BRPI1006160A2 - "método para gerar um composto de molécula pequena que pode alterar a atividade de uma proteína alvo, e, composto de molécula pequena." - Google Patents
"método para gerar um composto de molécula pequena que pode alterar a atividade de uma proteína alvo, e, composto de molécula pequena."Info
- Publication number
- BRPI1006160A2 BRPI1006160A2 BRPI1006160A BRPI1006160A BRPI1006160A2 BR PI1006160 A2 BRPI1006160 A2 BR PI1006160A2 BR PI1006160 A BRPI1006160 A BR PI1006160A BR PI1006160 A BRPI1006160 A BR PI1006160A BR PI1006160 A2 BRPI1006160 A2 BR PI1006160A2
- Authority
- BR
- Brazil
- Prior art keywords
- small molecule
- molecule compound
- alter
- activity
- generating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
- G16B15/20—Protein or domain folding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/50—Molecular design, e.g. of drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C99/00—Subject matter not provided for in other groups of this subclass
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Medicinal Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Theoretical Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Computing Systems (AREA)
- Evolutionary Biology (AREA)
- Food Science & Technology (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0900425.0A GB0900425D0 (en) | 2009-01-12 | 2009-01-12 | Biological products |
| PCT/GB2010/000040 WO2010079345A2 (en) | 2009-01-12 | 2010-01-12 | Antibody-guided fragment growth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1006160A2 true BRPI1006160A2 (pt) | 2016-02-23 |
Family
ID=40379445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1006160A BRPI1006160A2 (pt) | 2009-01-12 | 2010-01-12 | "método para gerar um composto de molécula pequena que pode alterar a atividade de uma proteína alvo, e, composto de molécula pequena." |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20110275857A1 (pt) |
| EP (1) | EP2386063A2 (pt) |
| JP (1) | JP2012515330A (pt) |
| CN (1) | CN102272605A (pt) |
| BR (1) | BRPI1006160A2 (pt) |
| CA (1) | CA2748928A1 (pt) |
| EA (1) | EA201101059A1 (pt) |
| GB (1) | GB0900425D0 (pt) |
| SG (1) | SG172816A1 (pt) |
| WO (1) | WO2010079345A2 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201103631D0 (en) * | 2011-03-03 | 2011-04-13 | Univ Leeds | Identification of candidate therapeutics |
| US10112988B2 (en) | 2012-01-09 | 2018-10-30 | Icb International, Inc. | Methods of assessing amyloid-beta peptides in the central nervous system by blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an anti-amyloid-beta peptide |
| US10112987B2 (en) * | 2012-01-09 | 2018-10-30 | Icb International, Inc. | Blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an amyloid-beta peptide |
| EP2834868B1 (en) | 2012-04-02 | 2023-12-27 | Hydrogenics Corporation | Fuel cell start up method |
| WO2015073971A1 (en) | 2013-11-15 | 2015-05-21 | InfiniteBio | Computer-assisted modeling for treatment design |
| JP7234690B2 (ja) * | 2019-02-27 | 2023-03-08 | 富士通株式会社 | 化合物探索方法、化合物探索装置、及び化合物探索プログラム |
| CN109994150B (zh) * | 2019-03-12 | 2022-11-01 | 华东师范大学 | 一种显性表示蛋白口袋表层原子与配体相互作用满足程度的方法 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4940670A (en) * | 1986-01-24 | 1990-07-10 | Rhodes Buck A | Method for compounding and testing patient specific monoclonal antibodies and monoclonal antibody fragments for in vivo use |
| DE68927933T2 (de) | 1988-09-02 | 1997-08-14 | Dyax Corp | Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| AU7247191A (en) | 1990-01-11 | 1991-08-05 | Molecular Affinities Corporation | Production of antibodies using gene libraries |
| US5780225A (en) | 1990-01-12 | 1998-07-14 | Stratagene | Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules |
| EP1690935A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| CA2090126C (en) | 1990-08-02 | 2002-10-22 | John W. Schrader | Methods for the production of proteins with a desired function |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
| DE69129154T2 (de) | 1990-12-03 | 1998-08-20 | Genentech, Inc., South San Francisco, Calif. | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
| PT100379B (pt) | 1991-04-10 | 1999-01-29 | Scripps Research Inst | Bibliotecas de receptores heterodimericos usando fagomideos |
| GB9113120D0 (en) | 1991-06-18 | 1991-08-07 | Kodak Ltd | Photographic processing apparatus |
| PT1024191E (pt) | 1991-12-02 | 2008-12-22 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| JPH09506262A (ja) | 1993-12-08 | 1997-06-24 | ジェンザイム・コーポレイション | 特異的抗体の製造方法 |
| ES2201097T3 (es) | 1994-01-31 | 2004-03-16 | Trustees Of Boston University | Bibliotecas de anticuerpos policlonales. |
| US5516637A (en) | 1994-06-10 | 1996-05-14 | Dade International Inc. | Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage |
| US5463564A (en) * | 1994-09-16 | 1995-10-31 | 3-Dimensional Pharmaceuticals, Inc. | System and method of automatically generating chemical compounds with desired properties |
| CZ206097A3 (cs) | 1995-10-30 | 1999-02-17 | Smithkline Beecham Corporation | Způsob inhibice kathepsinu K |
| JP2978435B2 (ja) | 1996-01-24 | 1999-11-15 | チッソ株式会社 | アクリロキシプロピルシランの製造方法 |
| ATE374248T1 (de) | 1996-06-27 | 2007-10-15 | Vlaams Interuniv Inst Biotech | Antikörpermoleküle, die spezifisch mit dem aktiven zentrum oder dem aktiven spalt eines zielmoleküls interagieren |
| US6613575B1 (en) * | 1998-03-27 | 2003-09-02 | Ole Hindsgaul | Methods for screening compound libraries |
| US6818396B1 (en) * | 2000-11-28 | 2004-11-16 | Proteus S.A. | Process for determination of the activity of a substance using an in vitro functional test |
| EP1456410A2 (en) | 2001-12-11 | 2004-09-15 | AlgoNomics N.V. | Method for displaying loops from immunoglobulin domains in different contexts |
| US6947847B2 (en) * | 2002-03-08 | 2005-09-20 | Wisconsin Alumni Research Foundation | Method to design therapeutically important compounds |
| CN100479859C (zh) * | 2002-03-20 | 2009-04-22 | 厦门大学 | 一种针对靶的空间变构现象筛选可抑制和/或激活所述靶生物活性的物质的方法 |
| EP1572950B1 (en) * | 2002-06-17 | 2012-10-10 | Thrasos, Inc. | Single domain tdf-related compounds and analogs thereof |
| WO2004051268A1 (en) | 2002-12-03 | 2004-06-17 | Celltech R & D Limited | Assay for identifying antibody producing cells |
| GB0312481D0 (en) | 2003-05-30 | 2003-07-09 | Celltech R&D Ltd | Antibodies |
| GB0315450D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| PT1644412E (pt) | 2003-07-01 | 2015-12-23 | Ucb Biopharma Sprl | Fragmentos de anticorpos fab modificados |
| GB0315457D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| DK1675961T3 (da) * | 2003-10-24 | 2009-02-23 | Oncalis Ag | Fremgangsmåde til identifikation og/eller validering af receptortyrosinkinaseinhibitorer |
| GB0411186D0 (en) | 2004-05-19 | 2004-06-23 | Celltech R&D Ltd | Biological products |
| US7498419B2 (en) | 2004-10-14 | 2009-03-03 | Washington University | Crystals and structure of domain III of West Nile Virus envelope protein in association with a Fab fragment of a neutralizing antibody |
| CN101415415A (zh) * | 2006-01-23 | 2009-04-22 | 约瑟夫·P·埃里科 | 定向药物开发的方法和组合物 |
-
2009
- 2009-01-12 GB GBGB0900425.0A patent/GB0900425D0/en not_active Ceased
-
2010
- 2010-01-12 US US13/143,747 patent/US20110275857A1/en not_active Abandoned
- 2010-01-12 BR BRPI1006160A patent/BRPI1006160A2/pt not_active IP Right Cessation
- 2010-01-12 EA EA201101059A patent/EA201101059A1/ru unknown
- 2010-01-12 SG SG2011047990A patent/SG172816A1/en unknown
- 2010-01-12 EP EP10725227A patent/EP2386063A2/en not_active Withdrawn
- 2010-01-12 CN CN2010800042818A patent/CN102272605A/zh active Pending
- 2010-01-12 CA CA2748928A patent/CA2748928A1/en not_active Abandoned
- 2010-01-12 WO PCT/GB2010/000040 patent/WO2010079345A2/en not_active Ceased
- 2010-01-12 JP JP2011544922A patent/JP2012515330A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010079345A3 (en) | 2010-11-25 |
| SG172816A1 (en) | 2011-08-29 |
| GB0900425D0 (en) | 2009-02-11 |
| US20110275857A1 (en) | 2011-11-10 |
| WO2010079345A2 (en) | 2010-07-15 |
| EA201101059A1 (ru) | 2012-02-28 |
| JP2012515330A (ja) | 2012-07-05 |
| EP2386063A2 (en) | 2011-11-16 |
| CA2748928A1 (en) | 2010-07-15 |
| CN102272605A (zh) | 2011-12-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0807756A2 (pt) | Método para produzir um l-aminoácido. | |
| BRPI0812639A2 (pt) | Aparelho para restringir o movimento de um animal para dentro para fora de uma área definida | |
| BRPI0915382A2 (pt) | composto, composição farmacêutica, e, método para tratar uma doença ou um distúrbio. | |
| CL2007001040A1 (es) | Proceso para la preparacion de antagonista de la sustancia p derivado de acil-amino-alquilen-amida. | |
| BRPI0912539A2 (pt) | composto, composição farmacêutica , método para tratar uma doença, e, uso do composto. | |
| BRPI0813311A2 (pt) | Composto, métodos para modulara a atividade de uma proteína quinase e para tratar câncer em um indivíduo, e, composição farmacêutica. | |
| CL2014000012A1 (es) | Composicion fungicida que comprende derivados de metilpiridina y al menos un fungicida seleccionado del grupo que esta compuesto de bixafen, fluxapiroxad, penflufen, isopirazam, fluopiram, ametoctradin, fenpirazamina y sedaxan; metodo para controlar enfermedades de plantas. | |
| BR112012004333A2 (pt) | composto, composição farmacêutica, e, método para o tratamento ou a prevenção de uma doença ou um distúrbio. | |
| BR112012002608A2 (pt) | composição lubrificante, e, método para melhorar o desempenho de uma composição lubrificante. | |
| BRPI0822756A2 (pt) | sistema de prótese de válvula cardíaca e processo para produzir prótese de válvula cardíaca. | |
| CL2007003849A1 (es) | Compuestos derivados de nafto[c]pirrol sustituidos con aminoacidos, utiles para tratar el cancer. | |
| SMP200900085B (it) | 3-imidazolil-indoli per il trattamento di malattieproliferative. | |
| CL2008000691A1 (es) | Compuestos derivados de dihidro y tetrahidro oxazolopirimidinonas sustituidas; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento de la esquizofrenia, epilepsia, entre otras enfermedades. | |
| BRPI0810710A2 (pt) | Método para estabilização de uma proteína. | |
| BRPI0912446A2 (pt) | "borrifador para líquidos" | |
| BRPI0816784A2 (pt) | Fatores neuro-endócrinos para o tratamento de doenças degenerativas | |
| BR112012003464A2 (pt) | composto, composição farmacêutica, usos de uma composição farmacêutica e de um composto, e, método para tratar uma doença ou um distúrbio." | |
| BRPI0911577A2 (pt) | derivados espiro-indol para o tratamento de doenças parasíticas. | |
| BRPI1013396A2 (pt) | composto, produto farmacêutico de combinação, uso de um composto, método para tratar uma doença ou condição, e, processo para a preparação de um composto. | |
| BRPI0815591A2 (pt) | Composto, composição farmacêutica, uso de um composto, e, método para tratar uma doença, condição ou distúrbio. | |
| EA201000258A1 (ru) | Новые гербициды | |
| BR112013029658A2 (pt) | "composição aquosa de revestimento, métodos para formar uma composição aquosa de revestimento, e para prover um revestimento, e, revestimento." | |
| BRPI0808081B8 (pt) | composição adjuvante, solução aquosa agroquímica para pulverização, e, método para pulverizar um produto agroquímico | |
| BRPI1010300A2 (pt) | processos para a preparação de um composto, para perparar dronedarone, ou um sal do mesmo, e para preparar uma formulação farmacêutica. | |
| BRPI0923856A2 (pt) | composto, composição farmacêutica, uso de um composto, e método para tratar uma doença ou distúrbio. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |