CL2009000916A1 - Compuestos derivados de 2-trifluorometil-1h-indol-5-metilcarboxamida, moduladores del receptor nicotinico de acetilcolina alfa7 (nachr); composicon farmaceutica; y uso para el tratamiento del deterioro cognitivo y de un trastorno psicotico como esquizofrenia. - Google Patents
Compuestos derivados de 2-trifluorometil-1h-indol-5-metilcarboxamida, moduladores del receptor nicotinico de acetilcolina alfa7 (nachr); composicon farmaceutica; y uso para el tratamiento del deterioro cognitivo y de un trastorno psicotico como esquizofrenia.Info
- Publication number
- CL2009000916A1 CL2009000916A1 CL2009000916A CL2009000916A CL2009000916A1 CL 2009000916 A1 CL2009000916 A1 CL 2009000916A1 CL 2009000916 A CL2009000916 A CL 2009000916A CL 2009000916 A CL2009000916 A CL 2009000916A CL 2009000916 A1 CL2009000916 A1 CL 2009000916A1
- Authority
- CL
- Chile
- Prior art keywords
- treatment
- methylcarboxamide
- schizophrenia
- indole
- trifluoromethyl
- Prior art date
Links
- 208000028698 Cognitive impairment Diseases 0.000 title abstract 2
- 208000028017 Psychotic disease Diseases 0.000 title abstract 2
- 208000010877 cognitive disease Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 201000000980 schizophrenia Diseases 0.000 title abstract 2
- 102000047725 alpha7 Nicotinic Acetylcholine Receptor Human genes 0.000 title 1
- 108700006085 alpha7 Nicotinic Acetylcholine Receptor Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuestos derivados de 2-trifluorometil-1h-indol-5-metilcarboxamida, composición farmacéutica, útil para el tratamiento de un deterioro cognitivo y para el tratamiento de un trastorno psicótico como esquizofrenia.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0807050A GB0807050D0 (en) | 2008-04-17 | 2008-04-17 | Novel compounds |
| GB0810229A GB0810229D0 (en) | 2008-06-04 | 2008-06-04 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2009000916A1 true CL2009000916A1 (es) | 2010-12-31 |
Family
ID=40791353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2009000916A CL2009000916A1 (es) | 2008-04-17 | 2009-04-16 | Compuestos derivados de 2-trifluorometil-1h-indol-5-metilcarboxamida, moduladores del receptor nicotinico de acetilcolina alfa7 (nachr); composicon farmaceutica; y uso para el tratamiento del deterioro cognitivo y de un trastorno psicotico como esquizofrenia. |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8377941B2 (es) |
| EP (2) | EP2279183B1 (es) |
| JP (2) | JP2011516599A (es) |
| KR (2) | KR20100133016A (es) |
| CN (2) | CN102066357B (es) |
| AR (1) | AR071203A1 (es) |
| AU (2) | AU2009237649B2 (es) |
| BR (2) | BRPI0910585A2 (es) |
| CA (2) | CA2721630A1 (es) |
| CL (1) | CL2009000916A1 (es) |
| EA (2) | EA018113B1 (es) |
| ES (2) | ES2392796T3 (es) |
| IL (2) | IL208575A (es) |
| MX (2) | MX2010011358A (es) |
| PE (1) | PE20091724A1 (es) |
| TW (1) | TW201004939A (es) |
| UY (1) | UY31769A1 (es) |
| WO (2) | WO2009127679A1 (es) |
| ZA (2) | ZA201006855B (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011500625A (ja) | 2007-10-18 | 2011-01-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | トリ置換された1,2,4−トリアゾール |
| JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
| CA2712885A1 (en) | 2008-01-30 | 2009-08-06 | Cephalon, Inc. | Substituted pyridazine derivatives which have histamine h3 antagonist activity |
| MY152486A (en) | 2008-03-19 | 2014-10-15 | Janssen Pharmaceutica Nv | Trisubstituted 1,2,4 - triazoles as nicotinic acetylcholine receptor modulators |
| WO2009135944A1 (en) | 2008-05-09 | 2009-11-12 | Janssen Pharmaceutica Nv | Trisubstituted pyrazoles as acetylcholine receptor modulators |
| AU2010238518A1 (en) * | 2009-04-16 | 2011-12-01 | Proximagen Limited | Indole derivative modulators of the alpha 7 nAChR |
| JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
| GB201012686D0 (en) * | 2010-07-28 | 2010-09-15 | Glaxo Group Ltd | Novel compounds |
| JO3078B1 (ar) * | 2009-11-27 | 2017-03-15 | Janssen Pharmaceutica Nv | مورفولينوثيازولات بصفتها منظمات الوستيرية نوع الفا 7 موجبة |
| CA2825519A1 (en) | 2011-02-03 | 2012-09-08 | Lupin Limited | Pyrrole derivatives used as modulators of alpha7 nachr |
| RS55433B1 (sr) | 2011-02-23 | 2017-04-28 | Lupin Ltd | Derivati heteroarila kao modulatori nachr alfa7 |
| US20140228398A1 (en) * | 2011-03-18 | 2014-08-14 | Novartis Ag | COMBINATIONS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATORS AND mGluR5 ANTAGONISTS FOR USE IN DOPAMINE INDUCED DYSKINESIA IN PARKINSON'S DISEASE |
| AU2012235779B2 (en) | 2011-03-31 | 2017-03-02 | Lupin Limited | Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as Alzheimer's and Parkinson's disease |
| TW201245185A (en) | 2011-04-01 | 2012-11-16 | Lundbeck & Co As H | New positive allosteric modulators of nicotinic acetylcholine receptor |
| US8946432B2 (en) | 2011-07-05 | 2015-02-03 | Lupin Limited | Biaryl derivatives as nAChR modulators |
| NZ629453A (en) | 2012-03-06 | 2016-04-29 | Lupin Ltd | Thiazole derivatives as alpha 7 nachr modulators |
| AU2013259565A1 (en) * | 2012-05-08 | 2014-11-13 | Anvyl Llc | Alpha 7 nicotinic acetylcholine receptor allosteric modulators, their derivatives and uses thereof |
| JPWO2014054635A1 (ja) * | 2012-10-02 | 2016-08-25 | 大日本住友製薬株式会社 | イミダゾール誘導体 |
| EP2945936A1 (en) | 2012-11-12 | 2015-11-25 | Lupin Limited | Thiazole derivatives as alpha 7 nachr modulators |
| CN103006642B (zh) * | 2013-01-04 | 2014-10-22 | 中国药科大学 | 一类炔亚甲基吲哚-2-酮类衍生物的用途 |
| EP2945941B1 (en) | 2013-01-16 | 2016-12-07 | Lupin Limited | Pyrrole derivatives as alpha 7 nachr modulators |
| US9617210B2 (en) | 2013-03-13 | 2017-04-11 | Lupin Limited | Pyrrole derivatives as alpha 7 NACHR modulators |
| US10058310B2 (en) | 2013-03-13 | 2018-08-28 | Ethicon Llc | Electrosurgical device with drum-driven articulation |
| TW201446243A (zh) | 2013-06-03 | 2014-12-16 | Lupin Ltd | 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑 |
| WO2014203150A1 (en) | 2013-06-17 | 2014-12-24 | Lupin Limited | Pyrrole derivatives as alpha 7 nachr modulators |
| US20170182058A1 (en) * | 2014-03-25 | 2017-06-29 | Emicipi Llc | Treatment of rett syndrome |
| JP6870304B2 (ja) * | 2016-12-05 | 2021-05-12 | 住友電気工業株式会社 | 半導体装置の製造方法 |
| EP3558992A4 (en) | 2016-12-15 | 2020-12-02 | ONO Pharmaceutical Co., Ltd. | TREK CHANNEL ACTIVATOR (K + CHANNELS ASSOCIATED WITH TWIK) |
| HU231414B1 (hu) | 2018-07-13 | 2023-08-28 | Richter Gedeon Nyrt. | Tiadiazin származékok |
| HU231333B1 (hu) | 2018-07-13 | 2023-01-28 | Richter Gedeon Nyrt | Spirokromán származékok |
| HU231478B1 (hu) | 2018-07-13 | 2024-02-28 | Richter Gedeon Nyrt. | Szubsztituált (aza)indol származékok |
| CN115151540A (zh) | 2019-12-02 | 2022-10-04 | 风暴治疗有限公司 | 作为mettl3抑制剂的多杂环化合物 |
| CN111285792B (zh) * | 2020-03-23 | 2023-05-02 | 三峡大学 | 2-取代吲哚化合物及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9903997D0 (sv) * | 1999-11-03 | 1999-11-03 | Astra Ab | New compounds |
| GB0403155D0 (en) * | 2004-02-12 | 2004-03-17 | Vernalis Res Ltd | Chemical compounds |
| BRPI0907492A2 (pt) * | 2008-02-07 | 2017-06-13 | Abbott Lab | derivados amida como moduladores alostéricos positivos e métodos de sua utilização |
-
2009
- 2009-04-16 CL CL2009000916A patent/CL2009000916A1/es unknown
- 2009-04-16 BR BRPI0910585A patent/BRPI0910585A2/pt not_active IP Right Cessation
- 2009-04-16 EA EA201071201A patent/EA018113B1/ru not_active IP Right Cessation
- 2009-04-16 CA CA2721630A patent/CA2721630A1/en not_active Abandoned
- 2009-04-16 MX MX2010011358A patent/MX2010011358A/es active IP Right Grant
- 2009-04-16 ES ES09733402T patent/ES2392796T3/es active Active
- 2009-04-16 EA EA201071202A patent/EA017726B1/ru not_active IP Right Cessation
- 2009-04-16 KR KR1020107025697A patent/KR20100133016A/ko not_active Withdrawn
- 2009-04-16 CN CN200980123031.3A patent/CN102066357B/zh not_active Expired - Fee Related
- 2009-04-16 US US12/936,431 patent/US8377941B2/en not_active Expired - Fee Related
- 2009-04-16 AU AU2009237649A patent/AU2009237649B2/en not_active Ceased
- 2009-04-16 AR ARP090101342A patent/AR071203A1/es not_active Application Discontinuation
- 2009-04-16 JP JP2011504458A patent/JP2011516599A/ja not_active Ceased
- 2009-04-16 MX MX2010011359A patent/MX2010011359A/es active IP Right Grant
- 2009-04-16 EP EP09732038A patent/EP2279183B1/en active Active
- 2009-04-16 WO PCT/EP2009/054495 patent/WO2009127679A1/en not_active Ceased
- 2009-04-16 JP JP2011504457A patent/JP2011516598A/ja not_active Ceased
- 2009-04-16 WO PCT/EP2009/054493 patent/WO2009127678A1/en not_active Ceased
- 2009-04-16 EP EP09733402A patent/EP2279184B1/en active Active
- 2009-04-16 PE PE2009000537A patent/PE20091724A1/es not_active Application Discontinuation
- 2009-04-16 US US12/936,408 patent/US8283365B2/en not_active Expired - Fee Related
- 2009-04-16 TW TW098112580A patent/TW201004939A/zh unknown
- 2009-04-16 KR KR1020107025698A patent/KR20100135911A/ko not_active Withdrawn
- 2009-04-16 BR BRPI0911682A patent/BRPI0911682A2/pt not_active IP Right Cessation
- 2009-04-16 ES ES09732038T patent/ES2392795T3/es active Active
- 2009-04-16 CA CA2725441A patent/CA2725441C/en not_active Expired - Fee Related
- 2009-04-16 UY UY031769A patent/UY31769A1/es not_active Application Discontinuation
- 2009-04-16 CN CN200980123025.8A patent/CN102066356B/zh not_active Expired - Fee Related
- 2009-04-16 AU AU2009237650A patent/AU2009237650B2/en not_active Ceased
-
2010
- 2010-09-27 ZA ZA2010/06855A patent/ZA201006855B/en unknown
- 2010-09-27 ZA ZA2010/06856A patent/ZA201006856B/en unknown
- 2010-10-07 IL IL208575A patent/IL208575A/en not_active IP Right Cessation
- 2010-10-07 IL IL208574A patent/IL208574A/en not_active IP Right Cessation
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