BRPI0919810A8 - Compostos heterocíclicos contendo nitrogênio, sua preparação e seu uso como medicamentos antibacterianos - Google Patents

Compostos heterocíclicos contendo nitrogênio, sua preparação e seu uso como medicamentos antibacterianos

Info

Publication number
BRPI0919810A8
BRPI0919810A8 BRPI0919810A BRPI0919810A BRPI0919810A8 BR PI0919810 A8 BRPI0919810 A8 BR PI0919810A8 BR PI0919810 A BRPI0919810 A BR PI0919810A BR PI0919810 A BRPI0919810 A BR PI0919810A BR PI0919810 A8 BRPI0919810 A8 BR PI0919810A8
Authority
BR
Brazil
Prior art keywords
nitrogen
preparation
equal
antibacterial drugs
heterocyclic compounds
Prior art date
Application number
BRPI0919810A
Other languages
English (en)
Inventor
Renaud Emilie
Lampilas Maxime
Rowlands David
Ledoussal Benoit
Gourdel Marie-Edith
Pierres Camille
Kebsi Adel
Original Assignee
Novexel
Astra Zeneca Holding France S A S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40548019&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0919810(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novexel, Astra Zeneca Holding France S A S filed Critical Novexel
Publication of BRPI0919810A2 publication Critical patent/BRPI0919810A2/pt
Publication of BRPI0919810A8 publication Critical patent/BRPI0919810A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

COMPOSTOS HETEROCÍCLICOS CONTENDO NITROGÊNIO, SUA PREPARAÇÃO E SEU USO COMO MEDICAMENTOS ANTIBACTERIANOS. A invenção relaciona-se a compostos heterocíclicos contendo nitrogênio de fórmula geral (1) em que: R1 representa um radical (CH2)n-NH2, n sendo igual a 1 ou 2; R2 representa um átomo de hidrogênio; R3 e R4 formam juntos um heterociclo contendo nitrogênio com aromaticidade com 5 ápices, contendo 1, 2 ou 3 átomos de nitrogênio, substituídos nesse átomo de nitrogênio ou em um desses átomos de nitrogênio por um grupo (CH2)m-(C{O))p-Rs, m sendo igual a O, 1, 2 ou 3, p sendo igual a O ou 1 e Rs representando um grupo hidróxi, em que p é igual a 1, ou um amino, (C1-C6)alquila de grupo di-(C1- C6)alquilamino ou um heterociclo contendo nitrogênio com aromaticidade com 5 ou 6 ápices contendo 1 ou 2 átomos de nitrogênio e, se necessário, um átomo de oxigênio ou enxofre; compreende-se que quando o subgrupo (C(O))p-Rs forma um grupo carbóxi, amino, (C1-C6)alquila ou di(C1-C6) lquilamino, m é diferente de O ou 1; na forma livre ou como zwitterions e sais com bases e ácidos minerais ou orgânicos farmaceuticamente aceitáveis, a sua preparação e a seu uso como medicamentos antibacterianos.
BRPI0919810A 2008-10-03 2009-08-03 Compostos heterocíclicos contendo nitrogênio, sua preparação e seu uso como medicamentos antibacterianos BRPI0919810A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0805472A FR2936798B1 (fr) 2008-10-03 2008-10-03 Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
PCT/IB2009/006433 WO2010038115A1 (fr) 2008-10-03 2009-08-03 Nouveaux composes heterocycliques azotes, leur préparation et leur utilisation comme médicaments antibactériens

Publications (2)

Publication Number Publication Date
BRPI0919810A2 BRPI0919810A2 (pt) 2017-10-31
BRPI0919810A8 true BRPI0919810A8 (pt) 2017-12-12

Family

ID=40548019

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0919810A BRPI0919810A8 (pt) 2008-10-03 2009-08-03 Compostos heterocíclicos contendo nitrogênio, sua preparação e seu uso como medicamentos antibacterianos

Country Status (18)

Country Link
US (1) US8067435B2 (pt)
EP (2) EP2845855A1 (pt)
JP (1) JP5555240B2 (pt)
KR (1) KR20110067137A (pt)
CN (1) CN102203094B (pt)
AU (1) AU2009299511A1 (pt)
BR (1) BRPI0919810A8 (pt)
CA (1) CA2739503A1 (pt)
CL (1) CL2011000729A1 (pt)
CO (1) CO6361957A2 (pt)
EA (1) EA021799B1 (pt)
EC (1) ECSP11010946A (pt)
FR (1) FR2936798B1 (pt)
IL (1) IL212059A0 (pt)
MX (1) MX2011003573A (pt)
PE (1) PE20110845A1 (pt)
WO (1) WO2010038115A1 (pt)
ZA (1) ZA201102429B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8772490B2 (en) 2010-12-22 2014-07-08 Meiji Seika Pharma Co., Ltd. Optically active diazabicyclooctane derivatives and process for preparing the same
CA2845108C (en) 2011-08-30 2015-06-16 Wockhardt Limited 1,6-diazabicyclo[3,2,1]octan-7-one derivatives and their use in the treatment of bacterial infections
CA2846107C (en) * 2011-09-13 2016-06-21 Wockhardt Limited Nitrogen containing compounds and their use
WO2013149136A1 (en) * 2012-03-30 2013-10-03 Cubist Pharmaceuticals, Inc. ISOXAZOLE β-LACTAMASE INHIBITORS
AR090539A1 (es) * 2012-04-02 2014-11-19 Astrazeneca Ab COMPUESTOS INHIBIDORES DE b LACTAMASA
HUE046893T2 (hu) 2012-05-30 2020-04-28 Meiji Seika Pharma Co Ltd Új ß-laktamáz inhibitor és eljárás elõállítására
RU2614418C2 (ru) * 2012-08-25 2017-03-28 Вокхардт Лимитед Производные 1,6-диазабицикло[3.2.1]октан-7-она и их применение для лечения бактериальных инфекций
JP6453222B2 (ja) 2013-09-24 2019-01-16 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 ジアザビシクロオクタン誘導体の製造法とその中間体
ES2901198T3 (es) 2013-10-08 2022-03-21 Meiji Seika Pharma Co Ltd Formas cristalinas de derivado de diazabiciclooctano y procedimiento de producción de las mismas
IN2013MU03216A (pt) * 2013-10-11 2015-07-03 Wockhardt Ltd
JP6764862B2 (ja) 2014-11-17 2020-10-07 エンタシス・セラピューティックス・リミテッド 耐性細菌感染症の治療のための併用療法
MY190283A (en) 2014-12-05 2022-04-12 Meiji Seika Pharma Co Ltd Method for producing crystals of diazabicyclooctane derivative and stable lyophilized preparation
EP3075733A1 (en) * 2015-03-31 2016-10-05 Mutabilis Novel heterocyclic compounds and their use in preventing or treating bacterial infections
US10072006B2 (en) 2015-03-31 2018-09-11 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
WO2016156597A1 (en) * 2015-04-03 2016-10-06 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
KR20180051559A (ko) 2015-10-02 2018-05-16 주식회사 레고켐 바이오사이언스 베타-락타마제의 억제용 조성물 및 억제 방법
DK3512851T3 (en) 2016-09-16 2022-10-17 Entasis Therapeutics Ltd Beta-lactamase inhibitor compounds
WO2018208769A1 (en) 2017-05-08 2018-11-15 Entasis Therapeutics, Inc. Compounds and methods for treating bacterial infections
EP3604315A1 (en) * 2018-07-30 2020-02-05 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
AU2024322286A1 (en) * 2023-08-08 2026-03-26 Chengdu Tetrahedral Drug Research Co., Ltd UREA-CONTAINING TRICYCLIC β-LACTAMASE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6387928B1 (en) * 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
DE69840599D1 (de) * 1997-09-15 2009-04-09 Procter & Gamble Antimikrobielle chinolone, ihre zusammensetzungen und ihre verwendungen
FR2812635B1 (fr) * 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
DE60113450T2 (de) * 2000-12-14 2006-07-13 The Procter & Gamble Company, Cincinnati Antimikrobielle chinolone
CA2427872A1 (en) * 2000-12-14 2002-06-20 The Procter & Gamble Company Antimicrobial 2-pyridones, their compositions and uses
FR2825705B1 (fr) * 2001-06-08 2005-05-20 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens
FR2833596B1 (fr) * 2001-12-14 2005-02-18 Aventis Pharma Sa Procede de preparation de derives d'echinocandine
FR2835186B1 (fr) * 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
FR2844273B1 (fr) 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
FR2844268B1 (fr) * 2002-09-11 2004-10-22 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent
FR2844270B1 (fr) * 2002-09-11 2006-05-19 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent
US7439253B2 (en) * 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
FR2848210B1 (fr) * 2002-12-06 2007-10-19 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases
US7232833B2 (en) * 2003-03-28 2007-06-19 Novexel 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them
US7449481B2 (en) * 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
FR2914923B1 (fr) * 2007-04-12 2013-06-14 Novexel Nouveaux composes heterocycliques azotes,leur preparation et leur utilisation comme medicaments antibacteriens.
FR2937034B1 (fr) * 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens

Also Published As

Publication number Publication date
EA021799B1 (ru) 2015-09-30
CO6361957A2 (es) 2012-01-20
MX2011003573A (es) 2011-08-12
US8067435B2 (en) 2011-11-29
EP2845855A1 (fr) 2015-03-11
JP5555240B2 (ja) 2014-07-23
PE20110845A1 (es) 2011-11-17
CN102203094B (zh) 2014-04-02
ZA201102429B (en) 2012-05-30
US20100087648A1 (en) 2010-04-08
KR20110067137A (ko) 2011-06-21
FR2936798A1 (fr) 2010-04-09
EA201170522A1 (ru) 2011-12-30
CL2011000729A1 (es) 2012-07-06
EP2344499A1 (fr) 2011-07-20
AU2009299511A1 (en) 2010-04-08
WO2010038115A1 (fr) 2010-04-08
IL212059A0 (en) 2011-06-30
FR2936798B1 (fr) 2012-09-28
JP2012504593A (ja) 2012-02-23
CN102203094A (zh) 2011-09-28
CA2739503A1 (fr) 2010-04-08
BRPI0919810A2 (pt) 2017-10-31
ECSP11010946A (es) 2011-05-31

Similar Documents

Publication Publication Date Title
BRPI0919810A8 (pt) Compostos heterocíclicos contendo nitrogênio, sua preparação e seu uso como medicamentos antibacterianos
MX2011011485A (es) Sulfonamidas nematocidas.
HN2009000502A (es) DERIVADOS DE 2- ARIL-6-FENIL-IMIDAZO[ 1,2-a] PIRIDINAS SU PREPARACION Y SU APLICACION EN TERAPEUTICA
MX343596B (es) Sulfonamidas nematocidas.
BRPI1008498B8 (pt) compostos de piridazinona úteis como inibidores da fosfodiesterase 10a, composição farmacêutica, e, uso de um composto
BR112015015275A8 (pt) composto heterocíclico substituído por halogênio, antagonista do receptor de lpa, composição farmacêutica e uso
AR067757A1 (es) Derivados de imidazo[4,5-c]piridin-2-ona, composiciones farmaceuticas que los contienen, procedimiento para su preparacion y uso de los mismos como agentes antivirales.
BRPI1013821A8 (pt) piridinas substituídas como antagonistas de ccr3.
BR112015009777A2 (pt) derivado de amina ou sal do mesmo
CO6640247A2 (es) Compuesto[5.6]heterociclico o una sal farmacológicamente aceptable del mismo útil para la prevención de enfermedades asociadas con el metabolismo óseo
BR112014024279A8 (pt) Compostos heterobicíclicos como inibidores de beta-lactamase, composição farmacêutica, uso de um composto
BRPI1011657A2 (pt) derivados aminopropiônicos substituídos como inibidores de neprilisina
CO6251282A2 (es) Oxazolidinonas sustituidas y su uso
BRPI0814231B8 (pt) derivados de pleuromutilina, seu uso e composição farmacêutica
BR112013011580A2 (pt) derivados de ácido bisfenil pentanoico substituído por amino como inibidores de nep
NI200900181A (es) Nuevos compuestos heterocíclicos nitrogenados, su preparación y su utilización como medicamentos antibacterianos.
AR078278A1 (es) Antagonistas de la tiazol y oxazol hepcidina, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de anemias y enfermedades asociadas a deficiencias de hierro.
BRPI0919812A8 (pt) Combinações de compostos antibacterianos heterocíclicos hirdrogenados com outros compostos antibacterianos e o uso dos mesmos como medicamentos
NO20092224L (no) Quiniklidinderivater av (hetero)arylcykloheptankarboksylsyre som muskarinreseptorantagonister
BR112018011788A2 (pt) formas sólidas de éster etílico de ácido (2r,4s)-5-(bifenil-4-il)-4-[(3-carboxipropionil)amino]-2-metil-pentanoico, seus sais e um método de preparação
ECSP13012664A (es) Formas cristalinas de la sal clorhidrato de (4a-r,9a-s)-1-(1h-benzoimidazol-5-carbonil-2,3,4,4a,9,9a-hexahidro-1h-inden[2,1-b]piridin-6-carbonitrilo y su uso como inhibidores de hsd 1
CO2019004978A2 (es) Compuestos terapéuticos y métodos para utilizarlos
BR112018010107A2 (pt) composição farmacêutica para o tratamento ou prevenção de nash
BR112012009861A2 (pt) composto, composição farmacêutica, e, uso do composto.
BR112012007179B8 (pt) composto inibidor da di-hidro-orotato desidrogenase, e, formulação farmacêutica

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: ASTRA ZENECA HOLDING FRANCE S.A.S. (FR)

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]