BRPI0820699A2 - derivados de espieoindolina - Google Patents

derivados de espieoindolina

Info

Publication number: BRPI0820699A2
Authority: BR; Brazil
Prior art keywords: spieindoline; derivatives; compounds; agents; enantiomers
Prior art date: 2007-12-19

Application number

BRPI0820699A

Other languages

English (en)

Inventor

Chen Li

Yang Song

Han Xingchun

He Yun

Zhang Zhuming

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-19

Filing date

2008-12-09

Publication date

2019-09-24

2008-12-09 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2019-09-24 Publication of BRPI0820699A2 publication Critical patent/BRPI0820699A2/pt

Links

150000001875 compounds Chemical class 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
230000001028 anti-proliverative effect Effects 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BRPI0820699A 2007-12-19 2008-12-09 derivados de espieoindolina BRPI0820699A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US1488807P	2007-12-19	2007-12-19
US10738108P	2008-10-22	2008-10-22
PCT/EP2008/067061 WO2009080488A1 (en)	2007-12-19	2008-12-09	Spiroindolinone derivatives as anticancer agents

Publications (1)

Publication Number	Publication Date
BRPI0820699A2 true BRPI0820699A2 (pt)	2019-09-24

Family

ID=40351961

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0820699A BRPI0820699A2 (pt)	2007-12-19	2008-12-09	derivados de espieoindolina

Country Status (16)

Country	Link
US (1)	US7776875B2 (pt)
EP (1)	EP2235017B1 (pt)
JP (1)	JP2011506524A (pt)
KR (1)	KR20100076075A (pt)
CN (1)	CN101903388A (pt)
AT (1)	ATE524470T1 (pt)
AU (1)	AU2008340473A1 (pt)
BR (1)	BRPI0820699A2 (pt)
CA (1)	CA2708312A1 (pt)
DK (1)	DK2235017T3 (pt)
ES (1)	ES2372903T3 (pt)
IL (1)	IL205506A0 (pt)
MX (1)	MX2010006332A (pt)
PL (1)	PL2235017T3 (pt)
PT (1)	PT2235017E (pt)
WO (1)	WO2009080488A1 (pt)

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US8217044B2 (en)	2010-04-28	2012-07-10	Hoffmann-La Roche Inc.	Spiroindolinone pyrrolidines
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AP2015008718A0 (en)	2013-03-15	2015-09-30	Global Blood Therapeutics Inc	Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en)	2013-03-15	2016-08-23	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en)	2013-03-15	2017-03-28	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en)	2013-03-15	2019-04-23	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
WO2014145040A1 (en) *	2013-03-15	2014-09-18	Global Blood Therapeutics, Inc.	Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US8952171B2 (en)	2013-03-15	2015-02-10	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en)	2013-03-15	2016-10-04	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
CN105358530A (zh)	2013-06-10	2016-02-24	美国安进公司	制备mdm2抑制剂的方法及其结晶形式
EA202092627A1 (ru)	2013-11-18	2021-09-30	Глобал Блад Терапьютикс, Инк.	Соединения и их применения для модуляции гемоглобина
ES2860648T5 (es)	2014-02-07	2024-11-27	Global Blood Therapeutics Inc	Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1H-pirazol-5-il)piridin-3-il)metoxi)benzaldehído
WO2016001376A1 (en)	2014-07-03	2016-01-07	Boehringer Ingelheim International Gmbh	New spiro[3h-indole-3,2´-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors
RS59111B1 (sr)	2014-08-21	2019-09-30	Boehringer Ingelheim Int	Nova jedinjenja spiro[3h-indol-3,2´-pirolidin]-2(1h)-ona i derivati kao mdm2-p53 inhibitori
CA2976752C (en)	2015-02-20	2019-12-17	Daiichi Sankyo Company, Limited	Method for treating cancer by combined use
MA41841A (fr)	2015-03-30	2018-02-06	Global Blood Therapeutics Inc	Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
JP6823587B2 (ja)	2015-04-13	2021-02-03	第一三共株式会社	Ｍｄｍ２阻害剤とｂｔｋ阻害剤との併用治療法
KR20240158360A (ko)	2015-10-09	2024-11-04	베링거 인겔하임 인터내셔날 게엠베하	Mdm2-p53 억제제로서의 스피로[3h-인돌-3,2'-피롤리딘]-2(1h)-온 화합물 및 유도체
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TWI825524B (zh)	2016-05-12	2023-12-11	美商全球血液治療公司	用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
CN118436801A (zh)	2016-05-20	2024-08-06	豪夫迈·罗氏有限公司	Protac抗体缀合物及其使用方法
TW202332423A (zh)	2016-10-12	2023-08-16	美商全球血液治療公司	包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
EP3527226A4 (en)	2016-10-17	2020-06-17	Daiichi Sankyo Company, Limited	COMBINATION THERAPY PROCEDURE WITH MDM2 INHIBITOR AND DNA METHYL TRANSFERASE INHIBITOR
EP3511334A1 (en) *	2018-01-16	2019-07-17	Adamed sp. z o.o.	1,2,3',5'-tetrahydro-2'h-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole]-2,3'-dione compounds as therapeutic agents activating tp53
EP3860975B1 (en)	2018-10-01	2023-10-18	Global Blood Therapeutics, Inc.	Modulators of hemoglobin for the treatment of sickle cell disease
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US12479816B2 (en)	2019-02-08	2025-11-25	University of Pittsburgh—of the Commonwealth System of Higher Education	20-HETE formation inhibitors
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WO2024240858A1 (en)	2023-05-23	2024-11-28	Valerio Therapeutics	Protac molecules directed against dna damage repair system and uses thereof
CN117069647B (zh) *	2023-07-27	2024-11-08	兰州大学	一种双官能团螺环催化剂及其合成方法和应用

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2008
- 2008-11-18 US US12/273,035 patent/US7776875B2/en not_active Expired - Fee Related
- 2008-12-09 BR BRPI0820699A patent/BRPI0820699A2/pt not_active IP Right Cessation
- 2008-12-09 MX MX2010006332A patent/MX2010006332A/es active IP Right Grant
- 2008-12-09 AU AU2008340473A patent/AU2008340473A1/en not_active Abandoned
- 2008-12-09 JP JP2010538565A patent/JP2011506524A/ja active Pending
- 2008-12-09 CN CN2008801217831A patent/CN101903388A/zh active Pending
- 2008-12-09 WO PCT/EP2008/067061 patent/WO2009080488A1/en not_active Ceased
- 2008-12-09 KR KR1020107013353A patent/KR20100076075A/ko not_active Abandoned
- 2008-12-09 ES ES08863724T patent/ES2372903T3/es active Active
- 2008-12-09 EP EP08863724A patent/EP2235017B1/en not_active Not-in-force
- 2008-12-09 DK DK08863724.4T patent/DK2235017T3/da active
- 2008-12-09 PL PL08863724T patent/PL2235017T3/pl unknown
- 2008-12-09 CA CA2708312A patent/CA2708312A1/en not_active Abandoned
- 2008-12-09 PT PT08863724T patent/PT2235017E/pt unknown
- 2008-12-09 AT AT08863724T patent/ATE524470T1/de active
2010
- 2010-05-03 IL IL205506A patent/IL205506A0/en unknown

Also Published As

Publication number	Publication date
CN101903388A (zh)	2010-12-01
ATE524470T1 (de)	2011-09-15
US7776875B2 (en)	2010-08-17
ES2372903T3 (es)	2012-01-27
PT2235017E (pt)	2011-10-13
JP2011506524A (ja)	2011-03-03
AU2008340473A1 (en)	2009-07-02
MX2010006332A (es)	2010-07-05
PL2235017T3 (pl)	2012-02-29
CA2708312A1 (en)	2009-07-02
DK2235017T3 (da)	2011-10-24
EP2235017A1 (en)	2010-10-06
US20090163512A1 (en)	2009-06-25
EP2235017B1 (en)	2011-09-14
WO2009080488A1 (en)	2009-07-02
IL205506A0 (en)	2010-12-30
KR20100076075A (ko)	2010-07-05

Legal Events

Date	Code	Title	Description
2019-10-01	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2020-01-21	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

Publication	Publication Date	Title
BRPI0820699A2 (pt)	2019-09-24	derivados de espieoindolina
BRPI0821255A2 (pt)	2015-06-16	Derivados de espiroindolinona
ATE495176T1 (de)	2011-01-15	Spiroindolinon-derivate
TW200801000A (en)	2008-01-01	Spiroindolinone derivatives
MY160424A (en)	2017-03-15	Substituted pyrrolidine-2-carboxyamides.
MX2011008176A (es)	2011-08-17	Derivados de 3,3'-espiroindolinona como agentes anticancerigenos.
MX2012009186A (es)	2012-08-23	Pirrolidina-2-carboxamidas sustituidas.
IN2012DN02487A (pt)	2015-08-28
MX2011007886A (es)	2011-08-15	Derivado de espiroindolinona piridina.
TW201129571A (en)	2011-09-01	Spiroindolinone pyrrolidines
BRPI0717266A2 (pt)	2014-12-09	Derivados de oxindol
MX2014014229A (es)	2015-02-17	Pirrolidina-2-carboxamidas sustituidas.
CR9980A (es)	2008-06-18	Imidazolinas 4,4,5,5 tetrasustituidas
ECSP12011625A (es)	2012-02-29	Derivados de imidazolidin-2-ona 1,3-disustituida como inhibidores de cyp17
WO2007084728A3 (en)	2008-01-17	2-imino-benzimidazoles
EP2581372A4 (en)	2013-12-04	CYANOCHINOLINDERIVATE
ATE528290T1 (de)	2011-10-15	Spiroindolinon-derivate
EP2578587A4 (en)	2013-12-04	PYRAZOLE DERIVATIVES
TNSN08369A1 (en)	2009-12-29	Benzimidazole derivatives
MX2014015345A (es)	2015-03-05	Inhibidores piranopiridona de tanquirasa.
ATE469647T1 (de)	2010-06-15	Thienoä3,2-cüpyridin-7-carbonsäure-derivate
EA200970692A1 (ru)	2010-02-26	Способы улучшения стабильности стероидных производных
UA103497C2 (en)	2013-10-25	Substituted pyrrolidine-2-carboxamides
CO6602120A2 (es)	2013-01-18	Pirrolidina-25-carboxamidas sustituidas
UA49889U (en)	2010-05-11	Derivatives of 3-aryl-2-(diarylhydroxymethyl)-4-oxo-3,4-dihydroquinasoline possess anticonvulsive activity