BRPI1009299A2 - derivado de fosfluconazol, sua composição farmacêutica, seu uso, seu processo de preparação, compostos intermediários, uso, método para melhorar o caráter lipofílico de fluconazol e método para prolongar a liberação de fluconazol - Google Patents

derivado de fosfluconazol, sua composição farmacêutica, seu uso, seu processo de preparação, compostos intermediários, uso, método para melhorar o caráter lipofílico de fluconazol e método para prolongar a liberação de fluconazol

Info

Publication number: BRPI1009299A2
Authority: BR; Brazil
Prior art keywords: fluconazole; phosfluconazole; prolonging; derivative; improving
Prior art date: 2009-03-19

Application number

BRPI1009299A

Other languages

English (en)

Inventor

Jody Firmin Marceline Voorspoels

Yves Rene Johanna Paul Gonnissen

Original Assignee

Seps Pharma N V

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-03-19

Filing date

2010-03-03

Publication date

2016-03-08

2009-03-19 Priority claimed from GB0904706A external-priority patent/GB0904706D0/en

2010-03-03 Application filed by Seps Pharma N V filed Critical Seps Pharma N V

2016-03-08 Publication of BRPI1009299A2 publication Critical patent/BRPI1009299A2/pt

Links

RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 title 2
229960004884 fluconazole Drugs 0.000 title 2
238000000034 method Methods 0.000 title 2
GHJWNRRCRIGGIO-UHFFFAOYSA-N Fosfluconazole Chemical class C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(OP(O)(=O)O)CN1C=NC=N1 GHJWNRRCRIGGIO-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
- C07F9/6518—Five-membered rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BRPI1009299A 2009-03-19 2010-03-03 derivado de fosfluconazol, sua composição farmacêutica, seu uso, seu processo de preparação, compostos intermediários, uso, método para melhorar o caráter lipofílico de fluconazol e método para prolongar a liberação de fluconazol BRPI1009299A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0904706A GB0904706D0 (en)	2009-03-19	2009-03-19	Phosphonyl-containing tertiary alcoholic derivatives useful as medicaments
EP09174129		2009-10-27
PCT/EP2010/052719 WO2010105910A1 (en)	2009-03-19	2010-03-03	Fosfluconazole derivatives, synthesis, and use in long acting formulations

Publications (1)

Publication Number	Publication Date
BRPI1009299A2 true BRPI1009299A2 (pt)	2016-03-08

Family

ID=42235661

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1009299A BRPI1009299A2 (pt)	2009-03-19	2010-03-03	derivado de fosfluconazol, sua composição farmacêutica, seu uso, seu processo de preparação, compostos intermediários, uso, método para melhorar o caráter lipofílico de fluconazol e método para prolongar a liberação de fluconazol

Country Status (9)

Country	Link
US (1)	US20120172336A2 (pt)
EP (1)	EP2408791A1 (pt)
JP (1)	JP2012520840A (pt)
CN (1)	CN102439018A (pt)
AU (1)	AU2010225035A1 (pt)
BR (1)	BRPI1009299A2 (pt)
CA (1)	CA2754168A1 (pt)
RU (1)	RU2011142154A (pt)
WO (1)	WO2010105910A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8746159B2 (en) *	2011-03-25	2014-06-10	Deere & Company	Metering member for a seed meter
CN103864844B (zh) *	2012-12-09	2016-10-05	正大天晴药业集团股份有限公司	一种福司氟康唑的制备方法
CN104211731B (zh) *	2013-06-01	2017-05-17	陕西合成药业股份有限公司	一种制备高纯度伏立康唑磷酸酯的方法
JP2017505778A (ja) *	2014-01-29	2017-02-23	ヒューメディックスカンパニー，リミテッド	ペグ化７−デヒドロコレステロール誘導体
CN103877031A (zh) *	2014-02-21	2014-06-25	安徽省先锋制药有限公司	一种常温稳定的福司氟康唑冻干制剂组合物及其制备方法
CN106279280A (zh) *	2015-05-25	2017-01-04	西藏卫信康医药股份有限公司	一种化合物及其制备方法和应用
CN106432337A (zh) *	2015-08-08	2017-02-22	陕西合成药业股份有限公司	福沙匹坦衍生物、合成和在长效制剂中的用途
CN106432338A (zh) *	2015-08-08	2017-02-22	陕西合成药业股份有限公司	泊沙康唑衍生物、合成和在长效制剂中的用途
CN106432339A (zh) *	2015-08-08	2017-02-22	陕西合成药业股份有限公司	伏立康唑衍生物、合成和在长效制剂中的用途
CN106546668A (zh) *	2015-09-22	2017-03-29	陕西合成药业股份有限公司	一种分离福司氟康唑或其药用盐有关物质的hplc方法
CN105753902B (zh) *	2016-04-11	2017-08-25	浙江诚意药业股份有限公司	一种福司氟康唑的制备方法
CN112979704A (zh) *	2021-03-09	2021-06-18	重庆西米瑞医药技术有限公司	一种伏立康唑磷酸胆碱酯内盐关键中间体及其制备方法
CN113004328A (zh) *	2021-03-09	2021-06-22	重庆西米瑞医药技术有限公司	伏立康唑磷酸胆碱酯内盐中间体、制备方法及制备伏立康唑磷酸胆碱酯内盐的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3106497A1 (de) *	1981-02-21	1982-09-09	Bayer Ag, 5090 Leverkusen	Cyanoalkylphosphorsaeureesterchloride und ein verfahren zu ihrer herstellung
JPS62108886A (ja) *	1985-11-06	1987-05-20	Hidetoshi Tsuchida	リン脂質誘導体
JPH04505005A (ja) *	1989-02-23	1992-09-03	ユニバーシティカレッジロンドン	ヌクレオシド類縁体
FR2679255B1 (fr) *	1991-07-17	1993-10-22	Bio Merieux	Procede d'immobilisation d'un fragment nucleique par fixation passive sur un support solide, support solide ainsi obtenu et son utilisation.
GB9521234D0 (en) *	1995-10-16	1995-12-20	Biocompatibles Ltd	Synthesis of polymerisable phospho diesters
US6657052B1 (en) *	1997-04-11	2003-12-02	University Of Arkansas	Biomolecular labeling
US7868162B2 (en) *	1998-12-30	2011-01-11	Lakewood-Amedex, Inc.	Antimicrobial and antiviral compounds and methods for their use
EP1646284A4 (en) *	2003-07-18	2008-09-24	Rhode Island Education	AZOL DERIVATIVES AND METHOD FOR THEIR PREPARATION
US20060063147A1 (en) *	2004-09-21	2006-03-23	Chernov Boris K	Omega-amino-PEG-phosphoramidites and conjugates thereof
US9637515B2 (en) *	2006-11-06	2017-05-02	Jina Pharmaceuticals, Inc.	Guggulphospholipid methods and compositions
AU2007327761A1 (en) *	2006-12-08	2008-06-12	Jado Technologies Gmbh	Cholesterylamines for the treatment and prevention of infectious diseases
EP2117603A2 (en) *	2006-12-19	2009-11-18	Bracco International B.V.	Targeting and therapeutic compounds and gas-filled microvesicles comprising said compounds

2010
- 2010-03-03 BR BRPI1009299A patent/BRPI1009299A2/pt not_active IP Right Cessation
- 2010-03-03 CA CA2754168A patent/CA2754168A1/en not_active Abandoned
- 2010-03-03 JP JP2012500176A patent/JP2012520840A/ja not_active Withdrawn
- 2010-03-03 AU AU2010225035A patent/AU2010225035A1/en not_active Abandoned
- 2010-03-03 RU RU2011142154/04A patent/RU2011142154A/ru unknown
- 2010-03-03 CN CN2010800222914A patent/CN102439018A/zh active Pending
- 2010-03-03 US US13/256,875 patent/US20120172336A2/en not_active Abandoned
- 2010-03-03 EP EP10711029A patent/EP2408791A1/en not_active Withdrawn
- 2010-03-03 WO PCT/EP2010/052719 patent/WO2010105910A1/en not_active Ceased

Also Published As

Publication number	Publication date
AU2010225035A1 (en)	2011-09-29
US20120172336A2 (en)	2012-07-05
EP2408791A1 (en)	2012-01-25
CN102439018A (zh)	2012-05-02
CA2754168A1 (en)	2010-09-23
US20120010173A1 (en)	2012-01-12
JP2012520840A (ja)	2012-09-10
RU2011142154A (ru)	2013-04-27
WO2010105910A1 (en)	2010-09-23

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Legal Events

Date	Code	Title	Description
2016-09-13	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 4A, 5A E 6A ANUIDADES.
2017-01-10	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.