BRPI0910072A2 - composto, composição farmaceutic, e, método para prover anestesia a um mamífero. - Google Patents

composto, composição farmaceutic, e, método para prover anestesia a um mamífero.

Info

Publication number
BRPI0910072A2
BRPI0910072A2 BRPI0910072A BRPI0910072A BRPI0910072A2 BR PI0910072 A2 BRPI0910072 A2 BR PI0910072A2 BR PI0910072 A BRPI0910072 A BR PI0910072A BR PI0910072 A BRPI0910072 A BR PI0910072A BR PI0910072 A2 BRPI0910072 A2 BR PI0910072A2
Authority
BR
Brazil
Prior art keywords
mammal
compound
pharmaceutical composition
providing anesthesia
anesthesia
Prior art date
Application number
BRPI0910072A
Other languages
English (en)
Inventor
E Raines Douglas
F Cotten Joseph
w miller Keith
A Forman Stuart
Shaukat Husain Syed
Original Assignee
Massachusetts Gen Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Gen Hospital filed Critical Massachusetts Gen Hospital
Publication of BRPI0910072A2 publication Critical patent/BRPI0910072A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI0910072A 2008-03-31 2009-03-31 composto, composição farmaceutic, e, método para prover anestesia a um mamífero. BRPI0910072A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4091108P 2008-03-31 2008-03-31
PCT/US2009/038872 WO2009146024A1 (en) 2008-03-31 2009-03-31 Etomidate analogues with improved pharmacokinetic and pharmacodynamic properties

Publications (1)

Publication Number Publication Date
BRPI0910072A2 true BRPI0910072A2 (pt) 2017-05-30

Family

ID=41377472

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0910072A BRPI0910072A2 (pt) 2008-03-31 2009-03-31 composto, composição farmaceutic, e, método para prover anestesia a um mamífero.

Country Status (11)

Country Link
US (2) US8557856B2 (pt)
EP (2) EP2271627A4 (pt)
JP (1) JP5580287B2 (pt)
KR (1) KR101636586B1 (pt)
CN (1) CN102046607B (pt)
AU (1) AU2009251659B2 (pt)
BR (1) BRPI0910072A2 (pt)
CA (1) CA2720228A1 (pt)
MX (1) MX2010010675A (pt)
RU (2) RU2540116C2 (pt)
WO (1) WO2009146024A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2559888C2 (ru) 2009-07-10 2015-08-20 Зе Дженерал Хоспитал Корпорэйшн Аналоги этомидата, которые не ингибируют синтез адренокортикостероидов
JP6196986B2 (ja) * 2012-01-13 2017-09-13 ザ ジェネラル ホスピタル コーポレイション 麻酔化合物および関連する使用方法
CN103588757B (zh) * 2013-01-04 2014-11-12 四川大学华西医院 超短效麻醉效应的n-取代咪唑羧酸酯类化合物、制备方法和用途
US9959546B2 (en) * 2013-01-23 2018-05-01 Facebook, Inc. Associating financial accounts with a social networking system user profile
CN103739553B (zh) * 2013-12-23 2014-11-12 四川大学华西医院 含有醚侧链的n-取代咪唑羧酸酯手性化合物、制备方法和用途
US20180022698A1 (en) 2014-10-16 2018-01-25 The Board Of Trustees Of The Leland Stanford Junior University Novel methods, compounds, and compositions for anesthesia
CN104569264B (zh) * 2014-12-30 2016-05-18 李宏 一种依托咪酯有关物质的测定方法
US10392352B2 (en) * 2015-10-10 2019-08-27 Jiangsu Nhwaluokang Pharmceutical Research And Development Co., Ltd. Etomidate derivative and intermediate, preparation method and use thereof
CN107382870A (zh) * 2016-05-17 2017-11-24 四川海思科制药有限公司 N‑取代咪唑羧酸酯类化合物及其制备方法和在医药上的用途
CN107445898A (zh) * 2016-05-30 2017-12-08 四川海思科制药有限公司 N‑取代咪唑羧酸酯类化合物及其制备方法和在医药上的用途
CN107522662A (zh) * 2016-06-16 2017-12-29 四川海思科制药有限公司 N‑取代咪唑羧酸酯类化合物及其制备方法和在医药上的用途
CN107641105A (zh) * 2016-07-22 2018-01-30 四川海思科制药有限公司 N‑取代咪唑羧酸酯类化合物及其制备方法和在医药上的用途
CN107652239B (zh) * 2017-02-24 2020-08-04 四川大学华西医院 N-取代咪唑羧酸酯类化合物、制备方法及用途
CN109748876A (zh) * 2017-11-02 2019-05-14 北京蓝丹医药科技有限公司 依托咪酯衍生物及其制备方法
CN109824656B (zh) 2018-01-30 2023-11-10 成都麻沸散医药科技有限公司 多取代咪唑甲酸酯类衍生物及其用途
CN112142746B (zh) * 2019-06-28 2021-09-24 四川大学华西医院 苯二氮卓类化合物及其制备方法和在医药上的作用
CN110669017B (zh) * 2019-10-11 2023-08-04 成都麻沸散医药科技有限公司 多取代三唑甲酸酯类衍生物及其用途
CN110922361B (zh) * 2019-11-21 2021-01-08 武汉大安制药有限公司 一种依托咪酯氧化杂质及其制备方法
CN117003699A (zh) * 2022-04-28 2023-11-07 江苏恩华药业股份有限公司 一种依托咪酯衍生物及其制备方法、用途
WO2025162115A1 (zh) * 2024-02-04 2025-08-07 成都麻沸散医药科技有限公司 一种杂环化合物及其制药用途
CN119462514B (zh) * 2025-01-16 2025-03-14 四川大学华西医院 依托咪酯衍生物及其制备方法和在制备麻醉药物中的用途

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US3354173A (en) * 1964-04-16 1967-11-21 Janssen Pharmaceutica Nv Imidazole carboxylates
US4038286A (en) * 1975-03-10 1977-07-26 Janssen Pharmaceutica N.V. Racemates and optical isomers of 1-(1-phenylethyl)-1h-imidazole-5-carboylic acid derivatives
CA1066709A (en) 1975-03-10 1979-11-20 Walter A.M. Helsen Preparation of loweralkyl imidazole carboxylates
GR64915B (en) * 1978-09-14 1980-06-09 Janssen Pharmaceutica Nv Improved etomidate-containing compositions
EP0277384A3 (en) * 1986-12-24 1990-05-23 Janssen Pharmaceutica N.V. 1h-imidazole-5-carboxylic acid derivatives
US4878940A (en) * 1987-04-02 1989-11-07 Janssen Pharmaceutica N.V. Herbicidal 1,5-substituted 1H-imidazoles
US5019583A (en) 1989-02-15 1991-05-28 Glaxo Inc. N-phenyl-N-(4-piperidinyl)amides useful as analgesics
US5466700A (en) 1993-08-30 1995-11-14 Glaxo Wellcome Inc. Anesthetic use of N-phenyl-N-(4-piperidinyl)amides
US5756528A (en) * 1995-06-06 1998-05-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CA2441744C (en) 2001-03-20 2011-07-12 Cydex, Inc. Formulations containing propofol and a sulfoalkyl ether cyclodextrin
US7189859B2 (en) * 2003-08-06 2007-03-13 Ilse Zolle Radiolabelled phenylethyl imidazole carboxylic acid ester derivatives
US20080206138A1 (en) * 2003-08-06 2008-08-28 Ilse Zolle Radiolabelled Phenylethyl Imidazole Carboxylic Acid Ester Derivatives
US8071785B2 (en) * 2006-06-09 2011-12-06 Ge Healthcare Limited Synthesis and evaluation of 18F-labelled-alkyl-1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate as a tracer for the quantification of β-11-hydroxylase enzyme in the adrenal glands

Also Published As

Publication number Publication date
KR101636586B1 (ko) 2016-07-05
MX2010010675A (es) 2010-11-25
US20140200251A1 (en) 2014-07-17
RU2014149337A3 (pt) 2018-07-30
CA2720228A1 (en) 2009-12-03
US9181197B2 (en) 2015-11-10
EP2271627A4 (en) 2012-04-11
EP2271627A1 (en) 2011-01-12
RU2010144523A (ru) 2012-05-10
WO2009146024A8 (en) 2010-04-08
CN102046607A (zh) 2011-05-04
KR20110002853A (ko) 2011-01-10
JP5580287B2 (ja) 2014-08-27
CN102046607B (zh) 2014-06-11
JP2011516487A (ja) 2011-05-26
EP3210976A1 (en) 2017-08-30
US8557856B2 (en) 2013-10-15
RU2540116C2 (ru) 2015-02-10
HK1156949A1 (en) 2012-06-22
AU2009251659A1 (en) 2009-12-03
US20110053998A1 (en) 2011-03-03
WO2009146024A1 (en) 2009-12-03
AU2009251659B2 (en) 2013-07-11
RU2014149337A (ru) 2016-06-27

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]