BRPI0923391A2 - método para preparar uma composição de micelas poliméricas contendo medicamento. - Google Patents

método para preparar uma composição de micelas poliméricas contendo medicamento.

Info

Publication number
BRPI0923391A2
BRPI0923391A2 BRPI0923391A BRPI0923391A BRPI0923391A2 BR PI0923391 A2 BRPI0923391 A2 BR PI0923391A2 BR PI0923391 A BRPI0923391 A BR PI0923391A BR PI0923391 A BRPI0923391 A BR PI0923391A BR PI0923391 A2 BRPI0923391 A2 BR PI0923391A2
Authority
BR
Brazil
Prior art keywords
medicament
preparing
containing polymeric
polymeric micelle
micelle composition
Prior art date
Application number
BRPI0923391A
Other languages
English (en)
Inventor
Min-Hyo Seo
Sa-Won Lee
Original Assignee
Samyang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samyang Corp filed Critical Samyang Corp
Publication of BRPI0923391A2 publication Critical patent/BRPI0923391A2/pt
Publication of BRPI0923391B1 publication Critical patent/BRPI0923391B1/pt
Publication of BRPI0923391B8 publication Critical patent/BRPI0923391B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
BRPI0923391A 2008-12-26 2009-06-29 método de preparo de micelas poliméricas contendo copolímero anfifílico em bloco contendo docetaxel ou paclitaxel BRPI0923391B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20080134506 2008-12-26
KR10-2008-0134506 2008-12-26
PCT/KR2009/003521 WO2010074379A1 (en) 2008-12-26 2009-06-29 Preparation method of polymeric micelles composition containing a poorly water-soluble drug

Publications (3)

Publication Number Publication Date
BRPI0923391A2 true BRPI0923391A2 (pt) 2016-01-12
BRPI0923391B1 BRPI0923391B1 (pt) 2020-09-15
BRPI0923391B8 BRPI0923391B8 (pt) 2021-05-25

Family

ID=42078057

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0923391A BRPI0923391B8 (pt) 2008-12-26 2009-06-29 método de preparo de micelas poliméricas contendo copolímero anfifílico em bloco contendo docetaxel ou paclitaxel

Country Status (11)

Country Link
US (1) US20110251269A1 (pt)
EP (1) EP2201935B1 (pt)
JP (1) JP5543492B2 (pt)
KR (1) KR101056508B1 (pt)
CN (1) CN102264351B (pt)
AU (1) AU2009331026B2 (pt)
BR (1) BRPI0923391B8 (pt)
CA (1) CA2746983C (pt)
MX (1) MX2011006771A (pt)
RU (1) RU2478371C2 (pt)
WO (1) WO2010074379A1 (pt)

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CN103156811B (zh) * 2013-01-08 2014-08-13 北京工业大学 一种具有磷酸钙壳的两亲性聚合物载药胶束的制备方法
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CN104761710B (zh) * 2014-02-14 2016-06-29 苏州海特比奥生物技术有限公司 一种聚乙二醇单甲醚-聚乳酸嵌段共聚物及其制备方法
CN104288758B (zh) * 2014-10-22 2018-04-03 中国科学院生物物理研究所 聚乙二醇化磷脂为载体的胶束多肽疫苗
CN104887627A (zh) * 2015-05-15 2015-09-09 海南圣欣医药科技有限公司 一种共聚物在抗肿瘤药物中的应用
CN104856974A (zh) * 2015-05-15 2015-08-26 海南圣欣医药科技有限公司 一种难溶性抗肿瘤药物胶束制剂及其制法
KR101787451B1 (ko) * 2015-07-28 2017-10-19 주식회사 삼양바이오팜 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법
KR101748191B1 (ko) * 2015-07-28 2017-06-19 주식회사 삼양바이오팜 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법
KR101787453B1 (ko) * 2015-07-28 2017-10-19 주식회사 삼양바이오팜 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법
KR101787447B1 (ko) * 2015-07-28 2017-10-19 주식회사 삼양바이오팜 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법
KR101726728B1 (ko) * 2015-07-28 2017-04-14 주식회사 삼양바이오팜 고분자 담체 함유 약학 조성물의 유연물질 분석 방법
CN105232459B (zh) * 2015-09-24 2018-10-16 沈阳药科大学 一种复溶自组装的水难溶性药物聚合物胶束组合物及其制备方法
PL3641730T3 (pl) 2017-06-22 2021-08-23 SNBioScience Inc. Cząstka i kompozycja farmaceutyczna zawierająca nierozpuszczalną pochodną kamptotecyny z podwójną strukturą rdzenia i powłoki oraz sposób ich wytwarzania
CN107625730B (zh) * 2017-09-21 2019-09-17 上海凯茂生物医药有限公司 制备极窄范围的8至35nm粒径的含紫杉烷的两亲嵌段共聚物胶束组合物的方法
CN107998405B (zh) * 2017-12-14 2019-05-07 江西本草天工科技有限责任公司 包含难溶性药物的no供体型聚合胶束组合物的制备方法及应用
RU2681933C1 (ru) * 2018-11-28 2019-03-14 Федеральное государственное бюджетное учреждение "Национальный исследовательский центр "Курчатовский институт" Способ получения полимерных противоопухолевых частиц в проточном микрореакторе и лиофилизата на их основе
CN110917149A (zh) * 2018-12-26 2020-03-27 银谷制药有限责任公司 一种包载难溶性抗肿瘤药物的聚合物胶束冻干制剂
KR102184768B1 (ko) * 2018-12-31 2020-11-30 중앙대학교 산학협력단 혼합 고분자 미셀 조성물 및 이의 용도
CN114025746B (zh) * 2019-05-10 2023-08-25 福多兹制药公司 抗血栓形成剂的可注射聚合物纳米颗粒组合物及其方法
KR102539414B1 (ko) * 2019-12-31 2023-06-05 주식회사 삼양홀딩스 저분자량의 양친성 블록 공중합체를 포함하는 나노입자의 제조 방법
WO2021139215A1 (zh) * 2020-01-10 2021-07-15 中国科学院化学研究所 一种自修复或可重复使用的制品及其制备方法与应用
KR102688394B1 (ko) * 2020-12-10 2024-07-25 주식회사 삼양홀딩스 재건 시간을 단축할 수 있는 고분자 미셀 나노입자의 제조 방법

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Also Published As

Publication number Publication date
CN102264351B (zh) 2016-04-20
BRPI0923391B8 (pt) 2021-05-25
BRPI0923391B1 (pt) 2020-09-15
CN102264351A (zh) 2011-11-30
JP2012513984A (ja) 2012-06-21
US20110251269A1 (en) 2011-10-13
AU2009331026B2 (en) 2013-09-05
RU2478371C2 (ru) 2013-04-10
JP5543492B2 (ja) 2014-07-09
CA2746983A1 (en) 2010-07-01
KR101056508B1 (ko) 2011-08-12
EP2201935A1 (en) 2010-06-30
AU2009331026A1 (en) 2011-07-14
MX2011006771A (es) 2011-08-03
WO2010074379A1 (en) 2010-07-01
KR20100076862A (ko) 2010-07-06
RU2011130247A (ru) 2013-02-10
CA2746983C (en) 2014-07-15
EP2201935B1 (en) 2020-07-08

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B25D Requested change of name of applicant approved

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B25A Requested transfer of rights approved

Owner name: SAMYANG BIOPHARMACEUTICALS CORPORATION (KR)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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B06A Patent application procedure suspended [chapter 6.1 patent gazette]
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Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 15/09/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 29/06/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

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Owner name: SAMYANG BIOPHARMACEUTICALS CORPORATION (KR)

B25A Requested transfer of rights approved

Owner name: SAMYANG HOLDINGS CORPORATION (KR)

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 16A ANUIDADE.