BRPI0819275B8 - Célula eucariótica recombinante produtora de ácido succínico e processo para a preparação de ácido succínico - Google Patents

Célula eucariótica recombinante produtora de ácido succínico e processo para a preparação de ácido succínico

Info

Publication number
BRPI0819275B8
BRPI0819275B8 BRPI0819275A BRPI0819275A BRPI0819275B8 BR PI0819275 B8 BRPI0819275 B8 BR PI0819275B8 BR PI0819275 A BRPI0819275 A BR PI0819275A BR PI0819275 A BRPI0819275 A BR PI0819275A BR PI0819275 B8 BRPI0819275 B8 BR PI0819275B8
Authority
BR
Brazil
Prior art keywords
succinic acid
eukaryotic cell
preparation
recombinant eukaryotic
cell producing
Prior art date
Application number
BRPI0819275A
Other languages
English (en)
Inventor
Verwaal René
Wu Liang
Antonius Damveld Robbertus
Maria Jacobus Sagt Cornelis
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of BRPI0819275A2 publication Critical patent/BRPI0819275A2/pt
Publication of BRPI0819275B1 publication Critical patent/BRPI0819275B1/pt
Publication of BRPI0819275B8 publication Critical patent/BRPI0819275B8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Fuel Cell (AREA)

Abstract

PRODUÇÃO DE ÁCIDO SUCCÍNICO EM UMA CÉLULA EUCARIÓTICA. A presente invenção relaciona-se a uma célula eucariótica recombinante selecionada de uma levedura de um fungo filamentoso compreendendo uma sequência de nucleotídeo codificando uma fumarato redutase dependente de NAD(H) que catalisa a conversão de ácido fumárico ao ácido succínico. A invenção ainda se relaciona a um processo para a produção de ácido succínico em que a célula eucariótica de acordo com a presente invenção é usada.
BRPI0819275A 2007-11-20 2008-11-14 Célula eucariótica recombinante produtora de ácido succínico e processo para a preparação de ácido succínico BRPI0819275B8 (pt)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
EP07121120 2007-11-20
EP07121113.0 2007-11-20
EP07121113 2007-11-20
EP07121117 2007-11-20
EP07121120.5 2007-11-20
EP07121117.1 2007-11-20
EP08156960 2008-05-27
EP08156961 2008-05-27
EP08156961.8 2008-05-27
EP08156959 2008-05-27
PCT/EP2008/065583 WO2009065778A1 (en) 2007-11-20 2008-11-14 Succinic acid production in a eukaryotic cell

Publications (3)

Publication Number Publication Date
BRPI0819275A2 BRPI0819275A2 (pt) 2014-10-14
BRPI0819275B1 BRPI0819275B1 (pt) 2022-05-17
BRPI0819275B8 true BRPI0819275B8 (pt) 2022-07-19

Family

ID=40268299

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0819273A BRPI0819273B8 (pt) 2007-11-20 2008-11-14 Célula microbiana eucariótica recombinante e processo para a preparação de um ácido dicarboxílico
BRPI0819275A BRPI0819275B8 (pt) 2007-11-20 2008-11-14 Célula eucariótica recombinante produtora de ácido succínico e processo para a preparação de ácido succínico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0819273A BRPI0819273B8 (pt) 2007-11-20 2008-11-14 Célula microbiana eucariótica recombinante e processo para a preparação de um ácido dicarboxílico

Country Status (10)

Country Link
US (3) US9340804B2 (pt)
EP (3) EP2687602A1 (pt)
JP (2) JP5641938B2 (pt)
CN (3) CN104818224A (pt)
AT (1) ATE555203T1 (pt)
BR (2) BRPI0819273B8 (pt)
CA (2) CA2704654C (pt)
EA (1) EA032726B1 (pt)
ES (2) ES2522622T3 (pt)
WO (2) WO2009065778A1 (pt)

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Also Published As

Publication number Publication date
BRPI0819275B1 (pt) 2022-05-17
CA2704654C (en) 2015-02-10
CN101978063A (zh) 2011-02-16
EP2220233A1 (en) 2010-08-25
ES2383473T3 (es) 2012-06-21
ES2522622T3 (es) 2014-11-17
US20140031587A1 (en) 2014-01-30
EA201000837A1 (ru) 2010-12-30
BRPI0819275A2 (pt) 2014-10-14
CA2875319A1 (en) 2009-05-28
US9340804B2 (en) 2016-05-17
EP2220233B1 (en) 2012-04-25
EA032726B1 (ru) 2019-07-31
CA2704654A1 (en) 2009-05-28
BRPI0819273B8 (pt) 2022-07-19
CN101903522A (zh) 2010-12-01
CN101978063B (zh) 2018-10-16
US9689005B2 (en) 2017-06-27
EP2220232B1 (en) 2014-09-03
JP2011502524A (ja) 2011-01-27
BRPI0819273A2 (pt) 2014-10-14
JP5641938B2 (ja) 2014-12-17
WO2009065778A1 (en) 2009-05-28
EP2220232A1 (en) 2010-08-25
BRPI0819273B1 (pt) 2022-05-17
US20120165569A1 (en) 2012-06-28
JP2014236739A (ja) 2014-12-18
WO2009065780A1 (en) 2009-05-28
US20110081694A1 (en) 2011-04-07
CN104818224A (zh) 2015-08-05
ATE555203T1 (de) 2012-05-15
CN101903522B (zh) 2015-08-05
EP2687602A1 (en) 2014-01-22

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