CA2185794C - Medicaments destines a soulager les effets secondaires provoques par des immunodepresseurs - Google Patents
Medicaments destines a soulager les effets secondaires provoques par des immunodepresseurs Download PDFInfo
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- CA2185794C CA2185794C CA002185794A CA2185794A CA2185794C CA 2185794 C CA2185794 C CA 2185794C CA 002185794 A CA002185794 A CA 002185794A CA 2185794 A CA2185794 A CA 2185794A CA 2185794 C CA2185794 C CA 2185794C
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- 239000007902 hard capsule Substances 0.000 description 1
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- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000003118 histopathologic effect Effects 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
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- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000001361 intraarterial administration Methods 0.000 description 1
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- 238000001990 intravenous administration Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 238000001325 log-rank test Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229960001428 mercaptopurine Drugs 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- 208000026775 severe diarrhea Diseases 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000004926 tubular epithelial cell Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1833—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention concerne un médicament contenant un facteur de croissance des hépatocytes (HGF), utilisé comme ingrédient actif pour soulager les effets secondaires provoqués par des immunodépresseurs, un procédé de soulagement d'effets secondaires provoqués par des immunodépresseurs par administration de HGF, ainsi que l'utilisation de ce dernier dans la production du médicament. Etant donné que le HGF est utilisé pour soulager des effets secondaires sur plusieurs organes ou sur l'organisme, ce médicament peut influer sur les limitations apportées aux schémas posologiques d'immunodépresseurs, il peut améliorer à la fois la vitesse de cicatrisation dans diverses maladies et le pourcentage de succès de transplantations d'organes dans lesquelles on utilise des immunodépresseurs, et il est remarquable dans son effet de soulagement des patients.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP07427294A JP3962097B2 (ja) | 1994-03-18 | 1994-03-18 | 免疫抑制剤による副作用の軽減剤 |
| JP74272/1994 | 1994-03-18 | ||
| PCT/JP1995/000329 WO1995025537A1 (fr) | 1994-03-18 | 1995-03-01 | Medicaments destines a soulager les effets secondaires provoques par des immunodepresseurs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2185794A1 CA2185794A1 (fr) | 1995-09-28 |
| CA2185794C true CA2185794C (fr) | 2007-01-30 |
Family
ID=13542322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002185794A Expired - Fee Related CA2185794C (fr) | 1994-03-18 | 1995-03-01 | Medicaments destines a soulager les effets secondaires provoques par des immunodepresseurs |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5776464A (fr) |
| EP (1) | EP0803256B1 (fr) |
| JP (1) | JP3962097B2 (fr) |
| AT (1) | ATE243527T1 (fr) |
| AU (1) | AU1860895A (fr) |
| CA (1) | CA2185794C (fr) |
| DE (1) | DE69531166T2 (fr) |
| WO (1) | WO1995025537A1 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4006058B2 (ja) * | 1997-03-11 | 2007-11-14 | 第一三共株式会社 | 多臓器不全予防及び／又は治療剤 |
| AU734766B2 (en) * | 1997-03-14 | 2001-06-21 | Atlas Pharmaceuticals Inc. | Agent for preventing and/or treating cachexia |
| EP1867996A1 (fr) * | 2000-08-28 | 2007-12-19 | Damavand Wound AB | Trousse pour déterminer d'HGF dans des excréments |
| US20050026893A1 (en) * | 2003-05-30 | 2005-02-03 | Kosan Biosciences, Inc. | Method for treating diseases using HSP90-inhibiting agents in combination with immunosuppressants |
| CN101102788A (zh) | 2005-01-24 | 2008-01-09 | 克霖固鲁制药股份有限公司 | 移植器官纤维化抑制剂 |
| US8575099B2 (en) * | 2006-04-20 | 2013-11-05 | Osaka University | Agent for treating polyglutamine aggregation-caused disease or suppressing onset thereof |
| JP2015000001A (ja) * | 2013-06-12 | 2015-01-05 | 株式会社明治 | 過敏性腸症候群モデル動物の作成方法 |
| EP3347034B1 (fr) | 2015-09-11 | 2024-05-29 | The Schepens Eye Research Institute, Inc. | Composition liant le récepteur du facteur de croissance des hépatocytes (hgfr) pour son utilisation dans une méthode de traitement du trouble ou de la cicatrisation de la cornée |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03204899A (ja) * | 1989-09-21 | 1991-09-06 | Otsuka Pharmaceut Co Ltd | ヒト肝再生因子、そのｄｎａ塩基配列、該配列を含むプラスミド及び形質転換体並びにリコンビナント肝再生因子 |
| JP2750372B2 (ja) * | 1990-06-19 | 1998-05-13 | 敏一 中村 | 賢疾患治療剤 |
| JP3030386B2 (ja) * | 1991-05-15 | 2000-04-10 | 敏一 中村 | 抗ガン剤 |
| JP3394982B2 (ja) * | 1991-11-07 | 2003-04-07 | 敏一 中村 | ガン療法用副作用防止剤 |
| EP0661993B1 (fr) * | 1992-09-16 | 1997-05-07 | Genentech, Inc. | Protection contre des lesions hepatiques au moyen du facteur de croissance d'hepatocytes (hgf) |
-
1994
- 1994-03-18 JP JP07427294A patent/JP3962097B2/ja not_active Expired - Fee Related
-
1995
- 1995-03-01 US US08/716,141 patent/US5776464A/en not_active Expired - Lifetime
- 1995-03-01 AU AU18608/95A patent/AU1860895A/en not_active Abandoned
- 1995-03-01 AT AT95910722T patent/ATE243527T1/de not_active IP Right Cessation
- 1995-03-01 CA CA002185794A patent/CA2185794C/fr not_active Expired - Fee Related
- 1995-03-01 DE DE69531166T patent/DE69531166T2/de not_active Expired - Lifetime
- 1995-03-01 WO PCT/JP1995/000329 patent/WO1995025537A1/fr not_active Ceased
- 1995-03-01 EP EP95910722A patent/EP0803256B1/fr not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0803256A4 (fr) | 2000-07-05 |
| EP0803256A1 (fr) | 1997-10-29 |
| JP3962097B2 (ja) | 2007-08-22 |
| CA2185794A1 (fr) | 1995-09-28 |
| DE69531166T2 (de) | 2004-05-06 |
| ATE243527T1 (de) | 2003-07-15 |
| WO1995025537A1 (fr) | 1995-09-28 |
| US5776464A (en) | 1998-07-07 |
| JPH07258111A (ja) | 1995-10-09 |
| DE69531166D1 (de) | 2003-07-31 |
| AU1860895A (en) | 1995-10-09 |
| EP0803256B1 (fr) | 2003-06-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20140303 |