CA1340672C - Derives de la cephalosporine - Google Patents

Derives de la cephalosporine

Info

Publication number: CA1340672C
Authority: CA; Canada
Prior art keywords: amino; compound; formula; mixture; thiadiazol
Prior art date: 1984-04-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA000616144A

Other languages

English (en)

Inventor

Takayuki Naito

Jun Okumura

Masahisa Oka

Haruhiro Yamashida

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bristol Myers Squibb Co

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-04-09

Filing date

1991-08-21

Publication date

1999-07-20

1991-08-21 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1999-07-20 Application granted granted Critical

1999-07-20 Publication of CA1340672C publication Critical patent/CA1340672C/fr

2005-02-14 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/79—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

CA000616144A 1984-04-09 1991-08-21 Derives de la cephalosporine Expired - Fee Related CA1340672C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US59794184A	1984-04-09	1984-04-09
US597,941		1984-04-09

Related Parent Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000615909A Division CA1340609C (fr)	1984-04-09	1990-10-25	Derives de la cephalosporine

Publications (1)

Publication Number	Publication Date
CA1340672C true CA1340672C (fr)	1999-07-20

Family

ID=24393575

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
CA000474260A Expired - Lifetime CA1276929C (fr)	1984-04-09	1985-02-14	Agents antibacteriens de cephalosporine
CA000616143A Expired - Fee Related CA1340638C (fr)	1984-04-09	1991-08-12	Derives de la cephalosporine
CA000616144A Expired - Fee Related CA1340672C (fr)	1984-04-09	1991-08-21	Derives de la cephalosporine

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
CA000474260A Expired - Lifetime CA1276929C (fr)	1984-04-09	1985-02-14	Agents antibacteriens de cephalosporine
CA000616143A Expired - Fee Related CA1340638C (fr)	1984-04-09	1991-08-12	Derives de la cephalosporine

Country Status (31)

Country	Link
JP (4)	JPS615084A (fr)
KR (1)	KR870002166B1 (fr)
AR (1)	AR244694A1 (fr)
AT (1)	AT388735B (fr)
AU (2)	AU580990B2 (fr)
BE (1)	BE902148A (fr)
CA (3)	CA1276929C (fr)
CH (1)	CH669197A5 (fr)
DD (3)	DD236735A5 (fr)
DE (1)	DE3512225A1 (fr)
DK (1)	DK155985A (fr)
ES (4)	ES8607318A1 (fr)
FI (1)	FI84830C (fr)
FR (1)	FR2563832B1 (fr)
GB (3)	GB2157293B (fr)
GR (1)	GR850883B (fr)
HU (2)	HU204277B (fr)
IE (2)	IE58408B1 (fr)
IL (1)	IL74826A (fr)
IT (1)	IT1190353B (fr)
LU (1)	LU85840A1 (fr)
MY (1)	MY101940A (fr)
NL (1)	NL192925C (fr)
NZ (1)	NZ211659A (fr)
OA (1)	OA07985A (fr)
PT (1)	PT80246B (fr)
RU (1)	RU2056425C1 (fr)
SE (4)	SE466205B (fr)
SU (4)	SU1367858A3 (fr)
YU (2)	YU46151B (fr)
ZA (1)	ZA852236B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS61145186A (ja) *	1984-12-20	1986-07-02	Meiji Seika Kaisha Ltd	新規セフエム化合物及びその製造法
US4708955A (en) *	1985-06-24	1987-11-24	Bristol-Myers Company	3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof
WO1987003875A1 (fr) *	1985-12-26	1987-07-02	Eisai Co., Ltd.	Derives de cephalosporine
IL84128A (en) *	1986-10-13	1992-12-01	Eisai Co Ltd	3-propenylcephem derivatives, their preparation and pharmaceutical compositions containing them
AU614723B2 (en) *	1986-10-13	1991-09-12	Eisai Co. Ltd.	3-propenylcephem derivative
JPH085897B2 (ja) *	1986-11-06	1996-01-24	エーザイ株式会社	３−プロペニルセフェム誘導体
FR2622585B1 (fr) *	1987-11-03	1991-04-19	Roussel Uclaf	Nouvelles cephalosporines comportant en position 3 un radical vinyle substitue, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus
JPH0699449B2 (ja) *	1988-03-16	1994-12-07	エーザイ株式会社	セフェム誘導体の合成中間体
DE68929368T2 (de) *	1988-03-16	2002-08-14	Eisai Co., Ltd.	Cephemderivate und Verfahren zu ihrer Herstellung
FR2655042B1 (fr) *	1989-11-29	1994-01-21	Adir Cie	Nouvelles benzothiazolinones substituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2663332B1 (fr) *	1990-06-15	1997-11-07	Roussel Uclaf	Nouvelles cephalosporines comportant en position 3 un radical propenyle substitue par un ammonium quaternaire, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus.
US5126336A (en) *	1990-08-23	1992-06-30	Bristol-Myers Squibb Company	Antibiotic c-3 catechol-substituted cephalosporin compounds, compositions and method of use thereof
AT396108B (de) *	1991-08-21	1993-06-25	Biochemie Gmbh	Neues verfahren und neue zwischenprodukte zur herstellung von 7-aminocephalosporansaeurederivaten
JPH0741484A (ja) *	1993-07-29	1995-02-10	Katayama Seiyakushiyo:Kk	セフェム化合物及び抗菌剤
KR100248851B1 (ko) *	1994-08-16	2000-04-01	이치로 키타사토	신규 세펨 유도체
JP4033630B2 (ja)	1998-06-22	2008-01-16	バジリアファルマスーチカアーゲー	プロペニルセファロスポリン誘導体
EP1666483B1 (fr)	2003-09-09	2011-08-17	Nippon Chemical Industrial Company Limited	Procede de production de derives de 3-chloromethyl-3-cepheme

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1342241A (en) *	1970-01-23	1974-01-03	Glaxo Lab Ltd	Cephalosporin compounds
US4390534A (en) *	1978-12-29	1983-06-28	Fujisawa Pharmaceutical Co., Ltd.	Cephem and cepham compounds
EP0025017A1 (fr) *	1979-08-28	1981-03-11	Ciba-Geigy Ag	Composés polyazathia, procédé pour leur préparation, compositions pharmaceutiques les contenant et utilisation de ces dernières
US4409214A (en) *	1979-11-19	1983-10-11	Fujisawa Pharmaceutical, Co., Ltd.	7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
GR75644B (fr) *	1980-06-18	1984-08-02	Fujisawa Pharmaceutical Co
GR78245B (fr) *	1980-09-12	1984-09-26	Ciba Geigy Ag
US4521413A (en) *	1981-09-14	1985-06-04	Fujisawa Pharmaceutical Co., Ltd.	Cephem compounds
US4486586A (en) *	1983-02-10	1984-12-04	Bristol-Myers Company	Cephalosporin derivatives

1985
- 1985-02-14 CA CA000474260A patent/CA1276929C/fr not_active Expired - Lifetime
- 1985-03-25 ZA ZA852236A patent/ZA852236B/xx unknown
- 1985-04-02 NZ NZ211659A patent/NZ211659A/xx unknown
- 1985-04-02 AR AR85299945A patent/AR244694A1/es active
- 1985-04-03 DK DK155985A patent/DK155985A/da not_active Application Discontinuation
- 1985-04-03 DD DD85274832A patent/DD236735A5/de unknown
- 1985-04-03 DE DE19853512225 patent/DE3512225A1/de active Granted
- 1985-04-03 SE SE8501680A patent/SE466205B/sv not_active IP Right Cessation
- 1985-04-03 DD DD85287524A patent/DD249024A5/de unknown
- 1985-04-04 AU AU40862/85A patent/AU580990B2/en not_active Expired
- 1985-04-04 PT PT80246A patent/PT80246B/pt unknown
- 1985-04-04 IE IE86685A patent/IE58408B1/en not_active IP Right Cessation
- 1985-04-04 CH CH1498/85A patent/CH669197A5/de not_active IP Right Cessation
- 1985-04-04 NL NL8501002A patent/NL192925C/nl not_active IP Right Cessation
- 1985-04-04 FI FI851379A patent/FI84830C/fi not_active IP Right Cessation
- 1985-04-04 OA OA58561A patent/OA07985A/fr unknown
- 1985-04-04 GB GB08508846A patent/GB2157293B/en not_active Expired
- 1985-04-05 IL IL74826A patent/IL74826A/xx not_active IP Right Cessation
- 1985-04-05 IT IT20267/85A patent/IT1190353B/it active
- 1985-04-05 FR FR8505281A patent/FR2563832B1/fr not_active Expired
- 1985-04-05 AT AT0103985A patent/AT388735B/de not_active IP Right Cessation
- 1985-04-05 LU LU85840A patent/LU85840A1/fr unknown
- 1985-04-08 ES ES542013A patent/ES8607318A1/es not_active Expired
- 1985-04-08 RU SU853878102A patent/RU2056425C1/ru active
- 1985-04-08 GR GR850883A patent/GR850883B/el not_active IP Right Cessation
- 1985-04-09 BE BE0/214810A patent/BE902148A/fr not_active IP Right Cessation
- 1985-04-09 YU YU60085A patent/YU46151B/sh unknown
- 1985-04-09 HU HU87151A patent/HU204277B/hu unknown
- 1985-04-09 HU HU851299A patent/HU193750B/hu unknown
- 1985-04-09 KR KR1019850002383A patent/KR870002166B1/ko not_active Expired
- 1985-04-09 JP JP60075233A patent/JPS615084A/ja active Granted
- 1985-11-12 JP JP60252139A patent/JPS61143391A/ja active Granted
- 1985-11-12 JP JP60252138A patent/JPS61143390A/ja active Granted
- 1985-11-12 JP JP60252140A patent/JPS61143387A/ja active Granted
1986
- 1986-01-31 ES ES551550A patent/ES8706155A1/es not_active Expired
- 1986-01-31 ES ES551551A patent/ES8706694A1/es not_active Expired
- 1986-02-06 SU SU864023036A patent/SU1367858A3/ru active
- 1986-02-06 SU SU864019975A patent/SU1487814A3/ru active
- 1986-02-06 SU SU864018257A patent/SU1375140A3/ru active
- 1986-02-06 SU SU864020682A patent/SU1436882A3/ru active
- 1986-03-03 DD DD86287525A patent/DD251752A5/de unknown
- 1986-09-10 ES ES557060A patent/ES8800949A1/es not_active Expired
1987
- 1987-06-25 YU YU118987A patent/YU46213B/sh unknown
- 1987-09-10 GB GB08721347A patent/GB2194790B/en not_active Expired
- 1987-09-10 GB GB08721346A patent/GB2194789B/en not_active Expired
- 1987-10-01 MY MYPI87002761A patent/MY101940A/en unknown
1988
- 1988-11-11 AU AU25041/88A patent/AU610278B2/en not_active Expired
1989
- 1989-04-04 IE IE121089A patent/IE58403B1/en not_active IP Right Cessation
- 1989-04-06 SE SE8901225A patent/SE505256C2/sv not_active IP Right Cessation
- 1989-04-06 SE SE8901226A patent/SE470260B/sv not_active IP Right Cessation
- 1989-04-06 SE SE8901224A patent/SE470259B/sv not_active IP Right Cessation
1991
- 1991-08-12 CA CA000616143A patent/CA1340638C/fr not_active Expired - Fee Related
- 1991-08-21 CA CA000616144A patent/CA1340672C/fr not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR850007424A (ko)	1985-12-04
SE8901226D0 (sv)	1989-04-06
IL74826A (en)	1990-01-18
JPH0350754B2 (fr)	1991-08-02
FI84830C (fi)	1992-01-27
IT8520267A0 (it)	1985-04-05
GB2157293A (en)	1985-10-23
GB2194789B (en)	1988-10-12
GB2194789A (en)	1988-03-16
SE470260B (sv)	1993-12-20
AU610278B2 (en)	1991-05-16
SE505256C2 (sv)	1997-07-21
SU1436882A3 (ru)	1988-11-07
DE3512225A1 (de)	1985-10-17
NL192925B (nl)	1998-01-05
KR870002166B1 (ko)	1987-12-14
SE466205B (sv)	1992-01-13
JPS615084A (ja)	1986-01-10
YU46213B (sh)	1993-05-28
SU1375140A3 (ru)	1988-02-15
JPS61143390A (ja)	1986-07-01
CA1276929C (fr)	1990-11-27
IE58403B1 (en)	1993-09-22
ES551550A0 (es)	1987-06-01
AU580990B2 (en)	1989-02-09
AU4086285A (en)	1985-10-17
YU46151B (sh)	1993-05-28
ES551551A0 (es)	1987-07-01
DD251752A5 (de)	1987-11-25
JPS61143387A (ja)	1986-07-01
JPS61143391A (ja)	1986-07-01
ES8706155A1 (es)	1987-06-01
DD249024A5 (de)	1987-08-26
SU1367858A3 (ru)	1988-01-15
YU118987A (en)	1988-10-31
IE58408B1 (en)	1993-09-22
GB2194790A (en)	1988-03-16
HU204277B (en)	1991-12-30
GB2157293B (en)	1988-10-05
SE8901225D0 (sv)	1989-04-06
PT80246B (pt)	1987-10-20
ATA103985A (de)	1989-01-15
JPH0351716B2 (fr)	1991-08-07
ZA852236B (en)	1985-11-27
FI851379A0 (fi)	1985-04-04
FI84830B (fi)	1991-10-15
SU1487814A3 (ru)	1989-06-15
CH669197A5 (de)	1989-02-28
GB8508846D0 (en)	1985-05-09
SE8901224D0 (sv)	1989-04-06
JPH0262557B2 (fr)	1990-12-26
SE8501680L (sv)	1985-10-10
IE850866L (en)	1985-10-09
NL8501002A (nl)	1985-11-01
AR244694A1 (es)	1993-11-30
DK155985A (da)	1985-10-10
MY101940A (en)	1992-02-15
SE8901225L (sv)	1989-04-06
HU193750B (en)	1987-11-30
SE470259B (sv)	1993-12-20
AT388735B (de)	1989-08-25
GR850883B (fr)	1985-11-25
SE8901224L (sv)	1989-04-06
NZ211659A (en)	1988-11-29
IT1190353B (it)	1988-02-16
OA07985A (fr)	1987-01-31
YU60085A (en)	1987-12-31
HUT37622A (en)	1986-01-23
AU2504188A (en)	1989-03-02
ES542013A0 (es)	1986-06-16
LU85840A1 (fr)	1985-12-16
DD236735A5 (de)	1986-06-18
ES8800949A1 (es)	1987-12-01
PT80246A (en)	1985-05-01
SE8501680D0 (sv)	1985-04-03
ES8607318A1 (es)	1986-06-16
JPH0357106B2 (fr)	1991-08-30
RU2056425C1 (ru)	1996-03-20
FR2563832A1 (fr)	1985-11-08
ES8706694A1 (es)	1987-07-01
NL192925C (nl)	1998-05-07
DK155985D0 (da)	1985-04-03
GB2194790B (en)	1988-10-05
ES557060A0 (es)	1987-12-01
FR2563832B1 (fr)	1989-08-18
GB8721346D0 (en)	1987-10-14
BE902148A (fr)	1985-10-09
CA1340638C (fr)	1999-07-06
FI851379L (fi)	1985-10-10
DE3512225C2 (fr)	1990-02-22
GB8721347D0 (en)	1987-10-14
IL74826A0 (en)	1985-07-31
SE8901226L (sv)	1989-04-06

Legal Events

Date	Code	Title	Description
2007-07-20	MKLA	Lapsed

Publication	Publication Date	Title
CA1340672C (fr)	1999-07-20	Derives de la cephalosporine
US4839350A (en)	1989-06-13	Cephalosporin compounds and the production thereof
US5244890A (en)	1993-09-14	Cephem compounds
US4487767A (en)	1984-12-11	7-[Amino or carboxy substituted oxyimino]-3-[amino or alkoxy substituted heterocyclic thiomethyl] cephalosporin derivatives
US4943567A (en)	1990-07-24	Cephalosporin compound and pharmaceutical composition thereof
US4751295A (en)	1988-06-14	Cephalosporin derivatives
US4703046A (en)	1987-10-27	Cephem compounds and processes for preparation thereof
JPH0723380B2 (ja)	1995-03-15	新規セフェム化合物
JPS5932475B2 (ja)	1984-08-09	２−アルキル−７−置換−２もしくは３−セフエム−４−カルボン酸化合物類およびその塩類およびそれらの製造法
US4988686A (en)	1991-01-29	Cephem compounds and anti-bacterial agent
CA1340609C (fr)	1999-06-22	Derives de la cephalosporine
US4687769A (en)	1987-08-18	3-(3,3,3-trifluoropropenyl) cephalosporins
US4350694A (en)	1982-09-21	Cephalosporin analogues and antimicrobial compositions
JPH0364503B2 (fr)	1991-10-07
US4761409A (en)	1988-08-02	Cephem derivatives
GB2034692A (en)	1980-06-11	New cephem compounds and processes for preparation thereof
US4408042A (en)	1983-10-04	Cephem compounds
JPH035486A (ja)	1991-01-11	チアゾリルアセトアミドセフェム誘導体
JPS6127991A (ja)	1986-02-07	セフアロスポリン誘導体その製造法およびそれを有効成分とする抗菌剤
CZ286386B6 (cs)	2000-03-15	3-Cefem-4-karboxylátové deriváty, způsob jejich přípravy, a farmaceutický prostředek, který je obsahuje
JPS62228084A (ja)	1987-10-06	セフアロスポリン誘導体
JPS6388187A (ja)	1988-04-19	３−アンモニオプロペニルセフエム誘導体
JPH06306081A (ja)	1994-11-01	新規セフェム化合物
JPH0240073B2 (ja)	1990-09-10	Shinkisefuarosuhorinkagobutsuoyobisoreojukoseibuntosurukokinzai