PL2235017T3 - Pochodne spiroindolinonu jako środki przeciwnowotworowe - Google Patents

Pochodne spiroindolinonu jako środki przeciwnowotworowe

Info

Publication number: PL2235017T3
Authority: PL; Poland
Prior art keywords: anticancer agents; spiroindolinone derivatives; spiroindolinone; derivatives; agents
Prior art date: 2007-12-19

Application number

PL08863724T

Other languages

English (en)

Inventor

Li Chen

Xingchun Han

Yun He

Song Yang

Zhuming Zhang

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-19

Filing date

2008-12-09

Publication date

2012-02-29

2008-12-09 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2012-02-29 Publication of PL2235017T3 publication Critical patent/PL2235017T3/pl

Links

239000002246 antineoplastic agent Substances 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
230000001028 anti-proliverative effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PL08863724T 2007-12-19 2008-12-09 Pochodne spiroindolinonu jako środki przeciwnowotworowe PL2235017T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US1488807P	2007-12-19	2007-12-19
US10738108P	2008-10-22	2008-10-22
PCT/EP2008/067061 WO2009080488A1 (en)	2007-12-19	2008-12-09	Spiroindolinone derivatives as anticancer agents
EP08863724A EP2235017B1 (en)	2007-12-19	2008-12-09	Spiroindolinone derivatives as anticancer agents

Publications (1)

Publication Number	Publication Date
PL2235017T3 true PL2235017T3 (pl)	2012-02-29

Family

ID=40351961

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL08863724T PL2235017T3 (pl)	2007-12-19	2008-12-09	Pochodne spiroindolinonu jako środki przeciwnowotworowe

Country Status (16)

Country	Link
US (1)	US7776875B2 (pl)
EP (1)	EP2235017B1 (pl)
JP (1)	JP2011506524A (pl)
KR (1)	KR20100076075A (pl)
CN (1)	CN101903388A (pl)
AT (1)	ATE524470T1 (pl)
AU (1)	AU2008340473A1 (pl)
BR (1)	BRPI0820699A2 (pl)
CA (1)	CA2708312A1 (pl)
DK (1)	DK2235017T3 (pl)
ES (1)	ES2372903T3 (pl)
IL (1)	IL205506A0 (pl)
MX (1)	MX2010006332A (pl)
PL (1)	PL2235017T3 (pl)
PT (1)	PT2235017E (pl)
WO (1)	WO2009080488A1 (pl)

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US9422279B2 (en)	2013-03-15	2016-08-23	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en)	2013-03-15	2017-03-28	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en)	2013-03-15	2019-04-23	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
WO2014145040A1 (en) *	2013-03-15	2014-09-18	Global Blood Therapeutics, Inc.	Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US8952171B2 (en)	2013-03-15	2015-02-10	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en)	2013-03-15	2016-10-04	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
CN105358530A (zh)	2013-06-10	2016-02-24	美国安进公司	制备mdm2抑制剂的方法及其结晶形式
EA202092627A1 (ru)	2013-11-18	2021-09-30	Глобал Блад Терапьютикс, Инк.	Соединения и их применения для модуляции гемоглобина
ES2860648T5 (es)	2014-02-07	2024-11-27	Global Blood Therapeutics Inc	Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1H-pirazol-5-il)piridin-3-il)metoxi)benzaldehído
WO2016001376A1 (en)	2014-07-03	2016-01-07	Boehringer Ingelheim International Gmbh	New spiro[3h-indole-3,2´-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors
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JP6823587B2 (ja)	2015-04-13	2021-02-03	第一三共株式会社	Ｍｄｍ２阻害剤とｂｔｋ阻害剤との併用治療法
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TWI825524B (zh)	2016-05-12	2023-12-11	美商全球血液治療公司	用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
CN118436801A (zh)	2016-05-20	2024-08-06	豪夫迈·罗氏有限公司	Protac抗体缀合物及其使用方法
TW202332423A (zh)	2016-10-12	2023-08-16	美商全球血液治療公司	包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
EP3527226A4 (en)	2016-10-17	2020-06-17	Daiichi Sankyo Company, Limited	COMBINATION THERAPY PROCEDURE WITH MDM2 INHIBITOR AND DNA METHYL TRANSFERASE INHIBITOR
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2008
- 2008-11-18 US US12/273,035 patent/US7776875B2/en not_active Expired - Fee Related
- 2008-12-09 BR BRPI0820699A patent/BRPI0820699A2/pt not_active IP Right Cessation
- 2008-12-09 MX MX2010006332A patent/MX2010006332A/es active IP Right Grant
- 2008-12-09 AU AU2008340473A patent/AU2008340473A1/en not_active Abandoned
- 2008-12-09 JP JP2010538565A patent/JP2011506524A/ja active Pending
- 2008-12-09 CN CN2008801217831A patent/CN101903388A/zh active Pending
- 2008-12-09 WO PCT/EP2008/067061 patent/WO2009080488A1/en not_active Ceased
- 2008-12-09 KR KR1020107013353A patent/KR20100076075A/ko not_active Abandoned
- 2008-12-09 ES ES08863724T patent/ES2372903T3/es active Active
- 2008-12-09 EP EP08863724A patent/EP2235017B1/en not_active Not-in-force
- 2008-12-09 DK DK08863724.4T patent/DK2235017T3/da active
- 2008-12-09 PL PL08863724T patent/PL2235017T3/pl unknown
- 2008-12-09 CA CA2708312A patent/CA2708312A1/en not_active Abandoned
- 2008-12-09 PT PT08863724T patent/PT2235017E/pt unknown
- 2008-12-09 AT AT08863724T patent/ATE524470T1/de active
2010
- 2010-05-03 IL IL205506A patent/IL205506A0/en unknown

Also Published As

Publication number	Publication date
CN101903388A (zh)	2010-12-01
BRPI0820699A2 (pt)	2019-09-24
ATE524470T1 (de)	2011-09-15
US7776875B2 (en)	2010-08-17
ES2372903T3 (es)	2012-01-27
PT2235017E (pt)	2011-10-13
JP2011506524A (ja)	2011-03-03
AU2008340473A1 (en)	2009-07-02
MX2010006332A (es)	2010-07-05
CA2708312A1 (en)	2009-07-02
DK2235017T3 (da)	2011-10-24
EP2235017A1 (en)	2010-10-06
US20090163512A1 (en)	2009-06-25
EP2235017B1 (en)	2011-09-14
WO2009080488A1 (en)	2009-07-02
IL205506A0 (en)	2010-12-30
KR20100076075A (ko)	2010-07-05

Publication	Publication Date	Title
IL205506A0 (en)	2010-12-30	Spiroindolinone derivatives as anticancer agents
IL205354A0 (en)	2010-12-30	Spiroindolinone derivatives
IL193620A0 (en)	2009-05-04	Spiroindolinone derivatives
TW200801000A (en)	2008-01-01	Spiroindolinone derivatives
MX2011008176A (es)	2011-08-17	Derivados de 3,3'-espiroindolinona como agentes anticancerigenos.
MY160424A (en)	2017-03-15	Substituted pyrrolidine-2-carboxyamides.
MX2012009186A (es)	2012-08-23	Pirrolidina-2-carboxamidas sustituidas.
MX2011007886A (es)	2011-08-15	Derivado de espiroindolinona piridina.
IN2012DN02487A (pl)	2015-08-28
TW201129571A (en)	2011-09-01	Spiroindolinone pyrrolidines
MX2013003019A (es)	2013-05-28	Compuestos de azabenzotiazol, composiciones y metodos de uso.
MX2014014229A (es)	2015-02-17	Pirrolidina-2-carboxamidas sustituidas.
WO2009057079A3 (en)	2009-12-03	Novel pyrimidine derivatives
MY156319A (en)	2016-02-15	Spiroheterocyclic n-oxypiperidines as pesticides
TW200612958A (en)	2006-05-01	Substituted imidazole derivatives
IL197197A0 (en)	2009-12-24	Oxindole derivatives as anticancer agents
WO2007084728A3 (en)	2008-01-17	2-imino-benzimidazoles
IL208025A0 (en)	2010-12-30	Spiroindolinone derivatives
TNSN08369A1 (en)	2009-12-29	Benzimidazole derivatives
MX2014015345A (es)	2015-03-05	Inhibidores piranopiridona de tanquirasa.
GB201305247D0 (en)	2013-05-01	Amide Compounds
MY152557A (en)	2014-10-31	3-aminocyclopentanecarboxamides as chemokine receptor modulators
ATE469647T1 (de)	2010-06-15	Thienoä3,2-cüpyridin-7-carbonsäure-derivate
EA200970692A1 (ru)	2010-02-26	Способы улучшения стабильности стероидных производных
PL2038288T3 (pl)	2011-05-31	Nowe pochodne kwasu 4-amino-3-(-azolilofenoksymetylo)tieno[3,2-c]pirydyno-7-karboksylowego