BRPI0823154A2 - Análogos de insulina com uma porção acila e alquileno glicol - Google Patents

Análogos de insulina com uma porção acila e alquileno glicol

Info

Publication number: BRPI0823154A2
Authority: BR; Brazil
Prior art keywords: alkylene glycol; acyl moiety; insulin analogs; insulin; analogs
Prior art date: 2007-08-15

Application number

BRPI0823154-0A

Other languages

English (en)

Inventor

Peter Madsen

Thomas Borglum Kjeldsen

Thomas Hoeg-Jensen

Tina Moller Tagmose

Palle Jakobsen

Janos Tibor Kodra

Patrick William Garibay

Dorte Xenia Gram

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-08-15

Filing date

2008-08-18

Publication date

2015-07-07

2008-08-18 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2015-07-07 Publication of BRPI0823154A2 publication Critical patent/BRPI0823154A2/pt

Links

125000002252 acyl group Chemical group 0.000 title 1
-1 alkylene glycol Chemical compound 0.000 title 1
LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 title 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Endocrinology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

BRPI0823154-0A 2007-08-15 2008-08-18 Análogos de insulina com uma porção acila e alquileno glicol BRPI0823154A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP07114386		2007-08-15
PCT/EP2008/060768 WO2009022013A1 (en)	2007-08-15	2008-08-15	Insulin analogues with an acyl and aklylene glycol moiety

Publications (1)

Publication Number	Publication Date
BRPI0823154A2 true BRPI0823154A2 (pt)	2015-07-07

Family

ID=38754600

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0823154-0A BRPI0823154A2 (pt)	2007-08-15	2008-08-18	Análogos de insulina com uma porção acila e alquileno glicol

Country Status (13)

Country	Link
US (1)	US9150633B2 (pt)
EP (2)	EP2708554A1 (pt)
JP (1)	JP5730569B2 (pt)
KR (1)	KR20100053561A (pt)
CN (1)	CN101784562B (pt)
AU (1)	AU2008288413B2 (pt)
BR (1)	BRPI0823154A2 (pt)
CA (1)	CA2695970A1 (pt)
ES (1)	ES2548304T3 (pt)
MX (1)	MX2010001645A (pt)
RU (1)	RU2514430C2 (pt)
WO (2)	WO2009022013A1 (pt)
ZA (1)	ZA201001416B (pt)

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EP2708554A1 (en)	2007-08-15	2014-03-19	Novo Nordisk A/S	Insulin analogues with an acyl and alkylene glycol moiety
AU2012216723B2 (en) *	2007-11-20	2014-08-28	Ambrx, Inc.	Modified insulin polypeptides and their uses
WO2009112583A2 (en)	2008-03-14	2009-09-17	Novo Nordisk A/S	Protease-stabilized insulin analogues
AU2013205275B2 (en) *	2008-03-18	2015-09-03	Novo Nordisk A/S	Protease stabilized, acylated insulin analogues
PT2910570T (pt) *	2008-03-18	2017-01-24	Novo Nordisk As	Análogos de insulina acilados, estabilizados contra proteases
ES2552401T3 (es)	2009-11-02	2015-11-27	Novo Nordisk A/S	Solución farmacéutica de albúmina unida no covalentemente e insulina acilada
AU2011206629B2 (en) *	2010-01-12	2014-07-17	Novo Nordisk A/S	Pharmaceutical compositions for oral administration of insulin peptides
CN102985440B (zh) *	2010-06-23	2016-10-26	诺沃-诺迪斯克有限公司	包含额外的二硫键的胰岛素衍生物
JP2013540771A (ja) *	2010-10-15	2013-11-07	ノヴォノルディスクアー／エス	新規ｎ末端修飾インスリン誘導体
JP6058646B2 (ja)	2011-06-15	2017-01-11	ノヴォノルディスクアー／エス	多置換インスリン
CA2870313A1 (en)	2012-04-11	2013-10-17	Novo Nordisk A/S	Insulin formulations
CN105636979B (zh)	2013-10-07	2020-01-10	诺和诺德股份有限公司	胰岛素类似物的新衍生物
FR3013049B1 (fr) *	2013-11-14	2015-11-13	You-Ping Chan	Analogue de l'insuline glargine
GB201321489D0 (en)	2013-12-05	2014-01-22	Chemical & Biopharmaceutical Lab Of Patras S A	Biologically active insulin derivatives
AU2015206890B2 (en)	2014-01-20	2019-05-23	Hanmi Pharm. Co., Ltd.	Long-acting insulin and use thereof
AR099569A1 (es) *	2014-02-28	2016-08-03	Novo Nordisk As	Derivados de insulina y los usos médicos de estos
US10640546B2 (en)	2014-06-10	2020-05-05	California Institute Of Technology	Non-canonical insulins and their uses
ES2908373T3 (es) *	2015-08-25	2022-04-28	Novo Nordisk As	Nuevos derivados de insulina y los usos médicos de los mismos
UY36870A (es)	2015-08-28	2017-03-31	Hanmi Pharm Ind Co Ltd	Análogos de insulina novedosos
RU2764197C1 (ru)	2016-09-23	2022-01-14	Ханми Фарм. Ко., Лтд.	Аналоги инсулина с пониженной аффинностью к рецептору инсулина и их применение
KR20190101963A (ko) *	2016-11-21	2019-09-02	케이스 웨스턴 리저브 유니버시티	안정성을 강화한 속효성 인슐린 유사체
DK3554534T3 (da)	2016-12-16	2021-08-23	Novo Nordisk As	Farmaceutisk sammensætning omfattende insulin
KR102629006B1 (ko)	2017-03-23	2024-01-25	한미약품 주식회사	인슐린 수용체와의 결합력이 감소된 인슐린 아날로그의 결합체 및 이의 용도
JOP20190273A1 (ar) *	2017-05-26	2019-11-24	Lilly Co Eli	مركب إنسولين معالج بأسيل
SG11202001077UA (en)	2017-08-17	2020-03-30	Novo Nordisk As	Novel acylated insulin analogues and uses thereof
US11098102B2 (en)	2018-12-11	2021-08-24	Sanofi	Insulin conjugates
CN110041219B (zh) *	2019-05-09	2020-09-25	南京工业大学	一种索马鲁肽侧链的液相合成方法
IL319162A (en)	2019-12-11	2025-04-01	Novo Nordisk As	New insulin analogs and their use
CN118598978A (zh) *	2019-12-30	2024-09-06	甘李药业股份有限公司	胰岛素衍生物
AU2020418207A1 (en) *	2019-12-30	2022-08-25	Gan & Lee Pharmaceuticals Co., Ltd.	Long-acting GLP-1 compound
CN114075273A (zh) *	2020-08-17	2022-02-22	四川科伦药物研究院有限公司	一种glp-1类似物片段活化酯的制备方法
CN115385843A (zh) *	2021-05-24	2022-11-25	广东东阳光药业有限公司	一种新型的酰化胰岛素类似物
US20250340610A1 (en) *	2022-01-28	2025-11-06	Gan & Lee Pharmaceuticals Co., Ltd.	Acylated insulin
CN115894719B (zh) *	2022-11-24	2023-10-20	武汉禾元生物科技股份有限公司	一种人血清白蛋白胰岛素偶联物及其制备方法
IL323039A (en)	2023-03-06	2025-10-01	Ascendis Pharma As	Drug compounds containing albumin-binding moieties
WO2026013136A1 (en)	2024-07-10	2026-01-15	Ascendis Pharma A/S	Albumin-binding compounds
WO2026013135A1 (en)	2024-07-10	2026-01-15	Ascendis Pharma A/S	Albumin-binding reagents

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DK58285D0 (da)	1984-05-30	1985-02-08	Novo Industri As	Peptider samt fremstilling og anvendelse deraf
PH25772A (en)	1985-08-30	1991-10-18	Novo Industri As	Insulin analogues, process for their preparation
NZ222907A (en)	1986-12-16	1990-08-28	Novo Industri As	Preparation for intranasal administration containing a phospholipid absorption enhancing system
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AR020047A1 (es) *	1997-10-24	2002-04-10	Lilly Co Eli	Composiciones insolubles de insulina, formulaciones en suspension que incluyen dicha composicion insoluble de insulina; y el uso de dicha composicionpara preparar medicamentos y procedimiento para preparar dichas composiciones insolubles.
BR0016867A (pt)	1999-12-29	2002-10-08	Novo Nordisk As	Precursor de análogo de insulina, sequência de polinucleotìdeo, vetor de expressão, célula hospedeira, e, processos para fabricar um precursor de análogo de insulina e para fabricar um análogo de insulina
SK2432004A3 (sk) *	2001-12-20	2005-04-01	Eli Lilly And Company	Inzulínová zlúčenina s protrahovaným účinkom
DE60328112D1 (de) *	2002-09-25	2009-08-06	Novo Nordisk As	Verfahren zur herstellung acylierter peptide
JP4463814B2 (ja)	2003-08-05	2010-05-19	ノボノルディスクアクティーゼルスカブ	新規のインスリン誘導体
JP5697831B2 (ja) *	2003-12-03	2015-04-08	ノヴォノルディスクアー／エス	単鎖インシュリン
ES2435522T3 (es)	2005-02-02	2013-12-20	Novo Nordisk A/S	Derivados de insulina
US8067362B2 (en) *	2005-02-02	2011-11-29	Novo Nordisk As	Insulin derivatives
US20100216690A1 (en)	2005-03-18	2010-08-26	Novo Nordisk A/S	Pegylated Single-Chain Insulin
ATE482977T1 (de)	2006-02-27	2010-10-15	Novo Nordisk As	Insulinderivate
CN101573133B (zh)	2006-07-31	2014-08-27	诺沃-诺迪斯克有限公司	Peg化延长的胰岛素
EP2708554A1 (en)	2007-08-15	2014-03-19	Novo Nordisk A/S	Insulin analogues with an acyl and alkylene glycol moiety

2008
- 2008-08-15 EP EP13180261.3A patent/EP2708554A1/en not_active Withdrawn
- 2008-08-15 WO PCT/EP2008/060768 patent/WO2009022013A1/en not_active Ceased
- 2008-08-15 WO PCT/EP2008/060733 patent/WO2009022005A1/en not_active Ceased
- 2008-08-15 US US12/673,516 patent/US9150633B2/en not_active Expired - Fee Related
- 2008-08-15 ES ES08803059.8T patent/ES2548304T3/es active Active
- 2008-08-15 CA CA2695970A patent/CA2695970A1/en not_active Abandoned
- 2008-08-15 RU RU2010107788/04A patent/RU2514430C2/ru not_active IP Right Cessation
- 2008-08-15 AU AU2008288413A patent/AU2008288413B2/en not_active Ceased
- 2008-08-15 KR KR1020107003525A patent/KR20100053561A/ko not_active Withdrawn
- 2008-08-15 MX MX2010001645A patent/MX2010001645A/es active IP Right Grant
- 2008-08-15 JP JP2010520597A patent/JP5730569B2/ja not_active Expired - Fee Related
- 2008-08-15 CN CN200880102999.3A patent/CN101784562B/zh not_active Expired - Fee Related
- 2008-08-15 EP EP08803059.8A patent/EP2178912B1/en not_active Not-in-force
- 2008-08-18 BR BRPI0823154-0A patent/BRPI0823154A2/pt not_active IP Right Cessation
2010
- 2010-02-26 ZA ZA2010/01416A patent/ZA201001416B/en unknown

Also Published As

Publication number	Publication date
US20110098440A1 (en)	2011-04-28
MX2010001645A (es)	2010-03-10
WO2009022005A1 (en)	2009-02-19
ES2548304T3 (es)	2015-10-15
EP2178912B1 (en)	2015-07-08
RU2514430C2 (ru)	2014-04-27
EP2178912A1 (en)	2010-04-28
AU2008288413A1 (en)	2009-02-19
US9150633B2 (en)	2015-10-06
KR20100053561A (ko)	2010-05-20
CA2695970A1 (en)	2009-02-19
ZA201001416B (en)	2011-06-29
JP2010535851A (ja)	2010-11-25
RU2010107788A (ru)	2011-09-20
JP5730569B2 (ja)	2015-06-10
WO2009022013A1 (en)	2009-02-19
CN101784562A (zh)	2010-07-21
EP2708554A1 (en)	2014-03-19
AU2008288413B2 (en)	2013-09-26
CN101784562B (zh)	2016-07-13

Legal Events

Date	Code	Title	Description
2016-09-13	B08F	Application fees: dismissal - article 86 of industrial property law	Free format text: REFERENTE A 8A ANUIDADE.
2017-01-10	B08K	Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

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