BRPI0907999A2 - processo de preparação de combretastatina - Google Patents

processo de preparação de combretastatina

Info

Publication number
BRPI0907999A2
BRPI0907999A2 BRPI0907999A BRPI0907999A BRPI0907999A2 BR PI0907999 A2 BRPI0907999 A2 BR PI0907999A2 BR PI0907999 A BRPI0907999 A BR PI0907999A BR PI0907999 A BRPI0907999 A BR PI0907999A BR PI0907999 A2 BRPI0907999 A2 BR PI0907999A2
Authority
BR
Brazil
Prior art keywords
formula
combretastatin
salt
compound
base
Prior art date
Application number
BRPI0907999A
Other languages
English (en)
Inventor
Malpart Joël
Frederic Marc
Masson Philippe
Mutti Stéphane
Lutz Sylviane
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39816950&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0907999(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of BRPI0907999A2 publication Critical patent/BRPI0907999A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

processo de preparação de combretastatina a presente invenção refere-se a um processo de preparação de uma combretastatina (a): fórmula (i) sob a forma de base ou de um sal de adição com um ácido, que consiste em acoplar em presença de uma base e de t3p o sal do composto (z)-amino de fórmula (11) com um derivado da lserina duplamente protegido de fórmula (111) no qual pg designa um grupo protetor da função amina de modo a obter o composto de fórmula (z)-(ib):fórmula (iv) e depois em desproteger e abrir o ciclo de (z)-(ib) em presença de um ácido de modo a obter a combretastatina (a) sob a forma de sal; e eventualmente em acrescentar uma base de modo a obter a combretastatina (a) sob a forma de base, o sal do composto (z)-amino tendo sido obtido por um enriquecimento do sal do composto amino de fórmula (v) em isômero (z).
BRPI0907999A 2008-02-28 2009-02-27 processo de preparação de combretastatina BRPI0907999A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0801092A FR2928148B1 (fr) 2008-02-28 2008-02-28 Procede de preparation de combretastatine
PCT/FR2009/000215 WO2009118474A1 (fr) 2008-02-28 2009-02-27 Procede de preparation de combretastatine

Publications (1)

Publication Number Publication Date
BRPI0907999A2 true BRPI0907999A2 (pt) 2019-01-15

Family

ID=39816950

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0907999A BRPI0907999A2 (pt) 2008-02-28 2009-02-27 processo de preparação de combretastatina

Country Status (28)

Country Link
US (1) US20110124899A1 (pt)
EP (2) EP2562154A1 (pt)
JP (1) JP2011513286A (pt)
KR (1) KR20100116644A (pt)
CN (1) CN102015620A (pt)
AR (1) AR072772A1 (pt)
AU (1) AU2009229027A1 (pt)
BR (1) BRPI0907999A2 (pt)
CA (1) CA2716541A1 (pt)
CL (3) CL2009000463A1 (pt)
CO (1) CO6241150A2 (pt)
CR (1) CR11635A (pt)
DO (1) DOP2010000250A (pt)
EA (2) EA201300249A1 (pt)
EC (1) ECSP10010421A (pt)
FR (1) FR2928148B1 (pt)
HN (1) HN2010001700A (pt)
IL (2) IL207754A0 (pt)
MA (1) MA32193B1 (pt)
MX (1) MX2010009514A (pt)
NI (1) NI201000144A (pt)
NZ (1) NZ587505A (pt)
PE (1) PE20091559A1 (pt)
SG (1) SG183658A1 (pt)
TW (1) TW200948753A (pt)
UY (1) UY31681A1 (pt)
WO (1) WO2009118474A1 (pt)
ZA (1) ZA201006137B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2953518B1 (fr) 2009-12-03 2012-01-20 Sanofi Aventis Procede de preparation d'un derive de combretastatine
WO2013084150A1 (en) * 2011-12-06 2013-06-13 Sanofi Novel crystal form of (2s)-2-amino-3-hydroxy-n-[2-methoxy-2-[(1z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl]propanamide and method of preparation thereof
EP3184095A1 (en) 2013-05-23 2017-06-28 IP Gesellschaft für Management mbH Administration units comprising polymorph 1 of 2-(2-methylamino-pyrimidin-4-yl]-1h-indole-5-carboxylic acid [(s)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide
CN104447598B (zh) * 2013-09-18 2017-09-22 浙江大德药业集团有限公司 Ca‑4的大环多胺衍生物及其抗肿瘤特性
CN104817519B (zh) * 2015-05-11 2016-11-16 中国药科大学 一类ca-4的衍生物、其制法及其医药用途
CN104892668B (zh) * 2015-05-12 2017-03-29 上海大学 考布他汀类似物水溶性前‑前药及其制备方法
WO2018144910A1 (en) 2017-02-02 2018-08-09 Bioventures, Llc Methods of protecting against neurodegeneration

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1217500A (en) * 1967-05-24 1970-12-31 Ici Ltd Separation of trans-trans enriched salts of 4,4'-diaminodicyclohexylmethane
TW325458B (en) 1993-09-08 1998-01-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer
US5731353A (en) 1993-09-08 1998-03-24 Ajinomoto Co., Inc. Stilbene derivatives and pharmaceutical compositions containing them
US5561122A (en) 1994-12-22 1996-10-01 Arizona Board Of Regents Acting On Behalf Of Arizona State University Combretastatin A-4 prodrug
TW334418B (en) * 1995-03-07 1998-06-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions
JPH08272028A (ja) * 1995-03-30 1996-10-18 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料およびその製造方法
JP2000239274A (ja) * 1998-12-16 2000-09-05 Nippon Kayaku Co Ltd 新規ナフチリジン誘導体の製造法
ES2281374T3 (es) * 1999-12-21 2007-10-01 Teva Pharmaceutical Industries Ltd. Nuevos polimorfos de hidrocloruro de sertralina, procedimientos para su preparacion, composiciones que los contienen y metodos para su utilizacion.
FR2838437B1 (fr) * 2002-04-11 2004-06-04 Aventis Pharma Sa Procedes de preparation de combretastatines
US6759555B2 (en) * 2002-04-11 2004-07-06 Aventis Pharma S.A. Process for the preparation of combretastatins
DE10333042B4 (de) * 2003-07-21 2005-09-29 Clariant Gmbh Verfahren zur Herstellung von cyclischen Phosphonsäureanhydriden und deren Verwendung

Also Published As

Publication number Publication date
CN102015620A (zh) 2011-04-13
TW200948753A (en) 2009-12-01
JP2011513286A (ja) 2011-04-28
AR072772A1 (es) 2010-09-22
WO2009118474A8 (fr) 2010-09-10
NI201000144A (es) 2011-03-09
CL2009000463A1 (es) 2010-12-03
ECSP10010421A (es) 2010-09-30
SG183658A1 (en) 2012-09-27
US20110124899A1 (en) 2011-05-26
KR20100116644A (ko) 2010-11-01
EA201300249A1 (ru) 2013-08-30
NZ587505A (en) 2012-06-29
AU2009229027A1 (en) 2009-10-01
FR2928148A1 (fr) 2009-09-04
FR2928148B1 (fr) 2013-01-18
CA2716541A1 (fr) 2009-10-01
CL2012001742A1 (es) 2012-11-16
CO6241150A2 (es) 2011-01-20
EP2562154A1 (fr) 2013-02-27
HN2010001700A (es) 2013-06-17
CL2012001744A1 (es) 2012-10-12
ZA201006137B (en) 2011-11-30
UY31681A1 (es) 2009-09-30
PE20091559A1 (es) 2009-10-30
MA32193B1 (fr) 2011-04-01
EP2252572A1 (fr) 2010-11-24
MX2010009514A (es) 2010-12-15
IL207754A0 (en) 2010-12-30
WO2009118474A1 (fr) 2009-10-01
CR11635A (es) 2011-02-04
EA201071001A1 (ru) 2011-02-28
DOP2010000250A (es) 2010-09-30
IL225776A0 (en) 2013-06-27

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A, 7A, 8A, 9A E 10A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2507 DE 22-01-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]