BRPI0911682A2 - indóis como moduladores do recpetor da acetilcolina nicotínico subtipo alfa-71 - Google Patents

indóis como moduladores do recpetor da acetilcolina nicotínico subtipo alfa-71

Info

Publication number
BRPI0911682A2
BRPI0911682A2 BRPI0911682A BRPI0911682A BRPI0911682A2 BR PI0911682 A2 BRPI0911682 A2 BR PI0911682A2 BR PI0911682 A BRPI0911682 A BR PI0911682A BR PI0911682 A BRPI0911682 A BR PI0911682A BR PI0911682 A2 BRPI0911682 A2 BR PI0911682A2
Authority
BR
Brazil
Prior art keywords
indoles
subtype
modulators
acetylcholine receptor
nicotinic acetylcholine
Prior art date
Application number
BRPI0911682A
Other languages
English (en)
Inventor
Andrew P Lightfoot
Howard Robert Marhsall
Kevin Dinnell
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0807050A external-priority patent/GB0807050D0/en
Priority claimed from GB0810229A external-priority patent/GB0810229D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BRPI0911682A2 publication Critical patent/BRPI0911682A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BRPI0911682A 2008-04-17 2009-04-16 indóis como moduladores do recpetor da acetilcolina nicotínico subtipo alfa-71 BRPI0911682A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0807050A GB0807050D0 (en) 2008-04-17 2008-04-17 Novel compounds
GB0810229A GB0810229D0 (en) 2008-06-04 2008-06-04 Novel compounds
PCT/EP2009/054493 WO2009127678A1 (en) 2008-04-17 2009-04-16 Indoles as modulators of nicotinic acetylcholin receptor subtype alpha-71

Publications (1)

Publication Number Publication Date
BRPI0911682A2 true BRPI0911682A2 (pt) 2015-10-13

Family

ID=40791353

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0911682A BRPI0911682A2 (pt) 2008-04-17 2009-04-16 indóis como moduladores do recpetor da acetilcolina nicotínico subtipo alfa-71
BRPI0910585A BRPI0910585A2 (pt) 2008-04-17 2009-04-16 indóis como moduladores de receptor de aceticolina nicotínica do subtipo alfa-7

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0910585A BRPI0910585A2 (pt) 2008-04-17 2009-04-16 indóis como moduladores de receptor de aceticolina nicotínica do subtipo alfa-7

Country Status (19)

Country Link
US (2) US8283365B2 (pt)
EP (2) EP2279184B1 (pt)
JP (2) JP2011516599A (pt)
KR (2) KR20100133016A (pt)
CN (2) CN102066356B (pt)
AR (1) AR071203A1 (pt)
AU (2) AU2009237650B2 (pt)
BR (2) BRPI0911682A2 (pt)
CA (2) CA2721630A1 (pt)
CL (1) CL2009000916A1 (pt)
EA (2) EA018113B1 (pt)
ES (2) ES2392796T3 (pt)
IL (2) IL208574A (pt)
MX (2) MX2010011359A (pt)
PE (1) PE20091724A1 (pt)
TW (1) TW201004939A (pt)
UY (1) UY31769A1 (pt)
WO (2) WO2009127678A1 (pt)
ZA (2) ZA201006856B (pt)

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JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
JP2011500625A (ja) 2007-10-18 2011-01-06 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ トリ置換された１，２，４−トリアゾール
CA2712885A1 (en) 2008-01-30 2009-08-06 Cephalon, Inc. Substituted pyridazine derivatives which have histamine h3 antagonist activity
AR070936A1 (es) 2008-03-19 2010-05-12 Janssen Pharmaceutica Nv 1,2,4 -triazoles trisustituidos
JP5486591B2 (ja) 2008-05-09 2014-05-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ アセチルコリン受容体モジュレーターとしての三置換ピラゾール
EA019518B1 (ru) * 2009-04-16 2014-04-30 Проксимаген Лимитед ПРОИЗВОДНЫЕ ИНДОЛА В КАЧЕСТВЕ МОДУЛЯТОРОВ РЕЦЕПТОРА α7 nAChR
TWI558398B (zh) 2009-09-22 2016-11-21 諾華公司 菸鹼乙醯膽鹼受體α７活化劑之用途
GB201012686D0 (en) * 2010-07-28 2010-09-15 Glaxo Group Ltd Novel compounds
JO3078B1 (ar) * 2009-11-27 2017-03-15 Janssen Pharmaceutica Nv مورفولينوثيازولات بصفتها منظمات الوستيرية نوع الفا 7 موجبة
EP2670744B1 (en) 2011-02-03 2015-05-27 Lupin Limited Pyrrole derivatives used as modulators of alpha7 nachr
AU2012221800B2 (en) 2011-02-23 2016-10-27 Lupin Limited Heteroaryl derivatives as alpha7 nAChR modulators
EA201391348A8 (ru) * 2011-03-18 2014-11-28 Новартис Аг КОМБИНАЦИИ АКТИВАТОРОВ АЛЬФА-7 НИКОТИНОВОГО АЦЕТИЛХОЛИНОВОГО РЕЦЕПТОРА И АНТАГОНИСТОВ mGluR5, ПРЕДНАЗНАЧЕННЫЕ ДЛЯ ПРИМЕНЕНИЯ ПРИ ВЫЗВАННОЙ ДОПАМИНОМ ДИСКИНЕЗИИ, СВЯЗАННОЙ С БОЛЕЗНЬЮ ПАРКИНСОНА
AU2012235779B2 (en) 2011-03-31 2017-03-02 Lupin Limited Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as Alzheimer's and Parkinson's disease
TW201245185A (en) 2011-04-01 2012-11-16 Lundbeck & Co As H New positive allosteric modulators of nicotinic acetylcholine receptor
ES2606043T3 (es) 2011-07-05 2017-03-17 Lupin Limited Derivados de biarilo como moduladores de nAChR
WO2013132380A1 (en) 2012-03-06 2013-09-12 Lupin Limited Thiazole derivatives as alpha 7 nachr modulators
HK1208154A1 (en) * 2012-05-08 2016-02-26 Anvyl, Llc Alpha 7 nicotinic acetylcholine receptor allosteric modulators, their derivatives and uses thereof
MX2015004285A (es) * 2012-10-02 2015-08-06 Sumitomo Dainippon Pharma Co Ltd Derivado de imidazol.
WO2014072957A1 (en) 2012-11-12 2014-05-15 Lupin Limited Thiazole derivatives as alpha 7 nachr modulators
CN103006642B (zh) * 2013-01-04 2014-10-22 中国药科大学 一类炔亚甲基吲哚-2-酮类衍生物的用途
US9617211B2 (en) 2013-01-16 2017-04-11 Lupin Limited Pyrrole derivatives as alpha 7 nAChR modulators
US9617210B2 (en) 2013-03-13 2017-04-11 Lupin Limited Pyrrole derivatives as alpha 7 NACHR modulators
US10058310B2 (en) 2013-03-13 2018-08-28 Ethicon Llc Electrosurgical device with drum-driven articulation
TW201446243A (zh) 2013-06-03 2014-12-16 Lupin Ltd 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑
WO2014203150A1 (en) 2013-06-17 2014-12-24 Lupin Limited Pyrrole derivatives as alpha 7 nachr modulators
WO2015148480A1 (en) * 2014-03-25 2015-10-01 Emicipi Llc Treatment of rett syndrome
JP6870304B2 (ja) * 2016-12-05 2021-05-12 住友電気工業株式会社 半導体装置の製造方法
EP3558992A4 (en) * 2016-12-15 2020-12-02 ONO Pharmaceutical Co., Ltd. TREK CHANNEL ACTIVATOR (K + CHANNELS ASSOCIATED WITH TWIK)
HU231478B1 (hu) 2018-07-13 2024-02-28 Richter Gedeon Nyrt. Szubsztituált (aza)indol származékok
HU231414B1 (hu) 2018-07-13 2023-08-28 Richter Gedeon Nyrt. Tiadiazin származékok
HU231333B1 (hu) * 2018-07-13 2023-01-28 Richter Gedeon Nyrt Spirokromán származékok
US12195458B2 (en) 2019-12-02 2025-01-14 Storm Therapeutics Limited Polyheterocyclic compounds as METTL3 inhibitors
CN111285792B (zh) * 2020-03-23 2023-05-02 三峡大学 2-取代吲哚化合物及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9903997D0 (sv) 1999-11-03 1999-11-03 Astra Ab New compounds
GB0403155D0 (en) * 2004-02-12 2004-03-17 Vernalis Res Ltd Chemical compounds
US8536221B2 (en) * 2008-02-07 2013-09-17 Abbvie Inc. Amide derivatives as positive allosteric modulators and methods of use thereof

Also Published As

Publication number Publication date
AU2009237649B2 (en) 2012-07-26
ES2392796T3 (es) 2012-12-13
CN102066356B (zh) 2014-06-11
CA2725441A1 (en) 2009-10-22
AU2009237649A1 (en) 2009-10-22
AU2009237650B2 (en) 2012-05-31
KR20100135911A (ko) 2010-12-27
IL208575A (en) 2014-04-30
EP2279184A1 (en) 2011-02-02
WO2009127678A1 (en) 2009-10-22
ZA201006856B (en) 2011-06-29
KR20100133016A (ko) 2010-12-20
UY31769A1 (es) 2009-09-30
JP2011516598A (ja) 2011-05-26
CL2009000916A1 (es) 2010-12-31
EA018113B1 (ru) 2013-05-30
IL208574A (en) 2014-04-30
US8377941B2 (en) 2013-02-19
PE20091724A1 (es) 2009-12-06
EP2279183B1 (en) 2012-08-08
TW201004939A (en) 2010-02-01
EA201071201A1 (ru) 2011-04-29
ES2392795T3 (es) 2012-12-13
IL208575A0 (en) 2010-12-30
CN102066357B (zh) 2014-04-09
EP2279184B1 (en) 2012-08-08
MX2010011358A (es) 2010-11-10
AU2009237650A1 (en) 2009-10-22
CA2721630A1 (en) 2009-10-22
ZA201006855B (en) 2011-06-29
EP2279183A1 (en) 2011-02-02
IL208574A0 (en) 2010-12-30
AR071203A1 (es) 2010-06-02
CN102066356A (zh) 2011-05-18
US20110034515A1 (en) 2011-02-10
US8283365B2 (en) 2012-10-09
EA201071202A1 (ru) 2011-06-30
US20110028486A1 (en) 2011-02-03
JP2011516599A (ja) 2011-05-26
WO2009127679A1 (en) 2009-10-22
EA017726B1 (ru) 2013-02-28
CA2725441C (en) 2014-05-27
MX2010011359A (es) 2010-11-12
BRPI0910585A2 (pt) 2015-09-22
CN102066357A (zh) 2011-05-18

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]