CA2172607C - Derives de la phorbine et leur emploi pour le diagnostic et le traitement du cancer - Google Patents

Derives de la phorbine et leur emploi pour le diagnostic et le traitement du cancer

Info

Publication number
CA2172607C
CA2172607C CA002172607A CA2172607A CA2172607C CA 2172607 C CA2172607 C CA 2172607C CA 002172607 A CA002172607 A CA 002172607A CA 2172607 A CA2172607 A CA 2172607A CA 2172607 C CA2172607 C CA 2172607C
Authority
CA
Canada
Prior art keywords
phorbine
tetramethyl
ethyl
derivative
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002172607A
Other languages
English (en)
Other versions
CA2172607A1 (fr
Inventor
Shimon Gatt
Rene Santus
Arie Dagan
Jean-Claude Maziere
J. Donald Chapman
Edward L. Engelhardt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Yissum Research Development Co of Hebrew University of Jerusalem
Fox Chase Cancer Center
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Yissum Research Development Co of Hebrew University of Jerusalem
Fox Chase Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM, Yissum Research Development Co of Hebrew University of Jerusalem, Fox Chase Cancer Center filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Publication of CA2172607A1 publication Critical patent/CA2172607A1/fr
Application granted granted Critical
Publication of CA2172607C publication Critical patent/CA2172607C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0485—Porphyrins, texaphyrins wherein the nitrogen atoms forming the central ring system complex the radioactive metal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Des dérivés de phorbine très puissants et d'une absorptivité comprise entre 650 et 780 nanomètres sont aptes à être utilisés pour le diagnostic et la thérapie du cancer, en particulier la thérapie photodynamique.
CA002172607A 1993-09-24 1994-09-15 Derives de la phorbine et leur emploi pour le diagnostic et le traitement du cancer Expired - Fee Related CA2172607C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/126,361 US5492924A (en) 1993-09-24 1993-09-24 Phorbine derivatives and their use in the diagnosis and therapy of cancer
US126,361 1993-09-24
PCT/US1994/010450 WO1995008551A1 (fr) 1993-09-24 1994-09-15 Derives de phorbine et leur utilisation pour le diagnostic et la therapie du cancer

Publications (2)

Publication Number Publication Date
CA2172607A1 CA2172607A1 (fr) 1995-03-30
CA2172607C true CA2172607C (fr) 1999-12-14

Family

ID=22424405

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002172607A Expired - Fee Related CA2172607C (fr) 1993-09-24 1994-09-15 Derives de la phorbine et leur emploi pour le diagnostic et le traitement du cancer

Country Status (4)

Country Link
US (1) US5492924A (fr)
EP (1) EP0720610A4 (fr)
CA (1) CA2172607C (fr)
WO (1) WO1995008551A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1318807A4 (fr) * 2000-08-11 2008-02-20 Ceramoptec Gmbh Onguent photosensibilisant
RU2291700C2 (ru) * 2002-11-20 2007-01-20 Артур Афанасьевич Мак Способ фотодинамического воздействия на вирусы или клетки
US7825153B2 (en) * 2004-08-16 2010-11-02 Ceramoptec Industries, Inc. Photosensitizer formulations and their use
WO2007064841A2 (fr) 2005-11-30 2007-06-07 North Carolina State University Composes porphyriniques destines a une cytometrie de flux
US20070299046A1 (en) * 2006-06-26 2007-12-27 Mai Nguyen Brooks Orally available light-independent antineoplastic compounds

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58981A (ja) * 1981-06-26 1983-01-06 Tama Seikagaku Kk 水溶性ポルフイリン誘導体
JPS6081128A (ja) * 1983-10-13 1985-05-09 Advance Res & Dev Co Ltd 腫瘍の光化学的診断乃至治療剤
JPS6092287A (ja) * 1983-10-24 1985-05-23 Toyo Hatsuka Kogyo Kk ９−デスオキソ−９−ハイドロオキシ−フエオホ−バイド誘導体およびそれらのアルカリ塩類
JPS617279A (ja) * 1984-06-22 1986-01-13 Toyo Hatsuka Kogyo Kk フエオホ−バイド誘導体及びそれらのアルカリ塩類
US4675338A (en) * 1984-07-18 1987-06-23 Nippon Petrochemicals Co., Ltd. Tetrapyrrole therapeutic agents
JPH0615545B2 (ja) * 1984-10-01 1994-03-02 東洋薄荷工業株式会社 金属フェオホーバイド誘導体および金属ポルフィリン誘導体
DD248282A1 (de) * 1984-10-08 1987-08-05 Univ Berlin Humboldt Mittel zur behandlung von hauterkrankungen und tumoren
US4977177A (en) * 1985-04-30 1990-12-11 Nippon Petrochemicals Company, Ltd. Tetrapyrrole polyaminomonocarboxylic acid therapeutic agents
KR910009202B1 (ko) * 1985-10-23 1991-11-04 니혼메디피직스 가부시끼가이샤 포르피린 유도체의 제조방법
JPS634805A (ja) * 1986-06-24 1988-01-09 Mitsui Eng & Shipbuild Co Ltd 低温熱源利用液体分離・濃縮・脱水装置
JPH0717646B2 (ja) * 1986-08-26 1995-03-01 株式会社アドバンス 新規フエオフオルバイド誘導体及び腫瘍診断薬
JPS63101384A (ja) * 1986-10-17 1988-05-06 Hamari Yakuhin Kogyo Kk フエオフオルバイド誘導体
JPS63196586A (ja) * 1987-02-12 1988-08-15 Toyo Hatsuka Kogyo Kk バクテリオフエオホ−バイド誘導体
JPH0825904B2 (ja) * 1987-03-30 1996-03-13 浜松ホトニクス株式会社 選択的腫瘍治療用組成物
JPS63290881A (ja) * 1987-04-20 1988-11-28 Hamari Yakuhin Kogyo Kk フエオフオルバイト誘導体
JPS6461481A (en) * 1987-09-01 1989-03-08 Toyo Hakka Kogyo Kk Porphyrin derivative
JPH0629196B2 (ja) * 1987-12-01 1994-04-20 甲子郎 梅村 超音波による腫瘍治療用生理作用増強剤
JPH0786109B2 (ja) * 1987-12-21 1995-09-20 浜理薬品工業株式会社 フェオフォルバイド誘導体
US5004811A (en) * 1987-12-24 1991-04-02 Nippon Petrochemicals Company, Ltd. Tetrapyrrole aminocarboxylic acids
JPH0249664A (ja) * 1988-03-17 1990-02-20 Terumo Corp シリンジ及び注射装置
US5093349A (en) * 1988-07-20 1992-03-03 Health Research Inc. Photosensitizing agents
US5002962A (en) * 1988-07-20 1991-03-26 Health Research, Inc. Photosensitizing agents
US5198460A (en) * 1988-07-20 1993-03-30 Health Research Inc. Pyropheophorbides and their use in photodynamic therapy
JPH03284681A (ja) * 1990-03-30 1991-12-16 Toyo Hatsuka Kogyo Kk ポルフィリン誘導体
JP2963178B2 (ja) * 1990-09-27 1999-10-12 株式会社エス・エル・ティ・ジャパン 水溶性フェオホーバイドａの製造方法
US5169944A (en) * 1991-04-12 1992-12-08 Board Of Regents Of The University Of Washington Methods and compositions for the enteral administration of hepatobiliary MRI contrast agents
FR2712493B1 (fr) * 1993-11-16 1996-01-19 Centre Nat Rech Scient Utilisation de photosensibilisateurs dérivés du noyau phorbine pour la décontamination du sang infecté par des parasites et/ou des virus.

Also Published As

Publication number Publication date
US5492924A (en) 1996-02-20
EP0720610A1 (fr) 1996-07-10
EP0720610A4 (fr) 1997-04-02
WO1995008551A1 (fr) 1995-03-30
CA2172607A1 (fr) 1995-03-30

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