ATE524470T1 - Spiroindolinonderivate als antikrebsmittel - Google Patents

Spiroindolinonderivate als antikrebsmittel

Info

Publication number: ATE524470T1
Authority: AT; Austria
Prior art keywords: anticancer agents; spiroindolinone derivatives; spiroindolinone; derivatives; agents
Prior art date: 2007-12-19

Application number

AT08863724T

Other languages

English (en)

Inventor

Li Chen

Xingchun Han

Yun He

Song Yang

Zhuming Zhang

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-19

Filing date

2008-12-09

Publication date

2011-09-15

2008-12-09 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2011-09-15 Application granted granted Critical

2011-09-15 Publication of ATE524470T1 publication Critical patent/ATE524470T1/de

Links

239000002246 antineoplastic agent Substances 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
230000001028 anti-proliverative effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT08863724T 2007-12-19 2008-12-09 Spiroindolinonderivate als antikrebsmittel ATE524470T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US1488807P	2007-12-19	2007-12-19
US10738108P	2008-10-22	2008-10-22
PCT/EP2008/067061 WO2009080488A1 (en)	2007-12-19	2008-12-09	Spiroindolinone derivatives as anticancer agents

Publications (1)

Publication Number	Publication Date
ATE524470T1 true ATE524470T1 (de)	2011-09-15

Family

ID=40351961

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08863724T ATE524470T1 (de)	2007-12-19	2008-12-09	Spiroindolinonderivate als antikrebsmittel

Country Status (16)

Country	Link
US (1)	US7776875B2 (de)
EP (1)	EP2235017B1 (de)
JP (1)	JP2011506524A (de)
KR (1)	KR20100076075A (de)
CN (1)	CN101903388A (de)
AT (1)	ATE524470T1 (de)
AU (1)	AU2008340473A1 (de)
BR (1)	BRPI0820699A2 (de)
CA (1)	CA2708312A1 (de)
DK (1)	DK2235017T3 (de)
ES (1)	ES2372903T3 (de)
IL (1)	IL205506A0 (de)
MX (1)	MX2010006332A (de)
PL (1)	PL2235017T3 (de)
PT (1)	PT2235017E (de)
WO (1)	WO2009080488A1 (de)

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US8088815B2 (en)	2009-12-02	2012-01-03	Hoffman-La Roche Inc.	Spiroindolinone pyrrolidines
US8288431B2 (en)	2010-02-17	2012-10-16	Hoffmann-La Roche Inc.	Substituted spiroindolinones
US8217044B2 (en)	2010-04-28	2012-07-10	Hoffmann-La Roche Inc.	Spiroindolinone pyrrolidines
JO2998B1 (ar)	2010-06-04	2016-09-05	Amgen Inc	مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
JP2014500870A (ja)	2010-11-12	2014-01-16	ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、ミシガン	スピロ−オキシインドールｍｄｍ２アンタゴニスト
SG193002A1 (en) *	2011-03-10	2013-09-30	Daiichi Sankyo Co Ltd	Dispiropyrrolidine derivative
WO2012155066A2 (en)	2011-05-11	2012-11-15	Shaomeng Wang	Spiro-oxindole mdm2 antagonists
US9376425B2 (en)	2011-09-27	2016-06-28	Amgen, Inc.	Heterocyclic compounds as MDM2 inhibitors for the treatment of cancer
WO2013102142A1 (en)	2011-12-28	2013-07-04	Global Blood Therapeutics, Inc.	Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
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CN102838610B (zh) *	2012-08-28	2014-09-10	吕叶叶	双吲哚二氧杂双环辛二酮
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EP3919056B1 (de)	2013-03-15	2024-08-28	Global Blood Therapeutics, Inc.	Verbindungen und verwendungen davon zur modulation von hämoglobin
US9802900B2 (en)	2013-03-15	2017-10-31	Global Blood Therapeutics, Inc.	Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
AP2015008718A0 (en)	2013-03-15	2015-09-30	Global Blood Therapeutics Inc	Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en)	2013-03-15	2016-08-23	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en)	2013-03-15	2017-03-28	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en)	2013-03-15	2019-04-23	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
WO2014145040A1 (en) *	2013-03-15	2014-09-18	Global Blood Therapeutics, Inc.	Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US8952171B2 (en)	2013-03-15	2015-02-10	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en)	2013-03-15	2016-10-04	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
CN105358530A (zh)	2013-06-10	2016-02-24	美国安进公司	制备mdm2抑制剂的方法及其结晶形式
EA202092627A1 (ru)	2013-11-18	2021-09-30	Глобал Блад Терапьютикс, Инк.	Соединения и их применения для модуляции гемоглобина
ES2860648T5 (es)	2014-02-07	2024-11-27	Global Blood Therapeutics Inc	Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1H-pirazol-5-il)piridin-3-il)metoxi)benzaldehído
WO2016001376A1 (en)	2014-07-03	2016-01-07	Boehringer Ingelheim International Gmbh	New spiro[3h-indole-3,2´-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors
RS59111B1 (sr)	2014-08-21	2019-09-30	Boehringer Ingelheim Int	Nova jedinjenja spiro[3h-indol-3,2´-pirolidin]-2(1h)-ona i derivati kao mdm2-p53 inhibitori
CA2976752C (en)	2015-02-20	2019-12-17	Daiichi Sankyo Company, Limited	Method for treating cancer by combined use
MA41841A (fr)	2015-03-30	2018-02-06	Global Blood Therapeutics Inc	Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
JP6823587B2 (ja)	2015-04-13	2021-02-03	第一三共株式会社	Ｍｄｍ２阻害剤とｂｔｋ阻害剤との併用治療法
KR20240158360A (ko)	2015-10-09	2024-11-04	베링거 인겔하임 인터내셔날 게엠베하	Mdm2-p53 억제제로서의 스피로[3h-인돌-3,2'-피롤리딘]-2(1h)-온 화합물 및 유도체
US11020382B2 (en)	2015-12-04	2021-06-01	Global Blood Therapeutics, Inc.	Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
TWI825524B (zh)	2016-05-12	2023-12-11	美商全球血液治療公司	用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
CN118436801A (zh)	2016-05-20	2024-08-06	豪夫迈·罗氏有限公司	Protac抗体缀合物及其使用方法
TW202332423A (zh)	2016-10-12	2023-08-16	美商全球血液治療公司	包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
EP3527226A4 (de)	2016-10-17	2020-06-17	Daiichi Sankyo Company, Limited	Kombinationstherapieverfahren mit mdm2-inhibitor und dna-methyltransferase-inhibitor
EP3511334A1 (de) *	2018-01-16	2019-07-17	Adamed sp. z o.o.	1,2,3',5'-tetrahydro-2'h-spiro[indol-3,1'-pyrrolo[3,4-c]pyrrol] -2,3'-dion-verbindungen als therapeutische mittel, die tp53 aktivieren
EP3860975B1 (de)	2018-10-01	2023-10-18	Global Blood Therapeutics, Inc.	Modulatoren von hämoglobin zur behandlung von sichelzellenanämie
US20220033407A1 (en) *	2018-12-18	2022-02-03	Novartis Ag	N-(pyridin-2-ylsulfonyl)cyclopropanecarboxamide Derivatives and their Use in the Treatment of Disease
US12479816B2 (en)	2019-02-08	2025-11-25	University of Pittsburgh—of the Commonwealth System of Higher Education	20-HETE formation inhibitors
WO2023056069A1 (en)	2021-09-30	2023-04-06	Angiex, Inc.	Degrader-antibody conjugates and methods of using same
WO2024240858A1 (en)	2023-05-23	2024-11-28	Valerio Therapeutics	Protac molecules directed against dna damage repair system and uses thereof
CN117069647B (zh) *	2023-07-27	2024-11-08	兰州大学	一种双官能团螺环催化剂及其合成方法和应用

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2008
- 2008-11-18 US US12/273,035 patent/US7776875B2/en not_active Expired - Fee Related
- 2008-12-09 BR BRPI0820699A patent/BRPI0820699A2/pt not_active IP Right Cessation
- 2008-12-09 MX MX2010006332A patent/MX2010006332A/es active IP Right Grant
- 2008-12-09 AU AU2008340473A patent/AU2008340473A1/en not_active Abandoned
- 2008-12-09 JP JP2010538565A patent/JP2011506524A/ja active Pending
- 2008-12-09 CN CN2008801217831A patent/CN101903388A/zh active Pending
- 2008-12-09 WO PCT/EP2008/067061 patent/WO2009080488A1/en not_active Ceased
- 2008-12-09 KR KR1020107013353A patent/KR20100076075A/ko not_active Abandoned
- 2008-12-09 ES ES08863724T patent/ES2372903T3/es active Active
- 2008-12-09 EP EP08863724A patent/EP2235017B1/de not_active Not-in-force
- 2008-12-09 DK DK08863724.4T patent/DK2235017T3/da active
- 2008-12-09 PL PL08863724T patent/PL2235017T3/pl unknown
- 2008-12-09 CA CA2708312A patent/CA2708312A1/en not_active Abandoned
- 2008-12-09 PT PT08863724T patent/PT2235017E/pt unknown
- 2008-12-09 AT AT08863724T patent/ATE524470T1/de active
2010
- 2010-05-03 IL IL205506A patent/IL205506A0/en unknown

Also Published As

Publication number	Publication date
CN101903388A (zh)	2010-12-01
BRPI0820699A2 (pt)	2019-09-24
US7776875B2 (en)	2010-08-17
ES2372903T3 (es)	2012-01-27
PT2235017E (pt)	2011-10-13
JP2011506524A (ja)	2011-03-03
AU2008340473A1 (en)	2009-07-02
MX2010006332A (es)	2010-07-05
PL2235017T3 (pl)	2012-02-29
CA2708312A1 (en)	2009-07-02
DK2235017T3 (da)	2011-10-24
EP2235017A1 (de)	2010-10-06
US20090163512A1 (en)	2009-06-25
EP2235017B1 (de)	2011-09-14
WO2009080488A1 (en)	2009-07-02
IL205506A0 (en)	2010-12-30
KR20100076075A (ko)	2010-07-05

Legal Events

Date

Code

Title

Description

2012-04-15

UEP

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Publication	Publication Date	Title
ATE524470T1 (de)	2011-09-15	Spiroindolinonderivate als antikrebsmittel
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