PL2373310T3 - Nowe związki 4-(heterocykloalkilo)benzeno-1,3-diolu jako inhibitory tyrozynazy, sposób ich otrzymywania oraz zastosowanie w medycynie i w kosmetykach - Google Patents

Nowe związki 4-(heterocykloalkilo)benzeno-1,3-diolu jako inhibitory tyrozynazy, sposób ich otrzymywania oraz zastosowanie w medycynie i w kosmetykach

Info

Publication number: PL2373310T3
Authority: PL; Poland
Prior art keywords: heterocycloalkyl; cosmetics; benzene; novel; preparation
Prior art date: 2008-12-02

Application number

PL09796990T

Other languages

English (en)

Inventor

Jean-Guy Boiteau

Jean-Claude Pascal

Original Assignee

Galderma Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-12-02

Filing date

2009-12-02

Publication date

2013-02-28

2009-12-02 Application filed by Galderma Res & Dev filed Critical Galderma Res & Dev

2013-02-28 Publication of PL2373310T3 publication Critical patent/PL2373310T3/pl

Links

150000005207 1,3-dihydroxybenzenes Chemical class 0.000 title 1
102000003425 Tyrosinase Human genes 0.000 title 1
108060008724 Tyrosinase Proteins 0.000 title 1
239000002537 cosmetic Substances 0.000 title 1
239000003814 drug Substances 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D309/06—Radicals substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4986—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with sulfur as the only hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Birds (AREA)
Medicinal Chemistry (AREA)
Dermatology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Furan Compounds (AREA)
Pyrane Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PL09796990T 2008-12-02 2009-12-02 Nowe związki 4-(heterocykloalkilo)benzeno-1,3-diolu jako inhibitory tyrozynazy, sposób ich otrzymywania oraz zastosowanie w medycynie i w kosmetykach PL2373310T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
FR0858206A FR2939136B1 (fr)	2008-12-02	2008-12-02	Nouveaux composes 4-(heterocycloalkyl)-benzene-1,3-diol comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique
US20212809P	2009-01-30	2009-01-30
PCT/EP2009/066267 WO2010063773A1 (en)	2008-12-02	2009-12-02	Novel 4-(heterocycloalkyl)benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and also in cosmetics
EP09796990A EP2373310B1 (en)	2008-12-02	2009-12-02	Novel 4-(heterocycloalkyl)benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and also in cosmetics

Publications (1)

Publication Number	Publication Date
PL2373310T3 true PL2373310T3 (pl)	2013-02-28

Family

ID=40845880

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL09796990T PL2373310T3 (pl)	2008-12-02	2009-12-02	Nowe związki 4-(heterocykloalkilo)benzeno-1,3-diolu jako inhibitory tyrozynazy, sposób ich otrzymywania oraz zastosowanie w medycynie i w kosmetykach
PL12182351T PL2529735T3 (pl)	2008-12-02	2009-12-02	Kompozycje zawierające pochodne 4-(heterocykloalkilo)benzeno-1,3-diolu o działaniu hamującym enzym tyrozynazę

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL12182351T PL2529735T3 (pl)	2008-12-02	2009-12-02	Kompozycje zawierające pochodne 4-(heterocykloalkilo)benzeno-1,3-diolu o działaniu hamującym enzym tyrozynazę

Country Status (20)

Country	Link
US (1)	US8372879B2 (pl)
EP (2)	EP2529735B1 (pl)
JP (1)	JP5395188B2 (pl)
KR (1)	KR101290504B1 (pl)
CN (1)	CN102238948B (pl)
AR (1)	AR074454A1 (pl)
AU (1)	AU2009324080B2 (pl)
BR (1)	BRPI0916504B8 (pl)
CA (1)	CA2742703C (pl)
DK (1)	DK2373310T3 (pl)
ES (2)	ES2506265T3 (pl)
FR (1)	FR2939136B1 (pl)
HR (1)	HRP20120954T1 (pl)
MX (1)	MX2011005479A (pl)
PL (2)	PL2373310T3 (pl)
PT (1)	PT2373310E (pl)
RU (1)	RU2482116C2 (pl)
SI (1)	SI2373310T1 (pl)
SM (1)	SMT201200057B (pl)
WO (1)	WO2010063773A1 (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2939135B1 (fr) *	2008-12-02	2010-12-03	Galderma Res & Dev	Nouveaux composes 4-(azacycloalkyl)-benzene-1,3-diol comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique
SI2688403T1 (sl) *	2011-03-23	2017-08-31	Trevena, Inc.	Ligandi opioidnih receptorjev in metode uporabe in izdelave istega
WO2014125231A1 (fr)	2013-02-14	2014-08-21	Galderma Research & Development	Procede de synthese de composes 4-(heterocycloalkyl)-benzene-1,3-diol
WO2014139080A1 (en) *	2013-03-12	2014-09-18	Boehringer Ingelheim International Trading (Shanghai) Co., Ltd.	Novel process for the manufacture of 3-oxo-tetrahydrofuran
FR3030252B1 (fr) *	2014-12-22	2018-11-02	L'oreal	Composition aqueuse comprenant un compose 4-(heterocycloalkyl)-benzene-1,3-diol, un monoalcool en c2-c4 et un glycol
FR3030250B1 (fr) *	2014-12-22	2018-11-02	L'oreal	Composition aqueuse comprenant un compose 4-(heterocycloalkyl)-benzene-1,3-diol et un hydrotrope
FR3030249B1 (fr) *	2014-12-22	2018-11-02	L'oreal	Composition aqueuse comprenant un compose 4-(heterocycloalkyl)-benzene-1,3-diol, un polymere et un glycol
FR3030251B1 (fr) *	2014-12-22	2018-11-02	L'oreal	Composition comprenant un compose 4-(heterocycloalkyl)-benzene-1,3-diol et un solvant particulier
JP6873598B2 (ja) *	2015-12-22	2021-05-19	ロレアル	活性成分のための改善された局所送達系

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0651619B2 (ja)	1988-05-09	1994-07-06	株式会社クラレ	美白剤
FR2704428B1 (fr)	1993-04-29	1995-06-09	Oreal	Utilisation de dérivés de la résorcine substitués en position(s) 4, 4 et 5 ou 4 et 6 dans des compositions cosmétiques ou dermopharmaceutiques à action dépigmentante.
US6068834A (en) *	1994-03-04	2000-05-30	The Procter & Gamble Company	Skin lightening compositions
BR9803596A (pt) *	1997-09-23	2000-04-25	Pfizer Prod Inc	Derivados do resorcinol.
JPH11255637A (ja) *	1998-03-13	1999-09-21	Kansai Kouso Kk	チロシナーゼ活性阻害剤及び化粧料
HN2000000033A (es) *	1999-03-22	2001-02-02	Pfizer Prod Inc	Composicion de resorcinol
AU2001272904A1 (en) *	2000-09-07	2002-03-22	Wisconsin Alumni Research Foundation	Synthesis of 17f labeled fluoroalkanes
BR0113798A (pt) *	2000-09-11	2003-07-08	Pfizer Prod Inc	Derivados de resorcinol
US6852310B2 (en)	2002-08-23	2005-02-08	Unilever Home & Personal Care Usa Division Of Conopco, Inc.	Skin lightening agents, compositions and methods
US6875425B2 (en) *	2002-12-12	2005-04-05	Unilever Home & Personal Care Usa	Skin lightening agents, compositions and methods
US7300646B2 (en)	2004-02-27	2007-11-27	Unilever Home & Personal Care Usa, Division Of Conopco, Inc.	Skin lightening agents, compositions and methods
US20060210497A1 (en)	2005-03-18	2006-09-21	Unilever Home & Personal Care Usa, Division Of Conopco, Inc.	Novel resorcinol derivatives
US20060210498A1 (en)	2005-03-18	2006-09-21	Unilever Home & Personal Care Usa, Division Of Conopco, Inc.	Novel resorcinol derivatives for skin
FR2917087B1 (fr) *	2007-06-05	2012-09-21	Galderma Res & Dev	Nouveaux 4-phenyl-imidazole-2-thiones comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique.

2008
- 2008-12-02 FR FR0858206A patent/FR2939136B1/fr not_active Expired - Fee Related
2009
- 2009-12-02 DK DK09796990.1T patent/DK2373310T3/da active
- 2009-12-02 CA CA2742703A patent/CA2742703C/en active Active
- 2009-12-02 EP EP12182351.2A patent/EP2529735B1/en not_active Not-in-force
- 2009-12-02 HR HRP20120954AT patent/HRP20120954T1/hr unknown
- 2009-12-02 PT PT97969901T patent/PT2373310E/pt unknown
- 2009-12-02 KR KR1020117015284A patent/KR101290504B1/ko not_active Expired - Fee Related
- 2009-12-02 AR ARP090104649A patent/AR074454A1/es unknown
- 2009-12-02 MX MX2011005479A patent/MX2011005479A/es active IP Right Grant
- 2009-12-02 EP EP09796990A patent/EP2373310B1/en not_active Not-in-force
- 2009-12-02 WO PCT/EP2009/066267 patent/WO2010063773A1/en not_active Ceased
- 2009-12-02 RU RU2011127120/04A patent/RU2482116C2/ru active
- 2009-12-02 SI SI200930399T patent/SI2373310T1/sl unknown
- 2009-12-02 AU AU2009324080A patent/AU2009324080B2/en not_active Ceased
- 2009-12-02 ES ES12182351.2T patent/ES2506265T3/es active Active
- 2009-12-02 BR BRPI0916504A patent/BRPI0916504B8/pt not_active IP Right Cessation
- 2009-12-02 CN CN200980148286.5A patent/CN102238948B/zh not_active Expired - Fee Related
- 2009-12-02 JP JP2011538010A patent/JP5395188B2/ja not_active Expired - Fee Related
- 2009-12-02 US US13/131,161 patent/US8372879B2/en not_active Expired - Fee Related
- 2009-12-02 PL PL09796990T patent/PL2373310T3/pl unknown
- 2009-12-02 ES ES09796990T patent/ES2393916T3/es active Active
- 2009-12-02 PL PL12182351T patent/PL2529735T3/pl unknown
2012
- 2012-11-30 SM SM201200057T patent/SMT201200057B/it unknown

Also Published As

Publication number	Publication date
US20120041213A1 (en)	2012-02-16
JP5395188B2 (ja)	2014-01-22
HRP20120954T1 (hr)	2012-12-31
JP2012510452A (ja)	2012-05-10
KR101290504B1 (ko)	2013-07-29
ES2506265T3 (es)	2014-10-13
RU2011127120A (ru)	2013-01-20
EP2373310B1 (en)	2012-10-10
AU2009324080A1 (en)	2010-06-10
PT2373310E (pt)	2012-12-06
DK2373310T3 (da)	2012-12-17
ES2393916T3 (es)	2013-01-02
CN102238948B (zh)	2015-03-25
RU2482116C2 (ru)	2013-05-20
EP2529735A1 (en)	2012-12-05
SMT201200057B (it)	2013-01-14
AR074454A1 (es)	2011-01-19
FR2939136A1 (fr)	2010-06-04
PL2529735T3 (pl)	2015-01-30
WO2010063773A1 (en)	2010-06-10
SI2373310T1 (sl)	2013-01-31
MX2011005479A (es)	2011-06-20
EP2529735B1 (en)	2014-06-25
CN102238948A (zh)	2011-11-09
CA2742703C (en)	2014-04-08
KR20110091583A (ko)	2011-08-11
AU2009324080B2 (en)	2012-10-04
EP2373310A1 (en)	2011-10-12
US8372879B2 (en)	2013-02-12
BRPI0916504B1 (pt)	2018-12-18
FR2939136B1 (fr)	2010-12-03
CA2742703A1 (en)	2010-06-10
BRPI0916504B8 (pt)	2019-04-02
BRPI0916504A2 (pt)	2015-11-10

Publication	Publication Date	Title
PL2373310T3 (pl)	2013-02-28	Nowe związki 4-(heterocykloalkilo)benzeno-1,3-diolu jako inhibitory tyrozynazy, sposób ich otrzymywania oraz zastosowanie w medycynie i w kosmetykach
IL225198A (en)	2016-02-29	Aminotetrahydropyrenic Compounds, Pharmaceutical Preparations Containing Them and Their Use in the Treatment of Diabetes
IL213259A0 (en)	2011-07-31	Composition for the use to treat alzheimer's disease
HK1213552A1 (zh)	2016-07-08	经取代的苯化合物
WO2011077043A3 (fr)	2011-08-18	Derives phenoliques, et leur utilisation pharmaceutique ou cosmetique
IL207546A0 (en)	2010-12-30	Pharmaceutical composition for use in the treatment or prevention of osteoarticular diseases
HUE049886T2 (hu)	2020-10-28	Tumorspecifikus neoantigéneket tartalmazó készítmények, tumorok kezelésében történõ alkalmazásra
IL205742A (en)	2014-12-31	4 - (4-Cyano-2-Theoaryl) dihydropyrimidinones, their preparation processes, medications containing them and their use
WO2014062720A3 (en)	2014-06-19	Methods of treating cancer
WO2011060049A3 (en)	2011-10-20	Spiro-oxindole mdm2 antagonists
MX2012007161A (es)	2012-07-03	Derivados fenolicos y su uso farmaceutico o cosmetico.
PT3135672T (pt)	2020-04-02	Composições e métodos para o tratamento distúrbios de utilização de álcool, dor e outras doenças
BRPI0917661A2 (pt)	2015-12-01	produto que contém macitentan, composição farmacêutica que o contém e uso de macitentan
IL206562A0 (en)	2010-12-30	Novel catechol derivative, pharmaceutical composition containing the same, use of the catechol derivative, and use of the pharmaceutical composition
IT1391866B1 (it)	2012-01-27	Composizione iniettabile di polinucleotidi per il trattamento di patologie osteoarticolari.
BRPI0717766A2 (pt)	2013-11-12	Processo para preparar composições contendo polifenol, composição, produto alimentício, medicamento, e, produto cosmético
IL211313A0 (en)	2011-04-28	Compounds, compositions and methods for the treatment of ??-amyloid diseases and synucleinopathies
WO2009099553A3 (en)	2009-12-30	Use of kinase inhibitor in treatment of atherosclerosis
IL215840A (en)	2015-06-30	Arylsulfonamide compounds are converted into two positions 2 and 5, their pharmaceutical composition containing them and their use in the treatment of ccr3-related diseases
WO2008107092A3 (en)	2008-11-13	Use of derivatives of 4-hydroxyphenoxy acetic acid
GB2479251B (en)	2012-08-29	Cosmetic or pharmaceutical composition, in particular intended for care or for makeup
GB0822486D0 (en)	2009-01-14	Compounds for use in the treatment of pain
MX2009012712A (es)	2009-12-08	Nuevas 4-fenil-imidazol-2-tionas como inhibidores de la tirosinasa, su procedimiento de preparacion y su uso en medicina humana asi como en cosmetica.
WO2014022807A3 (en)	2014-05-30	Compositions and methods of using the compositions for plaque softening
SI2146951T1 (sl)	2011-02-28	Novi ligandi agonisti receptorjev RAR, uporaba v humani medicini in kozmetiki