BRPI1007325A2 - "baixo peso molecular de polissulfatados derivados de ácido hialurônico e medicamentos que contenham o mesmo." - Google Patents

"baixo peso molecular de polissulfatados derivados de ácido hialurônico e medicamentos que contenham o mesmo."

Info

Publication number: BRPI1007325A2
Authority: BR; Brazil
Prior art keywords: hyaluronic acid; molecular weight; low molecular; drugs containing; polysulfated
Prior art date: 2009-02-02

Application number

BRPI1007325A

Other languages

English (en)

Inventor

Azuma Atsushi

Goto Fumitaka

Asai Hiroaki

Takaba Junji

Kakehi Kazuaki

Izumi Kazunari

Nishida Masaru

Kashimoto Minoru

Hayashi Naohiro

Nakazato Satoru

Shimizu Satoshi

Tomoyasu Takahiro

Taki Takao

Hayashi Takashi

Hirano Wakako

Koga Yasuo

Sakamoto Yoko

Kato Yusuke

Original Assignee

Otsuka Pharma Co Ltd

Otsuka Chemical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-02-02

Filing date

2010-02-01

Publication date

2019-09-24

2010-02-01 Application filed by Otsuka Pharma Co Ltd, Otsuka Chemical Co Ltd filed Critical Otsuka Pharma Co Ltd

2019-09-24 Publication of BRPI1007325A2 publication Critical patent/BRPI1007325A2/pt

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title 2
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
229920002674 hyaluronan Polymers 0.000 title 1
229960003160 hyaluronic acid Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Polymers & Plastics (AREA)
Materials Engineering (AREA)
Epidemiology (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
Otolaryngology (AREA)
Crystallography & Structural Chemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Saccharide Compounds (AREA)

BRPI1007325A 2009-02-02 2010-02-01 "baixo peso molecular de polissulfatados derivados de ácido hialurônico e medicamentos que contenham o mesmo." BRPI1007325A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2009021820		2009-02-02
PCT/JP2010/000583 WO2010087207A1 (ja)	2009-02-02	2010-02-01	低分子量多硫酸化ヒアルロン酸誘導体及びこれを含有する医薬

Publications (1)

Publication Number	Publication Date
BRPI1007325A2 true BRPI1007325A2 (pt)	2019-09-24

Family

ID=42395469

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1007325A BRPI1007325A2 (pt)	2009-02-02	2010-02-01	"baixo peso molecular de polissulfatados derivados de ácido hialurônico e medicamentos que contenham o mesmo."

Country Status (19)

Country	Link
US (1)	US8993536B2 (pt)
EP (1)	EP2392579B1 (pt)
JP (2)	JP4884559B2 (pt)
KR (1)	KR101678429B1 (pt)
CN (1)	CN102300870B (pt)
AR (1)	AR075224A1 (pt)
BR (1)	BRPI1007325A2 (pt)
CA (1)	CA2750188C (pt)
CO (1)	CO6362026A2 (pt)
ES (1)	ES2610240T3 (pt)
IL (1)	IL213323A (pt)
MX (1)	MX2011008119A (pt)
MY (1)	MY160359A (pt)
NZ (1)	NZ594854A (pt)
RU (1)	RU2519781C2 (pt)
SG (2)	SG173470A1 (pt)
TW (1)	TWI539955B (pt)
UA (1)	UA105781C2 (pt)
WO (1)	WO2010087207A1 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5758797B2 (ja)	2008-04-04	2015-08-05	ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション	アルキル化半合成グリコサミノグリカンエーテルならびにその製造および使用方法
EP2397484A1 (en) *	2010-06-11	2011-12-21	Immunovo B.V.	Trisaccharide derivates, and their use as adjuvants
JP2012046511A (ja) *	2010-07-30	2012-03-08	Otsuka Chem Co Ltd	低分子量多硫酸化ヒアルロン酸誘導体を含有する医薬
US9522162B2 (en)	2011-03-23	2016-12-20	University Of Utah Research Foundation	Methods for treating or preventing urological inflammation
JP5871500B2 (ja) *	2011-06-20	2016-03-01	公益財団法人先端医療振興財団	α−Ｋｌｏｔｈｏ／ＦＧＦ２３複合体形成阻害化合物
JP6273199B2 (ja) *	2012-03-22	2018-01-31	大塚製薬株式会社	オリゴ糖化合物及びその製造方法とその中間体
CN102579478A (zh) *	2012-03-30	2012-07-18	济南康众医药科技开发有限公司	玻璃酸钠在制备药物中的应用
JP2014047155A (ja) *	2012-08-30	2014-03-17	Tottori Univ	保護硫酸化オリゴ糖化合物及びその製造方法
SE538503C2 (en)	2014-11-11	2016-08-16	Tx Medic Ab	New dextran sulfate
ITUB20155623A1 (it) *	2015-11-16	2017-05-16	Fidia Farm Spa	Processo migliorato per la produzione di HA solfatato di elevata purezza
JP6225321B1 (ja)	2016-08-31	2017-11-08	王子ホールディングス株式会社	ポリ硫酸ペントサンの製造方法
CN111148749A (zh)	2016-08-31	2020-05-12	王子控股株式会社	酸性低聚木糖的生产方法和酸性低聚木糖
US11337994B2 (en)	2016-09-15	2022-05-24	University Of Utah Research Foundation	In situ gelling compositions for the treatment or prevention of inflammation and tissue damage
JP6281659B1 (ja)	2017-02-28	2018-02-21	王子ホールディングス株式会社	ポリ硫酸ペントサン、医薬組成物及び抗凝固剤
US11903963B2 (en)	2017-03-10	2024-02-20	The University Of North Carolina At Chapel Hill	Short-acting heparin-based anticoagulant compounds and methods
BR112019025030A2 (pt)	2017-05-31	2020-06-16	Oji Holdings Corporation	Preparação umidificante tópica.
WO2019010216A1 (en)	2017-07-03	2019-01-10	The University Of North Carolina At Chapel Hill	ENZYMATIC SYNTHESIS OF HOMOGENEOUS CHONDROITIN SULFATE OLIGOSACCHARIDES
CA3075485C (en)	2017-09-12	2025-07-08	Oji Holdings Corporation	PENTOSANE POLYSULFATE AND PROCESS FOR THE PRODUCTION OF PENTOSANE POLYSULFATE
EP3691653B1 (en)	2017-11-03	2025-03-12	The University Of North Carolina At Chapel Hill	Sulfated oligosaccharides having anti-inflammatory activity
MX2020006605A (es)	2017-12-20	2020-09-10	Oji Holdings Corp	Polisulfato de pentosano y medicamento que contiene polisulfato de pentosano.
EP3810152A4 (en) *	2018-06-20	2022-04-27	The University of North Carolina at Chapel Hill	CELL PROTECTION METHODS AND COMPOSITIONS
CN111228653A (zh)	2018-11-13	2020-06-05	格莱科米拉治疗公司	用电离辐射加强癌症治疗的方法
EP4041251A4 (en)	2019-11-13	2023-11-29	The University of North Carolina at Chapel Hill	Heparan sulfate (hs) oligosaccharides effect in liver ischemia reperfusion injury
KR20250083499A (ko)	2022-09-29	2025-06-10	아도라 애니멀 헬스 코포레이션	통증 및 다른 의학적 병태의 치료를 위한 황화 글리코사미노글리칸 및 이것에서 유래한 단편의 저장에 안정한 제형

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH08277224A (ja)	1995-02-07	1996-10-22	Shiseido Co Ltd	抗炎症剤
EP0754460B1 (en)	1995-02-07	2002-06-05	Shiseido Company Limited	Antiinflammatory agents
JPH10195107A (ja) *	1997-01-10	1998-07-28	Shiseido Co Ltd	オリゴ硫酸化ヒアルロン酸
JPH11147901A (ja)	1997-11-19	1999-06-02	Maruho Co Ltd	カリクレイン−キニン系阻害剤
JPH11269077A (ja) *	1998-03-19	1999-10-05	Maruho Co Ltd	ホスホリパーゼａ２阻害用医薬組成物
US6689748B1 (en) *	1998-04-08	2004-02-10	Theoharis C. Theoharides	Method of treating mast cell activation-induced diseases with a proteoglycan
JPH11335288A (ja)	1998-05-20	1999-12-07	Maruho Co Ltd	アレルギー性疾患の予防または治療薬
WO2000069917A1 (fr)	1999-05-18	2000-11-23	Maruho Kabushikikaisha	Compositions medicinales destinees a inhiber le systeme kallikreine-kinine ou la phospholipase a¿2?
JP2004059506A (ja) *	2002-07-29	2004-02-26	Taisho Pharmaceut Co Ltd	セレクチン及びケモカインに作用する過硫酸化オリゴ糖
FR2845686B1 (fr) *	2002-10-10	2013-08-30	Aventis Pharma Sa	Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
US20040171819A1 (en)	2002-10-10	2004-09-02	Aventis Pharma S.A.	Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
PL1778709T3 (pl) *	2004-08-05	2008-10-31	Ivax Drug Res Institute Ltd	Polisiarczany glikozydów i ich sole

2010
- 2010-02-01 US US13/143,129 patent/US8993536B2/en active Active
- 2010-02-01 ES ES10735677.6T patent/ES2610240T3/es active Active
- 2010-02-01 KR KR1020117017561A patent/KR101678429B1/ko not_active Expired - Fee Related
- 2010-02-01 RU RU2011136250/04A patent/RU2519781C2/ru not_active IP Right Cessation
- 2010-02-01 UA UAA201110592A patent/UA105781C2/uk unknown
- 2010-02-01 NZ NZ594854A patent/NZ594854A/xx unknown
- 2010-02-01 SG SG2011054913A patent/SG173470A1/en unknown
- 2010-02-01 CA CA2750188A patent/CA2750188C/en active Active
- 2010-02-01 MX MX2011008119A patent/MX2011008119A/es active IP Right Grant
- 2010-02-01 EP EP10735677.6A patent/EP2392579B1/en active Active
- 2010-02-01 BR BRPI1007325A patent/BRPI1007325A2/pt not_active IP Right Cessation
- 2010-02-01 WO PCT/JP2010/000583 patent/WO2010087207A1/ja not_active Ceased
- 2010-02-01 MY MYPI2011003178A patent/MY160359A/en unknown
- 2010-02-01 SG SG2014006985A patent/SG2014006985A/en unknown
- 2010-02-01 JP JP2010539078A patent/JP4884559B2/ja active Active
- 2010-02-01 CN CN201080005887.3A patent/CN102300870B/zh active Active
- 2010-02-02 AR ARP100100285A patent/AR075224A1/es unknown
- 2010-02-02 TW TW099103059A patent/TWI539955B/zh not_active IP Right Cessation
2011
- 2011-03-14 JP JP2011055681A patent/JP5554738B2/ja active Active
- 2011-06-02 IL IL213323A patent/IL213323A/en not_active IP Right Cessation
- 2011-07-21 CO CO11090783A patent/CO6362026A2/es active IP Right Grant

Also Published As

Publication number	Publication date
RU2519781C2 (ru)	2014-06-20
EP2392579B1 (en)	2016-11-23
JPWO2010087207A1 (ja)	2012-08-02
ES2610240T3 (es)	2017-04-26
JP5554738B2 (ja)	2014-07-23
CO6362026A2 (es)	2012-01-20
US8993536B2 (en)	2015-03-31
CA2750188A1 (en)	2010-08-05
IL213323A0 (en)	2011-07-31
NZ594854A (en)	2013-03-28
SG2014006985A (en)	2014-04-28
UA105781C2 (uk)	2014-06-25
SG173470A1 (en)	2011-09-29
MX2011008119A (es)	2011-08-24
AU2010209200A1 (en)	2011-06-30
CA2750188C (en)	2016-11-29
TWI539955B (zh)	2016-07-01
TW201032814A (en)	2010-09-16
JP2011168591A (ja)	2011-09-01
HK1159642A1 (en)	2012-08-03
JP4884559B2 (ja)	2012-02-29
EP2392579A1 (en)	2011-12-07
EP2392579A4 (en)	2012-09-26
WO2010087207A1 (ja)	2010-08-05
US20110281819A1 (en)	2011-11-17
KR101678429B1 (ko)	2016-11-22
RU2011136250A (ru)	2013-03-10
CN102300870A (zh)	2011-12-28
AR075224A1 (es)	2011-03-16
KR20110117118A (ko)	2011-10-26
IL213323A (en)	2014-12-31
CN102300870B (zh)	2014-12-03
MY160359A (en)	2017-02-28

Legal Events

Date	Code	Title	Description
2019-10-01	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2020-01-21	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

Publication	Publication Date	Title
BRPI1007325A2 (pt)	2019-09-24	"baixo peso molecular de polissulfatados derivados de ácido hialurônico e medicamentos que contenham o mesmo."
IT1398195B1 (it)	2013-02-14	"procedimento e sistema per la distribuzione di contenuti informativi, relativo prodotto informatico"
EP2132133A4 (en)	2013-04-17	RELEASE OF PARTICULATE ACTIVE SUBSTANCES
EP2265283A4 (en)	2012-04-25	Auristatin-DRUG-LINKER CONJUGATES
BRPI0810439A2 (pt)	2014-10-07	Formulações farmacêuticas contendo derivados de ácido lipóico
BRPI1010761A2 (pt)	2016-03-22	"composições semi-sólidas e produtos farmacêuticos"
BRPI0818604A2 (pt)	2015-04-22	Sistema de empacotamento com uma sobretampa
BRPI1011876A2 (pt)	2015-09-22	"composição farmacêutica estável e métodos de uso da mesma"
BRPI0908021A2 (pt)	2015-07-21	Composto, composição farmacêutica, e, usos do composto ou da composição farmacêutica
EP2474522A4 (en)	2013-03-20	AGOME ELITE AND PHARMACEUTICAL COMPOSITIONS THEREOF
BRPI0917661A2 (pt)	2015-12-01	produto que contém macitentan, composição farmacêutica que o contém e uso de macitentan
CR10229A (es)	2008-11-26	Derivados de 1,2,4,5,-tetrahidro-3h-benzazepinas, su procedimiento de preparación y las composiciones farmacéuticas que las contienen
BRPI1006040A2 (pt)	2016-05-10	uso de composições farmacêuticas, tipo de curativo médico, e, tipo de caixa de medicamento
BRPI0918206A2 (pt)	2015-12-08	derivados de animoéster e composição medicinal destes
EP2258426A4 (en)	2013-09-04	DRUGS CONTAINER
BRPI0916571A2 (pt)	2015-11-10	composto derivado de alquilaminometiloxazolidinona tricíclo, medicamento e composição farmacêutica que o contém e uso do composto
FR2943253B1 (fr)	2011-04-22	Composition contenant l'association de madecassoside, d'une arginine et de polysorbate
FR2939766B1 (fr)	2011-01-14	Pylone central d'aeronef.
BRPI0822782A2 (pt)	2015-09-29	composição farmacêutica que compreende rosuvastatina
EP2327406A4 (en)	2014-04-09	STABILIZED PHARMACEUTICAL COMPOSITION
SMT201400151B (it)	2015-01-15	Derivati diterpenoidi dotati di proprieta'biologiche
CY1112501T1 (el)	2015-12-09	Φαρμακευτικες συνθεσεις περιεχουσες λεφλουνομιδη
BRPI1010981A2 (pt)	2018-12-04	"derivados de fármaco redox"
BRPI0913709A2 (pt)	2015-10-13	"formulação farmacêutica"
BRPI0717453A2 (pt)	2013-12-24	Derivados indólicos, o respectivo processo de preparo e as composições farmacêuticas que os contêm