BRPI9809153B8 - composto, processo para a preparação da 5-amino-2,4,6-triiodo-n,n'-bis(2,3-dihidroxipropil)-isoftalamida, e, uso da mesma - Google Patents

composto, processo para a preparação da 5-amino-2,4,6-triiodo-n,n'-bis(2,3-dihidroxipropil)-isoftalamida, e, uso da mesma

Info

Publication number: BRPI9809153B8
Authority: BR; Brazil
Prior art keywords: triiodo; isophthalamide; dihydroxypropyl; bis; amino
Prior art date: 1997-05-23

Application number

Other languages

English (en)

Portuguese (pt)

Inventor

Dick Malthe-Sorenssen

Audun Aukrust

Original Assignee

Nycomed Imaging As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-23

Filing date

1998-05-22

Publication date

2021-07-06

1998-05-22 Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As

2000-08-01 Publication of BRPI9809153A publication Critical patent/BRPI9809153A/pt

2017-11-14 Publication of BRPI9809153B1 publication Critical patent/BRPI9809153B1/pt

2021-07-06 Publication of BRPI9809153B8 publication Critical patent/BRPI9809153B8/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Steroid Compounds (AREA)
Polyamides (AREA)
Indole Compounds (AREA)

BRPI9809153-0 1997-05-23 1998-05-22 composto, processo para a preparação da 5-amino-2,4,6-triiodo-n,n'-bis(2,3-dihidroxipropil)-isoftalamida, e, uso da mesma BRPI9809153B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9710726.2A GB9710726D0 (en)	1997-05-23	1997-05-23	Compound
GB9710726.2		1997-05-23
PCT/GB1998/001492 WO1998052911A1 (en)	1997-05-23	1998-05-22	Yellow polymorph of 5-amino-2,4,6-triiodo-n,n'-bis(2,3-dihydroxypropyl)-isophthalamide

Publications (3)

Publication Number	Publication Date
BRPI9809153A BRPI9809153A (pt)	2000-08-01
BRPI9809153B1 BRPI9809153B1 (pt)	2017-11-14
BRPI9809153B8 true BRPI9809153B8 (pt)	2021-07-06

Family

ID=10812988

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI9809153-0 BRPI9809153B8 (pt)	1997-05-23	1998-05-22	composto, processo para a preparação da 5-amino-2,4,6-triiodo-n,n'-bis(2,3-dihidroxipropil)-isoftalamida, e, uso da mesma

Country Status (18)

Country	Link
US (1)	US6337422B1 (cs)
EP (1)	EP0983230B1 (cs)
JP (1)	JP4476366B2 (cs)
KR (1)	KR100543856B1 (cs)
CN (1)	CN1161324C (cs)
AT (1)	ATE256101T1 (cs)
AU (1)	AU725565B2 (cs)
BR (1)	BRPI9809153B8 (cs)
CA (1)	CA2290544A1 (cs)
CZ (1)	CZ297243B6 (cs)
DE (1)	DE69820435T2 (cs)
GB (1)	GB9710726D0 (cs)
HU (1)	HU224128B1 (cs)
IL (1)	IL133100A (cs)
NO (1)	NO327490B1 (cs)
PL (1)	PL190905B1 (cs)
PT (1)	PT983230E (cs)
WO (1)	WO1998052911A1 (cs)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7524515B2 (en) *	2003-01-10	2009-04-28	Mutual Pharmaceuticals, Inc.	Pharmaceutical safety dosage forms
EP1989179B1 (en)	2006-02-15	2011-01-26	Ge Healthcare As	Contrast agents
US7662859B2 (en)	2007-02-16	2010-02-16	Ge Healthcare As	Contrast agents
CN102271715A (zh)	2009-01-09	2011-12-07	通用电气医疗集团股份有限公司	对比剂组合物
EP2281807A1 (en) *	2009-07-21	2011-02-09	GE Healthcare AS	Decolorizing 5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, a contrast media intermediate
US20110021834A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	Continuous process of preparing intermediate for non-ionic x-ray contrast agents
US20110021833A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	Crystallization of an intermediate for synthesizing non-ionic x-ray contrast agents
JP6210988B2 (ja)	2011-09-19	2017-10-11	オレクソ・アクチエボラゲット	オピオイド依存を治療するための新規乱用耐性医薬組成物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1548594A (en) *	1976-06-11	1979-07-18	Nyegaard & Co As	Triiodoisophthalic acid amides
US4256729A (en) *	1979-03-23	1981-03-17	Mallinckrodt, Inc.	N,N'-Bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-keto-L-gulonamido)isophthalamide and radiological compositions containing same
US4396598A (en) *	1982-01-11	1983-08-02	Mallinckrodt, Inc.	Triiodoisophthalamide X-ray contrast agent
JPH0625094B2 (ja) *	1988-03-01	1994-04-06	マリンクロット，インコーポレイテッド	非イオン性ｘ線コントラスト剤、組成物及び方法
US5013865A (en) *	1988-04-06	1991-05-07	Mallinckrodt, Inc.	Process for the preparation of 2,4,6-triiodo-5-amino-N-alkylisophthalamic acid and 2,4,6-triiodo-5-amino-isophthalamide compounds
US5256393A (en) *	1991-04-16	1993-10-26	Mallinckrodt Medical, Inc.	Use of azeotropic distillation in process to dry 5-amino-N,N'bis (2,3-dihydroxypropyl)-2,4,6-triiodoisphthalamide
DE69524088T2 (de) *	1994-06-21	2002-08-29	Mallinckrodt, Inc.	Verbesserte synthese von ioversol unter verwendung einer mit phosphorsäure modifizierten koaddition
GB9419206D0 (en) *	1994-09-23	1994-11-09	Nycomed Innovation Ab	Contrast media
AU5773396A (en) *	1995-05-24	1996-12-11	Nycomed Imaging As	Iodination process

1997
- 1997-05-23 GB GBGB9710726.2A patent/GB9710726D0/en active Pending
1998
- 1998-05-22 WO PCT/GB1998/001492 patent/WO1998052911A1/en not_active Ceased
- 1998-05-22 CA CA002290544A patent/CA2290544A1/en not_active Abandoned
- 1998-05-22 BR BRPI9809153-0 patent/BRPI9809153B8/pt not_active IP Right Cessation
- 1998-05-22 CZ CZ0417199A patent/CZ297243B6/cs not_active IP Right Cessation
- 1998-05-22 CN CNB988053217A patent/CN1161324C/zh not_active Expired - Lifetime
- 1998-05-22 AU AU75407/98A patent/AU725565B2/en not_active Ceased
- 1998-05-22 DE DE69820435T patent/DE69820435T2/de not_active Expired - Lifetime
- 1998-05-22 AT AT98922947T patent/ATE256101T1/de active
- 1998-05-22 PL PL336848A patent/PL190905B1/pl unknown
- 1998-05-22 HU HU0003637A patent/HU224128B1/hu active IP Right Grant
- 1998-05-22 EP EP98922947A patent/EP0983230B1/en not_active Expired - Lifetime
- 1998-05-22 KR KR1019997010757A patent/KR100543856B1/ko not_active Expired - Lifetime
- 1998-05-22 JP JP55014098A patent/JP4476366B2/ja not_active Expired - Lifetime
- 1998-05-22 IL IL13310098A patent/IL133100A/en not_active IP Right Cessation
- 1998-05-22 PT PT98922947T patent/PT983230E/pt unknown
1999
- 1999-11-12 US US09/438,385 patent/US6337422B1/en not_active Expired - Lifetime
- 1999-11-19 NO NO19995676A patent/NO327490B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT983230E (pt)	2004-04-30
JP2001526678A (ja)	2001-12-18
PL336848A1 (en)	2000-07-17
KR100543856B1 (ko)	2006-01-23
NO995676D0 (no)	1999-11-19
US6337422B1 (en)	2002-01-08
CN1257479A (zh)	2000-06-21
BRPI9809153A (pt)	2000-08-01
KR20010012794A (ko)	2001-02-26
CZ417199A3 (cs)	2000-05-17
GB9710726D0 (en)	1997-07-16
IL133100A0 (en)	2001-03-19
PL190905B1 (pl)	2006-02-28
HU224128B1 (hu)	2005-05-30
NO995676L (no)	1999-11-19
AU725565B2 (en)	2000-10-12
EP0983230A1 (en)	2000-03-08
CZ297243B6 (cs)	2006-10-11
JP4476366B2 (ja)	2010-06-09
HUP0003637A3 (en)	2001-06-28
CA2290544A1 (en)	1998-11-26
HUP0003637A1 (hu)	2001-02-28
IL133100A (en)	2004-07-25
AU7540798A (en)	1998-12-11
DE69820435D1 (en)	2004-01-22
WO1998052911A1 (en)	1998-11-26
NO327490B1 (no)	2009-07-13
EP0983230B1 (en)	2003-12-10
BRPI9809153B1 (pt)	2017-11-14
CN1161324C (zh)	2004-08-11
DE69820435T2 (de)	2004-10-07
ATE256101T1 (de)	2003-12-15

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Legal Events

Date	Code	Title	Description
2017-11-14	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
2021-07-06	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/05/98, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO
2023-03-21	B21F	Lapse acc. art. 78, item iv - on non-payment of the annual fees in time	Free format text: REFERENTE A 25A ANUIDADE.
2023-04-11	B21H	Decision of lapse of a patent or of a certificate of addition of invention cancelled [chapter 21.8 patent gazette]	Free format text: ANULADA A PUBLICACAO CODIGO 21.6 NA RPI NO 2724 DE 21/03/2023 POR TER SIDO INDEVIDA.