BRPI9909456A - ácido quinolonecarboxílico ou sais dos mesmos - Google Patents

ácido quinolonecarboxílico ou sais dos mesmos

Info

Publication number
BRPI9909456A
BRPI9909456A BRPI9909456A BRPI9909456A BRPI9909456A BR PI9909456 A BRPI9909456 A BR PI9909456A BR PI9909456 A BRPI9909456 A BR PI9909456A BR PI9909456 A BRPI9909456 A BR PI9909456A BR PI9909456 A BRPI9909456 A BR PI9909456A
Authority
BR
Brazil
Prior art keywords
group
optionally substituted
salts
alkoxy
substituted alkyl
Prior art date
Application number
BRPI9909456A
Other languages
English (en)
Inventor
Kazuya Hayashi
Tokunori Kito
Junichi Mitsuyama
Tetsumi Yamakawa
Hiroshi Kuroda
Hiroyo Kawafuchi
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of BRPI9909456A publication Critical patent/BRPI9909456A/pt
Publication of BRPI9909456B1 publication Critical patent/BRPI9909456B1/pt
Publication of BRPI9909456B8 publication Critical patent/BRPI9909456B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"derivados de ácido quinelonecarboxílico ou sais dos mesmos" a presente invenção se refere a derivados de ácido quinelonecarboxílico tendo a fórmula geral (1) ou sais dos mesmos os quais apresentam potente efeito bactericida em bactérias grampositiva, em particular <mu>propionibacterium acnes<mv> na qual r¹ representa um átomo de hidrogênio ou um grupo carboxila protetor; r² representa um grupo cicloalquila opcionalmente substituído; r³ representa um átomo de hidrogênio, um átomo de halogênio, um grupo alquila, alcóxi ou alquiltio opcionalmente substituído, um grupo amino ou hidroxila opcionalmente protegido, ou a grupo nitro; r^ 4^ representa um grupo alquila ou alcóxi opcionalmente substituído; e z representa um grupo piridin-4-il ou piridin-3-il o qual é opcionalmente substituído com pelo menos um grupo selecionado a partir de um átomo de halogênio, um grupo alquila, alquenila, cicloalquila, alcóxi, alquiltio ou amino opcionalmente substituído e um grupo amino ou hidroxila opcionalmente protegido.
BRPI9909456-8B1 1998-04-06 1999-04-06 Ácido quinolonecarboxílico ou sais dos mesmos BRPI9909456B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP11014698 1998-04-06
JP34021798 1998-11-30
PCT/JP1999/001799 WO1999051588A1 (en) 1998-04-06 1999-04-06 Quinolonecarboxylic acid derivatives or salts thereof

Publications (3)

Publication Number Publication Date
BRPI9909456A true BRPI9909456A (pt) 2001-10-02
BRPI9909456B1 BRPI9909456B1 (pt) 2013-10-29
BRPI9909456B8 BRPI9909456B8 (pt) 2021-07-06

Family

ID=26449822

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9909456-8B1 BRPI9909456B8 (pt) 1998-04-06 1999-04-06 Ácido quinolonecarboxílico ou sais dos mesmos

Country Status (14)

Country Link
US (1) US6335447B1 (pt)
EP (1) EP1070713B1 (pt)
JP (1) JP3346766B2 (pt)
KR (1) KR100550078B1 (pt)
CN (1) CN1152029C (pt)
AT (1) ATE342897T1 (pt)
BR (1) BRPI9909456B8 (pt)
CA (1) CA2327328C (pt)
CY (1) CY1105845T1 (pt)
DE (1) DE69933660T2 (pt)
DK (1) DK1070713T3 (pt)
ES (1) ES2273479T3 (pt)
PT (1) PT1070713E (pt)
WO (1) WO1999051588A1 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4061194B2 (ja) * 2001-02-08 2008-03-12 富山化学工業株式会社 ６−置換アルキルアミノ−３−ピリジルホウ酸誘導体またはその塩およびそれらの製造法
EP1698336A1 (en) * 2005-03-01 2006-09-06 Ferrer Internacional, S.A. Antifungal compositions comprising Sertaconazole and either Hydrocortisone or an antibacterial agent
ES2553179T3 (es) * 2005-08-01 2015-12-04 Maruho Co., Ltd. Preparación de una loción que contiene un derivado del ácido piridoncarboxílico
EP2177208A1 (en) 2008-10-17 2010-04-21 Ferrer Internacional, S.A. Pharmaceutical topical compositions
EP2177209A1 (en) 2008-10-17 2010-04-21 Ferrer Internacional, S.A. Intravenous solutions and uses
EP2177214A1 (en) 2008-10-17 2010-04-21 Ferrer Internacional, S.A. Solid Oral Dosage Forms and Uses
TWI513688B (zh) * 2010-04-06 2015-12-21 Ferrer Int １－環丙基－８－甲基－７－〔５－甲基－６－（甲胺基）－３－吡啶基〕－４－側氧基－１，４－二氫－３－喹啉羧酸鹽
AU2010350521B2 (en) 2010-04-06 2015-04-16 Ferrer Internacional S.A. 1-cyclopropyl-8-methyl-7-[5-methyl-6-(methylamino)-3-pyridinyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid salts
EP3034078A1 (en) * 2010-09-27 2016-06-22 Emergent Product Development Gaithersburg Inc. 2-pyridone antimicrobial compositions
HRP20180483T1 (hr) * 2011-08-31 2018-05-04 Otsuka Pharmaceutical Co., Ltd. Spoj kinolona
EP3257512A4 (en) * 2015-02-13 2018-07-25 Maruho Co., Ltd. External preparation comprising pyridonecarboxylic acid derivative
US10570152B2 (en) * 2015-07-28 2020-02-25 Vyome Therapeutics Limited Antibacterial therapeutics and prophylactics
JP7347915B2 (ja) * 2016-04-28 2023-09-20 マルホ株式会社 抗菌剤
EP3549586A1 (en) 2016-12-01 2019-10-09 Maruho Co., Ltd. Medical skin external preparation
CN107121506B (zh) * 2017-04-13 2019-06-07 杭州华东医药集团新药研究院有限公司 奥泽沙星杂质及其用途
CN108299480A (zh) * 2017-12-27 2018-07-20 山东百诺医药股份有限公司 一种奥泽沙星及其中间体的制备方法
WO2020065668A1 (en) * 2018-09-26 2020-04-02 Maithri Drugs Pvt Ltd Crystalline form of ozenoxacin and processes for preparation thereof
CN111675692A (zh) * 2020-06-08 2020-09-18 浙江科技学院 一种奥泽沙星的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3441788A1 (de) * 1984-11-15 1986-05-15 Bayer Ag, 5090 Leverkusen Alkyl-1-cyclopropyl-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US5075319A (en) * 1987-09-08 1991-12-24 Sterling Drug Inc. Pyridinyl-quinolone compounds, their preparation and use
US4959363A (en) 1989-06-23 1990-09-25 Sterling Drug Inc. Quinolonecarboxamide compounds, their preparation and use as antivirals.
JP3145487B2 (ja) 1992-06-12 2001-03-12 シスメックス株式会社 粒子分析装置
DE4301246A1 (de) * 1993-01-19 1994-07-21 Bayer Ag Chinolon- und Naphthyridoncarbonsäurederivate
NZ296532A (en) * 1994-11-24 2000-02-28 F Substituted 5-benzyl-2,4,-diaminopyrimidines
KR100276477B1 (ko) * 1996-02-09 2000-12-15 나카노 가쓰히코 퀴놀론카복실산유도체또는그의염

Also Published As

Publication number Publication date
DK1070713T3 (da) 2006-12-27
CN1152029C (zh) 2004-06-02
EP1070713A1 (en) 2001-01-24
KR100550078B1 (ko) 2006-02-08
WO1999051588A1 (en) 1999-10-14
DE69933660D1 (de) 2006-11-30
JP3346766B2 (ja) 2002-11-18
CA2327328A1 (en) 1999-10-14
CN1299356A (zh) 2001-06-13
EP1070713A4 (en) 2004-09-01
BRPI9909456B1 (pt) 2013-10-29
DE69933660T2 (de) 2007-08-23
US6335447B1 (en) 2002-01-01
CA2327328C (en) 2007-11-13
ATE342897T1 (de) 2006-11-15
CY1105845T1 (el) 2011-02-02
KR20010042463A (ko) 2001-05-25
ES2273479T3 (es) 2007-05-01
BRPI9909456B8 (pt) 2021-07-06
EP1070713B1 (en) 2006-10-18
HK1039484A1 (en) 2002-04-26
PT1070713E (pt) 2006-12-29

Similar Documents

Publication Publication Date Title
DE60032780D1 (de) Tetrahydroquinolin-derivate
BR9912571A (pt) Derivado de diamida de ácido dicarboxìlicoheterocìclico fundido, herbicida, e, processo paraa utilização de um herbicida
LU91133I2 (fr) Vesicare 10mg et 5 mg solifenacinum succinatum 10 mg et 5 mg.
IL72100A (en) 6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid derivatives,their preparation and pharmaceutical compositions comprising them
PT976748E (pt) Derivados de pirrolidina com actividade inibidora de fosfolipase a2
NO922215L (no) Heterocyklisk substituerte 2-acylamino-5-tiazoler, deres fremstilling og farmasoeytiske preparater inneholdende dem
ATE71372T1 (de) Benzothiazol-derivat und es als aktiven bestandteil enthaltendes antirheumatisches mittel.
NO308848B1 (no) Kromanforbindelse og farmasøytisk preparat som inneholder den
NO20002169L (no) Nye pyridazinderivater og medikamenter inneholdende disse som effektive ingredienser
ATE129714T1 (de) Heterocyclische biphosphonsäurederivate.
CA2327328A1 (en) Quinolonecarboxylic acid derivatives or salts thereof
DK0882725T3 (da) Quinoloncarboxylsyrederivater eller deres salte
DE69010100D1 (de) Pyrimidinyl herbizides Mittel.
EP1020453A4 (en) 6,7-ASYMMETRICALLY DISUBSTITUTED CHINOXALINE CARBONIC ACID DERIVATIVES, ADDITIONAL SALTS THEREOF AND METHOD FOR THE PRODUCTION OF BOTH
DE69023321D1 (de) Antipicornaviral-Pyridazinamine.
DE69921151D1 (de) Fluorszierende marker
DK291488D0 (da) Alkansulfonanilidderivater
DK314483D0 (da) Peenem-derivater, fremgangsmade til fremstilling deraf samt deres anvendelse som laegemidler
DK0385721T3 (da) Fremgangsmåde til fremstilling af lactamderivater
BR0112881A (pt) Remédios para demência contendo derivados de 2-aril-8-oxodihidropurina como o ingrediente ativo
DE60239324D1 (de) Phenyl- und pyridyl-piperidine mit tnf-wirkung
DK0826663T3 (da) Alkynylaminosyrederivater og deres anvendelse som farmaceutiske forbindelser

Legal Events

Date Code Title Description
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/10/2013, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 06/04/99, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 24A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2717 DE 31-01-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.