BRPI0916504A2 - composto e uso de pelo menos um composto - Google Patents

composto e uso de pelo menos um composto

Info

Publication number: BRPI0916504A2
Authority: BR; Brazil
Prior art keywords: compound
Prior art date: 2008-12-02

Application number

BRPI0916504A

Other languages

English (en)

Inventor

Jean-Claude Pascal

Jean-Guy Boiteau

Original Assignee

Galderma Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-12-02

Filing date

2009-12-02

Publication date

2015-11-10

2009-12-02 Application filed by Galderma Res & Dev filed Critical Galderma Res & Dev

2015-11-10 Publication of BRPI0916504A2 publication Critical patent/BRPI0916504A2/pt

2018-12-18 Publication of BRPI0916504B1 publication Critical patent/BRPI0916504B1/pt

2019-04-02 Publication of BRPI0916504B8 publication Critical patent/BRPI0916504B8/pt

Links

150000001875 compounds Chemical class 0.000 title 2

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D309/06—Radicals substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4986—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with sulfur as the only hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Birds (AREA)
Medicinal Chemistry (AREA)
Dermatology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Furan Compounds (AREA)
Pyrane Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

BRPI0916504A 2008-12-02 2009-12-02 composto e uso de pelo menos um composto BRPI0916504B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0858206A FR2939136B1 (fr)	2008-12-02	2008-12-02	Nouveaux composes 4-(heterocycloalkyl)-benzene-1,3-diol comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique
US20212809P	2009-01-30	2009-01-30
PCT/EP2009/066267 WO2010063773A1 (en)	2008-12-02	2009-12-02	Novel 4-(heterocycloalkyl)benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and also in cosmetics

Publications (3)

Publication Number	Publication Date
BRPI0916504A2 true BRPI0916504A2 (pt)	2015-11-10
BRPI0916504B1 BRPI0916504B1 (pt)	2018-12-18
BRPI0916504B8 BRPI0916504B8 (pt)	2019-04-02

Family

ID=40845880

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0916504A BRPI0916504B8 (pt)	2008-12-02	2009-12-02	composto e uso de pelo menos um composto

Country Status (20)

Country	Link
US (1)	US8372879B2 (pt)
EP (2)	EP2529735B1 (pt)
JP (1)	JP5395188B2 (pt)
KR (1)	KR101290504B1 (pt)
CN (1)	CN102238948B (pt)
AR (1)	AR074454A1 (pt)
AU (1)	AU2009324080B2 (pt)
BR (1)	BRPI0916504B8 (pt)
CA (1)	CA2742703C (pt)
DK (1)	DK2373310T3 (pt)
ES (2)	ES2506265T3 (pt)
FR (1)	FR2939136B1 (pt)
HR (1)	HRP20120954T1 (pt)
MX (1)	MX2011005479A (pt)
PL (2)	PL2373310T3 (pt)
PT (1)	PT2373310E (pt)
RU (1)	RU2482116C2 (pt)
SI (1)	SI2373310T1 (pt)
SM (1)	SMT201200057B (pt)
WO (1)	WO2010063773A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2939135B1 (fr) *	2008-12-02	2010-12-03	Galderma Res & Dev	Nouveaux composes 4-(azacycloalkyl)-benzene-1,3-diol comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique
SI2688403T1 (sl) *	2011-03-23	2017-08-31	Trevena, Inc.	Ligandi opioidnih receptorjev in metode uporabe in izdelave istega
WO2014125231A1 (fr)	2013-02-14	2014-08-21	Galderma Research & Development	Procede de synthese de composes 4-(heterocycloalkyl)-benzene-1,3-diol
WO2014139080A1 (en) *	2013-03-12	2014-09-18	Boehringer Ingelheim International Trading (Shanghai) Co., Ltd.	Novel process for the manufacture of 3-oxo-tetrahydrofuran
FR3030252B1 (fr) *	2014-12-22	2018-11-02	L'oreal	Composition aqueuse comprenant un compose 4-(heterocycloalkyl)-benzene-1,3-diol, un monoalcool en c2-c4 et un glycol
FR3030250B1 (fr) *	2014-12-22	2018-11-02	L'oreal	Composition aqueuse comprenant un compose 4-(heterocycloalkyl)-benzene-1,3-diol et un hydrotrope
FR3030249B1 (fr) *	2014-12-22	2018-11-02	L'oreal	Composition aqueuse comprenant un compose 4-(heterocycloalkyl)-benzene-1,3-diol, un polymere et un glycol
FR3030251B1 (fr) *	2014-12-22	2018-11-02	L'oreal	Composition comprenant un compose 4-(heterocycloalkyl)-benzene-1,3-diol et un solvant particulier
JP6873598B2 (ja) *	2015-12-22	2021-05-19	ロレアル	活性成分のための改善された局所送達系

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0651619B2 (ja)	1988-05-09	1994-07-06	株式会社クラレ	美白剤
FR2704428B1 (fr)	1993-04-29	1995-06-09	Oreal	Utilisation de dérivés de la résorcine substitués en position(s) 4, 4 et 5 ou 4 et 6 dans des compositions cosmétiques ou dermopharmaceutiques à action dépigmentante.
US6068834A (en) *	1994-03-04	2000-05-30	The Procter & Gamble Company	Skin lightening compositions
BR9803596A (pt) *	1997-09-23	2000-04-25	Pfizer Prod Inc	Derivados do resorcinol.
JPH11255637A (ja) *	1998-03-13	1999-09-21	Kansai Kouso Kk	チロシナーゼ活性阻害剤及び化粧料
HN2000000033A (es) *	1999-03-22	2001-02-02	Pfizer Prod Inc	Composicion de resorcinol
AU2001272904A1 (en) *	2000-09-07	2002-03-22	Wisconsin Alumni Research Foundation	Synthesis of 17f labeled fluoroalkanes
BR0113798A (pt) *	2000-09-11	2003-07-08	Pfizer Prod Inc	Derivados de resorcinol
US6852310B2 (en)	2002-08-23	2005-02-08	Unilever Home & Personal Care Usa Division Of Conopco, Inc.	Skin lightening agents, compositions and methods
US6875425B2 (en) *	2002-12-12	2005-04-05	Unilever Home & Personal Care Usa	Skin lightening agents, compositions and methods
US7300646B2 (en)	2004-02-27	2007-11-27	Unilever Home & Personal Care Usa, Division Of Conopco, Inc.	Skin lightening agents, compositions and methods
US20060210497A1 (en)	2005-03-18	2006-09-21	Unilever Home & Personal Care Usa, Division Of Conopco, Inc.	Novel resorcinol derivatives
US20060210498A1 (en)	2005-03-18	2006-09-21	Unilever Home & Personal Care Usa, Division Of Conopco, Inc.	Novel resorcinol derivatives for skin
FR2917087B1 (fr) *	2007-06-05	2012-09-21	Galderma Res & Dev	Nouveaux 4-phenyl-imidazole-2-thiones comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique.

2008
- 2008-12-02 FR FR0858206A patent/FR2939136B1/fr not_active Expired - Fee Related
2009
- 2009-12-02 DK DK09796990.1T patent/DK2373310T3/da active
- 2009-12-02 CA CA2742703A patent/CA2742703C/en active Active
- 2009-12-02 EP EP12182351.2A patent/EP2529735B1/en not_active Not-in-force
- 2009-12-02 HR HRP20120954AT patent/HRP20120954T1/hr unknown
- 2009-12-02 PT PT97969901T patent/PT2373310E/pt unknown
- 2009-12-02 KR KR1020117015284A patent/KR101290504B1/ko not_active Expired - Fee Related
- 2009-12-02 AR ARP090104649A patent/AR074454A1/es unknown
- 2009-12-02 MX MX2011005479A patent/MX2011005479A/es active IP Right Grant
- 2009-12-02 EP EP09796990A patent/EP2373310B1/en not_active Not-in-force
- 2009-12-02 WO PCT/EP2009/066267 patent/WO2010063773A1/en not_active Ceased
- 2009-12-02 RU RU2011127120/04A patent/RU2482116C2/ru active
- 2009-12-02 SI SI200930399T patent/SI2373310T1/sl unknown
- 2009-12-02 AU AU2009324080A patent/AU2009324080B2/en not_active Ceased
- 2009-12-02 ES ES12182351.2T patent/ES2506265T3/es active Active
- 2009-12-02 BR BRPI0916504A patent/BRPI0916504B8/pt not_active IP Right Cessation
- 2009-12-02 CN CN200980148286.5A patent/CN102238948B/zh not_active Expired - Fee Related
- 2009-12-02 JP JP2011538010A patent/JP5395188B2/ja not_active Expired - Fee Related
- 2009-12-02 US US13/131,161 patent/US8372879B2/en not_active Expired - Fee Related
- 2009-12-02 PL PL09796990T patent/PL2373310T3/pl unknown
- 2009-12-02 ES ES09796990T patent/ES2393916T3/es active Active
- 2009-12-02 PL PL12182351T patent/PL2529735T3/pl unknown
2012
- 2012-11-30 SM SM201200057T patent/SMT201200057B/it unknown

Also Published As

Publication number	Publication date
US20120041213A1 (en)	2012-02-16
JP5395188B2 (ja)	2014-01-22
HRP20120954T1 (hr)	2012-12-31
JP2012510452A (ja)	2012-05-10
KR101290504B1 (ko)	2013-07-29
ES2506265T3 (es)	2014-10-13
RU2011127120A (ru)	2013-01-20
EP2373310B1 (en)	2012-10-10
AU2009324080A1 (en)	2010-06-10
PT2373310E (pt)	2012-12-06
DK2373310T3 (da)	2012-12-17
ES2393916T3 (es)	2013-01-02
CN102238948B (zh)	2015-03-25
RU2482116C2 (ru)	2013-05-20
EP2529735A1 (en)	2012-12-05
SMT201200057B (it)	2013-01-14
AR074454A1 (es)	2011-01-19
FR2939136A1 (fr)	2010-06-04
PL2529735T3 (pl)	2015-01-30
WO2010063773A1 (en)	2010-06-10
SI2373310T1 (sl)	2013-01-31
MX2011005479A (es)	2011-06-20
EP2529735B1 (en)	2014-06-25
CN102238948A (zh)	2011-11-09
CA2742703C (en)	2014-04-08
KR20110091583A (ko)	2011-08-11
AU2009324080B2 (en)	2012-10-04
PL2373310T3 (pl)	2013-02-28
EP2373310A1 (en)	2011-10-12
US8372879B2 (en)	2013-02-12
BRPI0916504B1 (pt)	2018-12-18
FR2939136B1 (fr)	2010-12-03
CA2742703A1 (en)	2010-06-10
BRPI0916504B8 (pt)	2019-04-02

Legal Events

Date	Code	Title	Description
2017-10-10	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-04-24	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2018-07-10	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2018-11-06	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2018-12-18	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/12/2009, OBSERVADAS AS CONDICOES LEGAIS.
2019-04-02	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/12/2009, OBSERVADAS AS CONDICOES LEGAIS. (CO) REFERENTE A RPI 2502 DE 18/12/2018,QUANTO AO ENDERECO DO DEPOSITANTE.
2023-09-26	B21F	Lapse acc. art. 78, item iv - on non-payment of the annual fees in time	Free format text: REFERENTE A 14A ANUIDADE.
2024-01-16	B24J	Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)	Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2751 DE 26-09-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

Publication	Publication Date	Title
BRPI0906186A2 (pt)	2015-09-22	composto e uso de um composto
CR20130360A (es)	2013-09-03	Compuesto heterocíclico y su uso
BRPI0920263A2 (pt)	2016-07-12	composto, uso do composto, composição, e, método
BRPI1012533A2 (pt)	2015-09-22	composto de piradazinona e uso do mesmo
BRPI1005322A2 (pt)	2019-09-24	anticorpo, composição farmacêutica e uso de pelo menos um anticorpo
BRPI0915134A2 (pt)	2016-02-16	composto, e, uso de um composto
BRPI0913086A2 (pt)	2015-08-04	Composições antimicrobianas e métodos de uso
BRPI0917535A2 (pt)	2015-11-17	uso de insulina de ação ultra rápida
BRPI0813627A2 (pt)	2014-12-23	Peptídio antimicrobiano, composições e métodos de uso
BRPI0915231A2 (pt)	2018-06-12	compostos inibidores de quinase e métodos de uso
BRPI0908792A2 (pt)	2015-07-21	Composição, e, uso de uma combinação
BRPI0916480A2 (pt)	2016-06-14	composto de fórmula geral (i) e uso de pelo menos um composto
BRPI0919942A2 (pt)	2014-12-23	Composto, composição farmacêutica, e, uso de um composto
BRPI0907562A2 (pt)	2017-05-23	composto, composição farmacêutica, e, uso de um composto
BRPI0921375A2 (pt)	2015-12-29	composto, composição farmacêutica, e, uso de um composto
BRPI0716327A2 (pt)	2014-03-04	Composto de fenilpropionamida e uso
SMT201500218B (it)	2015-10-30	Composti aril-fenil-solfonammido-cicloalchile e loro uso
BRPI0915137A2 (pt)	2016-02-16	uso de pelo menos um composto, peptídeo, e, formulação farmacêutica
BRPI0717411A2 (pt)	2013-11-12	Uso de inibidores de iap
BRPI0917579A2 (pt)	2016-10-11	composto, composição farmacêutica, métodos, e, uso de um composto
BRPI0915136A2 (pt)	2019-09-24	uso de pelo menos um composto, peptídeo, e, formulação farmacêutica
BRPI0907365A2 (pt)	2015-07-14	Composição antimicrobiana e uso
BRPI1007494A2 (pt)	2016-02-16	composto e uso do mesmo
BRPI0921879A2 (pt)	2018-10-16	composto, composição farmacêutica , e, uso de um composto
BRPI0916504A2 (pt)	2015-11-10	composto e uso de pelo menos um composto