP2011502524A (ja) | 2011-01-27 |
| CN104818224A (zh) | 2015-08-05 |
| JP5641938B2 (ja) | 2014-12-17 |
| JP2014236739A (ja) | 2014-12-18 |
| US20120165569A1 (en) | 2012-06-28 |
| CN101978063A (zh) | 2011-02-16 |
| US9689005B2 (en) | 2017-06-27 |
| BRPI0819275A2 (pt) | 2014-10-14 |
| EA201000837A1 (ru) | 2010-12-30 |
| EA032726B1 (ru) | 2019-07-31 |
| CA2704654C (en) | 2015-02-10 |
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