BRPI0911682A2 - indóis como moduladores do recpetor da acetilcolina nicotínico subtipo alfa-71 - Google Patents

indóis como moduladores do recpetor da acetilcolina nicotínico subtipo alfa-71

Info

Publication number
BRPI0911682A2
BRPI0911682A2 BRPI0911682A BRPI0911682A BRPI0911682A2 BR PI0911682 A2 BRPI0911682 A2 BR PI0911682A2 BR PI0911682 A BRPI0911682 A BR PI0911682A BR PI0911682 A BRPI0911682 A BR PI0911682A BR PI0911682 A2 BRPI0911682 A2 BR PI0911682A2
Authority
BR
Brazil
Prior art keywords
indoles
subtype
modulators
acetylcholine receptor
nicotinic acetylcholine
Prior art date
Application number
BRPI0911682A
Other languages
English (en)
Inventor
Andrew P Lightfoot
Howard Robert Marhsall
Kevin Dinnell
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0807050A external-priority patent/GB0807050D0/en
Priority claimed from GB0810229A external-priority patent/GB0810229D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BRPI0911682A2 publication Critical patent/BRPI0911682A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BRPI0911682A 2008-04-17 2009-04-16 indóis como moduladores do recpetor da acetilcolina nicotínico subtipo alfa-71 BRPI0911682A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0807050A GB0807050D0 (en) 2008-04-17 2008-04-17 Novel compounds
GB0810229A GB0810229D0 (en) 2008-06-04 2008-06-04 Novel compounds
PCT/EP2009/054493 WO2009127678A1 (en) 2008-04-17 2009-04-16 Indoles as modulators of nicotinic acetylcholin receptor subtype alpha-71

Publications (1)

Publication Number Publication Date
BRPI0911682A2 true BRPI0911682A2 (pt) 2015-10-13

Family

ID=40791353

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0910585A BRPI0910585A2 (pt) 2008-04-17 2009-04-16 indóis como moduladores de receptor de aceticolina nicotínica do subtipo alfa-7
BRPI0911682A BRPI0911682A2 (pt) 2008-04-17 2009-04-16 indóis como moduladores do recpetor da acetilcolina nicotínico subtipo alfa-71

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0910585A BRPI0910585A2 (pt) 2008-04-17 2009-04-16 indóis como moduladores de receptor de aceticolina nicotínica do subtipo alfa-7

Country Status (19)

Country Link
US (2) US8283365B2 (pt)
EP (2) EP2279183B1 (pt)
JP (2) JP2011516599A (pt)
KR (2) KR20100133016A (pt)
CN (2) CN102066356B (pt)
AR (1) AR071203A1 (pt)
AU (2) AU2009237650B2 (pt)
BR (2) BRPI0910585A2 (pt)
CA (2) CA2721630A1 (pt)
CL (1) CL2009000916A1 (pt)
EA (2) EA018113B1 (pt)
ES (2) ES2392796T3 (pt)
IL (2) IL208574A (pt)
MX (2) MX2010011358A (pt)
PE (1) PE20091724A1 (pt)
TW (1) TW201004939A (pt)
UY (1) UY31769A1 (pt)
WO (2) WO2009127678A1 (pt)
ZA (2) ZA201006855B (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
CA2697974C (en) 2007-10-18 2015-06-30 Janssen Pharmaceutica Nv Trisubstituted 1,2,4-triazoles
EP2752406A1 (en) 2008-01-30 2014-07-09 Cephalon, Inc. Substituted pyridazine derivatives which have histamine H3 antagonist activity
WO2009115547A1 (en) 2008-03-19 2009-09-24 Janssen Pharmaceutica Nv Trisubstituted 1, 2, 4 -triazoiies as nicotinic acetylcholine receptor modulators
AR071763A1 (es) 2008-05-09 2010-07-14 Janssen Pharmaceutica Nv Pirazoles trisustituidos, composiciones farmaceuticas que los contienen, y usos de los mismos en el tratamiento de trastornos neurologicos y psiquiatricos
EP2419420B1 (en) * 2009-04-16 2013-03-13 Proximagen Limited Indole derivative modulators of the alpha 7 nachr
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
GB201012686D0 (en) * 2010-07-28 2010-09-15 Glaxo Group Ltd Novel compounds
JO3078B1 (ar) * 2009-11-27 2017-03-15 Janssen Pharmaceutica Nv مورفولينوثيازولات بصفتها منظمات الوستيرية نوع الفا 7 موجبة
KR20140041442A (ko) 2011-02-03 2014-04-04 루핀 리미티드 알파 7 ｎａｃｈｒ의 조절자로 사용된 피롤 유도체
EA024170B1 (ru) 2011-02-23 2016-08-31 Люпин Лимитед ГЕТЕРОАРИЛЬНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ nAChR АЛЬФА7
AU2012232711B2 (en) * 2011-03-18 2016-04-28 Novartis Ag Combinations of alpha 7 nicotinic acetylcholine receptor activators and mGluR5 antagonists for use in dopamine induced dyskinesia in Parkinson's Disease
EP2691368A1 (en) 2011-03-31 2014-02-05 Lupin Limited Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as alzheimer's and parkinson's disease
TW201245185A (en) 2011-04-01 2012-11-16 Lundbeck & Co As H New positive allosteric modulators of nicotinic acetylcholine receptor
EP2729455B1 (en) 2011-07-05 2016-09-14 Lupin Limited Biaryl derivatives as nachr modulators
EP2822946A1 (en) 2012-03-06 2015-01-14 Lupin Limited Thiazole derivatives as alpha 7 nachr modulators
CA2871651A1 (en) * 2012-05-08 2013-11-14 Anvyl Llc Alpha 7 nicotinic acetylcholine receptor allosteric modulators, their derivatives and uses thereof
MX2015004285A (es) * 2012-10-02 2015-08-06 Sumitomo Dainippon Pharma Co Ltd Derivado de imidazol.
US20150299178A1 (en) 2012-11-12 2015-10-22 Lupin Limited Thiazole Derivatives as Alpha 7 NACHR Modulators
CN103006642B (zh) * 2013-01-04 2014-10-22 中国药科大学 一类炔亚甲基吲哚-2-酮类衍生物的用途
US9617211B2 (en) 2013-01-16 2017-04-11 Lupin Limited Pyrrole derivatives as alpha 7 nAChR modulators
US10058310B2 (en) 2013-03-13 2018-08-28 Ethicon Llc Electrosurgical device with drum-driven articulation
AU2014229300A1 (en) 2013-03-13 2015-06-11 Lupin Limited Pyrrole derivatives as alpha 7 nAChR modulators
TW201446243A (zh) 2013-06-03 2014-12-16 Lupin Ltd 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑
AU2014282886A1 (en) 2013-06-17 2015-12-17 Lupin Limited Pyrrole derivatives as alpha 7 nAChR modulators
CA2944017C (en) * 2014-03-25 2022-08-09 Emicipi Llc Treatment of rett syndrome
JP6870304B2 (ja) * 2016-12-05 2021-05-12 住友電気工業株式会社 半導体装置の製造方法
JP7120549B2 (ja) * 2016-12-15 2022-08-17 小野薬品工業株式会社 Ｔｒｅｋ（ｔｗｉｋ関連ｋチャネル）チャネルのアクチベータ
HU231333B1 (hu) 2018-07-13 2023-01-28 Richter Gedeon Nyrt Spirokromán származékok
HU231414B1 (hu) 2018-07-13 2023-08-28 Richter Gedeon Nyrt. Tiadiazin származékok
HU231478B1 (hu) 2018-07-13 2024-02-28 Richter Gedeon Nyrt. Szubsztituált (aza)indol származékok
CN115151540A (zh) 2019-12-02 2022-10-04 风暴治疗有限公司 作为mettl3抑制剂的多杂环化合物
CN111285792B (zh) * 2020-03-23 2023-05-02 三峡大学 2-取代吲哚化合物及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9903997D0 (sv) * 1999-11-03 1999-11-03 Astra Ab New compounds
GB0403155D0 (en) * 2004-02-12 2004-03-17 Vernalis Res Ltd Chemical compounds
JP2011511800A (ja) * 2008-02-07 2011-04-14 アボット・ラボラトリーズ 正のアロステリックな修飾物質としてのアミド誘導体およびこれらの使用方法

Also Published As

Publication number Publication date
WO2009127678A1 (en) 2009-10-22
CA2725441C (en) 2014-05-27
US8377941B2 (en) 2013-02-19
EA018113B1 (ru) 2013-05-30
US20110034515A1 (en) 2011-02-10
EA201071202A1 (ru) 2011-06-30
UY31769A1 (es) 2009-09-30
WO2009127679A1 (en) 2009-10-22
KR20100133016A (ko) 2010-12-20
US8283365B2 (en) 2012-10-09
EP2279184B1 (en) 2012-08-08
CA2721630A1 (en) 2009-10-22
EA201071201A1 (ru) 2011-04-29
EP2279183A1 (en) 2011-02-02
EA017726B1 (ru) 2013-02-28
CN102066357A (zh) 2011-05-18
BRPI0910585A2 (pt) 2015-09-22
JP2011516598A (ja) 2011-05-26
TW201004939A (en) 2010-02-01
MX2010011359A (es) 2010-11-12
CL2009000916A1 (es) 2010-12-31
IL208575A (en) 2014-04-30
CN102066356A (zh) 2011-05-18
KR20100135911A (ko) 2010-12-27
CA2725441A1 (en) 2009-10-22
AU2009237650B2 (en) 2012-05-31
JP2011516599A (ja) 2011-05-26
IL208574A0 (en) 2010-12-30
IL208574A (en) 2014-04-30
AU2009237649A1 (en) 2009-10-22
EP2279184A1 (en) 2011-02-02
ZA201006855B (en) 2011-06-29
CN102066357B (zh) 2014-04-09
ES2392795T3 (es) 2012-12-13
EP2279183B1 (en) 2012-08-08
ZA201006856B (en) 2011-06-29
IL208575A0 (en) 2010-12-30
MX2010011358A (es) 2010-11-10
AR071203A1 (es) 2010-06-02
PE20091724A1 (es) 2009-12-06
AU2009237649B2 (en) 2012-07-26
CN102066356B (zh) 2014-06-11
US20110028486A1 (en) 2011-02-03
ES2392796T3 (es) 2012-12-13
AU2009237650A1 (en) 2009-10-22

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]