CA2041380C - Use of protein c or activated protein c for preparing a pharmaceutical preparation - Google Patents

Use of protein c or activated protein c for preparing a pharmaceutical preparation

Info

Publication number
CA2041380C
CA2041380C CA002041380A CA2041380A CA2041380C CA 2041380 C CA2041380 C CA 2041380C CA 002041380 A CA002041380 A CA 002041380A CA 2041380 A CA2041380 A CA 2041380A CA 2041380 C CA2041380 C CA 2041380C
Authority
CA
Canada
Prior art keywords
protein
activated protein
set forth
preparing
pharmaceutical preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002041380A
Other languages
English (en)
French (fr)
Other versions
CA2041380A1 (en
Inventor
Johann Eibl
Ludwig Pichler
Hans-Peter Schwarz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oesterreichisches Institut fuer Haemoderivate
Original Assignee
Immuno AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immuno AG filed Critical Immuno AG
Publication of CA2041380A1 publication Critical patent/CA2041380A1/en
Application granted granted Critical
Publication of CA2041380C publication Critical patent/CA2041380C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA002041380A 1990-08-16 1991-04-26 Use of protein c or activated protein c for preparing a pharmaceutical preparation Expired - Fee Related CA2041380C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ATA1697/90 1990-08-16
AT0169790A AT402260B (de) 1990-08-16 1990-08-16 Protein c-hältige pharmazeutische präparation
EP91890012.7 1991-01-28
EP91890012A EP0471660B1 (de) 1990-08-16 1991-01-28 Protein C zur Schmerzbekämpfung

Publications (2)

Publication Number Publication Date
CA2041380A1 CA2041380A1 (en) 1992-02-17
CA2041380C true CA2041380C (en) 1997-10-07

Family

ID=3519039

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002041380A Expired - Fee Related CA2041380C (en) 1990-08-16 1991-04-26 Use of protein c or activated protein c for preparing a pharmaceutical preparation

Country Status (12)

Country Link
EP (3) EP0533209B1 (cs)
JP (1) JP2530770B2 (cs)
AT (6) AT402260B (cs)
CA (1) CA2041380C (cs)
CZ (1) CZ280004B6 (cs)
DE (3) DE59108638D1 (cs)
DK (3) DK0533210T3 (cs)
ES (3) ES2102435T3 (cs)
HR (1) HRP921237A2 (cs)
HU (1) HUT60147A (cs)
RU (1) RU2066550C1 (cs)
YU (1) YU77591A (cs)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11491214B2 (en) 2014-04-16 2022-11-08 Zz Biotech Llc Treatment of abnormal cutaneous scarring
US11617785B2 (en) 2012-07-04 2023-04-04 Zz Biotech Llc Treatment of inflammatory skin disorders
US12214024B2 (en) 2014-04-16 2025-02-04 Zz Biotech Llc Use of APC analogue for wound healing

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571786A (en) * 1990-08-16 1996-11-05 Immuno Aktiengesellschaft Use of protein C or the activation peptide of protein C for preparing a pharmaceutical preparation
AT397615B (de) * 1991-05-14 1994-05-25 Immuno Ag Arzneimittel enthaltend protein c
DE4320294A1 (de) * 1993-06-18 1994-12-22 Immuno Ag Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen
DE19608218A1 (de) * 1995-03-21 1996-09-26 Immuno Ag Mittel zur subkutanen Verabreichung von Protein C
EP0733371B1 (de) * 1995-03-21 2002-06-19 Baxter Aktiengesellschaft Mittel zur subkutanen Verabreichung von Protein C
US20080293631A1 (en) * 2005-01-07 2008-11-27 Christopher John Jackson Treatment for Autoimmune and Inflammatory Conditions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2739050B2 (ja) * 1988-01-28 1998-04-08 ヘキスト薬品工業株式会社 抗血液凝固剤
US5093117A (en) * 1989-01-24 1992-03-03 Baxter International Inc. Compositions and method for the treatment or prophylaxis of sepsis or septic shock

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11617785B2 (en) 2012-07-04 2023-04-04 Zz Biotech Llc Treatment of inflammatory skin disorders
US11491214B2 (en) 2014-04-16 2022-11-08 Zz Biotech Llc Treatment of abnormal cutaneous scarring
US12214024B2 (en) 2014-04-16 2025-02-04 Zz Biotech Llc Use of APC analogue for wound healing

Also Published As

Publication number Publication date
CA2041380A1 (en) 1992-02-17
EP0533210A1 (de) 1993-03-24
HU911348D0 (en) 1991-10-28
EP0471660B1 (de) 1995-08-23
DE59108697D1 (de) 1997-06-05
ES2103861T3 (es) 1997-10-01
JPH04230633A (ja) 1992-08-19
ATA20492A (de) 1997-10-15
EP0533209A1 (de) 1993-03-24
EP0471660A2 (de) 1992-02-19
DE59108638D1 (de) 1997-04-30
EP0533210B1 (de) 1997-05-02
RU2066550C1 (ru) 1996-09-20
HUT60147A (en) 1992-08-28
AT403763B (de) 1998-05-25
DK0533210T3 (da) 1997-11-03
HRP921237A2 (en) 1995-10-31
ATE150649T1 (de) 1997-04-15
ES2102435T3 (es) 1997-08-01
AT402260B (de) 1997-03-25
DK0533209T3 (da) 1997-09-22
ES2080289T3 (es) 1996-02-01
EP0471660A3 (en) 1992-04-15
CZ280004B6 (cs) 1995-09-13
YU77591A (sh) 1995-10-24
DE59106292D1 (de) 1995-09-28
ATE152354T1 (de) 1997-05-15
EP0533209B1 (de) 1997-03-26
ATA20392A (de) 1997-07-15
ATA169790A (de) 1996-08-15
JP2530770B2 (ja) 1996-09-04
CS121391A3 (en) 1992-02-19
ATE126699T1 (de) 1995-09-15
DK0471660T3 (da) 1995-12-18
AT403439B (de) 1998-02-25

Similar Documents

Publication Publication Date Title
CA2071651C (en) A parenterally administrable drug having thrombolytic activity and containing protein c
AU630477B2 (en) Factor xa based anticoagulant compositions
CA2014470A1 (en) Plasminogen activator complex of pure pro-urokinase covalently bound by a disulfide bridge to human serum albumin
CA2068630C (en) Use of protein c or activated protein c
US5571786A (en) Use of protein C or the activation peptide of protein C for preparing a pharmaceutical preparation
EP0310065A2 (en) Fibrinolytic activity enhancer
JP2530770B2 (ja) プロテインｃおよび活性化プロテインｃの新規用途
US5830467A (en) Pharmaceutical preparation containing protein C and a thrombolytically active substance
EP0124613A1 (en) Novel plasminogen activator derived from human kidneys, process for its preparation, and thrombolytic drug containing the same
WO1988001175A1 (en) Cofactor of prourokinase

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed